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Condition: Heart Failure
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Total 321 results found since Jan 2013.

Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
This study is registered with ClinicalTrials.gov, number NCT00968708. Findings 5380 patients were assigned to alogliptin (n=2701) or placebo (n=2679) and followed up for a median of 533 days (IQR 280–751). The exploratory extended MACE endpoint was seen in 433 (16·0%) patients assigned to alogliptin and in 441 (16·5%) assigned to placebo (hazard ratio [HR] 0·98, 95% CI 0·86–1·12). Hospital admission for heart failure was the first event in 85 (3·1%) patients taking alogliptin compared with 79 (2·9%) taking placebo (HR 1·07, 95% CI 0·79–1·46). Alogliptin had no effect on composite events of cardiovascular d...
Source: The Lancet - March 12, 2015 Category: Journals (General) Source Type: research

Heart Failure Therapeutics on the Basis of a Biased Ligand of the Angiotensin-2 Type 1 Receptor Rationale and Design of the BLAST-AHF Study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure)
Publication date: March 2015 Source:JACC: Heart Failure, Volume 3, Issue 3 Author(s): G. Michael Felker , Javed Butler , Sean P. Collins , Gad Cotter , Beth A. Davison , Justin A. Ezekowitz , Gerasimos Filippatos , Phillip D. Levy , Marco Metra , Piotr Ponikowski , David G. Soergel , John R. Teerlink , Jonathan D. Violin , Adriaan A. Voors , Peter S. Pang The BLAST-AHF (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure) study is designed to test the efficacy and safety of TRV027, a novel biased ligand of the angiotensin-2 type 1 receptor, in patients with acute heart failure (AHF). AHF remains a majo...
Source: JACC: Heart Failure - April 18, 2015 Category: Cardiology Source Type: research

Hospitalization after fainting can do more harm than good
One morning not long ago, my teenage daughter started to black out. After an ambulance ride to our local hospital’s emergency department, an electrocardiogram, and some bloodwork, she was sent home with a follow-up doctor appointment. We got the good news that Alexa is perfectly healthy, but should avoid getting too hungry or thirsty so she doesn’t faint again. And I’m feeling lucky that she didn’t need to be hospitalized, because a research letter in this week’s JAMA Internal Medicine points out that hospitalization for low-risk fainting can do more harm than good. Doctors use something called th...
Source: New Harvard Health Information - April 22, 2015 Category: Consumer Health News Authors: Heidi Godman Tags: Health fainting San Francisco Syncope Rule Source Type: news

Incident Atrial Fibrillation Hazard in Hypertensive Population: A Risk Function From and For Clinical Practice Epidemiology/Population
Determining the risk of atrial fibrillation within the hypertensive population without ischemic vascular disease would aid in decision making on preventive approaches. Accordingly, we aimed to estimate the risk of incident atrial fibrillation in this population. We conducted an historical cohort study between July 1, 2006, and December 31, 2011, using anonymized longitudinal patient information from primary care and hospital discharge records contained in the System for the Development of Research in Primary Care database. We included 255 440 hypertensive patients, aged ≥55 years at the time of study entry. Individuals ...
Source: Hypertension - May 13, 2015 Category: Cardiology Authors: Alves-Cabratosa, L., Garcia-Gil, M., Comas-Cufi, M., Ponjoan, A., Marti, R., Parramon, D., Blanch, J., Ramos, R. Tags: Other hypertension Epidemiology/Population Source Type: research

Clinical effectiveness of the systematic use of the GRACE scoring system (in addition to clinical assessment) for ischaemic outcomes and bleeding complications in the management of NSTEMI compared with clinical assessment alone: a prospective study
Abstract We assessed the interest of systematically using the GRACE scoring system (in addition to clinical assessment) for in- hospital outcomes and bleeding complications in the management of NSTEMI compared with clinical assessments alone. Multicentre, randomized study that included 572 consecutive NSTEMI patients, randomized 1:1, into group A: clinical stratification alone and group B: clinical+ GRACE score stratification. Main outcome measures: in-hospital outcomes and bleeding complications. There was no significant difference between the two groups for baseline data or for in-hospital MACE. In multivaria...
Source: Heart and Vessels - June 6, 2015 Category: Cardiology Source Type: research

