Barriers and facilitators of adherence to a perioperative physical activity intervention for older adults with cancer and their family caregivers
ConclusionsBarriers and facilitators to a perioperative physical activity is multidimensional, and focused on social-ecological determinants of health behaviors, including intrapersonal, interpersonal, and environmental factors. Perioperative physical activity interventions for older adults with cancer and their FCGs should integrate strategies to promote self-efficacy, support realistic activity goals, enhance motivation, and optimize social support. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 16, 2019 Category: Cancer & Oncology Source Type: research

Treatment of older patients with immune checkpoint inhibitors in routine clinical care as compared to inclusion in pivotal registration trials
Publication date: Available online 14 June 2019Source: Journal of Geriatric OncologyAuthor(s): Marie-Rose B.S. Crombag, John B.A.G. Haanen, Paul Baas, Jos H. Beijnen, Alwin D.R. Huitema (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 16, 2019 Category: Cancer & Oncology Source Type: research

Breast cancer and aging: Standing on the shoulders of a giant
Publication date: Available online 11 June 2019Source: Journal of Geriatric OncologyAuthor(s): Meghan S. Karuturi, Mina S. Sedrak, Allison Magnuson, Rachel Freedman, Aminah Jatoi, Bejamin D. Smith, Gretchen G. KimmickAbstractWith the aging of the US population, the number of individuals age 65 or older who will be diagnosed with breast cancer is expected to rise. Despite this, older adults with breast cancer remain severely under-represented in cancer clinical trials. Numerous studies have highlighted disparites in care experienced by older patients with breast cancer. Dr. Arti Hurria was one of the most influential leader...
Source: Journal of Geriatric Oncology - June 13, 2019 Category: Cancer & Oncology Source Type: research

Arti Hurria, M.D.: A tribute to her shining legacy in the Alliance for Clinical Trials in Oncology
Publication date: Available online 11 June 2019Source: Journal of Geriatric OncologyAuthor(s): On behalf of the Alliance Cancer in the Older Adult Committee, Araba Adjei, Jan C. Buckner, Elizabeth Cathcart-Rake, Hongbin Chen, Harvey J. Cohen, Dyda Dao, Jo-Ellen De Luca, Josephine Feliciano, Rachel A. Freedman, Richard M. Goldberg, Judith Hopkins, Joleen Hubbard, Aminah Jatoi, Meghan Karuturi, Margaret Kemeny, Gretchen G. Kimmick, Heidi D. Klepin, Jessica L. Krok-Schoen, Jacqueline M. Lafky, Jennifer G. Le-Rademacher (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 13, 2019 Category: Cancer & Oncology Source Type: research

Dr. Arti Hurria: The marvelous disrupter
Publication date: Available online 6 June 2019Source: Journal of Geriatric OncologyAuthor(s): Margaret Sedenquist (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 7, 2019 Category: Cancer & Oncology Source Type: research

Geriatric assessment and treatment outcomes in older adults with cancer receiving immune checkpoint inhibitors
ConclusionsOlder adults treated with ICIs had a high prevalence of impairments in GA domains, and IADL impairments were associated with shorter duration of ICI treatment. Future prospective studies are needed to evaluate the role of the GA further in this vulnerable patient population in the immunotherapy era. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 5, 2019 Category: Cancer & Oncology Source Type: research

How do I best treat pain in my older patient with cancer?
Publication date: Available online 3 June 2019Source: Journal of Geriatric OncologyAuthor(s): Monica Malec, Stacie Levine (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 5, 2019 Category: Cancer & Oncology Source Type: research

Building a successful geriatric oncology research program: Lessons learned from Dr. Arti Hurria's cancer and aging research team
Publication date: Available online 4 June 2019Source: Journal of Geriatric OncologyAuthor(s): Vani Katheria, Ty Lee, Kemberly Charles, Elsa Roberts, Jessica Vazquez, Simone Fernandes Dos Santos Hughes, Leana Chien, Carolina Uranga, Can-Lan Sun, Heeyoung Kim, Rachel Morrison (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 5, 2019 Category: Cancer & Oncology Source Type: research

