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Genetics of Dravet Syndrome and its Targeted Therapy by Nanomedicine: A Roadmap for Future Treatment of Drug Resistant Seizures
Curr Mol Pharmacol. 2022 Aug 19. doi: 10.2174/1874467215666220819143105. Online ahead of print.ABSTRACTAccording to the World Health Organization (WHO), epilepsy is the 4th most prevalent neurological disorder after migraine, stroke, and Alzheimer's disease. There are numerous types of epileptic syndrome that are reported in children; one of them is Dravet syndrome. It is a neurological disorder of infants' outset during the first year of life. Dravet syndrome is a genetically determined syndrome and the most studied form of genetic epilepsy. Nearly 70-80% of its cases are due to genetic alterations in the SCN1A gene, and ...
Source: Epilepsy Curr - August 20, 2022 Category: Neurology Authors: Muhammad Ikram Sufian Rasheed Source Type: research

Extreme Heat Makes It Hard for Kids To Be Active. But Exercise Is Crucial In a Warming World
Getting kids to be active in a modern world is a tough sell. It can be hard to compete with indoor comforts like video games, television, and air conditioning. Sweltering weather is another formidable barrier to kids getting enough physical activity, finds a new scientific review published in the journal Temperature that analyzed more than 150 studies. Children today are about 30% less aerobically fit than their parents were at their same age, leaving them less prepared to acclimate to a hotter, more extreme climate as they age, the study concluded. “The outside world is becoming more of an extreme environment for hu...
Source: TIME: Health - August 5, 2022 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized Exercise & Fitness healthscienceclimate Source Type: news

Acute Occupational and Physical Therapy for COVID-19 Patients: A Retrospective Cohort Study
In March 2020, the World Health Organization (WHO) declared the novel coronavirus strain SARS-CoV2 (the virus causing COVID-19) a global pandemic.24 The severity of illness in those exhibiting symptoms ranges from mild (cough, shortness of breath, fatigue) to severe (acute respiratory distress syndrome (ARDS), thrombosis, stroke, and death).4,11 Patients have also acquired acute polyradiculoneuritis (Guillain Barre syndrome) at a disproportionately high rate, contributing to functional limitations that require specialized and intensive rehabilitation.
Source: Archives of Physical Medicine and Rehabilitation - July 31, 2022 Category: Rehabilitation Authors: Katie Coakley, Laura Friedman, Kaitlyn McLoughlin, Amy Wozniak, Paul Hutchison Tags: Original Research Source Type: research

Antiplatelet agents and anticoagulants for hypertension
CONCLUSIONS: There is no evidence that antiplatelet therapy modifies mortality in patients with elevated BP for primary prevention. ASA reduced the risk of cardiovascular events and increased the risk of major bleeding events. Antiplatelet therapy with ASA probably reduces the risk of non-fatal and all cardiovascular events when compared to clopidogrel. Clopidogrel increases the risk of major bleeding events compared to ASA in patients with elevated BP for secondary prevention. There is no evidence that warfarin modifies mortality in patients with elevated BP for secondary prevention. The benefits and harms of the newer dr...
Source: Cochrane Database of Systematic Reviews - July 28, 2022 Category: General Medicine Authors: Eduard Shantsila Monika Kozie ł-Siołkowska Gregory Yh Lip Source Type: research

Incidence and characteristics of stroke in Zanzibar –a hospital-based prospective study in a low-income island population
ConclusionZanzibar has high incidence of hospitalization for stroke, indicating a very high population incidence of stroke. The proportion of strokes due to ICH is substantially higher than in high-income countries. Most stroke patients had been in contact with health care providers prior to stroke onset and been diagnosed with hypertension. However, few were using antihypertensive medication at the time of stroke onset.www.ClinicalTrial.gov registration NCT04095806.
Source: Frontiers in Neurology - July 28, 2022 Category: Neurology Source Type: research

