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Very early infective endocarditis after transcatheter aortic valve replacement
ConclusionA significant proportion of IE episodes following TAVR occurs within a few weeks following the procedure and are associated with dismal outcomes. Some baseline and TAVR procedural factors were associated with VE-IE, andStaphylococcus aureus and enterococci were the main causative pathogens. These results may help to select the more appropriate antibiotic prophylaxis in TAVR procedures and guide the initial antibiotic therapy in those cases with a clinical suspicion of IE.Graphical abstractVery early infective endocarditis after trans-catheter aortic valve replacement. VE-IE indicates very early infective endocard...
Source: Clinical Research in Cardiology - March 9, 2022 Category: Cardiology Source Type: research

Hochuekkito can Prevent the Colonization of Methicillin-Resistant Staphylococcus aureus in Upper Respiratory Tract of Acute Stroke Patients
Conclusion: Our results indicate that the administration of HET may contribute to the prevention of MRSA colonization and promote rehabilitation in stroke patients.
Source: Frontiers in Pharmacology - June 28, 2021 Category: Drugs & Pharmacology Source Type: research

Implications of Methicillin-Resistant Staphylococcus aureus Carriage on Cardiac Surgical Outcomes.
CONCLUSIONS: MRSA carriers undergoing cardiac surgery are not at higher risk for mortality or SSI and can expect outcomes similar to those of non-carriers. Higher rates of postoperative MRSA infection and septicemia among carriers, although still very low, support the need for selective preoperative screening and prophylaxis when possible. PMID: 32387036 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - May 4, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Dewan KC, Dewan KS, Navale SM, Gordon SM, Svensson LG, Gillinov AM, Rich JB, Bakaeen F, Soltesz EG Tags: Ann Thorac Surg Source Type: research

“A contemporary description of staphylococcus aureus prosthetic valve endocarditis. Differences according to the time elapsed from surgery”
Staphylococcus aureus prosthetic valve endocarditis (SAPVE) has a poor prognosis. There are no large series that accurately describe this entity. This is a retrospective observational study on a prospective cohort from 3 Spanish reference hospitals for cardiac surgery, including 78 definitive episodes of left SAPVE between 1996 and 2016. Fifty percent had a Charlson Index score>5; 53% were health care-related. Twenty percent did not present fever. Complications at diagnosis included: severe heart failure (HF, 29%), septic shock (SS, 17.9%), central nervous system abnormalities (19%), septic metastasis (4%). Hemorrhagic s...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Clinical Issues —September 2017
Publication date: September 2017 Source:AORN Journal, Volume 106, Issue 3 Author(s): Amber Wood Performing Staphylococcus aureus decolonization for urgent procedures Key words: decolonization, Staphylococcus aureus, MRSA, MSSA, mupirocin. Hand hygiene before donning gloves Key words: hand hygiene, glove, personal protective equipment. Hand hygiene before skin prep Key words: hand hygiene, skin prep, sterile task, aseptic task. Scrubbing by stroke versus timed method Key words: surgical hand rub, surgical scrub, stroke method, timed method.
Source: AORN Journal - September 1, 2017 Category: Nursing Source Type: research

Stroke and myocardial infarction following bronchial artery embolization in a cystic fibrosis patient
A 31year-old male with advanced CF lung disease (genotype F508del/R560T) presented with massive hemoptysis in the context of a pulmonary exacerbation. Baseline lung function showed a forced expiratory volume in 1s of 0.89L (22% predicted), and respiratory cultures consistently grew Pseudomonas aeruginosa and methicillin resistant Staphylococcus aureus. He was actively listed for lung transplant but was considered a high risk candidate, given right lung volume loss associated with pronounced mediastinal shift.
Source: Journal of Cystic Fibrosis - December 5, 2016 Category: Respiratory Medicine Authors: Matt Hoffman, Joseph P. Gerding, Jonathan B. Zuckerman Tags: Letter to the Editor Source Type: research

Infective endocarditis requiring ICU admission: epidemiology and prognosis
Conclusions: Mortality in patients admitted to ICU for left-sided IE remains high, especially in cases of endocarditis due to methicillin resistant Staphylococcus aureus, when organ failures occur and ICU scores are high.
Source: Annals of Intensive Care - December 1, 2015 Category: Intensive Care Authors: Olivier LeroyHugues GeorgesPatrick DevosSteve BittonNathalie De SaCéline DedrieSébastien BeaguePierre DucqClaire Boulle-GeronimiDamien ThellierFabienne SaulnierSebastien Preau Source Type: research

