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Condition: Hypertension
Nutrition: Sodium Chloride

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Total 189 results found since Jan 2013.

Abstract P441: Accelerated Age-dependent Cardiovascular and Cognitive Decline in Dahl-S Rats is Associated with Elevated Levels of an Endogenous Na/K-ATPase Inhibitor Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Age-associated central arterial stiffening contributes to both cerebral arterial fibrosis and to cognitive impairment. Accelerated aging, accompanied by a gradual increase in blood pressure (BP) and aortic remodeling, occurs in Dahl-S rats (DSS) vs. normotensive Sprague-Dawley rats (S-D) counterparts even in the absence of a high salt intake. A novel pro-hypertensive factor marinobufagenin (MBG) is implicated in DSS hypertension. Here we determined whether an increase in MBG is also implicated in age-associated arterial remodeling in DSS.Methods: Life span was measured in 60 S-D and 78 DSS. BP, pulse wave velocity (PWV), b...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Olga V Fedorova, Yulia N Grigorova, Jeffrey M Long, Rebecca L McPherson, Ondrej Juhasz, Wen Wei, Valentina Zernetkina, Natalia Petrashevskaya, Kenneth W Fishbein, Richard G Spencer, Peter R Rapp, Edward G Lakatta Tags: Poster Abstract Presentations Source Type: research

Abstract P442: Estradiol Treatment Attenuates the Ovariectomy-induced Increase in Blood Pressure in the Middle Aged Dahl Salt Sensitive Rat as Long as Treatment is Initiated Immediately After Ovariectomy Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Introduction: Several studies have shown that ovariectomy increases blood pressure and that 17beta-estradiol (E2) treatment can attenuate this effect; however, the majority of these studies were conducted in young animals in which E2 replacement was initiated soon after ovariectomy. Since most women who experience ovarian hormone loss are middle aged rather than young, this study investigated the effect of E2 replacement in middle aged Dahl salt-sensitive (DS) rats. In addition, the time at which E2 replacement was initiated was examined.Methods: DS rats were ovariectomized (OVX) at 4.5 months (mo) (DS-OVXY) and 7mo (DS-OV...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hong Ji, Crystal A West, Xie Wu, Amrita Pai, Aline Souza, Parnika Kadam, David A West, Michelle J Zhu, Kathryn Sandberg Tags: Poster Abstract Presentations Source Type: research

Abstract P445: Sympathetic and Renal Mechanisms of Age-related Hypertension Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Hypothesis: Sympathoexcitation and sodium retention contribute to age-related hypertension (HTN).Methods: Three, 8, and 16 month old male SD rats underwent an IV volume expansion (VE; 5% BW) and MAP, HR, urine output and paraventricular nucleus (PVN) neuronal activation (c-Fos expression) were assessed. In separate groups of rats fed a 21 day normal (NS; 0.6% NaCl) or high salt (HS; 4% NaCl) diet, measures of 1) ex vivo afferent renal nerve (ARN) activity (norepinephrine (NE)-evoked substance P release) or 2) MAP, HR, NCC activity (ΔUNaV to IV HCTZ, 2mg/kg) and sympathetic tone (plasma and renal NE content, ΔMAP to IV he...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Richard D Wainford, Alissa A Frame Tags: Poster Abstract Presentations Source Type: research

Salt Sensitivity and its implication in clinical practice
Publication date: Available online 10 October 2017 Source:Indian Heart Journal Author(s): Sundeep Mishra, Shahu Ingole, Rishi Jain Hypertension (HTN) is a complex multi-factorial disease and is considered as one of the foremost modifiable risk factors for stroke, heart failure, ischemic heart disease and renal dysfunction. Over the past century, salt and its linkage to HTN and cardiovascular (CV) mortality has been the subject of intense scientific research. There is now consensus that different individuals have different susceptibilities to blood pressure (BP)-raising effects of salt and is called as salt sensitivity. Va...
Source: Indian Heart Journal - October 11, 2017 Category: Cardiology Source Type: research

Effects of Low Salt Diet on Gene Expression in Dog Heart
Low-salt(LS) always be abided as dietary principle by hypertension patients. However, recent studies found that the incidence of cardiopathy and stroke increases in subjects with LS diet(
Source: Value in Health - October 1, 2017 Category: International Medicine & Public Health Authors: X Ren, R Zhang Source Type: research

