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Can we go beyond surrogates?
Two years ago, data presented at the annual American Diabetes Association (ADA) meeting in New Orleans showed a marked decrease in deaths, especially those due to cardiovascular disease, with the use of empagliflozin. Two major questions have been asked: (i) was the result a fluke; and (ii) was it a class effect, or was it specific to the agent used? The hope that both questions would be answered by a second study has been answered: the conclusions of EMPA‐REG were not an anomaly and it is a class effect, not one caused by a specific drug. Importantly, do these studies require us to alter our algorithms for the treatment...
Source: Journal of Diabetes - October 19, 2017 Category: Endocrinology Authors: Andrew Drexler Tags: Editorial Source Type: research

Association of inflammatory biomarkers with comorbidity in chronic obstructive pulmonary disease - results from the COSYCONET cohort
Conclusion: WBC correlates with disease severity and is associated with relevant comorbidities. Other classical inflammatory biomarkers did not show a clear correlation with COPD severity of existing comorbidity.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Seiler, F., Trudzinski, F. C., Alquadrah, M., Fähndrich, S., Watz, H., Jörres, R. A., Koch, A., Welte, T., Vogelmeier, C. F., Biertz, F., Bals, R. Tags: Monitoring Airway Disease Source Type: research

The presence and impact of chronic kidney disease in COPD patients, data from the German COSYCONET cohort
Conclusion: COPD patients with CKD should receive special attention to detect other comorbidities.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Alqudrah, M., Trudzinski, F., Seiler, F., Biertz, F., Koch, A., Vogelmeier, C., Welte, T., Watz, H., Fähndrich, S., Bals, R., Rudolf, J. Tags: Clinical Problems COPD Source Type: research

How Loud Noise Exposure Is Linked to Heart Disease
If you live near an airport, railroad tracks or a busy road, you might be concerned about how fumes from those planes, trains and automobiles are affecting your health. But according to a new review in the Journal of the American College of Cardiology, there may be another threat to worry about: high levels of noise that may be bad for your heart. A connection between noise pollution and cardiovascular disease has been observed in numerous studies over the years, the authors of the new review said. High decibel levels from road traffic and airplanes, for example, has been linked to high blood pressure, coronary artery dise...
Source: TIME: Health - February 6, 2018 Category: Consumer Health News Authors: Amanda MacMillan Tags: Uncategorized are loud noises unhealthy healthytime Heart Disease heart disease risks heart health Journal of the American College of Cardiology noise level meter noise meter noise pollution noise-cancelling headphones onetime Rese Source Type: news

Assessing incident cardiovascular and metabolic diseases in epidemiological cohort studies in Germany.
CONCLUSIONS: Our results highlight the central role of self-reporting and the efforts associated with identification and verification of disease endpoints in cohort studies. They also provide a basis for future population-based studies that aim for standardized assessment of the incidence of cardiovascular and metabolic diseases. PMID: 29487975 [PubMed - as supplied by publisher]
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - February 27, 2018 Category: International Medicine & Public Health Authors: Herrmann WJ, Weikert C, Bergmann M, Boeing H, Katzke VA, Kaaks R, Tiller D, Greiser KH, Heier M, Meisinger C, Schmidt CO, Neuhauser H, Heidemann C, Jünger C, Wild PS, Schramm SH, Jöckel KH, Dörr M, Pischon T Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

EBR Systems launches trial for wireless pacer
EBR Systems said yesterday that it launched a 350-patient investigational device exemption trial of its Wise wireless pacemaker it hopes to use to win FDA approval. Sunnyvale, Calif.-based EBR’s device uses a subcutaneous generator to wirelessly deliver ultrasound energy to a “pellet” implanted in the right ventricle, which it uses to synchronize the left and right ventricles. The system is designed to eliminate the need for a left ventricular lead by allowing the operating physician to place the stimulation “pellet” in a patient-specific location inside the left ventricle. The FDA approved the Solve-CRT stu...
Source: Mass Device - March 8, 2018 Category: Medical Devices Authors: Brad Perriello Tags: Cardiovascular Clinical Trials Cardiac Rhythm Management EBR Systems Inc. Source Type: news

