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Total 94 results found since Jan 2013.

Incidence, outcome, risk factors, and long-term prognosis of cryptogenic transient ischaemic attack and ischaemic stroke: a population-based study
Publication date: Available online 27 July 2015 Source:The Lancet Neurology Author(s): Linxin Li, Gabriel S Yiin, Olivia C Geraghty, Ursula G Schulz, Wilhelm Kuker, Ziyah Mehta, Peter M Rothwell Background A third of transient ischaemic attacks (TIAs) and ischaemic strokes are of undetermined cause (ie, cryptogenic), potentially undermining secondary prevention. If these events are due to occult atheroma, the risk-factor profile and coronary prognosis should resemble that of overt large artery events. If they have a cardioembolic cause, the risk of future cardioembolic events should be increased. We aimed to asses...
Source: The Lancet Neurology - July 28, 2015 Category: Neurology Source Type: research

Heart attack, stroke and diabetes 'can shorten life by 23 years'
Conclusion This study used two large cohort-derived data sets to estimate the number of years of life lost as the result of a history of heart attack, stroke or diabetes across different ages. The study's large size, relevance to the UK and long-term follow-up increases our confidence in its conclusions and their relevance to England and Wales. As with all studies, it has limitations, but these were relatively small and unlikely to affect the main conclusions. This study shows a history of stroke, type 2 diabetes and heart attack can significantly shorten life expectancy, especially if these conditions are developed earli...
Source: NHS News Feed - July 8, 2015 Category: Consumer Health News Tags: Heart/lungs Diabetes Lifestyle/exercise Neurology Older people Source Type: news

GP receptionists 'could help prevent stroke deaths'
Conclusion This valuable and well-designed study assessed a cross-section of general practices from one UK region, looking at how well receptionists are able to recognise the signs of stroke and give appropriate advice – either immediately passing patients on to the GP or telling them to contact emergency services. The study has many strengths. These include the large sample of GP surgeries and calls assessed, and that receptionists weren't aware of the nature of the study and the calls were unannounced. At the end of each individual call receptionists were told the call was part of the study and no further action was n...
Source: NHS News Feed - June 29, 2015 Category: Consumer Health News Tags: Medical practice Neurology Source Type: news

Overweight diabetics 'live longer' than slimmer diabetics
Conclusion This large prospective cohort following over 10,000 older adults with type 2 diabetes for 10 years has found that while being overweight or obese is linked to increased risk of cardiovascular events, being overweight is linked to reduced risk of death. This is similar to the "obesity paradox" seen in some other studies, where being overweight or obese is associated with a survival benefit in people with established cardiovascular disease. The researchers note that 16 other studies have assessed the same question and found conflicting results. Their study aimed to improve on the methods in these studies...
Source: NHS News Feed - May 11, 2015 Category: Consumer Health News Tags: Diabetes Food/diet Obesity Source Type: news

Trial of early rehabilitation after stroke publishes initial findings
A trial funded by the HTA Programme comparing rehabilitation treatments for patients after they have had a stroke, has published its initial findings in The Lancet, this week. Results were also presented at the inaugural European Stroke Organisation Conference in Glasgow, today. A Very Early Rehabilitation Trial (AVERT) compares usual stroke rehabilitation methods to a...
Source: NIHR Evaluation, Trials and Studies News - April 17, 2015 Category: American Health Source Type: news

Stroke trial AVERT publishes initial findings in The Lancet
A trial funded by the HTA Programme comparing rehabilitation treatments for patients after they have had a stroke, has published its initial findings in The Lancet, this week. Results were also presented at the inaugural European Stroke Organisation Conference in Glasgow, today. A Very Early Rehabilitation Trial (AVERT) compares usual stroke rehabilitation methods to a...
Source: NIHR Evaluation, Trials and Studies News - April 17, 2015 Category: American Health Source Type: news

Following UK dietary advice may cut heart disease risk
Conclusion This study showed that following dietary recommendations closely for 12 weeks can reduce blood pressure by a significant amount, which is likely to cut the chances of having a heart attack or stroke for an average healthy middle-aged person. The diet also affects cholesterol levels, but the overall effect of this may be modest. The study appears to have been carefully conducted to avoid biasing the results. The researchers gave butter or margarine spread and cooking oil to people in both groups, for example, and asked everyone to fill out food diaries, as well as taking urine samples for nutrient analysis. Thi...
Source: NHS News Feed - March 19, 2015 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news

