The efficacy and toxicity of immune checkpoint inhibitors in a real-world older patient population
Publication date: Available online 10 August 2018Source: Journal of Geriatric OncologyAuthor(s): Joobin Sattar, Adi Kartolo, Wilma M. Hopman, Joshua Matthew Lakoff, Tara BaetzAbstractImportanceImmunotherapy has emerged as an effective treatment option for the management of advanced cancers. The effects of these immune checkpoint inhibitors in the older patient population has not been adequately assessed.ObjectiveTo understand the impact of aging on CTLA-4 and PDL-1 inhibitors efficacy and immune-related adverse events (irAE) in the context of real-world management of advanced solid cancers.Design, Setting, and Participants...
Source: Journal of Geriatric Oncology - August 10, 2018 Category: Cancer & Oncology Source Type: research

Demographic transition – Cancer trends in geriatric population of North India
Publication date: Available online 10 August 2018Source: Journal of Geriatric OncologyAuthor(s): Surbhi Kansal, Seema RaoAbstractDeveloping countries like India are witnessing a demographic transition resulting in population ageing. This population expansion will in future increase the burden of diseases more prevalent in older patients. Since cancer incidence increases with age, a surge in geriatric patients with cancer will soon overburden the health care system of our country. In anticipation of this change, present retrospective study done at a tertiary care centre highlights the cancer spectrum in all age groups with ...
Source: Journal of Geriatric Oncology - August 10, 2018 Category: Cancer & Oncology Source Type: research

The use of chemotherapy in older patients with stage II and III colon cancer: Variation by age and era of diagnosis
ConclusionAdministration of adjuvant chemotherapy for stage II/III colon cancer decreases with advancing age, but improved outcomes are seen in stage III patients under 90 years of age. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - August 10, 2018 Category: Cancer & Oncology Source Type: research

Symptom cluster of emotional distress, fatigue and cognitive difficulties among young and older breast cancer survivors: The mediating role of subjective stress
Publication date: Available online 6 August 2018Source: Journal of Geriatric OncologyAuthor(s): Inbar Levkovich, Miri Cohen, Shirly Alon, Iryna Kuchuk, Bella Nissenbaum, Ella Evron, Simon Pollack, Georgeta FriedAbstractObjectivesTo examine the nature of the symptom cluster of emotional distress, fatigue, and cognitive difficulties in young and older breast cancer survivors (BCS); To assess the mediating role of subjective stress and coping strategies (emotional control and meaning-focused coping) in the association between age and symptom cluster.Materials and MethodsParticipants were 170 BCS, stages I-III, 1–12 mo...
Source: Journal of Geriatric Oncology - August 7, 2018 Category: Cancer & Oncology Source Type: research

21-gene recurrence score testing in the older population with estrogen receptor-positive breast cancer
ConclusionOlder women are less likely to receive RS testing, but when tested, older patients have a similar distribution of RS as compared to younger patients. While high-risk categorization in the older cohort was prognostic, chemotherapy was not associated with improved survival. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - August 7, 2018 Category: Cancer & Oncology Source Type: research

Breast cancer treatment and its effects on aging
Publication date: Available online 2 August 2018Source: Journal of Geriatric OncologyAuthor(s): Leslie Chang, Lauren S. Weiner, Sheri J. Hartman, Steve Horvath, Dilip Jeste, Paul S. Mischel, Deborah M. KadoAbstractBreast cancer is the most common cancer of women in the United States. It is also proving to be one of the most treatable. Early detection, surgical intervention, therapeutic radiation, cytotoxic chemotherapies and molecularly targeted agents are transforming the lives of patients with breast cancer, markedly improving their survival. Although current breast cancer treatments are largely successful in producing c...
Source: Journal of Geriatric Oncology - August 3, 2018 Category: Cancer & Oncology Source Type: research