Initiating anticoagulant therapy after ICH is associated with patient characteristics and treatment recommendations
ConclusionsClear treatment recommendations by attending stroke physicians significantly influence OAC initiation after ICH. OAC were more frequently recommended and started in younger patients with better functional recovery independent from intracranial complications. This might represent an important determinant of observed beneficial associations, hinting towards an indication bias which might affect observational analyses.
Source: Journal of Neurology - August 20, 2018 Category: Neurology Source Type: research

Heart failure: ventricular assist devices and cardiac transplantation : A  review of current surgical innovations.
CONCLUSION: Not only the number of yearly performed cardiac transplantations has changed but also recipient profiles. While in the pioneering era of transplantation the typical candidate was young, not previously operated on and with lower levels of comorbidities, today's patients are significantly older, have been fitted with ventricular assist devices and have increased operative risk profiles. Modern methods of organ preservation enable longer transportation and operation times as well as an improved assessment of graft function and perspectives for graft optimization in the future. In the area of ventricular assist dev...
Source: Der Chirurg - January 3, 2019 Category: Surgery Authors: Rojas SV, Haverich A Tags: Chirurg Source Type: research

Incidence and in-hospital Safety Outcomes of Patients undergoing Percutaneous Mitral Valve Edge-to-Edge Repair Using MitraClip ® - 5 year German national patient sample including 13,575 implants.
CONCLUSIONS: MitraClip® implantations increased markedly 5.4-fold between 2011 and 2015, with a constant in-hospital mortality and MACCE rate. Our data indicate that edge-to-edge mitral valve repair in MitraClip® technique has acceptable in-hospital safety outcomes in a real world scenario. PMID: 30666965 [PubMed - as supplied by publisher]
Source: EuroIntervention - January 24, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Digitalis therapy is associated with higher comorbidities and poorer prognosis in patients undergoing ablation of atrial arrhythmias: data from the German Ablation Registry
ConclusionIn the present study of patients undergoing catheter ablation of supraventricular arrhythmias, an association of digitalis therapy with increased mortality and an increased rate of other severe adverse events were observed. The results from this ‘real-life’ registry are consistent with previously published studies. However, whether digitalis therapy promotes a poorer prognosis or may just serve as a marker for this aspect cannot be thoroughly interpreted.
Source: Clinical Research in Cardiology - February 23, 2019 Category: Cardiology Source Type: research

YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Repeated Changes to the Gravitational Field Negatively Affect the Serum Concentration of Select Growth Factors and Cytokines
This study was carried out in accordance with the recommendations of the ethical committee of the Ruhr-Universität Bochum with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the ethical committee of the Ruhr-Universität Bochum (Register-Number 5158–14). Author Contributions US, FS, LG, and AK performed the experiments. US and TR analyzed the data, created the figures, and drafted the manuscript. TW, FS, and NB designed the study. All authors revised the manuscript and approved its fina...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Breathing: Ambient Air Pollution and Health - Part II.
Authors: Schulz H, Karrasch S, Bölke G, Cyrys J, Hornberg C, Pickford R, Schneider A, Witt C, Hoffmann B Abstract The second part of the DGP-statement on adverse health effects of ambient air pollution provides an overview of the current ambient air quality in Germany and its development in the past 20 years. Further, effects of air pollution on the cardiovascular system und underlying pathophysiological mechanisms are introduced. Air pollutants form a highly complex and dynamic system of thousands of organic and inorganic components from natural and anthropogenic sources. The pollutants are produced locally or in...
Source: Pneumologie - June 13, 2019 Category: Respiratory Medicine Tags: Pneumologie Source Type: research

Rationale and Design of the Hamburg City Health Study
AbstractThe Hamburg City Health Study  (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinatio...
Source: European Journal of Epidemiology - November 7, 2019 Category: Epidemiology Source Type: research

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