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Exercise-Related Acute Cardiovascular Events and Potential Deleterious Adaptations Following Long-Term Exercise Training: Placing the Risks Into Perspective-An Update: A Scientific Statement From the American Heart Association.
and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council Abstract Epidemiological and biological plausibility studies support a cause-and-effect relationship between increased levels of physical activity or cardiorespiratory fitness and reduced coronary heart disease events. These data, plus the well-documented anti-aging effects of exercise, have likely contributed to the escalating numbers of adults who have embraced the notion that "more exercise is better." As a result, worldwide participation in endurance training, competitive long distance endurance events, and high-intensity interval training...
Source: Circulation - February 25, 2020 Category: Cardiology Authors: Franklin BA, Thompson PD, Al-Zaiti SS, Albert CM, Hivert MF, Levine BD, Lobelo F, Madan K, Sharrief AZ, Eijsvogels TMH, American Heart Association Physical Activity Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascula Tags: Circulation Source Type: research

Patient-Led Mass Screening for Atrial Fibrillation in the Older Population Using Handheld Electrocardiographic Devices Integrated With a Clinician-Coordinated Remote Central Monitoring System: Protocol for a Randomized Controlled Trial and Process Evaluation
CONCLUSIONS: By incorporating an integrated health care approach involving patient empowerment, centralized clinician-coordinated ECG monitoring, and facilitation of primary care and specialist services, it is possible to diagnose and treat AF early to reduce stroke risk. This study will provide new information on how to implement AF screening using digital health technology practicably and feasibly for older and frail populations residing in the community.TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12621000184875; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=380877.INTERNAT...
Source: Rural Remote Health - February 1, 2022 Category: Rural Health Authors: Kam Cheong Wong Tu N Nguyen Simone Marschner Samual Turnbull Mason Jenner Burns Jia Yi Anna Ne Vishal Gopal Anupama Balasuriya Indrawansa Steven A Trankle Tim Usherwood Saurabh Kumar Richard I Lindley Clara K Chow Source Type: research

Polygenic risk scores for cardiovascular diseases and type 2 diabetes
In this study, we u sed data from the UK Biobank and applied the stacked clumping and thresholding method and a variation called maximum clumping and thresholding method to develop PRSs to predict coronary artery disease, hypertension, atrial fibrillation, stroke and type 2 diabetes. We created case-control training da tasets in which age and sex were controlled by design. We also excluded prevalent cases to prevent biased estimation of disease risks. The maximum clumping and thresholding PRSs required many fewer single-nucleotide polymorphisms to achieve almost the same discriminatory ability as the stacked clump ing and ...
Source: PLoS One - December 2, 2022 Category: Biomedical Science Authors: Chi Kuen Wong Source Type: research

The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms.
Abstract Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%-26%). The aim of this article is to review the clinical epidemiological features of AF and to relate them to underlying mechanisms. Long-established risk factors for AF include aging, male sex, hypertension, valve disease, left ventricular dysfunction, obesity, and alcohol consumption. Emerging risk factors include prehypertension, increased pulse pressure, obstructive sleep apnea, high-level physical training, diastolic dysfunction, predisposing gene variants, hypertrophic cardiomyopathy, and congenital heart disease. Po...
Source: Circulation Research - April 25, 2014 Category: Cardiology Authors: Andrade J, Khairy P, Dobrev D, Nattel S Tags: Circ Res Source Type: research

Young, Healthy People Warned Not To Ignore Signs Of Atrial Fibrillation
BOSTON (CBS) – Heart problems are big problems for Americans, but if you think they only affect the elderly, think again. Younger and otherwise healthy people are having heart problems, too, even if they’re in great shape. Mark Marshall is only 51. The competitive wrestler was out for a training run when suddenly he felt a flutter in his chest and his vision blurred. “In my mind I’m thinking, you must be dehydrated. I had no idea I was in afib,” he remembers. But he was, even though Mark had none of the risk factors for atrial fibrillation like high blood pressure, high cholesterol and old ag...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 1, 2014 Category: Consumer Health News Authors: deanreddington Tags: Health Local News Seen On WBZ-TV Syndicated Local Watch Listen AFib Atrial Fibrillation Mallika Marshall Mark Marshall Source Type: news

