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Infectious Disease: SARS
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Total 158 results found since Jan 2013.
SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects
Various neurological symptoms have been associated to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection including headache, fever, anosmia, ageusia, but also, encephalitis, Guillain-Barre syndrome and ischemic stroke. Responsible for the current coronavirus disease (COVID-19) pandemic, SARS-CoV-2 may access and affect the central nervous system (CNS) by several pathways such as axonal retrograde transport or through interaction with the blood-brain barrier (BBB) or blood-cerebrospinal fluid (CSF) barrier. Here, we explored the molecular and cellular effects of direct SARS-CoV-2 infection of human BBB c...
Source: Frontiers in Immunology - July 27, 2021 Category: Allergy & Immunology Source Type: research
Emerging neurotropic features of SARS-CoV-2
J Mol Cell Biol. 2021 Jul 21:mjab044. doi: 10.1093/jmcb/mjab044. Online ahead of print.ABSTRACTThe prevailing coronavirus disease (COVID-19) caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has presented some neurological manifestations including hyposmia, hypogeusia, headache, stroke, encephalitis, Guillain‒Barre syndrome, and some neuropsychiatric disorders. Although several cell types in the brain express angiotensin converting enzyme-2 (ACE2), the main SARS-CoV-2 receptor, and other related proteins, it remains unclear whether the observed neurological manifestations are attributed to viru...
Source: Mol Biol Cell - July 21, 2021 Category: Molecular Biology Authors: Wen-Rong Zhan Jing Huang Peng-Ming Zeng Wei-Ya Tian Zhen-Ge Luo Source Type: research
COVID-19 Has Numerous Neuropsychiatric Consequences, Report Finds
Anarticle appearing today in theJournal of Neuropsychiatry and Clinical Neurosciences provides a comprehensive overview of the neurological and psychiatric impact of the COVID-19 pandemic.“Although best known for its severe effects on respiratory function, SARS-CoV-2 produces a broad range of acute and chronic neurological and neuropsychiatric problems,” wrote Theodora Manolis, M.D., of Red Cross Hospital in Athens, Greece, and colleagues. “The COVID-19 pandemic has also had an important impact on the mental health of many individuals in the general population as a result of loss of loved ones, fear of calamity or de...
Source: Psychiatr News - July 20, 2021 Category: Psychiatry Tags: COVID-19 delirium depression headache hypoxia Journal of Neuropsychiatry and Clinical Neurosciences muscle pain neurological problems psychiatric problems psychosis stroke Source Type: research
Neurological manifestations of patients infected with the SARS-CoV-2: a systematic review of the literature
ConclusionThis updated review of literature, shows that headache, skeletal muscle injury, psychiatric disorders, impaired consciousness, and gustatory/olfactory dysfunction were the most common neurological symptoms of COVID-19 patients. Impaired consciousness and acute cerebrovascular events were significantly higher among patients with a severe infection. AIS patients required ICU admission in 63% of cases, while intra-hospital mortality rate was close to 23%.
Source: Journal of Neurology - July 19, 2021 Category: Neurology Source Type: research
Focal cerebral arteriopathy in a young adult following SARS-CoV2 reinfection
Ten days after SARS-Cov2 reinfection with mild gastrointestinal symptoms and headache that occurred 2 months after an initial infection, a previously healthy 37-year-old woman developed fluctuating facial and upper limb paresthesia and weakness. Diffusion-weighted magnetic resonance imaging revealed ischemic lesions in the right parietal region of different stages within the same vascular territory. A cerebral angiography demonstrated an isolated focal arteriopathy with no other arterial involvement.
