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Specialty: Endocrinology
Condition: Diabetes

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Total 1416 results found since Jan 2013.

Gliptins‐mediated neuroprotection against stroke requires chronic pre‐treatment and is glucagon‐like peptide‐1 receptor independent
Abstract Gliptins are anti‐type 2 diabetic (T2D) drugs regulating glycaemia by preventing endogenous glucagon‐like peptide‐1 (GLP‐1) degradation. Chronically administered gliptins before experimental stroke can also induce neuroprotection and this effect is potentially relevant to reduce brain damage in high stroke‐risk T2D patients. However, it is unknown: 1) whether acute gliptins‐treatment after stroke (mimicking a post‐hospitalization treatment) is neuroprotective 2) whether gliptins‐mediated neuroprotection occurs via GLP‐1‐receptor (GLP‐1R) activation. To answer these two questions, wt and glp...
Source: Diabetes, Obesity and Metabolism - February 1, 2016 Category: Endocrinology Authors: Vladimer Darsalia, Martin Larsson, Grazyna Lietzau, David Nathanson, Thomas Nyström, Thomas Klein, Cesare Patrone Tags: LETTER TO THE EDITOR Source Type: research

Pre-stroke glycemia in patients with diabetes
Conclusion Insulin treatment and hyperlipidemia are associated with higher HbA1c levels in acute stroke patients with T2D. Poor adherence to diabetes treatment is associated with higher HbA1c levels only among patients with HbA1c ≥8%.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 4, 2017 Category: Endocrinology Source Type: research

Circulating Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 predict Three-months Outcome after Ischemic Stroke
Exp Clin Endocrinol Diabetes 2017; 125: 485-491 DOI: 10.1055/s-0043-103965 Reports on neuroprotective effects of Insulin-like growth factor-1 (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3) in ischemic brain tissue are inconsistent. The aim of this study was to determine if plasma levels of IGF-1 and IGFBP-3 in acute stroke patients are indicative of 3 months functional outcome. Plasma levels were measured via chemiluminescence immunoassay in heparin blood samples of patients included in the EARLY trial (NCT00562588). Plasma samples were drawn on admission and 8 days post-stroke. Neurological deficits we...
Source: Experimental and Clinical Endocrinology and Diabetes - July 19, 2017 Category: Endocrinology Authors: Armbrust, Moritz Worthmann, Hans Dengler, Reinhard Schumacher, Helmut Lichtinghagen, Ralf Eschenfelder, Christoph Cyrill Endres, Matthias Ebinger, Martin Tags: Article Source Type: research

Low ‐density lipoprotein cholesterol and stroke – how low should we go?
AbstractDiabetes is a well ‐established risk factor for both ischemic and hemorrhagic stroke. Individuals with diabetes not only have a higher risk of stroke, they also have worse clinical outcomes after stroke, including poorer neurological recovery, higher rates of stroke recurrence and mortality. In addition to optimizin g glycemia, control of cardiovascular risk factors like hypertension and dyslipidemia is crucial in stroke prevention in subjects with diabetes.
Source: Journal of Diabetes Investigation - May 28, 2020 Category: Endocrinology Authors: David TW Lui, Kathryn CB Tan Tags: EDITORIAL Source Type: research

Myocardial Infarction, Stroke, and All-Cause Mortality According to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study
CONCLUSION: Among the elderly, lower LDL-C was associated with decreased risks of MI and stroke. Lower LDL-C achieved by statins in the elderly was associated with a decreased risk of all-cause death during follow-up, suggesting that LDL-C paradox for the premature death risk in the elderly should not be applied to statin users. Intensive statin therapy should not be hesitated for older adults with cardiovascular risk factors including diabetes.PMID:35255552 | DOI:10.4093/dmj.2021.0225
Source: Diabetes and Metabolism Journal - March 7, 2022 Category: Endocrinology Authors: You-Bin Lee Minji Koo Eunjin Noh Soon Young Hwang Jung A Kim Eun Roh So-Hyeon Hong Kyung Mook Choi Sei Hyun Baik Geum Joon Cho Hye Jin Yoo Source Type: research

Correlation of Triglyceride-Rich Lipoprotein Cholesterol and Diabetes Mellitus in Stroke Patients
CONCLUSION: Positive associations were found between TRL-c and DM in patients with stroke.PMID:36389128 | PMC:PMC9652082 | DOI:10.1155/2022/7506767
Source: International Journal of Endocrinology - November 17, 2022 Category: Endocrinology Authors: Ruiqing Luo Huifang Jiang Tao Wang Yanfang Xu Xueliang Qi Source Type: research

Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled trial in a high-cardiovascular-risk population.
CONCLUSIONSOur novel results suggest that MedDiet may not only reduce increased fasting glucose and lipids in TT individuals, but also stroke incidence. PMID: 23942586 [PubMed - as supplied by publisher]
Source: Diabetes Care - August 13, 2013 Category: Endocrinology Authors: Corella D, Carrasco P, Sorlí JV, Estruch R, Rico-Sanz J, Martínez-González MA, Salas-Salvadó J, Covas MI, Coltell O, Arós F, Lapetra J, Serra-Majem L, Ruíz-Guiterrez V, Warnberg J, Fiol M, Pintó X, Ortega-Azorín C, Muñoz MA, Martínez JA, Gómez- Tags: Diabetes Care Source Type: research

Diabetic microangiopathy: impact of impaired cerebral vasoreactivity and delayed angiogenesis after permanent middle cerebral artery occlusion on stroke damage and cerebral repair in mice.
Abstract Diabetes increases the risk of stroke by 3, increases related mortality and delays recovery. We aimed to characterize functional and structural alterations in cerebral microvasculature before and after experimental cerebral ischemia in a mouse model of type 1 diabetes. We hypothesized that pre-existing brain microvascular disease in diabetics might partly explain increased stroke severity and impact on outcome.Diabetes was induced in 4-week-old C57Bl/6J mice by intraperitoneal injections of streptozotocin (60 mg/kg). After 8 weeks of diabetes, the vasoreactivity of the neurovascular network to CO2 was abo...
Source: Diabetes - October 6, 2014 Category: Endocrinology Authors: Poittevin M, Bonnin P, Pimpie C, Rivière L, Sebrié C, Dohan A, Pocard M, Charriaut-Marlangue C, Kubis N Tags: Diabetes Source Type: research

Metformin Treatment in the Period After Stroke Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes
Diabetes impedes vascular repair and causes vasoregression in the brain after stroke, but mechanisms underlying this response are still unclear. We hypothesized that excess peroxynitrite formation in diabetic ischemia/reperfusion (I/R) injury inactivates the p85 subunit of phosphoinositide 3-kinase (PI3K) by nitration and diverts the PI3K–Akt survival signal to the p38–mitogen-activated protein kinase apoptosis pathway. Nitrotyrosine (NY), Akt and p38 activity, p85 nitration, and caspase-3 cleavage were measured in brains from control, diabetic (GK), or metformin-treated GK rats subjected to sham or stroke surg...
Source: Diabetes - April 23, 2015 Category: Endocrinology Authors: Abdelsaid, M.; Prakash, R.; Li, W.; Coucha, M.; Hafez, S.; Johnson, M. H.; Fagan, S. C.; Ergul, A. Tags: Pharmacology and Therapeutics Source Type: research

Mitigating diabetes associated ischemic stroke risk: high-risk patient identification
While the past year has brought the medical community much excitement regarding expanded therapeutic options for acute ischemic stroke treatment, Benjamin Franklin’s declaration that “an ounce of prevention is worth a pound of cure” remains a maxim of the stroke community. Emphasis on gender for patient-focused stroke prevention has evolved in response to data illustrating how gender influences age of onset, incidence, prevalence, morbidity and mortality of stroke. Notably, a large review by Appelros et al.
Source: Journal of Diabetes and Its Complications - April 23, 2015 Category: Endocrinology Authors: Casey R. Dunn, Sheryl Martin-Schild Tags: Editorial Source Type: research

Case–control study of second‐line therapies for type 2 diabetes in combination with metformin and the comparative risks of myocardial infarction and stroke
ABSTRACT We conducted a population‐based case–control study to assess the myocardial infarction (MI) and stroke risks associated with sulfonylureas and insulin when used in combination with metformin. Cases had type 2 diabetes and used metformin + insulin or metformin + sulfonylureas at the time of a first MI or first stroke from 1995–2010; controls used the same treatment combinations and were randomly sampled from the same population. MI and stroke diagnoses and potential confounders were validated by medical record reviews. Compared with metformin + sulfonylurea, metformin + insulin was associated ...
Source: Diabetes, Obesity and Metabolism - July 14, 2015 Category: Endocrinology Authors: James S. Floyd, Kerri L. Wiggins, Colleen M. Sitlani, James H. Flory, Sascha Dublin, Nicholas L. Smith, Susan R. Heckbert, Bruce M. Psaty Tags: Research Letter Source Type: research

Detecting and Managing Diabetes Mellitus and Prediabetes in Patients With Acute Stroke
Conclusions The majority of acutely admitted stroke patients without known DM or pre-DM had A1C ≥5.7%. Newly diagnosed DM or pre-DM patients received inadequate diabetes education and follow-up care. These findings provide significant opportunities for improving acute stroke management.
Source: The Diabetes Educator - September 21, 2015 Category: Endocrinology Authors: Liu, A., Carmichael, K. A., Schallom, M. E., Riley, M. J., Klinkenberg, W. D. Tags: Features Source Type: research