Benefit and risk assessment of increasing potassium intake by replacement of sodium chloride with potassium chloride in industrial food products in Norway.
In conclusion, the number of Norwegians facing increased risk is far greater than the number likely to benefit from this replacement of sodium with potassium in industrially produced food. PMID: 29175183 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - November 22, 2017 Category: Food Science Authors: Steffensen IL, Frølich W, Dahl KH, Iversen PO, Lyche JL, Lillegaard ITL, Alexander J Tags: Food Chem Toxicol Source Type: research

Therapeutic Advances in the Management of Orthostatic Hypotension
Conclusions: Although there is no accepted protocol regarding how to manage hypertension in patients with OH, some studies favor the use of beta blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, over alpha-receptor antagonists and diuretics.
Source: American Journal of Therapeutics - January 1, 2018 Category: Drugs & Pharmacology Tags: Systematic Review and Clinical Guidelines Source Type: research

Health-related knowledge on hypertension among the Portuguese population: results from a population-based survey.
CONCLUSIONS: This study provided a quantitative estimate of the gaps in health-related knowledge about hypertension among the general population. Understanding the barriers that hinder the achievement of health-related knowledge on hypertension is expected to contribute for the global improvement of prevention and management of hypertension. PMID: 29366359 [PubMed - as supplied by publisher]
Source: Blood Pressure - January 26, 2018 Category: Hematology Tags: Blood Press Source Type: research

Taste perception and diet in people of Chinese ancestry.
CONCLUSIONS: There was a salty-sour confusion among Singaporean Chinese unlike the bitter-sour confusion reported for Caucasians. Most sodium came from sauces and was added during food preparation. In programs to address sodium: potassium ratio excess among Chinese prone to hypertension and stroke, sour as well as salty taste may need to be considered. PMID: 29384339 [PubMed - in process]
Source: Asia Pacific Journal of Clinical Nutrition - February 2, 2018 Category: Nutrition Authors: Leong CS, Forde CG, Tey SL, Henry CJ Tags: Asia Pac J Clin Nutr Source Type: research

Cardiac adaptation to hypertension in adult female Dahl salt ‐sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation
Abstract Aim of study was to examine experimentally the adult female hypertensive heart in order to determine the role of ovary function in the response of the heart to salt‐dependent hypertension. Dahl salt‐sensitive rats, age 12 weeks, with/without ovariectomy were fed a standard (0.3% NaCl) or high‐salt diet (8%) for 16 weeks. Mean arterial blood pressure monitored noninvasively in conscious state increased significantly by high salt. Echocardiography was performed at baseline and endpoint. Heart function and molecular changes were evaluated at endpoint by left ventricle catheterization, by sirius red staining f...
Source: Physiological Reports - February 8, 2018 Category: Physiology Authors: Stian Ludvigsen, Costantino Mancusi, Simon Kildal, Giovanni Simone, Eva Gerdts, Kirsti Ytrehus Tags: Original Research Source Type: research

High blood pressure diet: Avoid this burger ingredient to reduce symptoms of hypertension
HIGH blood pressure symptoms can be hard to spot, meaning many people do not even know they have it. But if the condition is left untreated it could lead to more serious health problems such as heart attacks and stroke. Because what you can eat can affect your blood pressure, experts say to avoid eating foods with high salt levels, such as pickles.
Source: Daily Express - Health - March 23, 2018 Category: Consumer Health News Source Type: news

Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies
Publication date: Available online 11 April 2018 Source:The Lancet Diabetes & Endocrinology Author(s): Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown Background In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying this superiority and the pathogenesis of resistant hypertension. Methods PATHWA...
Source: The Lancet Diabetes and Endocrinology - April 12, 2018 Category: Endocrinology Source Type: research

High blood pressure: Reduce your risk of condition with these five steps
HIGH BLOOD pressure is the second largest single risk factor for premature death in the UK, but it has few detectable symptoms. Caused by obesity, salt, and smoking, among others, it can result in heart attacks, kidney disease or a stroke. The Mayo Clinic in America recommends some lifestyle changes to combat this.
Source: Daily Express - Health - April 16, 2018 Category: Consumer Health News Source Type: news

Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies
Publication date: June 2018Source: The Lancet Diabetes & Endocrinology, Volume 6, Issue 6Author(s): Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown, The British Hypertension Society programme of Prevention And Treatment of Hypertension With Algorithm based Therapy (PATHWAY) Study GroupSummaryBackgroundIn the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did ...
Source: The Lancet Diabetes and Endocrinology - July 5, 2018 Category: Endocrinology Source Type: research