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Total 94 results found since Jan 2013.

Lack of vitamin D may 'raise dementia risk'
Conclusion This cohort study of more than 1,650 elderly people has found that over 5.6 years, severe vitamin D deficiency is associated with approximately twice the risk of developing dementia or Alzheimer's disease. It also found moderate deficiency is associated with a 50% increase in risk compared with healthy levels of vitamin D. With this being a cohort study, it was not able to show that low levels of vitamin D caused dementia or Alzheimer's disease – it was simply able to show an association. Other factors that can increase the risk of developing dementia, such as a poor diet, lack of activity and general poor h...
Source: NHS News Feed - August 7, 2014 Category: Consumer Health News Tags: Lifestyle/exercise Older people Neurology Mental health Source Type: news

Stroke Centre research makes national news
Focusing NHS stroke services in fewer but more highly specialised hospitals has saved lives and cut the length of time patients spend in hospital, according to research funded by the HS&DR Programme. The study, published in the BMJ, examined the centralisation of acute stroke services in London and Manchester.  It showed...
Source: NIHR Evaluation, Trials and Studies News - August 7, 2014 Category: American Health Source Type: news

New hope for stroke survivors with NHS robot research
A major new NIHR-funded study using robot assisted training to help NHS stroke patients regain movement in their affected arm, has been officially launched today.Led by stroke specialists at Northumbria Healthcare NHS Foundation Trust, with researchers at Newcastle University and other UK institutions, the research grant from the NIHR HTA Programme will see NHS...
Source: NIHR Evaluation, Trials and Studies News - July 2, 2014 Category: American Health Source Type: news

Accrual And Evolution Of Cortical Gray Matter Lesions In People With Relapse-Onset Multiple Sclerosis (P6.133)
CONCLUSIONS:People with SPMS have a significantly greater accrual of cortical demyelination than those with RRMS. In both clinical subgrops, a minority of IC lesions become LC at follow-up. A higher IC-CGM lesion load and accumulation appears to be a feature of SPMSStudy Supported by: MS Society of Great Britain and Northern Ireland, and the UCLH Comprehensive Biomedical Research Centre.Disclosure: Dr. Sethi has received personal compensation for activities with Biogen Idec and Novartis. Dr. Sethi has received research support from the Multiple Sclerosis Society of Great Britain and Northern Ireland. Dr. Yousry has receive...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sethi, V., Yousry, T., Muhlert, N., Tozer, D., Altmann, D., Ron, M., Wheeler-Kingshott, C., Miller, D., Chard, D. Tags: MS and CNS Inflammatory Disease: Neuroimaging Source Type: research

4-Year Follow-up of Delayed-Release Dimethyl Fumarate Treatment in Relapsing-Remitting Multiple Sclerosis (RRMS): Integrated Magnetic Resonance Imaging (MRI) Outcomes From DEFINE, CONFIRM, and the ENDORSE Extension Study (P3.160)
CONCLUSIONS: Reduced frequency of new MRI lesions is maintained over 4 years among patients continuing therapy. Switching from placebo to delayed-release DMF, patients demonstrated MRI outcomes similar to those with delayed-release DMF in DEFINE/CONFIRM. Together with clinical efficacy and an acceptable safety profile, results support delayed-release DMF as a potential long-term treatment option for relapsing MS.Study Supported by: Biogen IdecDisclosure: Dr. Arnold has received personal compensation for activities with Acorda Therapeutics, Bayer Pharmaceuticals Corporation, Biogen Idec, Coronado Biosciences, EMD Serono, Ge...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Arnold, D., Fox, R., Gold, R., Havrdova, E., Kappos, L., Yousry, T., Zhang, R., Yang, M., Viglietta, V., Sheikh, S., Miller, D. Tags: MS and CNS Inflammatory Disease: Clinical Trials Outcomes Source Type: research

Phenotypic Differences In The Distribution Of Gray Matter Lesions In Multiple Sclerosis And Their Relevance To Cognition (P5.013)
CONCLUSIONS:There is a fronto-temporal dominance and occipital paucity, of cortical lesions. Cognitive deficits commonly ascribed to frontal and temporal lobe functions are associated with cortical or juxtacortical lesion load in the corresponding lobe independent of any effect of white matter lesion load.Study Supported by:MS Society of Great Britain and Northern Ireland, and the UCLH Comprehensive Biomedical Research Centre.Disclosure: Dr. Sethi has received personal compensation for activities with Biogen Idec and Novartis. Dr. Sethi has received research support from the Multiple Sclerosis Society of Great Britain and ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sethi, V., Yousry, T., Muhlert, N., Tozer, D., Altmann, D., Ron, M., Wheeler-Kingshott, C., Miller, D., Chard, D. Tags: MS and CNS Inflammatory Disease II Source Type: research