Clinical Characteristics and Long-Term Outcomes of Hypertrophic Cardiomyopathy.
Authors: Yoshinaga M, Yoshikawa D, Ishii H, Hirashiki A, Okumura T, Kubota A, Sakai S, Harada K, Somura F, Mizuno T, Fujiwara W, Yokoi H, Hayashi M, Ishii J, Murohara T, Yoshida Y, Amano T, Izawa H Abstract Hypertrophic cardiomyopathy (HCM) has various morphological and clinical features. A decade has passed since the previous survey of the epidemiological and clinical characteristics of Japanese HCM patients. The Aichi Hypertrophic Cardiomyopathy (AHC) Registry is based on a prospective multicenter observational study of HCM patients. The clinical characteristics of 42 ambulant HCM patients followed up for up to 5...
Source: International Heart Journal - June 19, 2015 Category: Cardiology Tags: Int Heart J Source Type: research

Myocardial Function in Saudi Adolescents with Vitamin D Deficiency, Tissue Doppler Imaging Study
This study was conducted to evaluate the effect of 25 (OH)D deficiency on the myocardial function and other echocardiographic variables in adolescent, using Tissue Doppler Imaging (TDI) and to correlate these parameters with 25 (OH)D level. The study included 84 healthy adolescents, consecutively selected from adolescents attending the outpatient clinic of Saad Specialist Hospital, KSA between September 2013 and October 2014. The study population was classified into two groups; vitamin D deficient group with 25(OH)D level less than 20 ng/mL and normal vitamin D (control group) with 25(OH)D equal or more than 30 ng/mL. Both...
Source: Journal of the Saudi Heart Association - June 26, 2015 Category: Cardiology Source Type: research

Myocardial function in Saudi adolescents with vitamin D deficiency: Tissue Doppler imaging study
This study was conducted to evaluate the effect of 25(OH)D deficiency on the myocardial function and other echocardiographic variables in adolescent, using tissue Doppler imaging (TDI) and to correlate these parameters with 25(OH)D level. The study included 84 healthy adolescents, consecutively selected from adolescents attending the outpatient clinic of Saad Specialist Hospital, KSA between September 2013 and October 2014. The study population was classified into two groups; vitamin D deficient group with 25(OH)D level less than 20ng/mL and normal vitamin D (control group) with 25(OH)D equal or more than 30ng/mL. Both gro...
Source: Journal of the Saudi Heart Association - July 17, 2015 Category: Cardiology Source Type: research

Cardiovascular safety of albiglutide in the Harmony programme: a meta-analysis
Publication date: Available online 11 August 2015 Source:The Lancet Diabetes & Endocrinology Author(s): Miles Fisher, Mark C Petrie, Philip D Ambery, Jill Donaldson, John J V McMurray, June Ye Background Albiglutide is a glucagon-like peptide-1 receptor agonist, a new class of drugs used to treat type 2 diabetes. We did a prospective meta-analysis of the cardiovascular safety of albiglutide as stipulated by the US Food and Drug Administration recommendations for the assessment of new treatments for diabetes. Methods We did a meta-analysis of eight phase 3 trials and one phase 2b trial in which patients wer...
Source: The Lancet Diabetes and Endocrinology - August 12, 2015 Category: Endocrinology Source Type: research

Serum uric acid is associated with aortic dissection in Chinese men
Aortic dissection (AD) is a severe cardiovascular disease with high mortality. During the past decade, several risk factors have been identified associated with AD, including male sex, older age, hypertension and Marfan syndrome [1]. Recently, accumulating evidence has demonstrated that serum uric acid (UA) is positively associated with the development of hypertension, stroke, heart failure, atherosclerosis and aneurysm [2–6]. Therefore, we performed a hospital-based case–control study to investigate the association between serum UA levels and AD risk.
Source: International Journal of Cardiology - August 25, 2015 Category: Cardiology Authors: Wei-Long Jiang, Xu Qi, Xiao Li, Yu-Feng Zhang, Qing-Qing Xia, Jian-Chang Chen Source Type: research

