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Total 94 results found since Jan 2013.

Heat-Related Mortality in Japan after the 2011 Fukushima Disaster: An Analysis of Potential Influence of Reduced Electricity Consumption
Conclusions: In the prefectures with the greatest reductions in electricity consumption, heat-related mortality decreased rather than increased following the Great East Japan Earthquake. Additional research is needed to determine whether this finding holds for other populations and regions, and to clarify its implications for policies to reduce the consequences of climate change on health. https://doi.org/10.1289/EHP493 Received: 11 May 2016 Revised: 07 March 2017 Accepted: 13 March 2017 Published: 06 July 2017 Address correspondence to M. Hashizume, Dept. of Pediatric Infectious Diseases, Institute of Tropical Medic...
Source: EHP Research - July 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events: a population-based cohort study
Publication date: Available online 13 June 2017 Source:The Lancet Author(s): Linxin Li, Olivia C Geraghty, Ziyah Mehta, Peter M Rothwell Background Lifelong antiplatelet treatment is recommended after ischaemic vascular events, on the basis of trials done mainly in patients younger than 75 years. Upper gastrointestinal bleeding is a serious complication, but had low case fatality in trials of aspirin and is not generally thought to cause long-term disability. Consequently, although co-prescription of proton-pump inhibitors (PPIs) reduces upper gastrointestinal bleeds by 70–90%, uptake is low and guidelines are conflicti...
Source: The Lancet - June 15, 2017 Category: General Medicine Source Type: research

Risk of aspirin-related bleeding is higher in the over-75s
Conclusion This valuable cohort study helps to quantify the extent of bleeding risk in people taking aspirin for secondary prevention of cardiovascular disease. Aspirin is well known to carry bleeding risk – particularly in older adults – but this study suggests the risk may be higher than previously thought. The researchers say that for adults under the age of 75, the annual bleeding risk at around 1% is similar to that suggested by previous trials, as is the ratio of bleeds to the number of cardiovascular events. However, this risk increases for older adults, especially for major bleeds of the stomach and upper diges...
Source: NHS News Feed - June 14, 2017 Category: Consumer Health News Tags: Medication Older people Source Type: news

Microglial activation in recent ischemic stroke: comparison of two TSPO tracers
Conclusion: The apparent intensity of microglial activation in ischemic stroke is closely comparable between 18F-GE180 and 11C-(R)-PK11195 PET. Research Support: The study is funded by a grant from NIHR and supported by GEHC and INMIND (EC FP7).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Herholz, K., Hinz, R., Visi, E., Trigg, W., McDonald, K., Punter, M., Majid, A., Gerhard, A. Tags: Neurology Posters Source Type: research

NIHR Signal: Better prescribing might prevent thousands of strokes in the UK
Expert commentary is provided of a study which found that based on data from almost 30000 people who had a stroke, 60% had risk factors that meant they may have been eligible to take cholesterol-lowering, antiplatelet or BP medication, but 54% had no recent prescription for these
Source: Current Awareness Service for Health (CASH) - May 9, 2017 Category: Consumer Health News Source Type: news

Time-course of functional recovery after acute ischaemic stroke and its relationship to cause-specific mortality: Implications for follow-up of stroke trials (S19.004)
Conclusions:Functional recovery continues to occur between 3 months and 1 year post-stroke, but disability by 3 months strongly predicts long-term stroke-related death/dependency. By extending follow-up to 1 year, trials can capture most salient differences in long-term disability and index-stroke-related deaths.Study Supported by:The Oxford Vascular Study has been funded by the Wellcome Trust, Wolfson Foundation, UK Stroke Association and the NIHR Oxford Biomedical Research Centre. PMR is in receipt of an NIHR Senior Investigator Award and a Wellcome Trust Senior Investigator Award. AG is funded by the Rhodes Trust.Disclo...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ganesh, A., Luengo-Fernandez, R., Wharton, R. M., Gutnikov, S. A., Silver, L. E., Mehta, Z., Rothwell, P. M., on behalf of the Oxford Vascular Study Tags: Best Of: Cerbrovascular Disease and Interventional Neurology Source Type: research

