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Total 269 results found since Jan 2013.

Dihydrocapsiate improved age-associated impairments in mice by increasing energy expenditure
In this study, we investigated whether DCT supplementation in aged mice improves age-associated impairments. We obtained 5-wk-old and 1-yr-old male C57BL/6J mice and randomly assigned the aged mice to two groups, resulting in a total of three groups: 1) young mice, 2) old mice, and 3) old mice supplemented with 0.3% DCT. After 12 wk of supplementation, blood and tissue samples were collected and analyzed. DCT significantly suppressed age-associated fat accumulation, adipocyte hypertrophy, and liver steatosis. In addition, the DCT treatment dramatically suppressed age-associated increases in hepatic inflammation, immune cel...
Source: AJP: Endocrinology and Metabolism - November 29, 2017 Category: Endocrinology Authors: Ohyama, K., Suzuki, K. Tags: Research Article Source Type: research

Outpatient therapy for acute symptomatic pulmonary embolism diagnosed in the emergency department: Time to improve the evidence base
Pulmonary embolism (PE) remains a worldwide major public health issue [1 –4]. After myocardial infarction and stroke, PE is the third most common cause of vascular death. In addition, PE is the leading preventable cause of death in hospitalized patients [2]. Treatment of PE costs over 19 billion dollars annually in the USA [3], and more than 50% of that expenditure rel ates to the cost of in-patient care [4]. The initial decision to admit the patient diagnosed with acute symptomatic PE in the emergency department (ED) to the hospital or to treat the patient at home therefore has significant patient care and public health implications.
Source: Thrombosis Research - November 25, 2017 Category: Hematology Authors: David Jim énez, Roger D. Yusen Tags: Editorial Source Type: research

A review on irisin, a new protagonist that mediates muscle-adipose-bone-neuron connectivity.
This study presents irisin as a new champion of the molecule, which could be considered as the messenger in the muscle-fat-bone-brain axis. PMID: 29131244 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 14, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Burden of Catastrophic Health Expenditures for Acute Myocardial Infarction and Stroke Among Uninsured in the United States.
Abstract Acute myocardial infarction (AMI) and stroke are unanticipated major healthcare events that require emergent and expensive care. Given the potential financial implications of AMI and stroke among uninsured patients, we sought to evaluate rates of catastrophic healthcare expenditures (CHEs), defined as expenses beyond financial means, in a period before the implementation of insurance expansion and protections in the Affordable Care Act.(1). PMID: 29133601 [PubMed - as supplied by publisher]
Source: Circulation - November 13, 2017 Category: Cardiology Authors: Khera R, Hong JC, Saxena A, Arrieta A, Virani SS, Blankstein R, de Lemos JA, Krumholz HM, Nasir K Tags: Circulation Source Type: research

Cardiorespiratory responses to pool floor walking in people post-stroke
To compare energy expenditure between pool floor walking (PFW) and overground walking (OW) in people post-stroke.
Source: Archives of Physical Medicine and Rehabilitation - October 5, 2017 Category: Rehabilitation Authors: Brenda Jeng, Takuto Fujii, Hyosok Lim, Konstantinos Vrongistinos, Taeyou Jung Source Type: research

On the Adaptation of Pelvic Motion by Applying 3-dimensional Guidance Forces Using TPAD
Pelvic movement is important to human locomotion as the center of mass is located near the center of pelvis. Lateral pelvic motion plays a crucial role to shift the center of mass on the stance leg, while swinging the other leg and keeping the body balanced. In addition, vertical pelvic movement helps to reduce metabolic energy expenditure by exchanging potential and kinetic energy during the gait cycle. However, patient groups with cerebral palsy or stroke have excessive pelvic motion that leads to high energy expenditure. In addition, they have higher chances of falls as the center ofmass could deviate outside the base o...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - September 1, 2017 Category: Neuroscience Source Type: research

Dihydrocapsiate improved age-associated impairments in mice by increasing energy expenditure.
In this study, we investigated whether DCT supplementation in aged mice improves age-associated impairments. We obtained five-week-old and one-year-old male C57BL/6J mice and randomly assigned the aged mice to two groups, resulting in a total of three groups: 1) young mice, 2) old mice, and 3) old mice supplemented with 0.3% DCT. After 12 weeks of supplementation, blood and tissue samples were collected and analyzed. DCT significantly suppressed age-associated fat accumulation, adipocyte hypertrophy, and liver steatosis. In addition, the DCT treatment dramatically suppressed age-associated increases in hepatic inflammation...
Source: American Journal of Physiology. Endocrinology and Metabolism - August 15, 2017 Category: Physiology Authors: Ohyama K, Suzuki K Tags: Am J Physiol Endocrinol Metab Source Type: research

Overfed and Underfed: Global Food Extremes
The international community of nations has made commitments to eliminate hunger, achieve food security and improved nutrition by 2030 and also to promote and protect health through nutritious diet, healthy eating and increased physical activity. Credit: IPSBy Joseph ChamieNEW YORK, Jun 12 2017 (IPS)Global food extremes of chronic undernourishment and obesity have brought about a bipolar world of hundreds of millions of underfed and overfed people. Of the world’s population of 7.5 billion the proportions suffering from chronic undernourishment and those afflicted by obesity are similar, approximately 11 percent or togethe...
Source: IPS Inter Press Service - Health - June 12, 2017 Category: International Medicine & Public Health Authors: Joseph Chamie Tags: Development & Aid Food & Agriculture Global Headlines Health Poverty & SDGs Regional Categories Source Type: news