Targeted therapy for breast cancer in older patients
Publication date: Available online 4 June 2019Source: Journal of Geriatric OncologyAuthor(s): Noam Pondé, Hans Wildiers, Ahmad Awada, Evandro de Azambuja, Coralie Deliens, Lissandra Dal LagoAbstractOlder patients are one of the most relevant sub-groups of patients with breast cancer and will only gain in importance as demographic transition unfolds. Their management, in both the early and advanced settings, should take into consideration specific clinical needs and is made more difficult by the limited availability of evidence on the efficacy and safety of standard treatment regimens in older patients. At the root o...
Source: Journal of Geriatric Oncology - June 5, 2019 Category: Cancer & Oncology Source Type: research

The relevance of geriatric assessment for older patients receiving palliative chemotherapy
ConclusionFrailty was common in older patients who were considered fit to receive palliative chemotherapy. Treatment modification was necessary in half of the patients. Only TUGT was significantly associated with treatment modifications and grade 3 chemotherapy toxicities. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 1, 2019 Category: Cancer & Oncology Source Type: research

Mentoring pearls of wisdom: Lessons learned by mentees of Arti Hurria, MD
Publication date: Available online 31 May 2019Source: Journal of Geriatric OncologyAuthor(s): Allison Magnuson, Daneng Li, Tina Hsu, Kah Poh Loh, Amy MacKenzie, Carolyn J. Presley, Jessica L. Krok-Schoen, Ishwaria M. Subbiah, Grant R. Williams, Melisa Wong, Enrique Soto-Perez-de-Celis, Mina S. Sedrak, on behalf of the Junior Cancer and Aging Research Group (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 1, 2019 Category: Cancer & Oncology Source Type: research

Attributes of caregivers' quality of life: A perspective comparison between spousal and non-spousal caregivers of older patients with cancer
ConclusionThe needs of spousal caregivers and non-spousal caregivers might vary, which should inform the effective and efficient channeling of support for family caregivers. Future research suggestions, along with the study limitations, are discussed. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - June 1, 2019 Category: Cancer & Oncology Source Type: research

Falls in older patients with cancer: Nursing and Allied Health Group of International Society of Geriatric Oncology review paper
ConclusionAssessing older patients for falls and fall risks is an important first step to identify those who may require further follow-up and intervention. Oncology nurses play a key role in optimizing health outcomes of older adults with cancer - through the use of evidence-based information, such as presented in this publication - and have the capacity to help reduce fall risks during and after treatment through information provision, advocacy, support, and promotion of physical activity. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 30, 2019 Category: Cancer & Oncology Source Type: research

Autologous stem cell transplant in older patients (age ≥ 65) with newly diagnosed multiple myeloma: A systematic review and meta-analysis
Publication date: Available online 30 May 2019Source: Journal of Geriatric OncologyAuthor(s): Hira Mian, Owais S. Mian, Bram Rochwerg, Ronan Foley, Tanya M. WildesAbstractObjectiveWhile autologous stem cell transplant (ASCT) is a standard of care for newly-diagnosed younger patients with multiple myeloma, its role in older patients remains controversial. We conducted a systematic review and meta-analysis of observational studies and randomized controlled trials (RCTs) assessing the efficacy and toxicity of ASCT in older patients (age ≥ 65 years) with newly-diagnosed myeloma.MethodsWe searched Medline, Embase, and ...
Source: Journal of Geriatric Oncology - May 30, 2019 Category: Cancer & Oncology Source Type: research

Prehabilitation in geriatric oncology
Publication date: Available online 28 May 2019Source: Journal of Geriatric OncologyAuthor(s): Daniel Santa Mina, Shabbir M.H. Alibhai (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 29, 2019 Category: Cancer & Oncology Source Type: research

Gone too soon: Remembering Arti Hurria
Publication date: Available online 23 May 2019Source: Journal of Geriatric OncologyAuthor(s): Chadi Nabhan (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 24, 2019 Category: Cancer & Oncology Source Type: research

Developing a patient decision aid for women aged 70 and older with early stage, estrogen receptor positive, HER2 negative, breast cancer
ConclusionsThe investigative team developed a novel breast cancer treatment DA that is acceptable to women ≥70 years with a history of ER+, HER2-, early stage breast cancer. Next, the DA's efficacy needs to be tested with diverse older women newly diagnosed with breast cancer. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 24, 2019 Category: Cancer & Oncology Source Type: research