Mortality among methicillin-resistant Staphylococcus aureus carriers in long-term care facilities.
CONCLUSIONS: MRSA colonization among frail LTHCFs residents is highly prevalent, and is associated with higher mortality. Despite treatment of MRSA carriers, many remained colonized. Factors that promote persistence of MRSA colonization, and the impact of their modification on mortality rates in these patients, need further investigation. PMID: 25904516 [PubMed - in process]
Source: Revista Espanola de Quimioterapia - April 1, 2015 Category: Drugs & Pharmacology Authors: Vendrell E, Capdevila JA, Barrufet P, Force L, Sauca G, Martínez E, Palomera E, Serra-Prat M, Cornudella J, Llopis A, Robledo MA, Vázquez C Tags: Rev Esp Quimioter Source Type: research

CDC National Health Report: Leading Causes of Morbidity and Mortality and Associated Behavioral Risk and Protective Factors-United States, 2005-2013.
This report reviews population health in the United States and provides an assessment of recent progress in meeting high-priority health objectives. The health status indicators described in this report were selected because of their direct relation to the leading causes of death and other substantial sources of morbidity and mortality and should be the focus of prevention efforts. REPORTING PERIOD COVERED: Data are reported starting in 2005 (or the earliest available year since 2005) through the current data year. Because data sources and specific indicators vary regarding when data are available, the most recent yea...
Source: MMWR Surveill Summ - October 31, 2014 Category: Epidemiology Authors: Johnson NB, Hayes LD, Brown K, Hoo EC, Ethier KA Tags: MMWR Surveill Summ Source Type: research

Diffuse cerebral petechial hemorrhage in an 8-year-old girl with MRSA pneumonia and sepsis
An 8-year-old girl in septic shock due to necrotizing methicillin-resistant Staphylococcus aureus (MRSA) pneumonia developed signs of end-organ damage, new right hemiplegia, and left gaze preference. Susceptibility-weighted MRI demonstrated extensive multifocal petechial hemorrhage preferentially at the gray–white matter interface due to septic microemboli (figure). Mechanisms of hemorrhage include small-vessel occlusion leading to mycotic aneurysm formation with rupture or pyogenic arteritis without aneurysm formation.1 Intracranial hemorrhage associated with metastatic staphylococcal infections is rarely descr...
Source: Neurology - January 20, 2014 Category: Neurology Authors: Williams, M. T., Jiang, H. Tags: All Imaging, Bacterial infections, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke, Intracerebral hemorrhage NEUROIMAGES Source Type: research

Exploration of optimal dosing regimens of vancomycin in patients infected with methicillin‐resistant Staphylococcus aureus by modeling and simulation
Summary What is known and objectiveVancomycin is the drug of choice for methicillin‐resistant Staphylococcus aureus (MRSA) infection and shows time‐dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and simulation. MethodsPharmacokinetics study was performed for 20 patients who were treated with vancomycin intravenously, 1000 mg, every 12 h, and blood for PK was randomly drawn within prespecified time windows. PD study was in vitro time‐kill experiment for vancomycin against 20 MRSA strains i...
Source: Journal of Clinical Pharmacy and Therapeutics - January 16, 2014 Category: Drugs & Pharmacology Authors: H.‐S. Lim, Y. P. Chong, Y.‐H. Noh, J.‐A. Jung, Y. S. Kim Tags: Pharmacokinetics Source Type: research

Compartmentalization of Immune Responses during Staphylococcus aureus Cranial Bone Flap Infection.
Abstract Decompressive craniectomy is often required after head trauma, stroke, or cranial bleeding to control subsequent brain swelling and prevent death. The infection rate after cranial bone flap replacement ranges from 0.8% to 15%, with an alarming frequency caused by methicillin-resistant Staphylococcus aureus, which is problematic because of its recalcitrance to antibiotic therapy. Herein we report the establishment of a novel mouse model of S. aureus cranial bone flap infection that mimics several aspects of human disease. Bacteria colonized bone flaps for up to 4 months after infection, as revealed by scan...
Source: The American Journal of Pathology - June 6, 2013 Category: Pathology Authors: Cheatle J, Aldrich A, Thorell WE, Boska MD, Kielian T Tags: Am J Pathol Source Type: research