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Association Between Hyperhomocysteinemia Combined with Metabolic Syndrome and Higher Prevalence of Stroke in Chinese Adults Who Have Elevated Blood Pressure
CONCLUSIONS HHcy combined with MS was associated with higher prevalence of stroke in Chinese adults with elevated blood pressure.PMID:35013090 | DOI:10.12659/MSM.934100
Source: Medical Science Monitor - January 11, 2022 Category: Research Authors: Feng Hu Shichao Yu Juan Li Wei Zhou Tao Wang Xiao Huang Huihui Bao Xiaoshu Cheng Source Type: research

Cerebral cortical microvascular rarefaction in metabolic syndrome is dependent on insulin resistance and loss of nitric oxide bioavailability
ConclusionsFurther analyses revealed that the maintenance of glycemic control and vascular nitric oxide bioavailability were stronger predictors of cerebral cortical MVD in OZR than was prevention of hypertension, and this may have implications for chronic treatment of CVD risk under stroke‐prone conditions.This article is protected by copyright. All rights reserved.
Source: Microcirculation - May 1, 2015 Category: Research Authors: Paul D. Chantler, Carl D. Shrader, Lawrence E. Tabone, Alexandre C. d'Audiffret, Khumara Huseynova, Steven D. Brooks, Kayla W. Branyan, Kristin A. Grogg, Jefferson C. Frisbee Tags: Original Research Source Type: research

The Polyherbal Functional Ingredient Containing Ginger, Chinese Date, and Wood Ear Mushroom Protects against Dementia following Metabolic Syndrome
This study was performed to test this hypothesis and to explore the underlying mechanism. Male Wistar rats weighing 180-220 g were induced metabolic syndrome (MetS) with a 16-week high-carbohydrate high-fat diet (HCHF) feeding. The rats with MetS characteristics were orally administered GCJ at various doses (GCJ100, GCJ200, and GCJ300 mg kg-1 BW) 21 days pre-induction and 21 days post-induction of reperfusion injury (I/R) at the right middle cerebral artery (MCAO). Memory was evaluated every 7 days during the study period. At the end of the study, neuron density, AChE activity, and the expressions of eNOS, BDNF, and pERK/E...
Source: Biomed Res - August 11, 2023 Category: Research Authors: Thuntiva Nakyam Jintanaporn Wattanathorn Wipawee Thukham-Mee Supaporn Muchimapura Source Type: research

Grading of Japanese Diet Intakes by 24-Hour Urine Analysis of Taurine and Soy Isoflavones in Relation to Cardiovascular Risks
In conclusion, the higher the J score, which corresponds to Japanese dietary habits, the lower the BMI and cholesterol levels, as well as mortality rate from coronary heart disease, but the higher the average life expectancy among the Japanese. However, these higher J scorings were associated with high-salt intake and high Na/K ratios; therefore, they contributed to high blood pressure and high mortality rate caused by stroke in Japan. These results indicate that low-salt intake should be recommended to the Japanese who are consuming seafood and soy regularly in order to maintain lower blood pressure and to extend healthy ...
Source: Advances in Experimental Medicine and Biology - July 26, 2022 Category: Research Authors: Mari Mori Miki Sagara Hideki Mori Yukio Yamori Source Type: research

Adiponectin as a routine clinical biomarker.
Abstract Adiponectin is a protein synthesized and secreted predominantly by adipocytes into the peripheral blood. However, circulating adiponectin level is inversely related with body weight, especially visceral fat accumulation. The mechanism of this paradoxical relation remains obscure. Low circulating adiponectin concentrations (hypoadiponectinemia; <4 μg/mL) are associated with a variety of diseases, including dysmetabolism (type 2 diabetes, insulin resistance, hypertension, dyslipidemia, metabolic syndrome, hyperuricemia), atherosclerosis (coronary artery disease, stroke, peripheral artery disease), slee...
Source: Clin Med Res - January 1, 2014 Category: Research Authors: Kishida K, Funahashi T, Shimomura I Tags: Best Pract Res Clin Endocrinol Metab Source Type: research

Metabolic dysfunction and adipose tissue macrophages: Is there more to glean from studying the lean?
Metabolic syndrome is a serious health condition that affects approximately 34% of adults. Hallmarks of this syndrome include abdominal obesity, elevated triglyceride levels, reduced HDL cholesterol, hypertension, hyperglycemia, and insulin resistance, and those affected are at heightened risk for the development of Type 2 diabetes, cardiovascular disease, and stroke. Over the past 20 years, an increasing role for low grade, sterile inflammation in insulin resistance and metabolic syndrome has been appreciated.
Source: Translational Research - February 29, 2016 Category: Research Authors: David L. Morris, Carmella Evans-Molina Tags: Commentary Source Type: research

