Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis/Neurogenesis and Behavioral Recovery After Stroke

This study demonstrates that combination therapy is more effective than single therapy with either hUCBC or EPO for neurological recovery from subacute stroke. The common pathway underlying hUCBC and EPO treatment requires further study. Introduction Stroke, caused by the disruption of cerebral blood flow, is a leading cause of death and major disability throughout the world (1). However, the therapeutic options to deal with stroke are limited. Despite efforts to develop new therapies for stroke, all treatments have thus far failed to show a clinical effect or are known to have potential toxic effects. Although intra-arterial thrombolysis and intravenous tissue plasminogen activator therapy have been developed and used for ischemic stroke as effective approaches, those are actually significant only in acute phase with risk of cerebral hemorrhage (1–3). After the onset of stroke, patients experience the greatest amount of neurological recovery during the 3 months post-stroke, which does not last afterwards (4). Before fixation of the impairment in the chronic stage, subacute stroke patients require an effective therapeutic measure, which has remained elusive to date. While many drugs from successful preclinical experiments have failed in clinical trials for stroke (5), cell therapy has been introduced and expected to be effective by ameliorating neurological impairments due to stroke in vivo with relevant mechanisms identified in vitro (6–8). Although cell-b...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Publication date: Available online 23 January 2020Source: Stem Cell ReportsAuthor(s): Eduardo Fernandez-Rebollo, Julia Franzen, Roman Goetzke, Jonathan Hollmann, Alina Ostrowska, Matteo Oliverio, Torsten Sieben, Björn Rath, Jan-Wilhelm Kornfeld, Wolfgang WagnerSummaryLong-term culture of primary cells is characterized by functional and secretory changes, which ultimately result in replicative senescence. It is largely unclear how the metabolome of cells changes during replicative senescence and if such changes are consistent across different cell types. We have directly compared culture expansion of primary mesenchyma...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 23 January 2020Source: Journal of the American Society of CytopathologyAuthor(s): Haiyan Lu, Tarik M. Elsheikh, Yaxia ZhangBackfroundPolyoma virus cytopathic effect (BK-CPE) is classified as “Negative for high-grade urothelial carcinoma (NHGUC)” in the Paris System for Reporting Urinary Cytology (TPS). However, polyomaviruses have been historically associated with tumor development and recently reported as an independent risk factor for renourinary carcinoma in transplant patients. The aim of this study was to investigate the relationship between polyomavirus infection in the ...
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
CONCLUSION: Hospitalization or death was not influenced by the type of RO, Al accumulation, or TMV classification. An elevated prevalence of osteoporosis and Al accumulation was detected. PMID: 31967202 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
[Oral health and oral hygiene conditions and nutritional status in children attending a health facility in the Huánuco Region, Peru]. Rev Peru Med Exp Salud Publica. 2019 Oct-Dec;36(4):653-657 Authors: Vargas-Palomino KE, Chipana-Herquinio CR, Arriola-Guillén LE Abstract In order to determine the association between oral health and oral hygiene conditions and nutritional status in children using a health facility in the Huánuco region, a cross-sectional descriptive study was conducted in 118 children who attended the Growth and Development Control (CRED) of the health clinic "...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
Authors: Hernández-Vásquez A, Azañedo D Abstract Secondary analysis of data on 41,330 children aged one to 11 from the Demographic and Family Health Survey (ENDES) carried out in 2018. The frequency of brushing and the use of toothpaste were reported according to the level of fluoride (no brushing, adequate, inadequate, did not show/did not use toothpaste, and illegible), according to socioeconomic and geographical variables. The evaluation showed that 7.8% of children did not brush their teeth; there were significant percentage differences (p
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
Authors: Lancellotti P, De Pauw M, Claeys M Abstract Cardiovascular disease (CVD) and cancer represent the two main causes of death in industrialised countries. Both share common risk factors (diabetes, obesity, hypertension, diet, smoking, etc.). The associated timing of CVD and cancer onset is thus largely influenced by modifiable risk factors. Advances in cancer treatment have extended the lives of patients with cancer, but for some at the cost of adverse cardiovascular events. The rapidly growing number of patients surviving cancer, often in the setting of advanced age, new or pre-existing CV disease and risk f...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Acar RD, Acar Ş, Doğan C, Bayram Z, Karaduman A, Uysal S, Akbal ÖY, Hakgör A, Kaymaz C, Özdemir N Abstract INTRODUCTION: The aim of this study was to explore the relationship between the tricuspid annular plane systolic excursion/pulmonary arterial systolic pressure (TAPSE/PASP) ratio and model for end-stage liver disease (MELD) score in patients with advanced heart failure. METHODS: A total of 103 patients with advanced heart failure evaluated for candidacy for heart transplantation were included in this study. TAPSE was measured by M‑mode echocardiography and cardiac catheteri...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
CONCLUSION: In real-world patients at high risk of bleeding, implantation of the polymer-free metallic stent coated with Biolimus-A9 (Biofreedom®; Biosensors Europe, Morges, Switzerland) followed by 1 -month DAPT showed encouraging results without any stent thrombosis. PMID: 31965195 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
In conclusion, AZA could produce a hematologic response in ~53% of patients with MDS. Furthermore, IPSS-R may reflect MDS prognosis. Further studies are required to establish the criteria for identifying patients likely to obtain maximum benefit from AZA treatment. PMID: 31966063 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Koguchi M, Nakahara Y, Ito H, Wakamiya T, Yoshioka F, Ogata A, Inoue K, Masuoka J, Izumi H, Abe T Abstract Glioblastoma (GBM) is a malignant tumor with a high recurrence rate and has very poor prognosis in humans. The median survival is still
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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