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Total 94 results found since Jan 2013.
Functional electrical stimulation versus ankle foot orthoses for foot-drop: A meta-analysis of orthotic effects.
CONCLUSION: Data suggest that, in contrast to assumptions that predict FES superiority, ankle foot orthoses have equally positive combined-orthotic effects as FES on key walking measures for foot-drop caused by stroke. However, further long-term, high-quality RCTs are required. These should focus on measuring the mechanisms-of-action; whether there is translation of improvements in impairment to function, plus detailed reporting of the devices used across diagnoses. Only then can robust clinical recommendations be made.
PMID: 27563700 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - August 27, 2016 Category: Rehabilitation Tags: J Rehabil Med Source Type: research
Implementing major system change in healthcare
Research funded by the NIHR HS&DR Programme is looking into how changes in the delivery and organisation of stroke care are implemented to help inform future changes. The National Stroke Strategy for England, launched in 2007, aimed to improve the care of stroke patients around the UK, by addressing the variations across the country in...
Source: NIHR Evaluation, Trials and Studies News - June 10, 2016 Category: American Health Source Type: news
Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials
Publication date: Available online 18 May 2016 Source:The Lancet Author(s): Peter M Rothwell, Ale Algra, Zhengming Chen, Hans-Christoph Diener, Bo Norrving, Ziyah Mehta Background Aspirin is recommended for secondary prevention after transient ischaemic attack (TIA) or ischaemic stroke on the basis of trials showing a 13% reduction in long-term risk of recurrent stroke. However, the risk of major stroke is very high for only the first few days after TIA and minor ischaemic stroke, and observational studies show substantially greater benefits of early medical treatment in the acute phase than do longer-term trials. ...
Source: The Lancet - May 19, 2016 Category: Journals (General) Source Type: research
International Clinical Trials' Day 2016
International Clinical Trials' Day is celebrated around the world each year on or close to 20 May, commemorating the day in 1747 on which James Lind began the first known controlled trial, comparing different treatments for scurvy then in common use among sailors in the British Royal Navy. (Watch a video explaining the trial to see history in the making.) International Clinical Trials' Day seeks to raise awareness of the importance of research to health care, and draw attention to ways in which the research can become more relevant to practice.The European Clinical Research Infrastructures Network (ECRIN) helps to co-ordin...
Source: Cochrane News and Events - May 19, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news
Exercise benefits you - even in polluted city air
Conclusion
This modelling study aimed to assess exposure to air pollution through physical activity and the associated health risks around the world.
The study found the background pollution level required to reach the tipping point is only present in less than 1% of cities, according to the WHO.
In an average city physical exercise will remain beneficial up to seven hours a day for cycling or 16 hours for walking.
In highly polluted areas this became as low as 30 minutes a day for cycling and 90 minutes of walking.
The main limitation of this study is that it is only a model and we do not know how true to life the findi...
Source: NHS News Feed - May 6, 2016 Category: Consumer Health News Tags: Heart/lungs Lifestyle/exercise Source Type: news
The Stroke Prevention Programme: a programme of research to inform optimal stroke prevention in primary care, Programme Grants for Applied Research, Vol:4, Iss:3
Authors: Fletcher K, Mant J, McManus R, Hobbs R.
Source: NIHR Journals Library - April 1, 2016 Category: Global & Universal Source Type: research
An Occupational Therapy intervention for residents with stroke-related disabilities in UK Care Homes (OTCH): cluster randomised controlled trial with economic evaluation, Health Technology Assessment, Vol:20, Iss:15
Authors: Sackley CM, Walker MF, Burton CR, Watkins CL, Mant J, Roalfe AK, Wheatley K, Sheehan B, Sharp L, Stant KE, Fletcher-Smith J, Steel K, Barton GR, Irvine L, Peryer G.
Source: NIHR Journals Library - March 1, 2016 Category: Global & Universal Source Type: research
New study in stroke therapy investigates 160,000 patients’ records
A study funded by the HS&DR Programme, will investigate 160,000 recently available patient records to identify issues affecting the quality of stroke therapy in England. Around 1.2 million people in the UK are classed as stroke survivors with around 150,000 new incidences of stroke each year. Although three quarters of people survive their stroke, many...
