Effectiveness and toxicity of adjuvant chemotherapy in patients with non-small cell lung cancer
Conclusions: These results support the benefit of AC for NSCLC patients in a real-world setting. However, because the cisplatin-vinorelbine regimen was associated with alarming rates of toxicity, more effective and less toxic alternatives should be investigated.RESUMO Objetivo: A quimioterapia adjuvante melhora a sobrevida de pacientes com c âncer pulmonar de células não pequenas (CPCNP) ressecado. No entanto, o esquema cisplatina-vinorelbina está relacionado com risco significativo de toxicidade clinicamente relevante. Nosso objetivo foi avaliar a eficácia, segurança e viabilidade da quimioterapia adjuvante para pa...
Source: Jornal Brasileiro de Pneumologia - February 24, 2021 Category: Respiratory Medicine Source Type: research

Erratum
Conclusions: Protocols that include the mechanical removal of oral biofilm in combination with the use of chlorhexidine can reduce the incidence of VAP among ICU patients requiring MV.RESUMO Objetivo: A pneumonia associada à ventilação mecânica (PAVM) é uma infecção frequente em UTI. No entanto, essa infecção pode ser evitada através de protocolos de cuidados orais. O objetivo deste estudo foi comparar a eficiência de protocolos de higiene bucal (escovação e procedimentos clínicos) aliados ao uso de clor exidina (grupo intervenção) com a de protocolos que fazem uso somente de clorexidina (grupo controle) n...
Source: Jornal Brasileiro de Pneumologia - February 8, 2021 Category: Respiratory Medicine Source Type: research

Migratory pulmonary infiltrates in a patient with COVID-19 and lymphoma
ABSTRACT Environmental air pollution is a major risk factor for morbidity and mortality worldwide. Environmental air pollution has a direct impact on human health, being responsible for an increase in the incidence of and number of deaths due to cardiopulmonary, neoplastic, and metabolic diseases; it also contributes to global warming and the consequent climate change associated with extreme events and environmental imbalances. In this review, we present articles that show the impact that exposure to different sources and types of air pollutants has on the respiratory system; we present the acute effects — such as increa...
Source: Jornal Brasileiro de Pneumologia - February 8, 2021 Category: Respiratory Medicine Source Type: research

Environmental air pollution: respiratory effects
ABSTRACT Environmental air pollution is a major risk factor for morbidity and mortality worldwide. Environmental air pollution has a direct impact on human health, being responsible for an increase in the incidence of and number of deaths due to cardiopulmonary, neoplastic, and metabolic diseases; it also contributes to global warming and the consequent climate change associated with extreme events and environmental imbalances. In this review, we present articles that show the impact that exposure to different sources and types of air pollutants has on the respiratory system; we present the acute effects — such as increa...
Source: Jornal Brasileiro de Pneumologia - February 8, 2021 Category: Respiratory Medicine Source Type: research

Pulmonology approach in the investigation of chronic unexplained dyspnea
We present a proposal for a diagnostic workup and some illustrative cases assessed by CPET. Given that airway hyperresponsiveness and pulmonary vascular disorders, which are within the purview of pulmonology, are common causes of chronic unexplained dyspnea, we also aim to describe the role of bronchial challenge tests and the diagnostic reasoning for investigating the pulmonary circulation in this context.RESUMO A dispneia cr ônica inexplicada e a intolerância ao exercício representam sintomas comuns e angustiantes em pacientes ambulatoriais. O histórico clínico e o exame físico são as bases da avaliação diagnós...
Source: Jornal Brasileiro de Pneumologia - February 8, 2021 Category: Respiratory Medicine Source Type: research

Impact of extracorporeal membrane oxygenation in lung transplantation
ABSTRACT In this cross-sectional study, we investigated the relationship that levels of vitamin D had with eosinophil counts and IgE levels in 26 children with asthma (6-12 years of age) in the city of Londrina, Brazil. Vitamin D levels were found to correlate significantly, albeit moderately, with age (r = − 0.51) and eosinophilia (r = − 0.49), although not with IgE levels (r = − 0.12). When we stratified the sample into two groups by the median vitamin D level (< or ≥ 24 ng/mL), we found that those in the< 24 ng/mL group were older, had higher eosinophil counts, and had higher IgE levels. To our knowledge,...
Source: Jornal Brasileiro de Pneumologia - January 22, 2021 Category: Respiratory Medicine Source Type: research

Achievements of the last biennium, projections for the coming years, and the impact of COVID-19
(Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - January 22, 2021 Category: Respiratory Medicine Source Type: research

Erratum
Conclusions: Protocols that include the mechanical removal of oral biofilm in combination with the use of chlorhexidine can reduce the incidence of VAP among ICU patients requiring MV.RESUMO Objetivo: A pneumonia associada à ventilação mecânica (PAVM) é uma infecção frequente em UTI. No entanto, essa infecção pode ser evitada através de protocolos de cuidados orais. O objetivo deste estudo foi comparar a eficiência de protocolos de higiene bucal (escovação e procedimentos clínicos) aliados ao uso de clor exidina (grupo intervenção) com a de protocolos que fazem uso somente de clorexidina (grupo controle) n...
Source: Jornal Brasileiro de Pneumologia - January 18, 2021 Category: Respiratory Medicine Source Type: research