Efficacy of immune checkpoint inhibitors in older adults with advanced stage cancers: A meta-analysis
Publication date: Available online 23 May 2019Source: Journal of Geriatric OncologyAuthor(s): Lawrence Kasherman, Derrick Ho Wai Siu, Kirsty Wai Chung Lee, Sally Lord, Ian Marschner, Craig R. Lewis, Michael Friedlander, Chee Khoon LeeAbstractObjectivesThere is uncertainty whether older patients derive a similar benefit from immune checkpoint inhibitors (ICI) as younger patients. We performed a meta-analysis of ICI trials in advanced cancers to better estimate treatment benefit in the older population.Materials and MethodsWe performed an electronic search for randomized trials of ICI, either as monotherapy or in combination...
Source: Journal of Geriatric Oncology - May 23, 2019 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: May 2019Source: Journal of Geriatric Oncology, Volume 10, Issue 3Author(s): (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 22, 2019 Category: Cancer & Oncology Source Type: research

Subgroup analysis of older patients treated within the randomized phase 3 doxorubicin versus doxorubicin plus evofosfamide (SARC021) trial
Publication date: Available online 22 May 2019Source: Journal of Geriatric OncologyAuthor(s): Eugenie Younger, Karla Ballman, Yao Lu, Zsuzsanna Pápai, Brian A. Van Tine, Steven Attia, Patrick Schöffski, Denise Reinke, William D. Tap, Robin L. JonesAbstractBackgroundMore than half of patients with soft tissue sarcoma (STS) are aged ≥65 years (older), however contemporary data on the efficacy/safety of anthracycline chemotherapy in older patients with STS are lacking.MethodsSARC021 randomized patients to receive first-line doxorubicin or doxorubicin plus evofosfamide. The main aim of this study was to compar...
Source: Journal of Geriatric Oncology - May 22, 2019 Category: Cancer & Oncology Source Type: research

Healthcare providers' discussions of physical activity with older survivors of cancer: Potential missed opportunities for health promotion
Publication date: Available online 20 May 2019Source: Journal of Geriatric OncologyAuthor(s): Elizabeth J. Siembida, Erin E. Kent, Keith M. Bellizzi, Ashley Wilder SmithAbstractObjectivesPhysical activity (PA) promotes physical functioning and health-related quality of life in older survivors of cancer. Using a population-based sample of Medicare Advantage beneficiaries, we aimed to characterize the survivors who reported discussing PA with their healthcare provider.Materials and MethodsData from the Surveillance, Epidemiology, and End Results (SEER) cancer registries was linked with the 2008–2014 Medicare Health Out...
Source: Journal of Geriatric Oncology - May 21, 2019 Category: Cancer & Oncology Source Type: research

“I am busy surviving” - Views about physical exercise in older adults scheduled for colorectal cancer surgery
ConclusionsTo engage frail older adults with CRC in preoperative exercise programs information on exercise should improve. Exercise programs should be easily accessible and take personal preferences, needs and abilities into account. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 21, 2019 Category: Cancer & Oncology Source Type: research

Prognostic value of two geriatric screening tools in a cohort of older patients with early stage Non-Small Cell Lung Cancer treated with hypofractionated stereotactic radiotherapy
Publication date: Available online 20 May 2019Source: Journal of Geriatric OncologyAuthor(s): Francesco Cuccia, Gianluca Mortellaro, Rosario Mazzola, Alessandra Donofrio, Vito Valenti, Antonella Tripoli, Domenica Matranga, Antonio Lo Casto, Giuseppe Failla, Giuseppe Di Miceli, Giuseppe FerreraAbstractObjectivesTo investigate whether assessment with two geriatric screening tools shows a correlation with clinical outcomes of patients aged 65 years or more, with early-stage Non-Small Cell Lung Cancer (es-NSCLC) treated with hypofractionated stereotactic radiotherapy.MethodsFrom March 2014 to June 2018 we retrospectively eva...
Source: Journal of Geriatric Oncology - May 21, 2019 Category: Cancer & Oncology Source Type: research

Feasibility of Eribulin Mesylate in older patients with locally advanced or metastatic breast cancer: A post-hoc analysis of the ESEMPiO study
Publication date: Available online 13 May 2019Source: Journal of Geriatric OncologyAuthor(s): Sandro Barni, Luca Livraghi, Adriano Gravina, Francesca Martella, Loretta D'Onofrio, Maria Morritti, Andrea Michelotti, Patrizia Vici, Lucia Mentuccia, Luca Porcu, Michele Orditura, Fabio Puglisi, ESEMPiO Group (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 14, 2019 Category: Cancer & Oncology Source Type: research