Chronic inflammation and risk of lung cancer in older adults in the health, aging and body composition cohort study
ConclusionsBaseline CRP and IL-6 levels were associated with increased risk of lung cancer in Model 1 and both models, respectively. Chronic IL-6 inflammation, as quantified by repeated measures was associated with incident lung cancer in Model 1, but not Model 2. Further research is needed to understand the role of CRP and IL-6 in lung carcinogenesis. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - August 3, 2018 Category: Cancer & Oncology Source Type: research

Screening for frailty among older patients with cancer using blood biomarkers of inflammation
ConclusionFrailty and GPS two are strongly associated, and GPS two is a significant prognostic factor in frail, older patients with cancer. The inflammatory biomarkers investigated are not suitable screening tools for frailty. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 24, 2018 Category: Cancer & Oncology Source Type: research

CAMERA - complete assessment of elderly patients with cancer: A non-randomised feasibility study
Publication date: Available online 21 July 2018Source: Journal of Geriatric OncologyAuthor(s): Gillian Jackson, Rhian Gabe, Miriam Johnson, Kathryn Date, Daniel Harman, Anthony Maraveyas, Rajarshi Roy, Michael J. Lind (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 22, 2018 Category: Cancer & Oncology Source Type: research

Health status, emergency department visits, and oncologists' feedback: An analysis of secondary endpoints from a randomized phase II geriatric assessment trial
ConclusionsNo difference was found in terms of relationships between GA and utility-based health status or GA and healthcare use. Underreporting of healthcare use was possible. Oncologists welcome GA feedback and prefer to receive it in pre-treatment decision context. Larger trials with earlier GA are warranted. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 21, 2018 Category: Cancer & Oncology Source Type: research

Utilisation of geriatric assessment in oncology - a survey of Australian medical oncologists
ConclusionDespite an emerging evidence base for the potential benefits of GA and collaboration with geriatricians, medical oncologists reported a lack of access but a desire to engage with these services. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 21, 2018 Category: Cancer & Oncology Source Type: research

First validation of the G-8 geriatric screening tool in older patients with glioblastoma
This study was performed to establish whether the G8 scale can be used for screening older patients with glioblastoma.MethodsWe retrospectively reviewed the files of patients assessed by the G8 scale and diagnosed with glioblastoma at a single center from January 2010 to July 2017. Patients aged 65 years or older were classified into three groups (more efficiently than two groups) according to their G8 score to identify those with a poor prognosis: high score group, G8 score 14.5–17; intermediate score group, G8 score 10.5–14; and low score group, G8 score 
Source: Journal of Geriatric Oncology - July 21, 2018 Category: Cancer & Oncology Source Type: research

New technologies in geriatric oncology care
Publication date: Available online 20 July 2018Source: Journal of Geriatric OncologyAuthor(s): Armin Shahrokni, Ronald J. Maggiore, Hassan Ghassemzadeh (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Immunotherapy and targeted therapies in older patients with advanced melanoma; Young International Society of Geriatric Oncology review paper
Publication date: Available online 17 July 2018Source: Journal of Geriatric OncologyAuthor(s): Esther Bastiaannet, Nicolò Battisti, Kah Poh Loh, Nienke de Glas, Enrique Soto-Perez-de-Celis, Capucine Baldini, Ellen Kapiteijn, Stuart LichtmanAbstractMalignant melanoma is an aggressive cancer associated with a poor prognosis in patients with metastatic disease. As in many other cancers, the incidence of melanoma rises with age; and combined with the longer life expectancy, this led to an increasing prevalence of melanoma in the older population. Recently, immune checkpoint inhibitors significantly improved the treatmen...
Source: Journal of Geriatric Oncology - July 18, 2018 Category: Cancer & Oncology Source Type: research

Prioritizing the integration of geriatric oncology and palliative care
Publication date: Available online 17 July 2018Source: Journal of Geriatric OncologyAuthor(s): Karis Kin-fong Cheng, Caroline Nicholson (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 18, 2018 Category: Cancer & Oncology Source Type: research