Source: Journal of Stroke and Cerebrovascular Diseases - June 12, 2021 Category: Neurology Authors: Carla Zanferrari, Simona Fanucchi, Maria Teresa Sollazzo, Michela Ranieri, Daniel Volterra, Luca Valvassori Source Type: research
SARS-CoV-2 Infection: Symptoms of the Nervous System and Implications for Therapy in Neurological Disorders
AbstractIn this paper, the neurological aspects of COVID-19 are presented, which may be of significance for physicians. Knowledge about the neurological symptoms of COVID-19 infection should help physicians in diagnoses and in taking appropriate precautions, as some manifestations can appear before typical pulmonary symptoms. Various mechanisms of SARS-CoV-2 neuroinvasion are discussed and symptoms are described, which can be subdivided into manifestations of the central nervous system (CNS) (headache, dizziness, stroke, impaired consciousness, encephalitis, meningitis, seizures) and peripheral nervous system (PNS) (charac...
Source: Neurology and Therapy - May 22, 2021 Category: Neurology Source Type: research
Demyelination as a result of an immune response in patients with COVID-19
AbstractThe coronavirus disease of 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2), that already appeared as a global pandemic. Presentation of the disease often includes upper respiratory symptoms like dry cough, dyspnea, chest pain, and rhinorrhea that can develop to respiratory failure, needing intubation. Furthermore, the occurrence of acute and subacute neurological manifestations such as stroke, encephalitis, headache, and seizures are frequently stated in patients with COVID-19. One of the reported neurological complications of severe COVID-19 is the demolition of the my...
Source: Acta Neurologica Belgica - May 2, 2021 Category: Neurology Source Type: research
Neurological Complications of the COVID-19 Pandemic: What Have We Got So Far?
Adv Exp Med Biol. 2021;1321:21-31. doi: 10.1007/978-3-030-59261-5_2.ABSTRACTThe recently emerged coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-19, is the newest threat to human health. It has already infected more than 54.5 million people worldwide, currently leading to more than 1.3 million deaths. Although it causes a mild flu-like disease in most patients, lethality may increase to more than 20% in elderly subjects, especially in those with comorbidities, like hypertension, diabetes, or lung and cardiac disease, and the mechanisms are still elusive. Common symp...
Source: Advances in Experimental Medicine and Biology - March 3, 2021 Category: Research Authors: Isabelle Pastor Bandeira Marco Ant ônio Machado Schlindwein Leticia Caroline Breis Jean Pierre Schatzmann Peron Marcus Vin ícius Magno Gonçalves Source Type: research
COVID-19 and Neurology - An Emerging Association
CONCLUSIONS: Presentation of COVID-19 with neurological features is not uncommon, and these patients should be tested earlier to help in the prevention of transmission, early diagnosis, and management.PMID:33602080 | DOI:10.2174/1871526521666210218202226
Source: Infectious Disorders Drug Targets - February 19, 2021 Category: Infectious Diseases Authors: Amit Gupta Prakrati Yadav Deepak Kumar Source Type: research
COVID-19 and Neurology - An Emerging Association.
CONCLUSIONS: Presentation of COVID-19 with neurological features is not uncommon, and these patients should be tested earlier to help in the prevention of transmission, early diagnosis, and management.
PMID: 33602080 [PubMed - as supplied by publisher]
Source: Infectious Disorders Drug Targets - February 18, 2021 Category: Infectious Diseases Authors: Gupta A, Yadav P, Kumar D Tags: Infect Disord Drug Targets Source Type: research
Neurological associations of SARS-CoV-2 infection: A Systematic Review
CNS Neurol Disord Drug Targets. 2021 Feb 16. doi: 10.2174/1871527320666210216121211. Online ahead of print.ABSTRACTBACKGROUND: The current ongoing COVID-19 pandemic has compelled us to scrutinize major outbreaks in the past two decades, severe acute respiratory syndrome (SARS), in 2002, and Middle East respiratory syndrome (MERS), in 2012. We aimed to assess the associated neurological manifestations with SARS CoV-2 infection.METHODS: In this systematic review, a search was carried out by key-electronic databases, controlled vocabulary, and indexing of trials to evaluate the available pertinent studies which included both ...
Source: CNS and Neurological Disorders Drug Targets - February 17, 2021 Category: Drugs & Pharmacology Authors: Amaan Javed Source Type: research
