Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis/Neurogenesis and Behavioral Recovery After Stroke
In conclusion, our results suggest that hUCBC infusion in combination with EPO administration demonstrates therapeutic efficacy in the treatment of stroke-induced injury by promoting neurogenesis and angiogenesis. Further research that delineates the therapeutic mechanism of systemically administered hUCBC and EPO is required.
Ethics Statement
All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the U. S. National Institutes of Health and were approved by CHA University Institutional Animal Care & Use Committee (IACUC150018, IACUC180018, IACUC180181).
Author Contributions
SH conducted animal experiments, analyzed the data, and drafted the manuscript. JC performed in vitro assays and analyzed the data. MK designed and conceptualized this study, interpreted the results, and revised the manuscript.
Funding
This work was supported by Industrial Strategic Technology Development Program (10051152, Development of advanced cell therapy technology using growth factor for stroke treatment) funded by the Ministry of Trade, Industry, and Energy (MOTIE, Korea).
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
The hUCBCs were supplied from CHA Medical Center Cord Blood Bank. We thank to the Endit...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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