A Novel Noninvasive Device to Assess Sympathetic Nervous System Function in Patients With Heart Failure
Discussion: Although the VU-AMS version 5fs system detected anticipated hemodynamic and sympathetic nervous system changes to postural shift in participants (n = 10), the elimination of 64% (n = 18) of the sample because of scoring difficulties limits the use of this impedance cardiography device using standard scoring algorithms in persons with heart failure with reduced ejection fraction.
Source: Nursing Research - September 1, 2015 Category: Nursing Tags: Feature Articles Source Type: research

Safety and efficacy of glucose-insulin-potassium treatment in coronary artery bypass graft surgery and percutaneous coronary intervention
The purpose of this meta-analysis was to evaluate protective effects of glucose–insulin–potassium (GIK) on outcomes after coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). We systematically searched Medline/Pubmed, Elsevier, Embase, Web of Knowledge and Google Scholar. A total of 1206 studies were retrieved during the extensive literature search of all major databases; however, 38 trials reporting the end-point of interest were selected. We performed a pooled analysis of outcomes following PCI: incidence of cardiac arrest [odds ratio (OR) of 0.91; 95% confidence interval (CI): ...
Source: Interactive CardioVascular and Thoracic Surgery - October 19, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Ali-Hassan-Sayegh, S., Mirhosseini, S. J., Zeriouh, M., Dehghan, A. M., Shahidzadeh, A., Karimi-Bondarabadi, A. A., Sabashnikov, A., Popov, A.-F. Tags: Congestive Heart Failure Adult Cardiac Source Type: research

Air Pollution Exposure and Blood Pressure: an Updated Review of the Literature.
Abstract Both high arterial blood pressure (BP) and elevated levels of fine particulate matter (PM2.5) air pollution have been associated with an increased risk for several cardiovascular (CV) diseases, including stroke, heart failure, and myocardial infarction. Given that PM2.5 and high BP are each independently leading risk factors for premature mortality worldwide, a potential relationship between these factors would have tremendous public health repercussions. Therefore, the aim of this review is to summarize recent evidence linking air pollution and BP. Epidemiological findings demonstrate that particulate po...
Source: Current Pharmaceutical Design - November 8, 2015 Category: Drugs & Pharmacology Authors: Giorgini P, Di Giosia P, Grassi D, Rubenfire M, Brook RD, Ferri C Tags: Curr Pharm Des Source Type: research

Transfusion strategy in hematological intensive care unit: study protocol for a randomized controlled trial
Background: Packed red blood cell (PRBC) transfusion is required in hematology patients treated with chemotherapy for acute leukemia, autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT). In certain situations like septic shock, hip surgery, coronary disease or gastrointestinal hemorrhage, a restrictive transfusion strategy is associated with a reduction of infection and death. A transfusion strategy using a single PRBC unit has been retrospectively investigated and showed a safe reduction of PRBC consumption and costs. We therefore designed a study to prospectively demonstrate that the tra...
Source: Trials - November 23, 2015 Category: Journals (General) Authors: Sylvain ChantepieJean-Baptiste MearLydia GuittetBenoît DervauxJean-Pierre MarolleauFabrice JardinJean-Jacques DutheilJean-Jacques ParientiJean-Pierre VilqueOumedaly Reman Source Type: research

Hospital Charges for Pediatric Heart Failure-Related Hospitalizations from 2000 to 2009
Abstract Scarce data exist regarding costs of pediatric heart failure-related hospitalizations (HFRH) or how costs have changed over time. Pediatric HFRH costs, due to advances in management, will have increased significantly over time. A retrospective analysis of Healthcare Cost and Utilization Project Kids’ Inpatient Database was performed on all pediatric HFRH. Inflation-adjusted charges are used as a proxy for cost. There were a total of 33,189 HFRH captured from 2000 to 2009. Median charges per HFRH rose from $35,079 in 2000 to $72,087 in 2009 (p < 0.0001). The greatest median charges were incurred in ...
Source: Mammalian Genome - December 8, 2015 Category: Genetics & Stem Cells Source Type: research