The performance of three oncogeriatric screening tools - G8, optimised G8 and CARG - in predicting chemotherapy-related toxicity in older patients with cancer. A prospective clinical study
ConclusionThe CARG tool could be useful for predicting CRT. CGA showed clinically relevant supportive care needs in patients with a positive G8 screening. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 11, 2019 Category: Cancer & Oncology Source Type: research

Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in older patients with metastatic cancer
Publication date: Available online 10 May 2019Source: Journal of Geriatric OncologyAuthor(s): Kuan-Hung Chen, Ngan-Ming Tsang, Wen-Chi Chou, Shiao Fwu Tai, Shu-Chen Liu, Kin-Fong Lei, Kai-Ping Chang, Wen-Ching Chuang, Ping-Ching PaiAbstractBackgroundTreatment options for older patients with malignancies remain suboptimal. An accurate prognostic stratification could inform treatment decisions, which can potentially improve patient outcomes. Here, we sought to investigate whether the neutrophil-to-lymphocyte ratio (NLR) may have prognostic significance in patients with metastatic malignant tumors, with a special focus on old...
Source: Journal of Geriatric Oncology - May 11, 2019 Category: Cancer & Oncology Source Type: research

Age-related cytokine effects on cancer-related fatigue and quality of life in acute myeloid leukemia
ConclusionCytokines explain a relatively small amount of CRF and QOL scores in patients with AML and effects differ by age group. For cytokine-targeted therapies to improve either outcome, multiple cytokines may need to be substantially altered and therapeutic targets may vary with age. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 11, 2019 Category: Cancer & Oncology Source Type: research

A systematic review on the association of the G8 with geriatric assessment, prognosis and course of treatment in older patients with cancer
ConclusionThe G8 is a useful diagnostic tool to identify older patients with cancer who require full GA and is associated with survival and treatment-related complications. Future prospective studies should investigate whether the G8 is predictive for other relevant clinical outcomes such as treatment completion and patient-centred outcomes. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 9, 2019 Category: Cancer & Oncology Source Type: research

Frailty assessment in elective gastrointestinal oncogeriatric surgery: Predictors of one-year mortality and functional status
ConclusionsThis is the first study to investigate the prognostic accuracy of the 40-items FI as compared to CGA in a vulnerable octogenarian cancer population. Its results are consistent with patient functional status being a mediator of frailty and with both serving as intertwined markers of clinical vulnerability. In addition, according to our results, cancer and specific environmental stressors, such as surgery, are likely to affect the frailty trajectory. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 9, 2019 Category: Cancer & Oncology Source Type: research

The impact of colorectal surgery on health-related quality of life in older functionally dependent patients with cancer – A longitudinal follow-up study
Publication date: Available online 8 May 2019Source: Journal of Geriatric OncologyAuthor(s): Esteban T.D. Souwer, Simone Oerlemans, Lonneke V. van de Poll-Franse, Felice N. van Erning, Frederiek van den Bos, Johan S. Schuijtemaker, Franchette W.P.J. van den Berkmortel, Daan ten Bokkel Huinink, Marije E. Hamaker, Jan Willem T. Dekker, Caroline A. Wientjes, Johanna E.A. Portielje, Huub A.A. MaasAbstractBackgroundOlder patients who are functionally compromised or frail may be at risk for loss of quality of life (QoL) after colorectal cancer (CRC) surgery. We prospectively studied health-related QoL (HRQoL) and its association...
Source: Journal of Geriatric Oncology - May 9, 2019 Category: Cancer & Oncology Source Type: research

Perspectives on geriatric oncology research presented at the 2019 St. Gallen international breast cancer conference
Publication date: Available online 3 May 2019Source: Journal of Geriatric OncologyAuthor(s): Nicolò Matteo Luca Battisti, Roman Dubianski (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 5, 2019 Category: Cancer & Oncology Source Type: research

Screening for deficits using the G8 and VES-13 in older patients with Myelodysplastic syndromes
Publication date: Available online 1 May 2019Source: Journal of Geriatric OncologyAuthor(s): Angela Molga, Michelle Wall, Li Yan A. Wee, Rakchha Chhetri, Deepak Singhal, Nimit Singhal, Luen Bik To, Sepehr Shakib, Timothy To, Devendra Hiwase (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - May 1, 2019 Category: Cancer & Oncology Source Type: research