Clinical pharmacology of oncology agents in older adults: A comprehensive review of how chronologic and functional age can influence treatment-related effects
Publication date: Available online 13 July 2018Source: Journal of Geriatric OncologyAuthor(s): Ginah Nightingale, Rowena Schwartz, Ekaterina Kachur, Brianne N. Dixon, Christine Cote, Ashley Barlow, Brooke Barlow, Patrick MedinaAbstractUnique challenges exist when managing older adults with cancer. Associations between cancer and age-related physiologic changes have a direct impact on pharmacokinetics and pharmacodynamics of cancer therapies and can affect drug dosing, dose intensity, efficacy, safety and quality of life. The breadth and depth of these issues, however, have not been fully evaluated because the majority of c...
Source: Journal of Geriatric Oncology - July 14, 2018 Category: Cancer & Oncology Source Type: research

Gait speed and survival of older surgical patient with cancer: Prediction after machine learning
Publication date: Available online 13 July 2018Source: Journal of Geriatric OncologyAuthor(s): Keyvan Sasani, Helen N. Catanese, Alireza Ghods, Seyed Ali Rokni, Hassan Ghasemzadeh, Robert J. Downey, Armin ShahrokniAbstractPurposeGait speed in older patients with cancer is associated with mortality risk. One approach to assess gait speed is with the ‘Timed Up and Go’ (TUG) test. We utilized machine learning algorithms to automatically predict the results of the TUG tests and its association with survival, using patient-generated responses.MethodsA decision tree classifier was trained based on functional status d...
Source: Journal of Geriatric Oncology - July 14, 2018 Category: Cancer & Oncology Source Type: research

Utilization of hypofractionated radiation therapy in older glioblastoma patients
Publication date: Available online 13 July 2018Source: Journal of Geriatric OncologyAuthor(s): Kevin T. Nead, Samuel Swisher-McClureAbstractBackgroundThough the optimal treatment regimen in older patients with glioblastoma multiforme (GBM) remains to be established, multiple randomized studies have supported the use of hypofractionated (1–3 weeks) versus traditional regimens (6 weeks). Here we examine hypofractionated regimen practice patterns among older patients with GBM.MethodsWe used the National Cancer Database and included individuals aged ≥65 years with GBM diagnosed from 2005 to 2014 undergoing biops...
Source: Journal of Geriatric Oncology - July 13, 2018 Category: Cancer & Oncology Source Type: research

Management and supportive treatment of frail patients with metastatic pancreatic cancer
This article reviews the literature available regarding the management of the so-called frail patients and provide guidance for chemotherapy as well as supportive care treatments. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 11, 2018 Category: Cancer & Oncology Source Type: research

