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Specialty: Drugs & Pharmacology
Condition: Heart Failure

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Total 434 results found since Jan 2013.

Comparative cardiovascular safety of non ‐steroidal anti‐inflammatory drugs in patients with hypertension: a population‐based cohort study
ConclusionsOur results provide important information about the comparative cardiovascular safety of NSAIDs in patients with hypertension.
Source: British Journal of Clinical Pharmacology - February 22, 2018 Category: Drugs & Pharmacology Authors: Yaa ‐Hui Dong, Chia‐Hsuin Chang, Li‐Chiu Wu, Jing‐Shiang Hwang, Sengwee Toh Tags: DRUG SAFETY Source Type: research

Comparative cardiovascular safety of nonsteroidal anti ‐inflammatory drugs in patients with hypertension: a population‐based cohort study
ConclusionsOur results provide important information about the comparative cardiovascular safety of NSAIDs in patients with hypertension.
Source: British Journal of Clinical Pharmacology - March 13, 2018 Category: Drugs & Pharmacology Authors: Yaa ‐Hui Dong, Chia‐Hsuin Chang, Li‐Chiu Wu, Jing‐Shiang Hwang, Sengwee Toh Tags: DRUG SAFETY Source Type: research

Single-pill combination for hypertension linked with improved clinical outcomes and adherence, study finds
Single-pill fixed-dose combination treatment for hypertension improves medication adherence and is linked with a significantly lower risk of heart attack, heart failure or stroke, a study has found.
Source: The Pharmaceutical Journal - June 13, 2018 Category: Drugs & Pharmacology Source Type: research

Toll-like receptors signaling pathways as a potential therapeutic target in cardiovascular disease.
Abstract Cardiovascular disease (CVD) is one of the most important causes of morbidity and mortality, and associated with an important economic burden globally. Over the last decade, the prevalence of CVD has been rising globally, and is now associated with millions of death annually in both developed and developing countries. There is good evidence that the immune system is involved in the pathophysiology of CVD. Toll-like receptors (TLRs) and their down-stream signaling pathways play an important role in the immune system. Recent studies have suggested that the TLRs are involved in atherogenesis, including strok...
Source: Current Pharmaceutical Design - June 13, 2018 Category: Drugs & Pharmacology Authors: Parizadeh SM, Ghandehari M, Heydari-Majd M, Seifi S, Mardani R, Parizadeh SM, Ghayour-Mobarhan M, Ferns GA, Hassanian SM, Avan A Tags: Curr Pharm Des Source Type: research

Aspirin lowers risk of death in people with concomitant heart failure and diabetes
Aspirin reduces the risk of  all-cause death or hospitalisation for heart failure in patients with concomitant type 2 diabetes and heart failure but increases the risk of non-fatal heart attack or stroke.
Source: Clinical Pharmacist - June 22, 2018 Category: Drugs & Pharmacology Source Type: research

Current Strategies and Drug Targets in the Management of Type 2 Diabetes Mellitus.
CONCLUSION: This review discusses the strategies and future perspectives in the management of type 2 diabetes mellitus particularly antidiabetic agents which are helpful for the betterment of diabetic patients. PMID: 30051787 [PubMed - as supplied by publisher]
Source: Current Drug Targets - July 27, 2018 Category: Drugs & Pharmacology Authors: Kaur P, Mittal A, Nayak SK, Vyas M, Mishra V, Khatik GL Tags: Curr Drug Targets Source Type: research

Combining clinical predictors to better predict for the no-reflow phenomenon.
CONCLUSIONS: We have found that the combination of a CHA2DS2-VASc score and a pre-PCI thrombus load score was more sensitive in detecting the no-reflow phenomenon than only a CHA2DS2-VASc score in patients who underwent PPCIs for STEMIs. PMID: 30070335 [PubMed - in process]
Source: Pharmacological Reviews - August 1, 2018 Category: Drugs & Pharmacology Authors: Avci E, Yildirim T, Aydin G, Kiris T, Dolapoglu A, Kadi H, Safak O, Bayata S Tags: Eur Rev Med Pharmacol Sci Source Type: research