Identifying Continence OptioNs after Stroke (ICONS): an evidence synthesis, case study and exploratory cluster randomised controlled trial of the introduction of a systematic voiding programme for patients with urinary incontinence after stroke in secondary care, Programme Grants for Applied Research, Vol:3, Iss:1
Authors: Thomas LH, French B, Sutton CJ, Forshaw D, Leathley MJ, Burton CR, Roe B, Cheater FM, Booth J, McColl E, Carter B, Walker A, Brittain K, Whiteley G, Rodgers H, Barrett J, Watkins CL on behalf of the ICONS project team and the ICONS patient, public and carer involvement groups
Source: NIHR Journals Library - March 18, 2015 Category: Global & Universal Source Type: research

Occupational therapy intervention for residents with stroke living in UK care-homes.
Funded by the NIHR Health Technology Assessment (HTA) Programme, a study looking at the effects of occupational therapy delivered in care homes following a stroke has been published in the British Medical Journal. (BMJ)After dementia, a stroke is the most common health issue for people living in care homes. Stroke survivors admitted to care...
Source: NIHR Evaluation, Trials and Studies News - March 4, 2015 Category: American Health Source Type: news

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis
Publication date: Available online 26 February 2015 Source:The Lancet Diabetes & Endocrinology Background To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. Methods We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encoding the IL-1 receptor antagonist (IL-1Ra; an endogenous inhibitor of both IL-1α and IL-1β); both alleles increase soluble IL-1Ra ...
Source: The Lancet Diabetes and Endocrinology - February 26, 2015 Category: Endocrinology Source Type: research

The BRACELET study: implications for the design of randomised controlled trials in neonatal and paediatric intensive care
Research is essential to improving care and outcomes, but presents challenges when infants and children are the patients. Over the last few years, several thousand infants and children receiving intensive care have joined randomised controlled trials (RCT) in the UK, the majority of those conducted under the auspices of the National Institute for Health Research (NIHR) portfolio. Globally, tens of thousands of children and infants take part in RCTs. When those children survive, many continue to partake in studies with involvement over several years and potentially into adulthood. That is essential; in no other branch of me...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 18, 2015 Category: Perinatology & Neonatology Authors: Embleton, N. D., Rankin, J. Tags: Clinical trials (epidemiology), Stroke, Pregnancy, Reproductive medicine, Child health, Neonatal and paediatric intensive care, Neonatal health, Neonatal intensive care, Paediatric intensive care Editorials Source Type: research

Development and evaluation of tools and an intervention to improve patient- and carer-centred outcomes in Longer-Term Stroke care and exploration of adjustment post stroke: the LoTS care research programme, Programme Grants for Applied Research, Vol:2, Iss:6
Authors: Forster A, Mellish K, Farrin A, Bhakta B, House A, Hewison J, Murray J, Patel A, Knapp M, Breen R, Chapman K, Holloway I, Hawkins R, Shannon R, Nixon
Source: NIHR Journals Library - December 25, 2014 Category: Global & Universal Source Type: research

Stroke survivor and carer involvement in, and engagement with, studies adopted onto the NIHR Stroke Research Network portfolio: questionnaire survey
Source: International Journal of Stroke - December 10, 2014 Category: Neurology Authors: J. Boote, Z. Jones, C. J McKevitt, C. Wallace‐Watson, H. Rodgers Tags: Letter to the editor Source Type: research

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people
This study is registered at ClinicalTrials.gov (NCT01804439). Findings Our cohort consisted of 1 921 260 individuals, of whom 1 887 062 (98·2%) did not have diabetes and 34 198 (1·8%) had type 2 diabetes. We observed 113 638 first presentations of cardiovascular disease during a median follow-up of 5·5 years (IQR 2·1–10·1). Of people with type 2 diabetes, 6137 (17·9%) had a first cardiovascular presentation, the most common of which were peripheral arterial disease (reported in 992 [16·2%] of 6137 patients) and heart failure (866 [14·1%] of 6137 patients). Type 2 diabetes was positively associated wi...
Source: The Lancet Diabetes and Endocrinology - December 5, 2014 Category: Endocrinology Source Type: research