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Condition: Cerebral Palsy

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Total 550 results found since Jan 2013.

Impact of stroke volume on motor outcome in neonatal arterial ischemic stroke.
CONCLUSION: In addition to determining the involvement of affected brain areas, the volumetric quantification of stroke volume allows accurate prediction of cerebral palsy in newborns with NAIS. PMID: 31740218 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - October 31, 2019 Category: Neurology Authors: Wiedemann A, Pastore-Wapp M, Slavova N, Steiner L, Weisstanner C, Regényi M, Steinlin M, Grunt S, Swiss Neuropediatric Stroke Registry Group Tags: Eur J Paediatr Neurol Source Type: research

Brain stimulation and constraint for perinatal stroke hemiparesis: The PLASTIC CHAMPS Trial
Conclusions: Hemiparetic children participating in intensive, psychosocial rehabilitation programs can achieve sustained functional gains. Addition of CIMT and rTMS increases the chances of improvement. Classification of evidence: This study provides Class II evidence that combined rTMS and CIMT enhance therapy-induced functional motor gains in children with stroke-induced hemiparetic cerebral palsy.
Source: Neurology - May 1, 2016 Category: Neurology Authors: Kirton, A., Andersen, J., Herrero, M., Nettel-Aguirre, A., Carsolio, L., Damji, O., Keess, J., Mineyko, A., Hodge, J., Hill, M. D. Tags: All Rehabilitation, Plasticity, TMS, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke ARTICLE Source Type: research

Emerging Subspecialties in Neurology: Pediatric stroke and cerebrovascular disorders
In 1895, a neuropathologist at the University of Vienna observed that "a large number of cases of infantile cerebral palsy is caused by the same factors that bring about the majority of cases of cerebral paralysis of adults: by tearing, embolism, and thrombosis of cerebral vessels."1 While Sigmund Freud would go on to become better known for other endeavors, his observation that children can have strokes paved the way for the development of the emerging subspecialty of pediatric stroke and cerebrovascular disorders.
Source: Neurology - October 30, 2016 Category: Neurology Authors: Bernson-Leung, M. E., deVeber, G. A. Tags: Childhood stroke, All Cerebrovascular disease/Stroke, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke, All Education RESIDENT AND FELLOW SECTION Source Type: research

Health related quality of life and manual ability 5 years after neonatal ischemic stroke.
CONCLUSION: Five years after NAIS, HRQOL is comparable to that of typically developing peers, but reduced in children with CP. Poorer manual ability is associated with lower HRQOL. Interventions improving hand function might influence HRQOL and should be considered early on. PMID: 31473077 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - August 11, 2019 Category: Neurology Authors: Caspar-Teuscher M, Studer M, Regényi M, Steinlin M, Grunt S, Swiss Neuropediatric Stroke Registry Group Tags: Eur J Paediatr Neurol Source Type: research

Transcranial direct current stimulation for children with perinatal stroke and hemiparesis
Conclusion: tDCS trials appear feasible and safe in hemiparetic children. Lack of change in objective motor function may reflect underdosing of therapy. Marked gains in subjective function with tDCS warrant further study. ClinicalTrials.gov identifier: NCT02170285. Classification of evidence: This study provides Class II evidence that for children with perinatal stroke and hemiparetic cerebral palsy, the addition of tDCS to moderate-dose motor learning therapy does not significantly improve motor function as measured by the AHA.
Source: Neurology - January 15, 2017 Category: Neurology Authors: Kirton, A., Ciechanski, P., Zewdie, E., Andersen, J., Nettel-Aguirre, A., Carlson, H., Carsolio, L., Herrero, M., Quigley, J., Mineyko, A., Hodge, J., Hill, M. Tags: Childhood stroke, Clinical trials Randomized controlled (CONSORT agreement), All Rehabilitation, Plasticity, TMS ARTICLE Source Type: research

Methylprednisolone Reduces Persistent Post-ischemic Inflammation in a Rat Hypoxia-Ischemia Model of Perinatal Stroke
In conclusion, we demonstrated that administration of MPSS during the tertiary phase of perinatal stroke results in attenuation of the chroni c inflammatory response, leading to pathophysiological and functional recovery. This work validates the high clinical impact of MPSS to treat neonatal conditions linked to chronic inflammation.
Source: Translational Stroke Research - March 4, 2020 Category: Neurology Source Type: research

Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis/Neurogenesis and Behavioral Recovery After Stroke
In conclusion, our results suggest that hUCBC infusion in combination with EPO administration demonstrates therapeutic efficacy in the treatment of stroke-induced injury by promoting neurogenesis and angiogenesis. Further research that delineates the therapeutic mechanism of systemically administered hUCBC and EPO is required. Ethics Statement All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the U. S. National Institutes of Health and were approved by CHA University Institutional Animal Care & Use Com...
Source: Frontiers in Neurology - April 9, 2019 Category: Neurology Source Type: research

