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Total 101 results found since Jan 2013.

Elevated CA125 is Related to Stroke Due to Cancer- Associated Hypercoagulation
It is well-known that cancer patients commonly have ischemic stroke and the incidence is getting increased with the development of cancer therapy prolonging survival.1 Ischemic stroke in cancer patients is caused by various etiologies. Cancer-associated hypercoagulation is one of the major important pathophysiological mechanisms of stroke in cancer patients.2,3 This hypercoagulation is mediated by multiple mechanisms associated with tissue factor, mucin, and cysteine proteinase. Carcinomatous mucins are considered to trigger thrombogenicity by interacting with P and L selectins and inducing the formation of platelet-rich microthrombi.
Source: Journal of Stroke and Cerebrovascular Diseases - September 27, 2021 Category: Neurology Authors: Keiko Maezono-Kandori, Tomoyuki Ohara, Jun Fujinami, Naoki Makita, Eijirou Tanaka, Toshiki Mizuno Source Type: research

The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection —evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology
AbstractDue to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by ischaemia and reperfusion, occurring during an acute myocardial infarction and the subsequent reperfusion therapy, can wipe out upwards of a billion cardiomyocytes. A similar program of cell death can cause the irreversible loss of neurons in ischaemic stroke. Similar pathways of lethal cell injury can contribute to other pathologies such as left ventricular dysfunction and heart failure caused by cancer therapy. Consequently, strategies designed to protect the ...
Source: Basic Research in Cardiology - October 11, 2018 Category: Cardiology Source Type: research

Atrial Fib, Elevated Lipids Raise Stroke Risk in Cancer Patients Atrial Fib, Elevated Lipids Raise Stroke Risk in Cancer Patients
New-onset or pre-existing AF predicted acute ischemic stroke or TIA in patients with cancer -- as did renal disease, dyslipidemia, and active cancer therapy -- in a case-control study.First Look
Source: Medscape Hematology-Oncology Headlines - February 24, 2022 Category: Cancer & Oncology Tags: Cardiology News Source Type: news

From cancer to stroke, the past ten years have seen astounding advances in medical science
Breakthrough cancer therapies, life-saving stroke procedures and 'rebooted' donor hearts - these are just a few of the medical advances over the past decade that are transforming our health.
Source: the Mail online | Health - December 31, 2019 Category: Consumer Health News Source Type: news

Prevalence of cardiovascular late sequelae in long ‐term survivors of childhood cancer: A systematic review and meta‐analysis
ConclusionThis review showed the vast range of cardiovascular late effects after childhood or adolescent cancer therapy. The differences between the papers prevented drawing a conclusive picture of the prevalence of cardiovascular late effects. Large cohort studies and better reporting are needed to improve the knowledge on this topic.
Source: Pediatric Blood and Cancer - February 16, 2017 Category: Cancer & Oncology Authors: Peter Scholz ‐Kreisel, Claudia Spix, Maria Blettner, Susan Eckerle, Jörg Faber, Philipp Wild, Hiltrud Merzenich, Ulrike Hennewig Tags: Research Article Source Type: research

Isotropic Generalized Diffusion Tensor MRI
Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring and mapping features of the bulk or average apparent diffusion coefficient (ADC) of water in tissue – aiding in stroke diagnosis and cancer therapy assessment. The pulse sequences and software enable MRI scanners to yield diffusion weighted images (DWI) that are orientationally ...
Source: NIH OTT Licensing Opportunities - August 16, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

The Most Promising Cancer-Fighter In Years
For a while now, I’ve been recommending a powerful antioxidant with the unpronounceable name, pyrroloquinoline quinine – or PQQ for short. And although I recommend this compound to almost everyone who comes to see me at my wellness clinic in South Florida because of its energy-giving qualities, I’ve also observed its extraordinary power to fight cancer. For years, I’ve seen PQQ work wonders with my older patients, because it keeps you feeling young by giving your cells extra energy. PQQ was first discovered back in 1979 by a team of Japanese scientists, who knew little about the substance, except that i...
Source: Al Sears, MD Natural Remedies - March 24, 2015 Category: Complementary Medicine Authors: Andrew Britton Tags: Anti-Aging antioxidants Cancer energy Source Type: news

