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Total 470 results found since Jan 2013.

Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial.
Conclusion: The effects of CEE did not differ by BSO status in the overall cohort, but some findings varied by age. Among women with prior BSO, in those aged 70 years or older, CEE led to adverse effects during the treatment period, whereas women randomly assigned to CEE before age 60 seemed to derive mortality benefit over the long term. Primary Funding Source: The WHI program is funded by the National Heart, Lung, and Blood Institute; National Institutes of Health; and U.S. Department of Health and Human Services. Wyeth Ayerst donated the study drugs. PMID: 31499528 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 9, 2019 Category: Internal Medicine Authors: Manson JE, Aragaki AK, Bassuk SS, Chlebowski RT, Anderson GL, Rossouw JE, Howard BV, Thomson CA, Stefanick ML, Kaunitz AM, Crandall CJ, Eaton CB, Henderson VW, Liu S, Luo J, Rohan T, Shadyab AH, Wells G, Wactawski-Wende J, Prentice RL, WHI Investigators Tags: Ann Intern Med Source Type: research

589PFluoropyrimidine-induced cardiotoxicity in colorectal cancer patients: Preliminary data from the prospective observational CHECKPOINT trial (NCT02665312)
ConclusionsA high incidence of CV events, with no apparent correlation with CV comorbidities or risk factors, was observed. Prompt identification and treatment of CV events allowed most pts to complete the treatment with FP.Clinical trial identificationNCT02665312.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureM. Aglietta: Advisory / Consultancy: Bristol-Myers Squibb; Advisory / Consultancy: Merck; Advisory / Consultancy: Roche. All other authors have declared no conflicts of interest.
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

U.S. Cancer Death Rates Continue to Drop, But Progress Is Stalling for Some Cancers
Over the last few decades, the death rate from cancer dropped by 29% in the U.S., according to the latest data from the American Cancer Society (ACS). That, the ACS’s new study estimates, saved 2.9 million lives from 1991 to 2017, largely owing to declines in mortality from the four leading cancer types: lung, breast, prostate and colon. From 2016 to 2017—the latest year for which data are available—the overall cancer death rate declined by 2.2%, the largest single-year reduction ever recorded. These new figures were reported in a study published in CA: A Cancer Journal for Clinicians. The declines are a...
Source: TIME: Health - January 8, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Cancer Source Type: news

The Women's Health Initiative Estrogen-alone Trial had differential disease and medical expenditure consequences across age groups
Conclusion: The decline in ET utilization had differential disease and expenditure consequences by age groups in the United States. These results are limited by the lack of inclusion of vasomotor symptom benefit and costs of alternative medications for these symptoms in the analysis.
Source: Menopause - May 29, 2020 Category: OBGYN Tags: Original Studies Source Type: research

IJERPH, Vol. 17, Pages 4216: Predictive Model of the Risk of In-Hospital Mortality in Colorectal Cancer Surgery, Based on the Minimum Basic Data Set
Conclusions: This mortality model is the first to be based on administrative clinical databases and hospitalization episodes. The model achieves a moderate–high level of discrimination.
Source: International Journal of Environmental Research and Public Health - June 11, 2020 Category: Environmental Health Authors: Garc ía-Torrecillas Olvera-Porcel Ferrer-M árquez Rosa-Garrido Rodr íguez-Barranco Lea-Pereira Rubio-Gil S ánchez Tags: Article Source Type: research

Prognostic significance of pre-procedural prognostic nutritional index in patients with carotid artery stenting
Inflammation and malnutrition play a critical role in the outcomes of patients undergoing carotid artery stenting (CAS). Prognostic nutritional index (PNI) is commonly utilized to evaluate the peri-operative immune-nutritional status of patients undergoing colorectal cancer surgery and is independently associated with survival. We assessed the association between immune-nutritional status, indexed by PNI, and outcomes in CAS patients.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: L ütfi Öcal, Ayhan Küp, Muhammed Keskin, Sinan Cerşit, Mehmet Çelik, Hayati Eren, Mustafa Ozan Gürsoy, Burak Öztürkeri, Bayram Öztürk, Mehmet Muhsin Turkmen Source Type: research

Factors Associated with Participation in Stool Based Colorectal Screening in Brunei Darussalam.
CONCLUSIONS: Our study showed that older age and professional employment status were significantly associated with willingness to participate in a stool based CRC screening. PMID: 32856849 [PubMed - as supplied by publisher]
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Lancet: Many countries falling behind on global commitments to tackling premature deaths from chronic diseases, such as diabetes, lung cancer and heart disease
(The Lancet) Around the world, the risk of dying prematurely from preventable and largely treatable chronic diseases such as stroke, heart disease, and stomach cancer has declined steadily over the past decade, but death rates from other chronic diseases such as diabetes, lung cancer, colon cancer, and liver cancer are declining too slowly or worsening in many countries.
Source: EurekAlert! - Social and Behavioral Science - September 3, 2020 Category: International Medicine & Public Health Source Type: news