Corticospinal Tract Integrity and Long-Term Hand Function Prognosis in Patients With Stroke
Conclusions: The present study showed that CST integrity (at 6 months after onset) in patients with chronic stroke was related to functional hand status. In addition, the mid-pons FA value was more predictive of functional restoration of the hand than the FN or FA value at the pontomedullary junction. These results may be useful in predicting the functional restoration of the hand and understanding the functional prognosis of stroke. Introduction Restoration of hand function is one of the most important goals for patients with stroke (1). Thus, techniques that aid in predicting restoration of hand function are also i...
Source: Frontiers in Neurology - April 14, 2019 Category: Neurology Source Type: research

What Are the Classifications of Perinatal Stroke?
Discussion Perinatal stroke occurs in about 1:1000 live births and is a “focal vascular injury from the fetal period to 28 days postnatal age.” Perinatal stroke is the most common cause of hemiparetic cerebral palsy and causes other significant morbidity including cognitive deficits, learning disabilities, motor problems, sensory problems including visual and hearing disorders, epilepsy, and behavioral and psychological problems. Family members are also affected because of the potential anxiety and guilt feelings that having a child with a stroke presents, along with the care that may be needed over the child&#...
Source: PediatricEducation.org - May 1, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Bihemispheric alterations in myelination in children following unilateral perinatal stroke
Conclusion Myelination of apparently uninjured brain in both the ipsilesional and contralesional hemispheres is decreased after perinatal stroke. Differences appear to radiate outward from the lesion. Further study is needed to determine clinical significance.
Source: NeuroImage: Clinical - June 28, 2018 Category: Radiology Source Type: research

Bedside neurophysiological tests can identify neonates with stroke leading to cerebral palsy.
CONCLUSIONS: Absent SEP combined with continuous EEG background in near-term neonates indicates an MCA stroke and a high risk for cerebral palsy. SIGNIFICANCE: EEG-SEP offers a bedside method for diagnostic screening and a reliable prediction of neuromotor outcome in neonates suspected of having a stroke. PMID: 30904770 [PubMed - as supplied by publisher]
Source: Clinical Neurophysiology - March 14, 2019 Category: Neurology Authors: Nevalainen P, Metsäranta M, Toiviainen-Salo S, Lönnqvist T, Vanhatalo S, Lauronen L Tags: Clin Neurophysiol Source Type: research

Parent and family impact of raising a child with perinatal stroke
Background: Perinatal stroke is a leading cause of early brain injury, cerebral palsy, and lifelong neurological morbidity. No study to date has examined the impact of raising a child with perinatal stroke on parents and families. However, a large breadth of research suggests that parents, and mothers in particular, may be at increased risk for psychological concerns. The primary aim of this study was to examine the impact of raising a child with perinatal stroke on mothers' wellbeing. A secondary aim was to examine how caring for a child with perinatal stroke differentially affects mothers and fathers. Methods: In Study I...
Source: BioMed Central - July 14, 2014 Category: Journals (General) Authors: Taryn B BemisterBrian L BrooksRichard H DyckAdam Kirton Source Type: research

Perspectives in neonatal and childhood arterial ischemic stroke.
Authors: Fluss J, Dinomais M, Kossotoroff M, Vuillerot C, Darteyre S, Chabrier S Abstract INTRODUCTION: Over the last decade considerable advances have been made in the identification, understanding and management of pediatric arterial ischemic stroke. Such increasing knowledge has also brought new perspectives and interrogations in the current acute and rehabilitative care of these patients. AREAS COVERED: In developed countries, focal cerebral arteriopathy is one of the most common causes of arterial ischemic stroke in childhood and imaging features are well characterized. However, there are ongoing debates regar...
Source: Expert Review of Neurotherapeutics - October 1, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Thrombophilia risk is not increased in children after perinatal stroke
Perinatal stroke causes cerebral palsy and lifelong disability. Specific diseases are definable, but mechanisms are poorly understood. Evidence suggests possible associations between arterial perinatal stroke and prothrombotic disorders, but population-based, controlled, disease-specific studies are limited. Understanding thrombophilia in perinatal stroke informs pathogenesis models and clinical management. We conducted a population-based, prospective, case-control study to determine the association of specific perinatal stroke diseases with known thrombophilias. Children with idiopathic magnetic resonance imaging–cl...
Source: Blood - May 18, 2017 Category: Hematology Authors: Curtis, C., Mineyko, A., Massicotte, P., Leaker, M., Jiang, X. Y., Floer, A., Kirton, A. Tags: Pediatric Hematology, Free Research Articles, Thrombosis and Hemostasis, Vascular Biology, CME article Source Type: research

Bihemispheric alterations in myelination in children following unilateral perinatal stroke
ConclusionMyelination of apparently uninjured brain in both the ipsilesional and contralesional hemispheres is decreased after perinatal stroke. Differences appear to radiate outward from the lesion. Further study is needed to determine clinical significance.
Source: NeuroImage: Clinical - July 5, 2018 Category: Radiology Source Type: research