Board #153 - Research Abstract The Creation of a Simulator Value Index Tool by Connected Consensus (Submission #8590).
Conclusion: The product from this work (SVI Worksheet tool) can be applied aid the simulator purchase process across countries, institutions, and stakeholder. We are hopeful that simulator purchase processes might include the SVI Worksheet with the intention to maintain alignment with educational goals, while still accounting for other factors considered at the institutional level. At the same time, common measures might facilitate future communication across academic medical institutions and simulator industry. More evaluation is required following broad-scaled implementation. References: 1. Britt RC, Novosel TJ, Britt LD...
Source: Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare - December 1, 2014 Category: Medical Equipment Tags: Abstracts: 2ND PLACE AWARD WINNER: PDF Only Source Type: research

Vagal atrial fibrillation: what is it and should we treat it?
Vagal atrial fibrillation (AF) remains an under-recognised entity, affecting younger patients often with structurally normal hearts. Although there remains no universal definition or diagnostic criteria, in this review we describe recognised triggers and associated features, including a well-established association with athletic training. We explore potential mechanisms, including the role of the autonomic nervous system and ganglionated plexi in initiating and maintaining the arrhythmia. We discuss the limited evidence base addressing the question of progression to persistent AF, and debate the merits of anti-arrhythmic t...
Source: International Journal of Cardiology - August 10, 2015 Category: Cardiology Authors: Alexander Carpenter, Antonio Frontera, Richard Bond, Edward Duncan, Glyn Thomas Source Type: research

Assessment of Device Related Thrombus and Associated Clinical Outcomes with the WATCHMAN Left Atrial Appendage Closure Device for Embolic Protection in Patients with Atrial Fibrillation (From the PROTECT-AF Trial)
Left atrial appendage (LAA) closure with the WATCHMAN device is an alternative to anticoagulation for stroke prevention in selected patients with atrial fibrillation (AF). LA device related thrombus (DRT) is poorly defined and understood. We aimed to 1) develop consensus echocardiographic diagnostic criteria for DRT 2) estimate the incidence of DRT and 3) determine clinical event rates in patients with DRT. In Phase 1 (Training), a training manual was developed and reviewed by 3 echocardiographers with LAA closure device experience.
Source: The American Journal of Cardiology - February 1, 2016 Category: Cardiology Authors: Michael L. Main, Dali Fan, Vivek Y. Reddy, David R. Holmes, Nicole T. Gordon, Tina R. Coggins, John A. House, Lawrence Liao, Dawn Rabineau, George G. Latus, Kenneth C. Huber, Horst Sievert, Richard F. Wright, Shephal K. Doshi, Pamela S. Douglas Source Type: research

Assessment of Device-Related Thrombus and Associated Clinical Outcomes With the WATCHMAN Left Atrial Appendage Closure Device for Embolic Protection in Patients With Atrial Fibrillation (from the PROTECT-AF Trial)
Left atrial appendage closure with the WATCHMAN device is an alternative to anticoagulation for stroke prevention in selected patients with atrial fibrillation (AF). LA device-related thrombus (DRT) is poorly defined and understood. We aimed to (1) develop consensus echocardiographic diagnostic criteria for DRT; (2) estimate the incidence of DRT; and (3) determine clinical event rates in patients with DRT. In phase 1 (training), a training manual was developed and reviewed by 3 echocardiographers with left atrial appendage closure device experience.
Source: The American Journal of Cardiology - February 1, 2016 Category: Cardiology Authors: Michael L. Main, Dali Fan, Vivek Y. Reddy, David R. Holmes, Nicole T. Gordon, Tina R. Coggins, John A. House, Lawrence Liao, Dawn Rabineau, George G. Latus, Kenneth C. Huber, Horst Sievert, Richard F. Wright, Shephal K. Doshi, Pamela S. Douglas Tags: Arrhythmias and Conduction Disturbances Source Type: research

