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Condition: Hypertension
Therapy: Statin Therapy

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Total 489 results found since Jan 2013.

Assessing Patient Decision-Making Capacity: It’s About the Thought Process
Fred Jones is a 64-year-old man who presents to the emergency department with visual changes and left-sided facial numbness that started 2 hours earlier, after an argument with his wife. He states, “I want to make sure I’m not having a stroke.” His medical history is significant for hypertension. His medications include lisinopril, hydrochlorothiazide, and simvastatin. He is being evaluated for a cerebral vascular accident (CVA) with an onset of symptoms of less than 4 hours. Nursing assessment finds a National Institutes of Health Stroke Scale score of 1, with the loss of left upper quadrant peripheral visual fields.
Source: Journal of Emergency Nursing: JEN - January 9, 2015 Category: Nursing Authors: Melanie A. Mitchell Tags: Clinical Source Type: research

Cardiovascular Risk Factors and Disease in Women
Coronary artery disease and stroke predominantly affect older women as opposed to younger women, but the risk factors that contribute to atherosclerotic cardiovascular disease risk often start in young women. Young women with polycystic ovary syndrome (PCOS), with migraine, and who use oral contraceptive pills (OCPs) have short-term increases in thrombotic complications that can result in coronary events or stroke. Attention should be focused on risk reduction in women of all ages. Screening for and discussing diabetes, hypertension, obesity, smoking, migraine, PCOS, and pregnancy complication history and discussing the pr...
Source: Medical Clinics of North America - March 6, 2015 Category: Primary Care Authors: Sharon K. Gill Source Type: research

Cardiovascular Risk Factors and Disease in Women.
Abstract Coronary artery disease and stroke predominantly affect older women as opposed to younger women, but the risk factors that contribute to atherosclerotic cardiovascular disease risk often start in young women. Young women with polycystic ovary syndrome (PCOS), with migraine, and who use oral contraceptive pills (OCPs) have short-term increases in thrombotic complications that can result in coronary events or stroke. Attention should be focused on risk reduction in women of all ages. Screening for and discussing diabetes, hypertension, obesity, smoking, migraine, PCOS, and pregnancy complication history and...
Source: The Medical Clinics of North America - April 7, 2015 Category: Journals (General) Authors: Gill SK Tags: Med Clin North Am Source Type: research

Middle-age spread 'seems to reduce dementia risk'
Conclusion This cohort study of more than 1.9 million UK adults aged over 40 links being overweight or obese to a lower risk of dementia, compared with healthy weight people. Underweight people were at a higher risk of dementia. The study has many strengths, such as its large size and applicability to the UK. However, the authors note their results buck the trend of other research, which found being overweight or obese was linked to an increase risk. They suggest their study is probably more reliable than the past ones as they were smaller. They aren't quite sure what this means, and say: "The reasons for and publi...
Source: NHS News Feed - April 10, 2015 Category: Consumer Health News Tags: Neurology Obesity Source Type: news

Antiplatelet therapy in Takotsubo cardiomyopathy: does it improve cardiovascular outcomes during index event?
Abstract Plasma catecholamines may play an important role in Takotsubo cardiomyopathy (TCM) pathophysiology. Patients with disproportionately high catecholamine responses to stressful events are prone to worse clinical outcomes. Catecholamines stimulate platelet activation and, therefore, may determine the clinical presentation and outcomes of TCM. We conducted a retrospective, descriptive study TCM patients admitted between 2003 and 2013 to Einstein Medical Center, Philadelphia, PA, USA and Danbury Hospital, Danbury, CT, USA. A total of 206 patients met Modified Mayo TCM criteria. Using a multiple logistic model,...
Source: Heart and Vessels - August 13, 2015 Category: Cardiology Source Type: research

NHS Health Checks 'prevented thousands of heart attacks'
ConclusionThis descriptive study has provided information about how many people took part in the NHS Health Check programme in the first four years it was available. While the uptake was initially relatively low, it is increasing. It is also encouraging that some of the more vulnerable groups – those who are older and those in the most deprived social group – are most likely to attend the checks. There were limitations to the data available. For example, it was not possible to directly assess whether all new prescriptions and treatments after the checks were as a direct result of the checks. The proportion of people wh...
Source: NHS News Feed - January 15, 2016 Category: Consumer Health News Tags: Heart/lungs Neurology Medical practice Source Type: news

Better than Aspirin for Your Heart
If you’ve been diagnosed with heart disease, the chances are you’ve been told to take low-dose aspirin every day as a preventative measure against heart attack and stroke. It’s most commonly prescribed for patients with congestive heart failure. This is the inability of your heart to pump as much blood as your body needs. And this is a big worry to me, because there is very little evidence that aspirin helps. In fact, regular use of aspirin — even baby aspirin — can do you more harm than good. Common Aspirin Beliefs The idea is that aspirin thins the blood, making it easier to pump.  It is also s...
Source: Al Sears, MD Natural Remedies - April 1, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health Source Type: news

Pharmacological modification of the perioperative stress response in non-cardiac surgery
Publication date: Available online 7 April 2016 Source:Best Practice & Research Clinical Anaesthesiology Author(s): Hans-Joachim Priebe The perioperative period is associated with alterations in the neuroendocrine, metabolic, and immune systems, referred to as 'stress response'. The resultant increased sympathetic activity and elevated serum concentrations of catecholamines may adversely affect the cardiovascular system resulting in cardiovascular instability (hypertension, tachycardia, arrhythmia), morbidity (myocardial ischemia, myocardial infarction, stroke) and mortality (cardiac death, fatal stroke), partic...
Source: Best Practice and Research Clinical Anaesthesiology - April 6, 2016 Category: Anesthesiology Source Type: research

