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Condition: Diabetes Mellitus

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Total 6126 results found since Jan 2013.

Glycosylated Hemoglobin for Diagnosis of Prediabetes in Acute Ischemic Stroke Patients
Background: Prediabetes (PD) is an independent risk factor for stroke. The American Diabetes Association (ADA) has recently published new guidelines recommending glycosylated hemoglobin A1c (HbA1c) as a marker to diagnose diabetes and PD. Diagnosis of diabetes Mellitus (DM) is often made at the time of hospitalization for stroke. Less is known about identifying PD in acute ischemic stroke (AIS) patients. We aim to investigate the frequency of new-onset PD in the hospitalized AIS patients using the new ADA guidelines.Methods: We retrospectively studied 362 AIS patients from our local database. Stroke risk factors, type of s...
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2013 Category: Neurology Authors: Branko N. Huisa, Gulmohor Roy, Jorge Kawano, Ronald Schrader Tags: Original Articles Source Type: research

Metformin-inclusive Therapy Reduces the Risk of Stroke in Patients with Diabetes: A 4-Year Follow-up Study
Metformin is a kind of oral hypoglycemic agents commonly prescribed to patients with diabetes mellitus. Although past studies had proven its protective effect on cardiovascular risk and related mortality, the evidence of metformin on stroke prevention was still insufficient and conflicting. Our study randomly selected 14,856 patients with diabetes from the database provided by the Taiwan National Health Research Institute, and 2 cohorts were formulated according to whether metformin was in the prescription record. All cases were followed up for 4 years to track their stroke incidence. As a result, 701 (17.5%) of 3999 diabe...
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2013 Category: Neurology Authors: Yuan-Yang Cheng, Hsin-Bang Leu, Tzeng-Ji Chen, Chen-Ling Chen, Chia-Hua Kuo, Shin-Da Lee, Chung-Lan Kao Tags: Original Articles Source Type: research

Implementation of a Structured Guideline-Based Program for the Secondary Prevention of Ischemic Stroke in China Clinical Sciences
Conclusions— The implementation of a program to improve adherence to secondary ischemic stroke prevention efforts in China is feasible, but these programs had only a limited impact on adherence and no impact on 1-year outcomes. Further development of a structured program to reduce vascular events after stroke is needed. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00664846.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Peng, B., Ni, J., Anderson, C. S., Zhu, Y., Wang, Y., Pu, C., Wu, J., Wang, J., Zhou, L., Yao, M., He, J., Shan, G., Gao, S., Xu, W., Cui, L., on behalf of the SMART Investigators Tags: Secondary prevention Clinical Sciences Source Type: research

Age Dependence of Risk Factors for Stroke and Death in Young Patients With Atrial Fibrillation: A Nationwide Study Clinical Sciences
Conclusions— The CHA2DS2-VASc score is an applicable tool for all age groups and in nonvalvular atrial fibrillation patients <65 years old, the same risk factors apply.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Melgaard, L., Rasmussen, L. H., Skjoth, F., Lip, G. Y. H., Larsen, T. B. Tags: Acute Cerebral Infarction, Anticoagulants Clinical Sciences Source Type: research

Sex Differences in Trends of Incidence and Mortality of First-Ever Stroke in Rural Tianjin, China, From 1992 to 2012 Clinical Sciences
Conclusions— There was a significant increase in the incidence of first-ever stroke in women annually and a declining trend in the male/female rate ratio in rural China during the past 21 years. These results suggest that stroke will become one of the major diseases affecting women in future decades in China.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Wang, J., Ning, X., Yang, L., Tu, J., Gu, H., Zhan, C., Zhang, W., Su, T.-C. Tags: Epidemiology Clinical Sciences Source Type: research

The Long-term Nutritional Status in Stroke Patients and its Predictive Factors
Conclusions: Malnutrition was highly prevalent, with an important role of change in food intake and food preferences, which could result from brain lesions and specific regimens. Living in an institution needs consideration, as its negative effects can be prevented.
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2014 Category: Neurology Authors: Julie Paquereau, Etienne Allart, Monique Romon, Marc Rousseaux Tags: Original Articles Source Type: research

Changes in Functional Outcome Over the First Year After Stroke: An Observational Study From the Swedish Stroke Register Clinical Sciences
Conclusions— Transition from ADL independence to dependence was observed in a high proportion of patients between 3 and 12 months, challenging the common belief that functioning after stroke is stable beyond 3 months. Deterioration occurred more commonly in women, among whom 1/6 converted to dependency.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Ullberg, T., Zia, E., Petersson, J., Norrving, B. Tags: Acute Cerebral Infarction Clinical Sciences Source Type: research

Clinical profile, risk factors, etiology and outcome of stroke in young Filipino adults. (P7.147)
Conclusion - Stroke occurs at a younger age in Filipinos compared to other Asian and European countries. The incidence of stroke in young Filipinos were similar to Asian figures but higher compared to European studies. Hypertension is the most common risk factor in the world followed by diabetes mellitus and dyslipidemia. In Filipinos however, cultural vices such as smoking and alcoholism were the second and third leading risk factors. This paper to the best of our knowledge is the first to report the unique profile of stroke in young Filipino patients.Disclosure: Dr. Talamera has nothing to disclose. Dr. San Jose has noth...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Talamera, T. A., San Jose, M. C., Sanchez, J. A., Pascual IV, J. L. Tags: Cerebrovascular Disease and Interventional Neurology: Race, Ethnicity, and Stroke Source Type: research

Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men Epidemiology/Population
We report findings from a UK cohort study of 1375 European and 1074 South Asian men, not receiving antihypertensive medication, aged 40 to 69 years at baseline (1988–1991). Assessment included BP, blood tests, anthropometry, and questionnaires. Incident stroke was established at 20 years from death certification, hospital and primary care records, and participant report. South Asians had higher systolic BP, diastolic BP, and mean arterial pressure than Europeans, and similar pulse pressure. Associations between systolic BP or diastolic BP and stroke were stronger in South Asians than Europeans, after adjustment for a...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Eastwood, S. V., Tillin, T., Chaturvedi, N., Hughes, A. D. Tags: Cerebrovascular disease/stroke, Risk Factors, Epidemiology Epidemiology/Population Source Type: research

Association of Hemoglobin A1c and Baseline Ischemic Stroke Severity: A Population-Based Study (P1.187)
Conclusions: We found that elevated HbA1c was associated with decreased stroke severity at presentation. However, this effect is mediated by the history of DM rather than a specific dose-effect of glycemic control. Our results provide evidence that although chronic hyperglycemia increases risk of stroke, it is not associated with increased stroke severity.Disclosure: Dr. Yang has nothing to disclose. Dr. Khoury has nothing to disclose. Dr. Alwell has nothing to disclose. Dr. Moomaw has received research support from the National Institutes of Health. Dr. Yeramaneni has nothing to disclose. Dr. Woo has received research sup...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Yang, Y., Khoury, J., Alwell, K., Moomaw, C., Yeramaneni, S., Woo, D., Flaherty, M., Adeoye, O., Ferioli, S., De Los Rios La Rosa, F., Kissela, B., Kleindorfer, D. Tags: Ischemic Stroke Outcomes Source Type: research

Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke Basic Sciences
Conclusions— Our data suggest that DM exacerbates neurovascular damage and hinders brain repair processes, which likely contribute to the impairment of stroke recovery.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Zhang, L., Chopp, M., Zhang, Y., Xiong, Y., Li, C., Sadry, N., Rhaleb, I., Lu, M., Zhang, Z. G. Tags: Basic Science Research, Cognitive Impairment, Neurogenesis Basic Sciences Source Type: research

Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke Stroke
This study aimed to estimate the association between post–glucose load measures of insulin resistance and prognosis of nondiabetic patients with ischemic stroke.Methods and ResultsData were derived from the ACROSS‐China (Abnormal Glucose Regulation in Patients with Acute Stroke across China) registry. Patients with ischemic stroke without a history of diabetes mellitus were included. Two post–glucose load measures of insulin sensitivity, the insulin sensitivity indices ISI(composite) and the ISI0,120, were calculated. Outcomes included stroke recurrence, all‐cause death, and poor functional outcome at 12 months. A...
Source: JAHA:Journal of the American Heart Association - January 20, 2017 Category: Cardiology Authors: Pan, Y., Jing, J., Chen, W., Zheng, H., Jia, Q., Mi, D., Li, H., Zhao, X., Liu, L., Wang, C., Gaisano, H. Y., He, Y., Wang, Y., Tags: Ischemic Stroke Original Research Source Type: research

Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke
Conclusions: Higher serum MMP-9 levels in the acute phase of ischemic stroke were associated with increased risk of mortality and major disability, suggesting that serum MMP-9 could be an important prognostic factor for ischemic stroke.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Zhong, C., Yang, J., Xu, T., Xu, T., Peng, Y., Wang, A., Wang, J., Peng, H., Li, Q., Ju, Z., Geng, D., Zhang, Y., He, J., For the CATIS Investigators Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Cohort studies ARTICLE Source Type: research

The Impact Factors on the Cost and Length of Stay among Acute Ischemic Stroke
Conclusions: Age 65 and over, atrial fibrillation, stroke treatment, and subtypes were the significant predictive factors affecting hospital costs and LOS. Compared to other countries, Taiwan spent the least while Canada had the highest expense. The United States had the shortest LOS (6 days) in contrast to Canada with the longest LOS (34-47 days). Regarding mean daily cost of stroke, the United States had the highest cost per day while China spent the least.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2012 Category: Neurology Authors: Ying-Chih Huang, Chaur-Jong Hu, Tsong-Hai Lee, Jen-Tsung Yang, Hsu-Huei Weng, Leng Chieh Lin, Shiao-Lin Lai Tags: Original Articles Source Type: research

Validation of the Totaled Health Risks In Vascular Events (THRIVE) score for outcome prediction in endovascular stroke treatment
ConclusionsThe THRIVE score reliably predicts outcomes after endovascular stroke treatment and may be useful as a clinical prognostic tool and to perform severity adjustments in stroke clinical research.
Source: International Journal of Stroke - August 29, 2012 Category: Neurology Authors: Alexander C. Flint, Hooman Kamel, Vivek A. Rao, Sean P. Cullen, Bonnie S. Faigeles, Wade S. Smith Tags: Research Source Type: research