Randomized Trial Evaluation of Benefits and Risks of Menopausal Hormone Therapy Among Women Aged 50-59.
Abstract The health benefits and risks of menopausal hormone therapy among women aged 50-59 years are examined in the Women's Health Initiative randomized, placebo-controlled trials using long-term follow-up data and a parsimonious statistical model that leverages data from older participants to increase precision. These trials enrolled 27,347 healthy post-menopausal women aged 50-79 at 40 U.S. clinical centers during 1993-1998, including 10,739 post-hysterectomy participants in a trial of conjugated equine estrogens, and 16,608 participants with uterus in the trial of these estrogens plus medroxyprogesterone acet...
Source: Am J Epidemiol - October 7, 2020 Category: Epidemiology Authors: Prentice RL, Aragaki AK, Chlebowski RT, Rossouw JE, Anderson GL, Stefanick ML, Wactawski-Wende J, Kuller LH, Wallace R, Johnson KC, Shadyab AH, Gass M, Manson JAE Tags: Am J Epidemiol Source Type: research

How does occupational physical activity influence health? An umbrella review of 23 health outcomes across 158 observational studies.
CONCLUSIONS: We found favourable associations for most health-related outcomes with high OPA levels, but we also found some evidence for unfavourable associations due to high OPA levels. At this point, there is a need for better quality evidence to provide a unequivocal statement on the health effects of OPA. PMID: 33239353 [PubMed - in process]
Source: British Journal of Sports Medicine - November 28, 2020 Category: Sports Medicine Authors: Cillekens B, Lang M, van Mechelen W, Verhagen E, Huysmans MA, Holtermann A, van der Beek AJ, Coenen P Tags: Br J Sports Med Source Type: research

An update on the role of miR-124 in the pathogenesis of human disorders.
Abstract MicroRNA-124 (miR-124) is a copious miRNA in the brain, but it is expressed in a wide range of human/animal tissues participating in the pathogenesis of several disorders. Based on its important function in the development of the nervous system, abnormal expression of miR-124 has been detected in nervous system diseases including Alzheimer's disease, Parkinson's disease, Hypoxic-Ischemic Encephalopathy, Huntington's disease, and ischemic stroke. In addition to these conditions, miR-124 contributes to the pathogenesis of cardiovascular disorders, hypertension, and atherosclerosis. Besides, it has been show...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 4, 2021 Category: Drugs & Pharmacology Authors: Ghafouri-Fard S, Shoorei H, Bahroudi Z, Abak A, Majidpoor J, Taheri M Tags: Biomed Pharmacother Source Type: research

Lynch syndrome-associated repeated stroke with MLH1 frame-shift mutation
We describe the case of a 34-year-old female patient with 50  days of sudden dizziness and left limb weakness, whose head CT scan showed large infarction in the right frontal temporal parietal lobe and basal ganglia area. Imaging examinations and pathological biopsy indicated high-grade serous carcinoma (HGSC) IIIA1 of the right ovary. In addition, a novel f rame-shift mutation in the MLH1 gene (c.1621dupG, p.A541Gfs*16) was found in the genetic panel sequence. It may render declining of MLH1 protein and also associate with the patient’s progressive clinical manifestations of multiple systems. Therefore, the timely use ...
Source: Neurological Sciences - January 12, 2021 Category: Neurology Source Type: research

IJERPH, Vol. 18, Pages 612: Effects of Behavioral Risk Factors and Social-Environmental Factors on Non-Communicable Diseases in South Korea: A National Survey Approach
This study investigates the effects of social-environmental and behavioral risk factors on NCDs as well as the effects of social-environmental factors on behavioral risk factors using an integrated research model. This study used a dataset from the 2017 Korea National Health and Nutrition Examination Survey. After filtering incomplete responses, 5462 valid responses remained. Items including one’s social-environmental factors (household income, education level, and region), behavioral factors (alcohol use, tobacco use, and physical activity), and NCDs histories were used for analyses. To develop a comprehensi...
Source: International Journal of Environmental Research and Public Health - January 12, 2021 Category: Environmental Health Authors: Nam Jeong Jeong Eunil Park Angel P. del del Pobil Tags: Article Source Type: research

Sensors, Vol. 21, Pages 831: Affimer-Based Europium Chelates Allow Sensitive Optical Biosensing in a Range of Human Disease Biomarkers
Paul Millner The protein biomarker measurement has been well-established using ELISA (enzyme-linked immunosorbent assay), which offers good sensitivity and specificity, but remains slow and expensive. Certain clinical conditions, where rapid measurement or immediate confirmation of a biomarker is paramount for treatment, necessitate more rapid analysis. Biosensors offer the prospect of reagent-less, processing-free measurements at the patient’s bedside. Here, we report a platform for biosensing based on chelated Eu3+ against a range of proteins including biomarkers of cardiac injury (human myoglobin), st...
Source: Sensors - January 27, 2021 Category: Biotechnology Authors: Eiman Al-Enezi Alexandre Vakurov Amy Eades Mingyu Ding Gin Jose Sikha Saha Paul Millner Tags: Article Source Type: research

Nut and legume consumption and human health: an umbrella review of observational studies.
Authors: Martini D, Godos J, Marventano S, Tieri M, Ghelfi F, Titta L, Lafranconi A, Trigueiro H, Gambera A, Alonzo E, Sciacca S, Buscemi S, Ray S, Galvano F, Del Rio D, Grosso G Abstract Consumption of nuts and legumes has been associated with several health benefits. The aim of this study was to systematically review existing meta-analyses of observational studies on nut and legume intake and non-communicable diseases, and assess the level of evidence. Out of the six meta-analyses focussed on legume and 15 on nut intake, a possible association with decreased risk of colorectal adenoma and coronary heart disease w...
Source: International Journal of Food Sciences and Nutrition - February 7, 2021 Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research