Grading of Japanese Diet Intakes by 24-Hour Urine Analysis of Taurine and Soy Isoflavones in Relation to Cardiovascular Risks
In conclusion, the higher the J score, which corresponds to Japanese dietary habits, the lower the BMI and cholesterol levels, as well as mortality rate from coronary heart disease, but the higher the average life expectancy among the Japanese. However, these higher J scorings were associated with high-salt intake and high Na/K ratios; therefore, they contributed to high blood pressure and high mortality rate caused by stroke in Japan. These results indicate that low-salt intake should be recommended to the Japanese who are consuming seafood and soy regularly in order to maintain lower blood pressure and to extend healthy ...
Source: Advances in Experimental Medicine and Biology - July 26, 2022 Category: Research Authors: Mari Mori Miki Sagara Hideki Mori Yukio Yamori Source Type: research

P-006 The 'hub-spoke telemedicine model in a large cohort of stroke patients
ConclusionTele-stroke networks have proven to be a pivotal development in the treatment of strokes, especially those that are remote. With the additional expertise and the shorter duration from onset to diagnosis to treatment, these networks have substantially improved patient care and decreased healthcare costs, avoiding unnecessary transfers from spoke hospitals to hub.Abstract P-006 Figure 1Abstract P-006 Figure 2Disclosures K. El Naamani: None. N. Herial: None. R. Abbas: None. G. Sioutas: None. A. Amllay: None. A. Munoz: None. A. Sweid: None. C. Morse: None. D. Moylan: None. D. Joffe: None. M. Knapp: None. S. Tjoumakar...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: El Naamani, K., Herial, N., Abbas, R., Sioutas, G., Amllay, A., Munoz, A., Sweid, A., Morse, C., Moylan, D., Joffe, D., Knapp, M., Tjoumakaris, S., Gooch, M., Rosenwasser, R., Jabbour, P. Tags: SNIS 19th annual meeting oral poster abstracts Source Type: research

Climate Experts Are Testing New Ways To Reach the People Most Affected by Extreme Heat
As heat waves become longer, hotter, and more widespread across the planet, human responses to them are becoming increasingly local and specialized. Both scientific researchers and government officials are finding that the best strategies to keep cool are ones that are specially tailored to a community. That may seem obvious, given that outdoor laborers need different cooling resources than school teachers, for instance. But existing national and regional policies aren’t always that fine tuned—and they run the risk of wasting resources or missing the most vulnerable people. [time-brightcove not-tgx=”tru...
Source: TIME: Health - July 19, 2022 Category: Consumer Health News Authors: Emily Barone Tags: Uncategorized climate climate change Climate Is Everything extreme weather healthscienceclimate Source Type: news

Investigation of the Molecular Mechanisms Underlying the Antiatherogenic Actions of Kaempferol in Human THP-1 Macrophages
Int J Mol Sci. 2022 Jul 5;23(13):7461. doi: 10.3390/ijms23137461.ABSTRACTCardiovascular disease (CVD) is causing high mortality worldwide (World Health Organization-WHO, 2015). Atherosclerosis, the hardening and narrowing of arteries caused by the accumulation of fatty acids and lipids (cholesterol plaques), is a main reason of stroke, myocardial infarction, and angina. Present therapies for cardiovascular disease basically use statins such as β-Hydroxy β-methylglutaryl-CoA, with <70% efficacy and multiple side effects. An in vitro investigation was conducted to evaluate the impact of kaempferol, a natural medicat...
Source: Atherosclerosis - July 9, 2022 Category: Cardiology Authors: Etimad Huwait Maha Ayoub Sajjad Karim Source Type: research

A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era*
CONCLUSIONS: Maintenance-only fluid therapy normalized clinical and myocardial perturbations in shock without compromising cardiac or hemodynamic function whereas fluid-bolus management of WHO shock resulted in high fatality. Troponin and lactate biomarkers of cardiac dysfunction could be promising outcome predictors in pediatric septic shock in resource-limited settings.
Source: Pediatric Critical Care Medicine - July 1, 2022 Category: Pediatrics Tags: Feature Articles Source Type: research