The natural phenolic compounds as modulators of NADPH oxidases in hypertension
ConclusionIt is clear that natural phenolic compounds have some potential inhibitory effect on NADPH oxidase activity. In comparison to other phenolic plant compounds, the structural varability of the flavonoids should off different impacts on oxidative stress in hypertension including inhibition of nadph oxisdase and direct scavenging of free radicals.
Source: Phytomedicine - August 7, 2018 Category: Drugs & Pharmacology Source Type: research

Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension.
Abstract Hypertension-induced cardiovascular and renal damage can be mediated by activation of the renin-angiotensin-aldosterone system. There are different factors beyond renin-angiotensin-aldosterone system involved in hypertension and renal damage. Inflammation has emerged as an important mediator of hypertension and cardiovascular and kidney damage. Angiotensin-(1-9), a peptide of the renin-angiotensin system, counter-regulates both the physiological and pathological actions of angiotensin II. Recent data has shown that angiotensin-(1-9) protects the heart and blood vessels from adverse cardiovascular remodeli...
Source: Biochemical Pharmacology - September 1, 2018 Category: Drugs & Pharmacology Authors: Gonzalez L, Novoa U, Moya J, Gabrielli L, Jalil JE, García L, Chiong M, Lavandero S, Ocaranza MP Tags: Biochem Pharmacol Source Type: research

Cardiovascular and microvascular outcomes of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled cardiovascular outcome trials with trial sequential analysis.
CONCLUSIONS: Meta-analysis with trial sequential analysis suggested that GLP1R agonists significantly reduced the risk for all-cause mortality and composite cardiovascular outcomes, but the reduction of cardiovascular mortality remains to be confirmed. PMID: 30223891 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - September 19, 2018 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Fractal properties and morphological investigation of Nano hydrochlorothiazide is used to treat hypertension.
CONCLUSIONS: In this research, the association between Hctz treatment effects with the point of view of the fractal dimension of the drug was demonstrated to prove the properties of the drug in the body. in the near future, drug fractal studies can improve the development of new drugs and treatments with minimal cost than clinical approaches by linking chemistry, mathematical sciences and pharmaceutical sciences. PMID: 30413182 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - November 11, 2018 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

A Critical Review of Nebivolol and its Fixed-Dose Combinations in the Treatment of Hypertension
Abstractβ-Adrenergic receptor blockers (β-blockers) are well-known useful and cost-effective drugs for managing hypertensive patients with coronary heart disease, stroke, and heart failure. However, it is often difficult to use β-blockers for patients with asthma or chronic obstructive pulmonary disease (COPD). Moreover, most β-blockers negatively influence glucose or lipid metabolism. Nebivolol is a third-generation lipophilic β-1 receptor-selective blocker with nitric oxide-mediated vasodilatory effects, metabolically neutral and usually well tolerated by patients with asthma or COPD. Nebivolol has significant effec...
Source: Drugs - November 13, 2018 Category: Drugs & Pharmacology Source Type: research

Managing Diabetes and Preventing Heart Disease: Have We Found a Safe and Effective Agent?
CONCLUSION: Liraglutide, empagliflozin, and canagliflozin have been shown to be superior to placebo in improving CV outcomes. However, there are differences among agents in terms of HF and peripheral arterial disease outcomes. Future studies should focus on evaluating other clinical CV outcomes in patients without existing CVD and perhaps single drug regimens for diabetes. PMID: 30516068 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - December 5, 2018 Category: Drugs & Pharmacology Authors: Cheng JWM, Colucci VJ, Kalus JS, Spinler SA Tags: Ann Pharmacother Source Type: research

Venous Thromboembolism Prophylaxis and Risk in the Inpatient and Outpatient Continuum of Care Among Hospitalized Acutely Ill Patients in the US: A Retrospective Analysis
ConclusionIn this retrospective analysis of nearly 18,000 patients hospitalized for acute illnesses, 59.1% did not receive any VTE prophylaxis and only 7.1% received VTE prophylaxis in both the inpatient and outpatient continuum of care, despite significant VTE risk extending from hospitalization into the post-discharge period.FundingPortola Pharmaceuticals.
Source: Advances in Therapy - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

Increased serum nardilysin is associated with worse long-term outcome of ST-elevation myocardial infarction.
CONCLUSIONS: The increased serum NRDC level at admission is associated with a higher risk of all-cause mortality for ST-elevation myocardial infarction patients. PMID: 30536341 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 13, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research