Statins side effects are minimal, study argues
ConclusionThis meta-analysis pooled results from 29 studies and has shown a very small increased risk of newly diagnosed diabetes mellitus. This is the same as the decreased risk of any cause of death in people taking statins, compared to placebo, to prevent a heart attack or stroke.The researchers point out some limitations to the meta-analysis: Each study did not report on all of the side effects, meaning that for each category of side effect, the number of participants differed. The side effect categories were only included if at least 500 people had reported suffering from it. This means there may be numerous other si...
Source: NHS News Feed - March 13, 2014 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

National Institute for Health Research launches “Focus on Stroke” as ground-breaking stroke trial opens in the UK
EuroHYP-1, the largest worldwide clinical trial of a new revolutionary stroke treatment called Therapeutic Hypothermia, is due to open in the UK. The study is just one of those featured on “Focus on Stroke”, a new online resource from the National Institute for Health Research (NIHR) aimed at raising public awareness of the exciting developments...
Source: NIHR Evaluation, Trials and Studies News - February 24, 2014 Category: American Health Source Type: news

Flu jab "may cut" stroke risk by a quarter
ConclusionThis research finds that, overall, having the flu vaccine reduced the risk of a person experiencing a stroke by about 25%. The reduction in risk seemed to be greatest within the first three months of vaccination, but remained for up to 12 months.  However, the effect lasted only if the vaccine was given early in the flu season (September to mid-November); giving the vaccine late in the flu season (mid-November to February) was not associated with significantly reduced risk.The research benefits from using data coded within the General Practice Research Database for England and Wales for almost 50,000 people with...
Source: NHS News Feed - February 21, 2014 Category: Consumer Health News Tags: Heart/lungs Neurology Older people Source Type: news

Walking reduces heart disease in people at risk
Conclusion This study of adults at high risk of type 2 diabetes and heart disease has found that every 2,000 steps they normally took each day was associated with a 10% lower risk of a cardiovascular event. And 12 months later, each extra 2,000 steps per day people did beyond their original number of steps was associated with an additional 8% difference in the cardiovascular event rate. This large study recruited participants from around the world and the researchers adjusted for a number of potential confounders. However, the study had a number of limitations, including: A large amount of information on the number of s...
Source: NHS News Feed - December 23, 2013 Category: Consumer Health News Tags: Lifestyle/exercise Source Type: news

Assessing the cost‐effectiveness of Type 1 diabetes interventions: the Sheffield Type 1 Diabetes Policy Model
ConclusionsThe model is highly flexible and has broad potential application to evaluate the Dose Adjustment for Normal Eating research programme, other structured diabetes education programmes and other interventions for Type 1 diabetes.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - December 3, 2013 Category: Endocrinology Authors: P. Thokala, J. Kruger, A. Brennan, H. Basarir, A. Duenas, A. Pandor, M. Gillett, J. Elliott, S. Heller Tags: Research Article Source Type: research

The medical research council neuromuscular centre for translational research mitochondrial disease patient cohort study uk: from conceptualisation to utilisation
Conclusion For the first time in the UK it is possible to access a large cohort of well–characterised patients with mitochondrial disease. The cohort provides objective data on mitochondrial disease progression, in children and adults, allowing evidence–based guidelines to be developed, and prognostic advice to be provided to patients and families. There is a vast amount of data still to be analysed that will provide systematic evidence and allow the development of disease prevention strategies.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Nesbitt, V., Pitceathly, R., Cockell, S., Poulton, J., Rahman, S., Hanna, M., Taylor, R., Chinnery, P., Turnbull, D., McFarland, R. Tags: Genetics, Epilepsy and seizures, Headache (including migraine), Muscle disease, Neuromuscular disease, Stroke, Musculoskeletal syndromes Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 Oc Source Type: research

Reducing the impact of stroke
An emerging treatment for stroke will be trialled in new research funded by the NIHR Health Technology Assessment (HTA) Programme. The trial, with over 2000 patients across 120 hospitals, will examine the use of tranexamic acid and assess its impact on those affected by haemorrhagic stroke. Stroke can be a devastating condition. As the most common cause...
Source: NIHR Evaluation, Trials and Studies News - September 26, 2013 Category: American Health Source Type: news

Intermittent pneumatic compression reduces risk of deep vein thrombosis in stroke patients
Intermittent pneumatic compression is effective in reducing the risk of deep vein thrombosis in stroke patients, according to the findings of a National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme study.In a paper published in The Lancet, the research team conclude that intermittent pneumatic compression (IPC) could potentially improve the survival...
Source: NIHR Evaluation, Trials and Studies News - September 26, 2013 Category: American Health Source Type: news

Stroke survivors' recovery not enhanced with communications therapy, HTA study finds
An NIHR Health Technology Assessment (HTA) Programme funded project, AcT NoW, has published in the British Medical Journal (BMJ). The study found that there is no evidence to suggest that strengthening the provision of early communication therapy will enhance stroke patients' recovery, over and above the usual care.Stroke is the leading cause of long-term...
Source: NIHR Evaluation, Trials and Studies News - September 20, 2013 Category: American Health Source Type: news