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease
Alzheimer's disease (AD) is a leading cause of death and disability among older adults. Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes mellitus, sleep apnea, and metabolic syndrome. Here, interactions between cerebrovascular function and development of AD are reviewed, as are interventions to improve cerebral blood flow and reduce VRF. Atherosclerosis and small vessel cerebral disease impair metabolic regulation of cerebral blood flow and, along with microvascular rarefaction and altered trans-capillary exchange, create conditions favoring AD development. Although currently the...
Source: Experimental Biology and Medicine - June 13, 2016 Category: Research Authors: Manukhina, E. B., Downey, H. F., Shi, X., Mallet, R. T. Tags: Physiology Source Type: research

Is there any relationship between different phenotypes of metabolic syndrome and cardiovascular mortality rate?
CONCLUSION: This study showed different phenotypes of MetS related with all-cause mortality rate and existing HTN in the phenotype of MetS increased the incidence of CVD mortality. PMID: 28028525 [PubMed]
Source: Biomed Res - December 30, 2016 Category: Research Authors: Khosravi A, Ahmadzadeh S, Gharipour M, Golshahi J, Sadeghi M, Jozan M, Sarrafzadegan N Tags: Adv Biomed Res Source Type: research

Association of Whole Blood Viscosity With Metabolic Syndrome in Type 2 Diabetic Patients: Independent Association With Post-Breakfast Triglyceridemia.
CONCLUSIONS: Both the presence of MS and the number of MS components were associated with higher WBV in patients with type 2 diabetes. Physicians need to perform a close follow-up of type 2 diabetes patients with MS on inhibitors of sodium-glucose co-transporters 2, which may increase stroke risk associated with an increase in hematocrit and therefore blood viscosity. Post-breakfast TG was an independent determinant of WBV. Elevated WBV may represent an important confounder of the relationship between MS, postprandial hyperlipidemia and elevated cardiovascular risk in this population. PMID: 28270893 [PubMed - in process]
Source: Clin Med Res - March 10, 2017 Category: Research Authors: Minato S, Takenouchi A, Uchida J, Tsuboi A, Kurata M, Fukuo K, Kazumi T Tags: J Clin Med Res Source Type: research

Preventing Muscle Atrophy Following Strokes: A Reappraisal.
Authors: Munakomi S Abstract Muscle atrophy leading to muscle weakness accounts for major cause of disabilities among stroke survivors. It amounts to compromised gait and prevails to viscous cycle of diminished physical capacities and compromised participation in rehabilitative tasks. There is predisposition to recurrent strokes due to added risk of developing metabolic syndrome. Therefore, beyond the shadow of doubt, there is ripple effect of rehabilitation and thereby muscle protection in these subsets of patients. Herein, we highlight upon the newer insights with regard to preventing muscle atrophy following str...
Source: Advances in Experimental Medicine and Biology - November 6, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Association of Cystatin C with Metabolic Syndrome and Its Prognostic Performance in Non-ST-Segment Elevation Acute Coronary Syndrome with Preserved Renal Function.
Conclusion: Cystatin C may be an independent predictor of metabolic syndrome and therefore valuable for management of NSTE-ACS patients. Further multicenter, large-scale studies are required to assess the implication of these results. PMID: 31317040 [PubMed - indexed for MEDLINE]
Source: Biomed Res - December 21, 2019 Category: Research Authors: Mao Q, Zhao N, Wang Y, Li Y, Xiang C, Li L, Zheng W, Xu S, Zhao XH Tags: Biomed Res Int Source Type: research

Hyperviscosity syndrome in COVID-19 and related vaccines: exploring of uncertainties
In conclusion, COVID-19 and related vaccines are linked with the development of HVS, mainly in patients with previous COVID-19 and underlying metabolic derangements. The possible mechanism of HVS in COVID-19 and related vaccines is increasing levels of fibrinogen and immunoglobulins. However, dehy dration, oxidative stress, and inflammatory reactions are regarded as additional contributing factors in the pathogenesis of HVS in COVID-19. However, this critical review cannot determine the final causal relationship between COVID-19 and related vaccines and the development of HVS. Prospective and retrospective studies are warranted in this field.
Source: Clinical and Experimental Medicine - May 24, 2022 Category: Research Source Type: research