Source: NIHR Evaluation, Trials and Studies News - February 2, 2016 Category: American Health Source Type: news
Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
Publication date: Available online 24 December 2015 Source:The Lancet Author(s): Dena Ettehad, Connor A Emdin, Amit Kiran, Simon G Anderson, Thomas Callender, Jonathan Emberson, John Chalmers, Anthony Rodgers, Kazem Rahimi Background The benefits of blood pressure lowering treatment for prevention of cardiovascular disease are well established. However, the extent to which these effects differ by baseline blood pressure, presence of comorbidities, or drug class is less clear. We therefore performed a systematic review and meta-analysis to clarify these differences. Method For this systematic review and meta-ana...
Source: The Lancet - December 25, 2015 Category: Journals (General) Source Type: research
No significant benefit found in new treatment method for coronary artery bypass surgery
A study looking at ways to reduce damage to heart muscle during coronary artery bypass graft surgery (CABG) found using remote ischaemic preconditioning (RIPC) treatment did not provide greater protection against events including stroke, heart attack and cardiovascular death.RIPC is a virtually cost free, non-pharmacological and non-invasive treatment. The process involves using a blood pressure...
Source: NIHR Evaluation, Trials and Studies News - October 15, 2015 Category: American Health Source Type: news
The ms-smart trial in secondary progressive multiple sclerosis: a multi-arm, multi-centre trial of neuroprotection
There is currently no treatment for secondary progressive multiple sclerosis (SPMS) which determines the majority of disability in multiple sclerosis. The MS-SMART trial is a multi-arm, multi-centre, phase 2 randomised trial for patients with SPMS. A total of 440 patients with progressing SPMS will be recruited in England and Scotland and randomised to one of 4 blinded arms: amiloride 5mg bd, riluzole 50mg bd, fluoxetine 20mg bd or placebo. These agents have been chosen after an extensive systematic review which has suggested putative neuroprotective properties. Patients will be followed up for 96 weeks with outcome data c...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Chataway, J., Chandran, S., Miller, D., Giovannoni, G., Wheeler-Kingshott, C., Pavitt, S., Stallard, N., Hawkins, C., Sharrack, B., for the MS-SMART trialists Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Radiology, Radiology (diagnostics) Thur 21, Parallel session 5: Therapeutics Source Type: research
Next generation sequencing in familial cerebral small vessel disease - an ongoing study
Cerebral small vessel disease (SVD) is the most common form of stroke and vascular dementia. CADASIL (notch3 mutations) is most frequent but other monogenic causes more recently identified include CARASIL (HTRA1 gene), RVCL (TREX1 gene) and COL4A1 and 2. Diagnostic tests for these are often inaccessible and expensive and there are families with clinical monogenic SVD in whom no known variants are detected.
Next generation sequencing offers the potential to screen for these diseases, which present with similar phenotypes, more cost-effectively and rapidly in a single test. It could also identify novel genes underlying SVD. ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Tan, R., Markus, H. Tags: Dementia, Stroke, Memory disorders (psychiatry) Thur 21, Parallel session 5: Therapeutics Source Type: research
The Clots in Legs Or sTockings after Stroke (CLOTS) 3 trial: a randomised controlled trial to determine whether or not intermittent pneumatic compression reduces the risk of post-stroke deep vein thrombosis and to estimate its cost-effectiveness, Health Technology Assessment, Vol:19, Iss:76
Authors: Dennis M, Sandercock P, Graham C, Forbes J.
Source: NIHR Journals Library - September 30, 2015 Category: Global & Universal Source Type: research
Prophylactic antibiotics after acute stroke for reducing pneumonia in patients with dysphagia (STROKE-INF): a prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial
This study assessed the effectiveness of antibiotic prophylaxis for reducing pneumonia in patients with dysphagia after acute stroke. Methods We did a prospective, multicentre, cluster-randomised, open-label controlled trial with masked endpoint assessment of patients older than 18 years with dysphagia after new stroke recruited from 48 stroke units in the UK, accredited and included in the UK National Stroke Audit. We excluded patients with contraindications to antibiotics, pre-existing dysphagia, or known infections, or who were not expected to survive beyond 14 days. We randomly assigned the units (1:1) by computer to ...
Source: The Lancet - September 5, 2015 Category: Journals (General) Source Type: research