Moving beyond symptom management towards cancer rehabilitation for older adults: Answering the 5W's
This report utilizes examples of three popular geriatric, distress and symptom measures to help answer these questions. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Melanoma in the very elderly, management in patients 85 years of age and over
ConclusionsOlder patients have thick, mitotically active and frequently ulcerated melanomas. An excision margin ≥ 10 mm should be considered to reduce risk of local recurrence. SNB did not impact on survival. With increasing age, patients will more commonly die of causes other than melanoma regardless of the extent of surgical care. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Reply to “Adherence to oral cancer therapy in older adults: The International Society of Geriatric Oncology (SIOG) taskforce recommendations” by Mislang et al.
Publication date: Available online 14 February 2018Source: Journal of Geriatric OncologyAuthor(s): Olivia Le Saux, Christine Ravot, Elisabeth Castel-Kremer, Claire Falandry (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Assessment of treatment factors and clinical outcomes in cervical cancer in older women compared to women under 65 years old
This study aims to understand the treatment patterns and clinical outcomes of older women with cervical cancer compared to younger women.MethodsWomen undergoing care for cervical cancer between 2000 and 2013 at two academic institutions were identified. The cohort of older patients was defined as>65 years old at diagnosis. Patient charts were retrospectively reviewed, and clinical variables were extracted. Fisher's exact tests, logistic regression, and Kaplan-Meier analyses were performed.ResultsFrom 2000 to 2013 1119 women with cervical cancer were identified. Of these, 191 (17.0%) were>65 years old at the time ...
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Elucidating the associations between sleep disturbance and depression, fatigue, and pain in older adults with cancer
Publication date: Available online 3 March 2018Source: Journal of Geriatric OncologyAuthor(s): Kah Poh Loh, Jason Zittel, Sindhuja Kadambi, Chintan Pandya, Huiwen Xu, Marie Flannery, Allison Magnuson, Javier Bautista, Colin McHugh, Karen Mustian, William Dale, Paul Duberstein, Supriya G. MohileAbstractObjectivesSleep disturbance is prevalent and often coexists with depression, fatigue, and pain in the cancer population. The aim of this study was to describe the prevalence of sleep disturbance with co-existing depression, fatigue, and pain in older patients with cancer. We also examined the associations of several socio-dem...
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Outcomes of postoperative radiation therapy for breast cancer in older women according to age and comorbidity status: An observational retrospective study in 752 patients
Publication date: Available online 7 March 2018Source: Journal of Geriatric OncologyAuthor(s): Kim I. Cao, Flore Salviat, Fatima Laki, Marie-Christine Falcou, Matthieu Carton, Philip Poortmans, Alain Fourquet, Youlia M. KirovaAbstractObjectivesThe aim of this study was to assess efficacy, tolerability, and the impact of comorbidities on outcomes in older women treated by radiation therapy (RT) for non-metastatic breast cancer.Materials and MethodsWomen aged ≥70 years at diagnosis who received postoperative RT for primary non-metastatic BC between 2003 and 2009 were retrieved from the Institut Curie registry. We calcul...
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Preoperative frailty is a risk factor for non-home discharge in patients undergoing surgery for endometrial cancer
Publication date: Available online 9 March 2018Source: Journal of Geriatric OncologyAuthor(s): Pelumi Adedayo, Kimberly Resnick, Sareena SinghAbstractObjectiveOur objective was to examine the association of the modified frailty index (mFI) and non-home discharge in patients undergoing surgery for endometrial cancer (EMCA).MethodsPatients who underwent surgery for EMCA from 2011 to 2012 were identified from the American College of Surgeons - Nastional Surigical Quality Improvement Project (ACS-NSQIP) database. Current Procedural Terminology (CPT) codes were used to identify surgical characteristics. We excluded patients who...
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Geriatric assessment-driven polypharmacy discussions between oncologists, older patients, and their caregivers
ConclusionIn this secondary analysis, a GA-driven intervention increased PP discussions, particularly about total number of medications and medication management. PP/PIM concerns were more commonly addressed in the intervention group, except for the subset of conversations about supportive care medications. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Neurocognitive deficits in older patients with cancer
ConclusionNeurocognitive deficits (MCI and dementia) are more common in older adults with cancer. Factors associated with neurocognitive deficits include high comorbidity, stroke, warfarin use and metastatic cancer. Identification and management of these conditions is of great relevance in the course of cancer therapy. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Nivolumab in routine practice for older patients with advanced or metastatic non-small cell lung cancer
ConclusionsEven though frequency and patterns of IrAEs are different from pivotal studies, these results don't seem specific to older patients. Further prospective investigations are needed to better characterize and predict the impact of Nivolumab on older patients with NSCLC. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Geriatric oncology screening tools for CGA-based interventions: results from a phase II study of geriatric assessment and management for older adults with cancer
The objective of this study was to assess the performance of three geriatric oncology screening tools for their ability to predict for CGA-based interventions.Materials and MethodsG8, Vulnerable Elders Survey (VES-13) and a modified frailty phenotype (mFP) screening tools were collected prospectively for patients enrolled in a phase II trial of geriatric evaluation and management. Interventions were defined as a new clinical diagnosis, change in management of a comorbidity, or referral to an allied health professional. Performance characteristics were calculated for each screening tool based on the outcomes of ≥2 abnorm...
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Self-reported major mobility disability and mortality among cancer survivors
This study included patients with a history of cancer who participated in the National Health and Nutrition Examination Survey 19992010. SR-MMD was defined as self-reported difficulty or inability to walk a quarter of a mile. Vital status through December 15, 2011 was ascertained from the United States National Center for Health Statistics. Multivariable-adjusted Cox regression models were used to quantify the hazard ratio (HR) and 95% confidence interval (CI) between SR-MMD and mortality.ResultsThe study included 1458 cancer survivors who averaged 67.1 years of age. At baseline, 201 (13.7%) participants had SR-MMD. Duri...
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