Left atrial appendage closure: patient, device and post-procedure drug selection.
Authors: Tzikas A, Bergmann MW Abstract Left atrial appendage closure (LAAC), a device-based therapy for stroke prevention in patients with atrial fibrillation, is considered an alternative to oral anticoagulation therapy, particularly for patients at high risk of bleeding. Proof of concept has been demonstrated by the PROTECT AF and PREVAIL trials which evaluated the WATCHMAN device (Boston Scientific, Marlborough, MA, USA) versus warfarin, showing favourable outcome for the device group. The most commonly used devices for LAAC are the WATCHMAN and its successor, the WATCHMAN FLX (Boston Scientific) and the AMPLAT...
Source: EuroIntervention - May 15, 2016 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

The use of a portable three-lead ECG monitor to detect atrial fibrillation in general practice.
CONCLUSIONS: The inexpensive portable PEM device recording diagnosed AF with a high sensitivity and specificity. KEY POINTS Simple ECG monitors could be useful to identify atrial fibrillation and thereby lead to a better prevention of stroke. The PEM device was easy to use and 95.7% of the recordings were technically acceptable for detecting atrial fibrillation. The PEM device has a high sensitivity and specificity in detecting atrial fibrillation compared to a standard 12-lead ECG. Further studies should evaluate the clinical usefulness of the PEM device, e.g. to detect intermittent atrial fibrillation. PMID: 2740915...
Source: Primary Care - July 12, 2016 Category: Primary Care Authors: Kristensen AN, Jeyam B, Riahi S, Jensen MB Tags: Scand J Prim Health Care Source Type: research

Benefits and Challenges of Going Abroad for Research or Clinical Training
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 17, 2016 Category: Hematology Authors: Nicoletta Riva, Mandy Lauw Tags: Early Career Series Source Type: research

Benefits and Challenges of Going Abroad for Research or Clinical Training.
This article is protected by copyright. All rights reserved. PMID: 27425373 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 17, 2016 Category: Hematology Authors: Riva N, Lauw M Tags: J Thromb Haemost Source Type: research

The role of physical exercise in obstructive sleep apnea
ABSTRACT Obstructive sleep apnea (OSA) is a common clinical condition, with a variable and underestimated prevalence. OSA is the main condition associated with secondary systemic arterial hypertension, as well as with atrial fibrillation, stroke, and coronary artery disease, greatly increasing cardiovascular morbidity and mortality. Treatment with continuous positive airway pressure is not tolerated by all OSA patients and is often not suitable in cases of mild OSA. Hence, alternative methods to treat OSA and its cardiovascular consequences are needed. In OSA patients, regular physical exercise has beneficial effects other...
Source: Jornal Brasileiro de Pneumologia - January 9, 2017 Category: Respiratory Medicine Source Type: research

An uncommon tomographic association: amiodarone pulmonary toxicity and adenocarcinoma
ABSTRACT Obstructive sleep apnea (OSA) is a common clinical condition, with a variable and underestimated prevalence. OSA is the main condition associated with secondary systemic arterial hypertension, as well as with atrial fibrillation, stroke, and coronary artery disease, greatly increasing cardiovascular morbidity and mortality. Treatment with continuous positive airway pressure is not tolerated by all OSA patients and is often not suitable in cases of mild OSA. Hence, alternative methods to treat OSA and its cardiovascular consequences are needed. In OSA patients, regular physical exercise has beneficial effects other...
Source: Jornal Brasileiro de Pneumologia - January 9, 2017 Category: Respiratory Medicine Source Type: research

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