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Palliative and End-of-Life Care in Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Scientific Statement
Conclusions— Addressing the palliative care needs of patients and families throughout the course of illness can complement existing practices and improve the quality of life of stroke patients, their families, and their care providers. There is an urgent need for further research in this area.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Holloway, R. G., Arnold, R. M., Creutzfeldt, C. J., Lewis, E. F., Lutz, B. J., McCann, R. M., Rabinstein, A. A., Saposnik, G., Sheth, K. N., Zahuranec, D. B., Zipfel, G. J., Zorowitz, R. D., on behalf of the American Heart Association Stroke Council, Coun Tags: AHA Statements and Guidelines AHA/ASA Scientific Statement Source Type: research

Palliative Care for Hospitalized Patients With Stroke Clinical Sciences
This study explores patterns of palliative care utilization and death in hospitalized patients with stroke across the United States.Methods—Using the 2010 to 2012 nationwide inpatient sample databases, we included all patients discharged with stroke identified by International Classification of Diseases-Ninth Revision codes. Strokes were subclassified as ischemic, intracerebral, and subarachnoid hemorrhage. We compared demographics, comorbidities, procedures, and outcomes between patients with and without a palliative care encounter (PCE) as defined by the International Classification of Diseases-Ninth Revision code V66....
Source: Stroke - August 28, 2017 Category: Neurology Authors: Tarvinder Singh, Steven R. Peters, David L. Tirschwell, Claire J. Creutzfeldt Tags: Race and Ethnicity, Quality and Outcomes, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Seizures after decompressive hemicraniectomy for ischaemic stroke
Conclusions In this case series, patients were at high risk of developing seizures after malignant MCA stroke with DHC, especially after cranioplasty. Assuming these findings are replicated, means should be sought to reduce the occurrence of this complication.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Creutzfeldt, C. J., Tirschwell, D. L., Kim, L. J., Schubert, G. B., Longstreth, W. T., Becker, K. J. Tags: Epilepsy and seizures, Stroke Cerebrovascular disease Source Type: research

Palliative Care: A Core Competency for Stroke Neurologists Topical Reviews
Source: Stroke - August 24, 2015 Category: Neurology Authors: Creutzfeldt, C. J., Holloway, R. G., Curtis, J. R. Tags: Other Ethics and Policy, Emergency treatment of Stroke, Other Stroke Treatment - Medical Topical Reviews Source Type: research

A Case of Creutzfeldt-Jakob Disease with Stroke-Like Onset
Creutzfeldt-Jakob disease (CJD) is a prion disease characterized by rapidly progressive dementia that is often followed by behavioral disturbances, ataxia, myoclonus, and akinetic mutism. The initial symptoms of CJD reportedly vary, but the onset is usually gradual. Here, we report a case of CJD with a sudden, stroke-like onset of right hemiparesis to alert readers that CJD can mimic a stroke during its early stage.
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2020 Category: Neurology Authors: Kosuke Okamoto, Takato Abe, Yoshiaki Itoh Tags: Case Report Source Type: research

Creutzfeldt-Jakob Disease Presenting as Stroke: Case Report and Literature Review (P1.022)
CONCLUSIONS CJD develops primarily within a population in whom stroke risk factors are common and represents a rare but important stroke mimic. Negative sensitive imaging in elderly patients with apparent acute vascular syndromes should prompt diagnostic review including consideration of prion diseases.Disclosure: Dr. Van Heuven has nothing to disclose. Dr. Boggild has nothing to disclose. Dr. White has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Van Heuven, A., Boggild, M., White, R. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Creutzfeldt-Jakob Disease Presenting as Stroke: A Case Report and Systematic Literature Review
Conclusions: CJD develops primarily within a population in whom stroke risk factors are common and represents a rare but important stroke mimic. Negative vascular imaging in elderly patients with apparent acute stroke syndromes should prompt diagnostic review including consideration of prion diseases.
Source: The Neurologist - March 1, 2017 Category: Neurology Tags: Review Article Source Type: research