An overview of the toxicities of checkpoint inhibitors in older patients with cancer
This article reviews the tolerability of checkpoint inhibitors in older patients with cancer in clinical practice. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Significance of stereotactic body radiotherapy in older patients with early stage non-small cell lung cancer
ConclusionSBRT may be effective, even in older adults. Regardless of age, SBRT improved the long-term survival of patients only with G8 scores ≥13. The G8 screening tool may aid in determining whether older patients with comorbidities would benefit from SBRT. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Systematic review of care needs for older patients treated with anticancer drugs
ConclusionInformation demand seemed moderate but a great deal of attention was paid to nutrition and well-being. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Treatment outcomes in older patients with advanced gastrointestinal stromal tumor (GIST)
Publication date: Available online 27 March 2018Source: Journal of Geriatric OncologyAuthor(s): Piotr Rutkowski, Elżbieta Bylina, Iwona Lugowska, Paweł Teterycz, Anna Klimczak, Joanna Streb, Anna M. Czarnecka, Czesław OsuchAbstractBackgroundThe aim of the study was to analyze the treatment results of advanced GIST in the largest, homogenous series of older patients.MethodsBetween 2001 and 2016, 686 patients with metastatic/unresectable GIST were treated initially with imatinib and 656 were included in the analysis. Subsequently 232 patients were treated with sunitinib after imatinib failure. We have analyzed the outcome...
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Beyond the black box of geriatric assessment: Understanding enhancements to care by the geriatric oncology clinic
Publication date: Available online 6 April 2018Source: Journal of Geriatric OncologyAuthor(s): Shabbir M.H. Alibhai, Rana Jin, Allison Loucks, Daniel W. Yokom, Sarah Watt, Martine Puts, Narhari Timilshina, Arielle BergerAbstractObjectiveComprehensive geriatric assessment (CGA) of older adults with cancer aids treatment decision-making and prognostication. Much less is known about the supportive care elements or enhancements to care afforded by the CGA. We characterized the enhancements to care provided by a geriatric oncology clinic and determined how these vary by indication for referral.Materials and MethodsAll patients ...
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

The effect of a geriatric evaluation on treatment decisions and outcome for older cancer patients – A systematic review
ConclusionA geriatric evaluation affects oncologic and non-oncologic treatment and appears to improve treatment tolerance and completion for older cancer patients. Fine-tuning the decision-making process for this growing patient population will require more specific and robust data on the effect of a geriatric evaluation on relevant oncologic and non-oncologic outcomes such as survival and quality of life. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Is age a risk factor for depression among the oldest old with cancer?
DiscussionDepression among older patients with cancer rises with increasing age, being extremely common among the oldest old. Age independently predicted depression, irrespective of medical variables, social support, or functional status. Findings highlight the importance of addressing the potentially unmet psychological needs of this rapidly growing patient population. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

The prevalence of major drug-drug interactions in older adults with cancer and the role of clinical decision support software
ConclusionsThere was a high prevalence of major DDIs in older adults with cancer. Utilizing clinical decision support software was beneficial for detecting DDIs however, variability existed with severity reporting. Future studies need to identify the relevant DDIs with clinical implications in order to optimize medication safety in this population. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