Efficiency of different protocols for oral hygiene combined with the use of chlorhexidine in the prevention of ventilator-associated pneumonia
Conclusions: Protocols that include the mechanical removal of oral biofilm in combination with the use of chlorhexidine can reduce the incidence of VAP among ICU patients requiring MV.RESUMO Objetivo: A pneumonia associada à ventilação mecânica (PAVM) é uma infecção frequente em UTI. No entanto, essa infecção pode ser evitada através de protocolos de cuidados orais. O objetivo deste estudo foi comparar a eficiência de protocolos de higiene bucal (escovação e procedimentos clínicos) aliados ao uso de clor exidina (grupo intervenção) com a de protocolos que fazem uso somente de clorexidina (grupo controle) n...
Source: Jornal Brasileiro de Pneumologia - January 18, 2021 Category: Respiratory Medicine Source Type: research

Reference equations for plethysmographic lung volumes in White adults in Brazil as derived by linear regression
ABSTRACT In this cross-sectional study, we investigated the relationship that levels of vitamin D had with eosinophil counts and IgE levels in 26 children with asthma (6-12 years of age) in the city of Londrina, Brazil. Vitamin D levels were found to correlate significantly, albeit moderately, with age (r = − 0.51) and eosinophilia (r = − 0.49), although not with IgE levels (r = − 0.12). When we stratified the sample into two groups by the median vitamin D level (< or ≥ 24 ng/mL), we found that those in the< 24 ng/mL group were older, had higher eosinophil counts, and had higher IgE levels. To our knowledge,...
Source: Jornal Brasileiro de Pneumologia - January 18, 2021 Category: Respiratory Medicine Source Type: research

Calcified metastases of teratoma
ABSTRACT In this cross-sectional study, we investigated the relationship that levels of vitamin D had with eosinophil counts and IgE levels in 26 children with asthma (6-12 years of age) in the city of Londrina, Brazil. Vitamin D levels were found to correlate significantly, albeit moderately, with age (r = − 0.51) and eosinophilia (r = − 0.49), although not with IgE levels (r = − 0.12). When we stratified the sample into two groups by the median vitamin D level (< or ≥ 24 ng/mL), we found that those in the< 24 ng/mL group were older, had higher eosinophil counts, and had higher IgE levels. To our knowledge,...
Source: Jornal Brasileiro de Pneumologia - January 18, 2021 Category: Respiratory Medicine Source Type: research

Pericardial effusion
(Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - January 18, 2021 Category: Respiratory Medicine Source Type: research

Knowledge of and attitudes toward the WHO MPOWER policies to reduce tobacco use at the population level: a comparison between third-year and sixth-year medical students
Conclusions: Knowledge of smoking cessation strategies and self-recognition as role models for patients/society increase over the course of medical school and are associated with the implementation of smoke-free policies.RESUMO Objetivo: Avaliar estudantes de medicina do terceiro e sexto anos no Brasil em rela ção a seu conhecimento e atitudes sobre as políticas MPOWER da OMS para redução do uso do tabaco. Métodos: A Pesquisa Global de Estudantes de Profissões da Saúde da OMS foi aplicada em cinco coortes de estudantes de medicina avaliados no terceiro e sexto anos da graduação, entre 2008 e 20 15. Foram feita...
Source: Jornal Brasileiro de Pneumologia - January 8, 2021 Category: Respiratory Medicine Source Type: research

Protective mechanical ventilation in patients with risk factors for ARDS: prospective cohort study
Conclusions: The MDP seems to be a useful tool, better than VT, for adjusting MV in patients at risk for ARDS.RESUMO Objetivo: Avaliar a associa ção da ventilação mecânica (VM) protetora, com base no VT e na pressão de distensão máxima (PDM), com a mortalidade em pacientes com fator de risco para SDRA. Métodos: Este estudo de coorte prospectivo foi conduzido em uma UTI e incluiu 116 pacientes em VM que apresentavam pelo menos um fa tor de risco para o desenvolvimento de SDRA. Os parâmetros ventilatórios foram coletados duas vezes ao dia durante sete dias, e os pacientes foram divididos em dois grupos (VM prote...
Source: Jornal Brasileiro de Pneumologia - January 8, 2021 Category: Respiratory Medicine Source Type: research

Evolution of the surgical treatment of lung cancer at a tertiary referral center in Brazil, 2011-2018
Conclusions: The clinical and epidemiological evolution presented in this study corroborates global trends. The decrease in 30-day mortality w as probably due to better patient selection and improved surgical techniques.RESUMO Objetivo: Avaliar a evolu ção de dados clínicos e epidemiológicos, assim como dados sobre diagnóstico, estadiamento, tratamento e sobrevida em pacientes submetidos a tratamento cirúrgico curativo de câncer de pulmão em uma instituição terciária na cidade de São Paulo (SP). Métodos: Estudo retrospectivo baseado nos casos inseridos no banco de dados da International Association for the S...
Source: Jornal Brasileiro de Pneumologia - December 17, 2020 Category: Respiratory Medicine Source Type: research