Soluble Guanylate Cyclase Stimulators: a Novel Treatment Option for Heart Failure Associated with Cardiorenal Syndromes?
Abstract Heart failure in the setting of chronic kidney disease (CKD) is an increasingly common scenario and carries a poor prognosis. Clinicians lack tools for primary or secondary heart failure prevention in patients with cardiorenal syndromes. In patients without CKD, angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB) and statins mitigate cardiovascular risk in large part due to salutary effects on the endothelium. In the setting of CKD, use of these therapies is limited by adverse effects of hyperkalemia in pre-dialysis CKD (ACE-I/ARB), or potential increased risk of stroke...
Source: Current Heart Failure Reports - April 26, 2016 Category: Cardiology Source Type: research

Pharmacological modification of the perioperative stress response in noncardiac surgery
Publication date: June 2016 Source:Best Practice & Research Clinical Anaesthesiology, Volume 30, Issue 2 Author(s): Hans-Joachim Priebe The perioperative period is associated with alterations in the neuroendocrine, metabolic, and immune systems, referred to as “stress response.” The resultant increased sympathetic activity and elevated serum concentrations of catecholamines may adversely affect the cardiovascular system, resulting in cardiovascular instability (hypertension, tachycardia, and arrhythmia), morbidity (myocardial ischemia, myocardial infarction, and stroke), and mortality (cardiac death and fata...
Source: Best Practice and Research Clinical Anaesthesiology - July 8, 2016 Category: Anesthesiology Source Type: research

Impact of Chronic Nitrate Therapy in Patients With Ischemic Heart Failure
Conclusion: Long-term nitrates use in patients with ischemic HF was associated with higher occurrence of ischemic events, defined as fatal or nonfatal myocardial infarction or stroke. Our results, although from a retrospective analysis, do not support a role for chronic nitrate use in HF.
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 4, 2016 Category: Cardiology Authors: Moreira-Silva, S., Urbano, J., Nogueira-Silva, L., Bettencourt, P., Pimenta, J. Tags: Clinical Study Source Type: research

Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men: The Veterans Administration Normative Aging Study
Conclusions: In this longitudinal sample of older men, the findings supported the hypothesis that long-term PM2.5 exposure negatively affects renal function and increases renal function decline. Citation: Mehta AJ, Zanobetti A, Bind MC, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. 2016. Long-term exposure to ambient fine particulate matter and renal function in older men: the VA Normative Aging Study. Environ Health Perspect 124:1353–1360; http://dx.doi.org/10.1289/ehp.1510269 Address correspondence to A.J. Mehta, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Landmark Ce...
Source: EHP Research - September 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article September 2016 Source Type: research

Effects of vascular comorbidity in parkinson's disease
Vascular disease and risk factors are common in Parkinson's disease (PD) and may influence phenotype. Statin therapy may thus be indicated. 1759 recently diagnosed PD cases from a multicentre prospective study underwent a Montreal Cognitive Assessment and the Unified PD Rating Scale part 3 (UPDRS 3). History of vascular events, risk factors and statin usage was recorded. QRISK2 quantified cardiovascular risk. Mean age was 67.5 (SD 9.3), disease duration 1.3 (SD 0.9) years, 65.2% male. 4.7% had prior stroke/TIA, 12.5% cardiac disease, 30.4% hypertension, 27.3% high cholesterol, 20.7% obesity, 7.2% diabetes and 4.6% smokers....
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Swallow, D. M. A., Malek, N., Grosset, K. A., Lawton, M. A., Bajaj, N. P., Barker, R. A., Ben-Shlomo, Y., Burn, D. J., Morris, H. R., Williams, N., Wood, N. W., Grosset, D. G., on behalf of the PRoBaND collaborators Tags: Drugs: CNS (not psychiatric), Parkinson's disease, Hypertension, Memory disorders (psychiatry) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Prognostic Analysis for Cardiogenic Shock in Patients with Acute Myocardial Infarction Receiving Percutaneous Coronary Intervention.
Abstract Cardiogenic shock (CS) is uncommon in patients suffering from acute myocardial infarction (AMI). Long-term outcome and adverse predictors for outcomes in AMI patients with CS receiving percutaneous coronary interventions (PCI) are unclear. A total of 482 AMI patients who received PCI were collected, including 53 CS and 429 non-CS. Predictors for AMI patients with CS including recurrent MI, cardiovascular (CV) mortality, all-cause mortality, and repeated-PCI were analyzed. The CS group had a lower central systolic pressure and central diastolic pressure (both P < 0.001). AMI patients with hypertension h...
Source: Biomed Res - March 4, 2017 Category: Research Authors: Lin MJ, Chen CY, Lin HD, Wu HP Tags: Biomed Res Int Source Type: research

Effect of Addition of a Statin to Warfarin on Thromboembolic Events in Japanese Patients With Nonvalvular Atrial Fibrillation and Diabetes Mellitus
Statins have been shown to decrease stroke risk in patients with cardiovascular risk factors, but not to prevent recurrence of ischemic stroke in patients with atrial fibrillation (AF). The present subanalysis aimed to clarify the efficacy of combined use of warfarin and statins in nonvalvular AF (NVAF) patients with coronary artery disease (CAD), diabetes mellitus (DM) or hypertension. The effects of adding statins to warfarin were compared with those of warfarin alone in NVAF patients with the data set of J-RHYTHM Registry, a prospective, observational study with a 2-year follow-up.
Source: The American Journal of Cardiology - April 26, 2017 Category: Cardiology Authors: Naoko Kumagai, John A. Nusser, Hiroshi Inoue, Ken Okumura, Takeshi Yamashita, Toru Kubo, Hiroaki Kitaoka, Hideki Origasa, Hirotsugu Atarashi, J-RHYTHM Registry Investigators Source Type: research