The challenges of Bacillus of Calmette-Guerin (BCG) therapy for high risk non muscle invasive bladder cancer treatment in older patients
Publication date: Available online 16 April 2018Source: Journal of Geriatric OncologyAuthor(s): Marco Racioppi, Luca Di Gianfrancesco, Mauro Ragonese, Giuseppe Palermo, Emilio Sacco, PierFrancesco BassiAbstractObjectivesTo evaluate the efficacy and safety of a tailored endovesical immunotherapy protocol with biweekly BCG for elderly Patients with high risk non muscle invasive bladder cancer (HG-NMIBC).Materials and MethodsWe retrospectively evaluated data from 200 patients older than 80 years newly diagnosed with HG-NMIBC: 100 (group 1) with multiple comorbidities (WHO PS 2–3, ASA score ≥3, Charlson Comorbidity index ≥3, GFR
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Using Big Data in oncology to prospectively impact clinical patient care: A proof of concept study
ConclusionThis study establishes a proof of concept of the feasibility of real time use of Big Data for clinical practice. The geriatric screening and the consultation report influenced treatment in 38.7% of cases and modified it in 19.4%, which compares very well with oncogeriatric literature. Additional steps are needed to render it financially and clinically viable. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

The effect of music on postoperative recovery in older patients: A systematic review
ConclusionIt seems worthwhile to further explore live music making in music interventions with older hospitalised surgical patients. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Functional and cognitive impairment, social functioning, frailty and adverse health outcomes in older patients with esophageal cancer, a systematic review
ConclusionFunctional and cognitive impairment, depression and social isolation are prevalent in patients with esophageal cancer, and associate with adverse health outcomes. Geriatric measurements may guide decision-making and customize treatments, but more large studies are needed to explore the clinical usability. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Low levels of intra-tumoural T cells in breast cancer identify clinically frail patients with shorter disease-specific survival
ConclusionsThis is the first study to show that low relative levels of intra-tumoural T cells are associated with inferior patient fitness. In contrast to T cells, we observed that intra-tumoural granulocytic cells displayed an inverse relationship with patient performance. Further research is needed to determine whether boosting the level of intra-tumoural T cells in older non-fit patients can result in improved outcome. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Black-white disparity in physical performance among older women with newly diagnosed non-metastatic breast cancer: Exploring the role of inflammation and physical activity
ConclusionAmong older women with newly diagnosed non-metastatic breast cancer, poor physical performance was prevalent and AA were disproportionately affected. Less engagement in physical activity and subclinical inflammation partly contributed to this disparity. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Patient- and tumor-related predictors of chemotherapy intolerance in older patients with cancer: A systematic review
ConclusionThe included studies were heterogeneous with respect to endpoints and included parameters. Nevertheless, the size of the association and the consistency of results suggest that all these factors are relevant for everyday oncological practice. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

The impact of actual body weight-based chemotherapy dosing and body size on adverse events and outcome in older patients with breast cancer: Results from Cancer and Leukemia Group B (CALGB) trial 49907 (Alliance A151436)
ConclusionObesity was not correlated with adverse relapse or survival outcome, and grade ≥ 3 toxicities were not greater with ABW-based dosing. This supports safety and efficacy of ABW-based dosing as per the 2012 ASCO clinical practice guideline.ClinicalTrials.gov Identifier: NCT00024102 (49907). (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Safety and efficacy of eribulin for “real-world” older patients with metastatic breast cancer
Publication date: May 2018Source: Journal of Geriatric Oncology, Volume 9, Issue 3Author(s): Alexandre de Nonneville, Renaud Sabatier, Anthony Gonçalves, Jean-Marc Extra, Carole Tarpin, Simon Launay, Louis Tassy, Patrice Viens, Frederique Rousseau (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Trimodality therapy for older patients with bladder cancer: Overtreatment or benefit?
Publication date: May 2018Source: Journal of Geriatric Oncology, Volume 9, Issue 3Author(s): Marta Bonet, Teresa Bonfill, Miriam Nuñez, Encarna Mur, Meritxell Arenas (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Brachytherapy for conservative treatment of invasive penile carcinoma in older patients: Single institution experience
ConclusionBrachytherapy is feasible in selected older patients with penile carcinoma, with efficacy and toxicity rates comparable to that of other series in younger patients. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research