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Total 269 results found since Jan 2013.

Metabolomic analysis and pharmacological validation of the cerebral protective effect of 3,4 ‑dihydroxybenzaldehyde on cerebral ischemia‑reperfusion injury
Mol Med Rep. 2023 Jan;27(1):9. doi: 10.3892/mmr.2022.12896. Epub 2022 Nov 11.ABSTRACT3,4‑Dihydroxybenzaldehyde (DBD), one of the active components of Gastrodia elata, has a cerebral protective effect and can effectively combat cerebral ischemia/reperfusion (I/R) injury in rats. However, the metabolite profiles and underlying mechanisms associated with DBD remain unclear. To explore the level of energy metabolism and pharmacological targets in brain tissue following DBD treatment of stroke. The right middle cerebral artery of the rats was occluded for 2 h and reperfused for 24 h to simulate brain I/R injury. Pharmacologic...
Source: Molecular Medicine Reports - November 11, 2022 Category: Molecular Biology Authors: Yuan Luo Pu Chen Liping Yang Xiaohua Duan Source Type: research

IJERPH, Vol. 19, Pages 12174: Health Promotion Programs Can Mitigate Public Spending on Hospitalizations for Stroke: An Econometric Analysis of the Health Gym Program in the State of Pernambuco, Brazil
da Health promotion programs can reduce morbidity and mortality from chronic diseases, as well as public spending on health. The current study aims to evaluate the effects of the Health Gym Program on expenditures on hospitalizations for stroke in the state of Pernambuco, Brazil. This public policy impact assessment used an econometric model that combines the difference-in-difference estimator with propensity score matching. Data referring to the health, demographic, and socioeconomic characteristics of the 185 municipalities in Pernambuco were collected for the period from 2007 to 2019. Validation tests were carried o...
Source: International Journal of Environmental Research and Public Health - September 26, 2022 Category: Environmental Health Authors: da Guarda Tags: Article Source Type: research

Emerging role of neutrophil extracellular traps in the complications of diabetes mellitus
Front Med (Lausanne). 2022 Aug 23;9:995993. doi: 10.3389/fmed.2022.995993. eCollection 2022.ABSTRACTImmune dysfunction is widely regarded as one of the central tenants underpinning the pathophysiology of diabetes mellitus (DM) and its complications. When discussing immunity, the role of neutrophils must be accounted for: neutrophils are the most abundant of the circulating immune cells and are the first to be recruited to sites of inflammation, where they contribute to host defense via phagocytosis, degranulation, and extrusion of neutrophil extracellular traps (NETs). NETs are composed of DNA associated with nuclear and c...
Source: Atherosclerosis - September 9, 2022 Category: Cardiology Authors: Areez Shafqat Saleha Abdul Rab Osama Ammar Sulaiman Al Salameh Anas Alkhudairi Junaid Kashir Khaled Alkattan Ahmed Yaqinuddin Source Type: research

A questionnaire-based survey of acceptability and satisfaction of virtual neurology clinic during COVID-19 lockdown: a preliminary study
DiscussionTeleneurology facility is not only feasible but also affordable and acceptable in various neurological conditions. The chief reasons being no waiting time, saving of travelling time and travel expenditure with good satisfaction.
Source: Acta Neurologica Belgica - July 7, 2022 Category: Neurology Source Type: research

EE404 Associations of Comprehensive Stroke Center Scores with Medical and Long-Term Care Expenditures in Ischemic Stroke Patients after Hospital Discharge: J-Aspect & Life Study
This study aimed to investigate the relationships between CSC scores and medical and long-term care (LTC) expenditures in ischemic stroke patients after hospital discharge.
Source: Value in Health - June 26, 2022 Category: International Medicine & Public Health Authors: Y Ono, H Fukuda, T Shimogawa, M Takegami, K Yoshimoto, K Iihara Source Type: research

Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review
Crit Rev Food Sci Nutr. 2022 Jun 16:1-66. doi: 10.1080/10408398.2022.2084600. Online ahead of print.ABSTRACTAge-related diseases are associated with increased morbidity in the past few decades and the cost associated with the treatment of these age-related diseases exerts a substantial impact on social and health care expenditure. Anti-aging strategies aim to mitigate, delay and reverse aging-associated diseases, thereby improving quality of life and reducing the burden of age-related pathologies. The natural dietary antioxidant supplementation offers substantial pharmacological and therapeutic effects against various dise...
Source: Atherosclerosis - June 16, 2022 Category: Cardiology Authors: Phaniendra Alugoju V K D Krishna Swamy Naga Venkata Anusha Anthikapalli Tewin Tencomnao Source Type: research