Expert consensus on the management of breakthrough cancer pain in older patients. A Delphi study
ConclusionsThe present Delphi has generated a set of recommendations that will help healthcare professionals in the management of BTcP in older patients. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 27, 2019 Category: Cancer & Oncology Source Type: research

Catching Arti's kisses
Publication date: Available online 27 April 2019Source: Journal of Geriatric OncologyAuthor(s): Mina S. Sedrak (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 27, 2019 Category: Cancer & Oncology Source Type: research

How to incorporate geriatric assessment in clinical decision-making for older patients with cancer. An implementation study
DiscussionImplementing an onco-geriatric care trajectory, using GA and assessment of patient preferences, resulted in an adjustment of treatment recommendations for a quarter of patients. Thirteen percent needed subsequent referral to a geriatrician. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 27, 2019 Category: Cancer & Oncology Source Type: research

Comprehensive geriatric assessment predicts azacitidine treatment duration and survival in older patients with myelodysplastic syndromes
Publication date: Available online 22 April 2019Source: Journal of Geriatric OncologyAuthor(s): Angela Molga, Michelle Wall, Rakchha Chhetri, Li Yan Wee, Deepak Singhal, Suzanne Edwards, Nimit Singhal, David Ross, Luen Bik To, Gillian Caughey, Sepehr Shakib, Ulrich Germing, Timothy To, Devendra HiwaseAbstractBackgroundTreatment of older patients with myelodysplastic syndrome (MDS) is based on disease biology and performance status. Performance status, however, does not reflect increasing co-morbidities, functional dependence or psychosocial issues in older patients.Patients and MethodsThis prospective study evaluated the b...
Source: Journal of Geriatric Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research

The effect of age and comorbidities on early postoperative complications after radical cystectomy: A contemporary population-based analysis
ConclusionsMost of early postoperative RC complications are related to patients age, but its impact varies according to comorbidity profile. Further studies are needed to validate our findings that may be then considered for individual counselling and informed consent, as well as for health expenditure planning. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 21, 2019 Category: Cancer & Oncology Source Type: research

Detecting geriatric needs in older patients with breast cancer through use of a brief geriatric screening tool
ConclusionThis screening tool identified geriatric syndromes requiring attention in many patients with breast cancer presenting for medical oncology appointments. In oncology practice, need for referral networks to address geriatric syndromes should be assessed. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Role of multidimensional assessment of frailty in predicting outcomes in elderly glioblastoma patients treated with adjuvant concurrent chemo-radiation
ConclusionThe appropriate management of elderly cancer patients with GBM is an important concern in oncology. Our data suggest that in elderly patients in good clinical conditions and with a low FI score, extensive surgery, when feasible without adding neurological impairment, followed by adjuvant RT-TMZ, should be considered. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Ofatumumab is safe and effective as front-line treatment in older patients with chronic lymphocytic leukemia and severe co-morbidities, including other malignancies
ConclusionSingle-agent ofatumumab is a well-tolerated and effective therapeutic approach for treatment-naïve older patients with CLL; it can be safely administered to patients with significant comorbidities and other cancer diagnoses. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Health related quality of life in older patients with solid tumors and prognostic factors for decline
This study aims to investigate health-related quality of life (HRQOL) at baseline and at follow-up in older patients with cancer and to determine prognostic factors for HRQOL decline.MethodsA prospective Belgian multicentre (n = 22) study was performed. Patients ≥70 years with a malignant tumor and abnormal G8 (≤14/17) screening tool were included. Patients underwent geriatric assessment (GA) and HRQOL evaluation with follow up at three months. Uni- and multivariate regression models were performed to determine factors associated (p 
Source: Journal of Geriatric Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Integrating geriatric assessment into routine gastrointestinal (GI) consultation: The Cancer and Aging Resilience Evaluation (CARE)
ConclusionsPerforming a GA in the routine care of older adults with GI malignancies is feasible, and GA impairments are common among this population. A fully patient-reported GA such as the CARE may facilitate broader incorporation of GA in the routine clinic work flow. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Caring for patients with dementia undergoing radiation therapy–A national audit
Publication date: Available online 18 April 2019Source: Journal of Geriatric OncologyAuthor(s): Jessica Flood, Shane O'Hanlon, Matthew Gibb, Anita O'Donovan (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Accelerating adjuvant breast irradiation in women over 65 years: Matched case analysis comparing a 5-fractions schedule with 15 fractions in early and locally advanced breast cancer
Publication date: Available online 17 April 2019Source: Journal of Geriatric OncologyAuthor(s): Hans Van Hulle, Dieter Naudts, Ellen Deschepper, Vincent Vakaet, Leen Paelinck, Giselle Post, Annick Van Greveling, Bruno Speleers, Pieter Deseyne, Yolande Lievens, Wilfried De Neve, Liv Veldeman, Chris Monten (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