Organisation and Quality of stroke services
The National Institute for Health Research has published Roads to recovery: organisation and quality of stroke services. This themed review brings together recent evidence relevant to those planning and delivering stroke services, those delivering treatments to people with stroke and to those living with stroke. Together with other evidence, this review may be particularly useful for those developing stroke pathways and care across a system
Source: Current Awareness Service for Health (CASH) - March 28, 2017 Category: Consumer Health News Source Type: news

Orgranisation and Quality of stroke services
The National Institute for Health Research has published Roads to recovery: organisation and quality of stroke services. This themed review brings together recent evidence relevant to those planning and delivering stroke services, those delivering treatments to people with stroke and to those living with stroke. Together with other evidence, this review may be particularly useful for those developing stroke pathways and care across a system
Source: Current Awareness Service for Health (CASH) - March 28, 2017 Category: Consumer Health News Source Type: news

Moderate drinking may reduce heart disease risk
Conclusion This study paints a more complicated picture than the "Pint a day keeps the doctor away" story proffered by The Sun. It seems to confirm the findings of other studies, which have shown that non-drinkers tend to have a higher risk of cardiovascular diseases than people who drink moderately. It suggests that some cardiovascular diseases (mainly those directly affecting the heart) seem to have a stronger link to a possible protective effect from alcohol than other vascular diseases, such as mini-strokes and bleeding in the brain. However, this can't be concluded with certainty due to the study design. We ...
Source: NHS News Feed - March 23, 2017 Category: Consumer Health News Tags: Heart/lungs Food/diet Lifestyle/exercise Source Type: news

Weekend-only workouts 'still give an important health boost'
Conclusion This survey aimed to investigate patterns of physical activity in adults over the age of 40 and the potential impact on their cause of death. The study found that, compared with those who were not physically active, all active groups saw a reduction in their risk of death from any cause and cardiovascular disease. Being active at the weekend only had no effect on cancer mortality. However, interpretations around the optimal level of activity are difficult when you note that insufficient activity gave similar mortality reductions as the recommended regular activity. This study has both strengths and limitations...
Source: NHS News Feed - January 10, 2017 Category: Consumer Health News Tags: Lifestyle/exercise Heart/lungs Cancer Source Type: news

Handful of nuts 'cuts heart disease and cancer' risk
Conclusions This systematic review finds evidence that nut intake may be linked with reduced risk of cardiovascular disease, cancer and death. The systematic review has several strengths. It identified a large number of studies with a large total sample size. It also included only prospective cohorts assessing nut consumption and then followed up later disease outcomes. It excluded cross sectional studies, which assess diet and disease at the same time, and so can't show the direction of effect. It also excluded cohorts that have retrospectively questioned diet when the person already has the disease, which could be subjec...
Source: NHS News Feed - December 5, 2016 Category: Consumer Health News Tags: Food/diet Cancer Heart/lungs Source Type: news

Research tackles major cause of death following stroke
Source: HTA - NIHR Evaluation, Trials and Studies - November 22, 2016 Category: UK Health Source Type: news

The ms-smart trial in secondary progressive ms - current update
MS-SMART is an ongoing multicentre, multi-arm, double blind, placebo-controlled phase IIb randomised controlled trial to establish whether putative neuroprotective drugs (fluoxetine,riluzole,amiloride or placebo) can slow down the progression of brain volume loss in secondary progressive multiple sclerosis (SPMS) over 96 weeks using MRI-derived Percentage Brain Volume Change (PBVC) as the primary outcome. 360 patients have been screened so far, 328 (92%) consented and 272 randomized (65% of the total UK cohort–440). Patients will have outcome-data collected after 0,24,48 and 96 weeks. The trial is using a range of co...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Chataway, J., Chandran, S., Miller, D., Connick, P., Giovannoni, G., Pavitt, S., Stallard, N., Hawkins, C., Sharrack, B., Plantone, D. Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Radiology, Radiology (diagnostics) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis
Publication date: Available online 3 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Natriuretic Peptides Studies Collaboration Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present by predicting heart failure and enhancing coronary heart disease and stroke risk assessment. Methods In this individual-participant-data meta-analysis, we generated and harmoni...
Source: The Lancet Diabetes and Endocrinology - September 2, 2016 Category: Endocrinology Source Type: research