Pyruvate Kinase M2: a novel regulator of adipogenesis
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.L7944.ABSTRACTObesity is the cornerstone of many other conditions, with far-reaching impacts on numerous body systems and quality of life. Obesity is closely and likely causally associated with metabolic syndrome and consequent atherosclerosis, heart disease, stroke, and type 2 diabetes as well as diseases such as cancer and osteoarthritis. Recent studies suggest exploring the possibility of activating brown adipose tissue as a potential anti-obesity strategy. However, understanding the mechanisms underlying the processes of brown adipogenesis and browning is fou...
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Presley D Dowker Jenna B Demeter Ahmed Bettaieb Source Type: research

Cardiometabolic and neuromuscular analyses of the sit-to-stand transition to question its role in reducing sedentary patterns
AbstractTo counteract the detrimental health effect of sitting all day long, it has been suggested to regularly break sitting time by standing. However, while the difference in energy expenditure, neuromuscular and/or cardiovascular demand of various postures from lying, sitting, and standing is well documented, little is known regarding the dynamic changes occurring during the sit-to-stand transition itself. The aim of the present study was then to describe the cardiometabolic and neuromuscular responses from sitting to standing and specifically during the time-course of this transition. Twelve healthy young participants ...
Source: European Journal of Applied Physiology - April 27, 2022 Category: Physiology Source Type: research

First Systematic Review and Meta-analysis of the Validity and Test-Retest Reliability of Physical Activity Monitors for Estimating Energy Expenditure During Walking in Individuals With Stroke
To evaluate the validity and test-retest reliability of physical activity trackers (accelerometer, multisensor, smartphone, pedometer) for estimating energy expenditure during walking in individuals with stroke.
Source: Archives of Physical Medicine and Rehabilitation - April 16, 2022 Category: Rehabilitation Authors: Mathilde Cabot, Jean Christophe Daviet, Noemie Duclos, David Bernikier, Jean Yves Salle, Maxence Compagnat Tags: REVIEW ARTICLE (META-ANALYSIS) Source Type: research

First systematic review and meta-analysis of the validity and test retest reliability of physical activity monitors for estimating energy expenditure during walking in individuals with stroke
To evaluate the validity and test retest reliability of physical activity trackers (accelerometer, multi-sensor, smartphone, pedometer) for estimating energy expenditure during walking in individuals with stroke.
Source: Archives of Physical Medicine and Rehabilitation - April 16, 2022 Category: Rehabilitation Authors: Mathilde Cabot, Jean Christophe Daviet, Noemie Duclos, David Bernikier, Jean Yves Salle, Maxence Compagnat Tags: Review Article (Meta-Analysis) Source Type: research

Metabolic Energy Expenditure and Accelerometer-Determined Physical Activity Levels in Post-Stroke Hemiparetic Patients
Assessment of metabolic energy expenditure in post-stroke patients using accelerometers is clinically important. However, understanding of the best placement of accelerometers on the body and methods for calculating activity counts are limited.
Source: Journal of Stroke and Cerebrovascular Diseases - February 25, 2022 Category: Neurology Authors: Garance Fonte, C éline Schreiber, Gilles Areno, Xavier Masson, Frédéric Chantraine, Gaston Schütz, Frédéric Dierick Source Type: research

POSA365 Does Undiagnosed Depression in Stroke Patients Affect the Total Healthcare Expenditures and Health-Related Quality of Life: An Analysis Using Medical Expenditure Panel Survey Data, 2016-2018
This study evaluates the impact of depression diagnosis on health-related quality of life (HRQoL) and healthcare expenditures in stroke patients.
Source: Value in Health - January 1, 2022 Category: International Medicine & Public Health Authors: M Pathan, G Dhingra Source Type: research

Endothelial Cell CD36 Reduces Atherosclerosis and Controls Systemic Metabolism
Front Cardiovasc Med. 2021 Nov 23;8:768481. doi: 10.3389/fcvm.2021.768481. eCollection 2021.ABSTRACTHigh-fat Western diets contribute to tissue dysregulation of fatty acid and glucose intake, resulting in obesity and insulin resistance and their sequelae, including atherosclerosis. New therapies are desperately needed to interrupt this epidemic. The significant idea driving this research is that the understudied regulation of fatty acid entry into tissues at the endothelial cell (EC) interface can provide novel therapeutic targets that will greatly modify health outcomes and advance health-related knowledge. Dysfunctional ...
Source: Atherosclerosis - December 10, 2021 Category: Cardiology Authors: Umar R Rekhi Mohamed Omar Maria Alexiou Cole Delyea Linnet Immaraj Shokrollah Elahi Maria Febbraio Source Type: research