Healing through music
The last time I had a mammogram, I got a big surprise — and it was a good one. A string quartet was playing just outside the doors of the breast imaging center, and my thoughts immediately shifted from “What are they going to find on the mammogram?” to “Is that Schubert, or Beethoven?” By the time my name was called, I had almost forgotten why I was there. The unexpected concert was the work of Holly Chartrand and Lorrie Kubicek, music therapists and co-coordinators of the Environmental Music Program at Massachusetts General Hospital. But bringing music to hospital corridors is just a sideline for music therapist...
Source: New Harvard Health Information - November 5, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Behavioral Health Mental Health Pain Management Surgery Source Type: news

Neurocognitive deficits in older patients with cancer
Conclusion Neurocognitive deficits (MCI and dementia) are more common in older adults with cancer. Factors associated with neurocognitive deficits include high comorbidity, stroke, warfarin use and metastatic cancer. Identification and management of these conditions is of great relevance in the course of cancer therapy.
Source: Journal of Geriatric Oncology - April 3, 2018 Category: Cancer & Oncology Source Type: research

Impact of ivabradine in decompensated heart failure due to cancer therapy ‐related cardiac dysfunction
In cases of decompensated heart failure related to cancer therapy-related cardiac dysfunction, ivabradine administration could lead to an increased stroke volume by reducing the sinus heart rate, resulting in favorable hemodynamics. Assessment of the overlap between the E- and A-waves facilitates understanding the effects of ivabradine in such cases. Key Clinical MessageIn cases of decompensated heart failure related to cancer therapy-related cardiac dysfunction, ivabradine administration could lead to an increased stroke volume by reducing the sinus heart rate, resulting in favorable hemodynamics. Assessment of the overla...
Source: Clinical Case Reports - May 5, 2021 Category: General Medicine Authors: Yusuke Nakano, Hirohiko Ando, Wataru Suzuki, Hirofumi Ohashi, Yasushi Suzuki, Hiroaki Takashima, Tetsuya Amano Tags: CASE REPORT Source Type: research

Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development
Summary The rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by the development of several experimental anticancer‐ and anti‐ischaemia (stroke or myocardial infarction) drugs. Activation of apoptotic pathways or the removal of cellular apoptotic inhibitors has been suggested to aid cancer therapy and the inhibition of apoptosis was thought to limit ischaemia‐induced damage. However, initial clinical studies on apoptosis‐modulating drugs led to unexpected results in different clinical conditions and this may have been due to co‐effects on non‐apoptotic interconnected cell death m...
Source: Journal of Cellular and Molecular Medicine - January 10, 2013 Category: Molecular Biology Authors: Mayur V. Jain, Anna M. Paczulla, Thomas Klonisch, Florence N. Dimgba, Sahana B. Rao, Karin Roberg, Frank Schweizer, Claudia Lengerke, Padideh Davoodpour, Vivek R. Palicharla, Subbareddy Maddika, Marek Łos Tags: Review Article Source Type: research

Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development.
Abstract The rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by the development of several experimental anticancer- and anti-ischaemia (stroke or myocardial infarction) drugs. Activation of apoptotic pathways or the removal of cellular apoptotic inhibitors has been suggested to aid cancer therapy and the inhibition of apoptosis was thought to limit ischaemia-induced damage. However, initial clinical studies on apoptosis-modulating drugs led to unexpected results in different clinical conditions and this may have been due to co-effects on non-apoptotic interconnected cell death mec...
Source: J Cell Mol Med - January 10, 2013 Category: Molecular Biology Authors: Jain MV, Paczulla AM, Klonisch T, Dimgba FN, Rao SB, Roberg K, Schweizer F, Lengerke C, Davoodpour P, Palicharla VR, Maddika S, Los M Tags: J Cell Mol Med Source Type: research

Managing the Risks of Cardiac Therapy in Cancer Patients
The purpose of this review was to highlight the more commonly used cardiac medications that should be closely monitored or possibly discontinued during cancer therapy. Often, older cancer patients are taking multiple pharmacotherapy agents for the treatment or prevention of cardiac disease when they face decisions about cancer treatment. Concurrent administration of drugs can result either in increased toxicity or decreased efficacy of either therapy. The benefits of the cardiac medications must be weighed against the effects of cancer therapy, and the role of drug metabolism also must be considered. For example, the benef...
Source: Seminars in Oncology - April 1, 2013 Category: Cancer & Oncology Authors: Carol L. Chen, Rekha Parameswaran Tags: Marc L. Schwartz, ME, Guest Editor Source Type: research