Estimating lifetime medical costs from censored claims data
In this study, we propose a survival‐adjusted estimator for estimating mean lifetime costs, which integrates the product of the survival function and the mean cost function over the lifetime horizon. The survival function is estimated by a new algorithm of rolling extrapolation, aided by external information of age‐ and sex‐matched referents simulated from national vital statistics. The mean cost function is estimated by a weighted average of mean expenditures of patients in a number of months prior to their death, of which the number could be determined by observed costs in their final months, and the weights depend...
Source: Health Economics - May 12, 2017 Category: Health Management Authors: Jing ‐Shiang Hwang, Tsuey‐Hwa Hu, Lukas Jyuhn‐Hsiarn Lee, Jung‐Der Wang Tags: RESEARCH ARTICLE Source Type: research

The future of atrial fibrillation management: integrated care and stratified therapy
Publication date: Available online 28 April 2017 Source:The Lancet Author(s): Paulus Kirchhof Atrial fibrillation is one of the major cardiovascular health problems: it is a common, chronic condition, affecting 2–3% of the population in Europe and the USA and requiring 1–3% of health-care expenditure as a result of stroke, sudden death, heart failure, unplanned hospital admissions, and other complications. Early diagnosis of atrial fibrillation, ideally before the first complication occurs, remains a challenge, as shown by patients who are only diagnosed with the condition when admitted to hospital for acute cardiac d...
Source: The Lancet - April 29, 2017 Category: Journals (General) Source Type: research

Seminar The future of atrial fibrillation management: integrated care and stratified therapy
Atrial fibrillation is one of the major cardiovascular health problems: it is a common, chronic condition, affecting 2 –3% of the population in Europe and the USA and requiring 1–3% of health-care expenditure as a result of stroke, sudden death, heart failure, unplanned hospital admissions, and other complications. Early diagnosis of atrial fibrillation, ideally before the first complication occurs, remains a ch allenge, as shown by patients who are only diagnosed with the condition when admitted to hospital for acute cardiac decompensation or stroke.
Source: LANCET - April 28, 2017 Category: General Medicine Authors: Paulus Kirchhof Tags: Seminar Source Type: research

Mind the Treatment Gap
getty images/ istock photoBy Vani S. Kulkarni and Raghav GaihaPHILADELPHIA AND NEW DELHI, Apr 14 2017 (IPS)Implementation of the Mental Healthcare Act will require a restructuring of health-care services The Mental Healthcare Bill, 2016, which was passed in the Lok Sabha on March 27, 2017, has been hailed as a momentous reform. According to the Bill, every person will have the right to access mental health care operated or funded by the government; good quality and affordable health care; equality of treatment and protection from inhuman practices; access to legal services; and right to complain against coercion and cruelt...
Source: IPS Inter Press Service - Health - April 14, 2017 Category: Global & Universal Authors: Vani Kulkarni and Raghav Gaiha Tags: Asia-Pacific Development & Aid Gender Gender Violence Headlines Health Human Rights Women's Health Source Type: news

Patients With CKD Incur the Highest Out-of-Pocket Expenses Patients With CKD Incur the Highest Out-of-Pocket Expenses
Dr Desai discusses a study on the total and out-of-pocket healthcare expenditures incurred by patients with nondialysis CKD in the US vs patients with cancer or stroke, published in BMC Nephrology.Medscape Nephrology
Source: Medscape Today Headlines - March 3, 2017 Category: Consumer Health News Tags: Nephrology Viewpoint Source Type: news

Cardiovascular Drift during Training for Fitness in Patients with Metabolic Syndrome
Purpose: The health benefits of a training program are largely influenced by the exercise dose and intensity. We sought to determine whether during a training bout of continuous versus interval exercise the workload needs to be reduced to maintain the prescribed target heart rate (HR). Methods: Fourteen obese (31 ± 4 kg·m−2) middle-age (57 ± 8 yr) individuals with metabolic syndrome, underwent two exercise training bouts matched by energy expenditure (i.e., 70 ± 5 min of continuous exercise [CE] or 45 min of interval exercise, high-intensity interval training [HIIT]). All subjects completed both trials in a randomiz...
Source: Medicine and Science in Sports and Exercise - February 18, 2017 Category: Sports Medicine Tags: Applied Sciences Source Type: research

Making Sense of Nutraceuticals in China
The Chinese nutraceutical market is considered the third largest in the world after the US and Japan, or the fourth largest if Europe is counted as a single market.Despite strong fundamentals and high rates of annual growth, though, the Chinese market remains some way from realizing its true potential. Its evolution is muddied by ambiguities around what nutraceuticals actually are and how they should be managed.The result has been polarization between over-zealous regulation of so-called health foods, and a grey market where products have skirted approval procedures through questionable positioning or by exploiting alterna...
Source: EyeForPharma - February 10, 2017 Category: Pharmaceuticals Authors: Marc Yates Source Type: news