Associations of inflammation with frailty in patients with breast cancer aged 50 and over receiving chemotherapy
Publication date: Available online 13 April 2019Source: Journal of Geriatric OncologyAuthor(s): Nikesha Gilmore, Sindhuja Kadambi, Lianlian Lei, Kah Poh Loh, Mostafa Mohamed, Allison Magnuson, Sharon Cole, Benjamin T. Esparaz, Jeffrey K. Giguere, Supriya Mohile, Michelle JanelsinsAbstractPurposeChronic inflammation is a significant physiologic feature of frailty; however, its role and clinical utility in cancer-related frailty remains unknown. We sought to determine if pre-chemotherapy inflammation is predictive of frailty after chemotherapy in patients with breast cancer.MethodsFemale patients (N = 144; age ≥ 5...
Source: Journal of Geriatric Oncology - April 15, 2019 Category: Cancer & Oncology Source Type: research

Perspectives on Geriatric Oncology Research presented at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium
Publication date: Available online 11 April 2019Source: Journal of Geriatric OncologyAuthor(s): John Shen, Mark Prentice, YaoYao Pollock, Marcos Franca, Ravindran Kanesvaran (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 13, 2019 Category: Cancer & Oncology Source Type: research

Prevalence and factors associated with malnutrition in older patients with cancer
ConclusionsDespite significant advances in cancer and supportive care, malnutrition remains a significant and highly prevalent public health problem among older patients with cancer. Identifying factors associated with risk for malnutrition in this patient population can help develop preventive strategies as part of care. Prospective studies are recommended. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 13, 2019 Category: Cancer & Oncology Source Type: research

Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia
Publication date: Available online 5 April 2019Source: Journal of Geriatric OncologyAuthor(s): Kah Poh Loh, Janet A. Tooze, Barbara J. Nicklas, Stephen B. Kritchevsky, Jeff D. Williamson, Leslie R. Ellis, Bayard L. Powell, Timothy S. Pardee, Neha G. Goyal, Heidi D. KlepinAbstractObjectivesTo investigate changes in inflammatory biomarkers during induction therapy for older adults with acute myeloid leukemia (AML) and their associations with geriatric assessment (GA) measures and outcomes.MethodsThis was a single institution ancillary study to a prospective observational study (N = 20 consecutive adults aged ≥60 with ...
Source: Journal of Geriatric Oncology - April 7, 2019 Category: Cancer & Oncology Source Type: research

Use of comprehensive geriatric assessment (CGA) to define frailty in geriatric oncology: Searching for the best threshold. Cross-sectional study of 418 old patients with cancer evaluated in the geriatric frailty clinic (G.F.C.) of Toulouse (France)
Publication date: Available online 4 April 2019Source: Journal of Geriatric OncologyAuthor(s): Delphine Bréchemier, Sandrine Sourdet, Philippe Girard, Zara Steinmeyer, Loic Mourey, Stéphane Gérard, Laurent BalardyAbstractObjectivesA consensual and operational definition of frailty is necessary in geriatric oncology. While many studies have focused on geriatric syndromes evaluated in the comprehensive geriatric assessment (CGA) to select patients at higher risk of poor outcomes, few have compared CGA data with Fried's phenotype of frailty, the most consensual measurement of frailty in geriatrics. Our ob...
Source: Journal of Geriatric Oncology - April 6, 2019 Category: Cancer & Oncology Source Type: research

Falls in older cancer patients: Nursing and Allied Health Group of International Society of Geriatric Oncology review paper
ConclusionAssessing older patients for falls and fall risks is an important first step to identify those who may require further follow-up and intervention. Oncology nurses play a key role in optimizing health outcomes of older adults with cancer - through the use of evidence-based information, such as presented in this publication - and have the capacity to help reduce fall risks during and after treatment through information provision, advocacy, support, and promotion of physical activity. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - April 6, 2019 Category: Cancer & Oncology Source Type: research