Rapidly Progressing Sporadic Creutzfeldt-Jakob Disease Presenting as a Stroke
Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, fatal human prion disease that is characterized by progressive dementia and neurologic degeneration. It can mimic multiple other neurological disorders, and a high index of clinical suspicion is necessary to make a diagnosis. A 74-year-old woman with a 3-month history of a stroke and progressive neurologic deterioration was found to have sCJD. She expired within a week of her diagnosis. Autopsy revealed spongiform encephalopathy consistent with prion disease, and genetic analysis revealed 129 polymorphism and no pathologic mutation, confirming the diagnosis of nonfamilia...
Source: Case Reports in Neurology - September 17, 2018 Category: Neurology Source Type: research

Acute Anticoagulation after Ischemic Stroke in Patients with Left Ventricular Assist Devices
Despite reductions in major adverse events with the latest generation of left ventricular assist devices (LVADs), the incidence of stroke remains high. The timing of anticoagulation resumption is controversial. We aim to explore practices of anticoagulation management following ischemic stroke in LVAD patients and identify optimal strategies.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: C. Ibeh, D.L. Tirschwell, C. Mahr, C.J. Creutzfeldt Tags: (995) Source Type: research

Palliative and End-of-Life Care After Severe Stroke
This study sought to determine the prevalence, predictors, and outcomes associated with PCC for patients hospitalized with severe ischemic stroke.
Source: Journal of Pain and Symptom Management - January 4, 2022 Category: Palliative Care Authors: Amber R. Comer, Linda S. Williams, Stephanie Bartlett, Lynn D'Cruz, Katlyn Endris, McKenzie Marchand, Isabel Zepeda, Sumeet Toor, Carly Waite, Areeba Jawed, Robert Holloway, Claire J. Creutzfeldt, James E. Slaven, Alexia M. Torke Tags: Original Article Source Type: research

Seizures after craniectomy: an under-recognised complication?
Decompressive craniectomy for ischaemic stroke is being increasingly used, at least in the USA.1 This has likely been stimulated by three randomised clinical trials reporting improved survival in appropriately selected patients.2 As the number of patients so treated, and surviving, increases, a better picture of the complications and outcomes is emerging, with recognition of the relatively high risk of infection when the cranium is reconstructed after the craniectomy, as well as the occurrence of postoperative extra-axial haemorrhages and delayed hydrocephalus.3 Creutzfeldt et al4 highlight another surprisingly frequent se...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Macdonald, R. L. Tags: Epilepsy and seizures, Hydrocephalus, Neurooncology, Stroke, CNS cancer, Drugs: psychiatry, Drugs: musculoskeletal and joint diseases, Surgical oncology Editorial commentaries Source Type: research

Creutzfeldt-Jakob Disease
(CJD) information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: NINDS Disorders: National Institute of Neurological Disorders and Stroke - October 26, 2014 Category: Neurology Source Type: research

A toxic byproduct of hemoglobin could provide treatments for Creutzfeldt-Jakob disease
Scientists at Case Western Reserve University School of Medicine have identified a novel mechanism that could be used to protect the brain from damage due to stroke and a variety of...
Source: Parkinson's Disease News From Medical News Today - March 8, 2016 Category: Neurology Tags: Stroke Source Type: news

Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury
Conclusion and Future Aspects This review summarizes available NTF expression data, compiles existing evidence on the effects of glial NTF signaling in healthy conditions and in disease models (Figure 1), and highlights the importance of this topic for future studies. The relationship between NTFs and glia is crucial for both the developing and adult brain. While some of these factors, such as NT-3 and CNTF, have highly potent effects on gliogenesis, others like BDNF and GDNF, are important for glia-mediated synapse formation. Neurotrophic factors play significant roles during neurodegenerative disorders. In many cases, ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Creutzfeldt-Jakob and Vascular Brain Diseases: Their Overlap and Relationships
In conclusion, a complex of clinical, radiological, and laboratory manifestations of stroke-like onset of CJD is outlined. The clinical relationships between CJD and stroke are considered, in an attempt to highlight this rare presentation of an uncommon disease.
Source: Frontiers in Neurology - February 25, 2021 Category: Neurology Source Type: research

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