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Total 13 results found since Jan 2013.

Potential association between bacterial infections and ischemic stroke based on fifty case-control studies: A systematic review and meta-analysis
CONCLUSIONS: In this meta-analysis, a significant relationship was observed between infection by three bacteria such as C. pneumoniae, H. pylori, and M. tuberculosis with the occurrence of ischemic stroke. Furthermore, due to the similarity between TLRVYK domain in β2-glycoprotein-I and TLRVYK peptide in various of microorganisms, produced antibodies against pathogens interact with β2-glycoprotein-I, hence the cross-reaction phenomenon increases the positive relationship between infectious diseases and ischemic stroke.PMID:35592534 | PMC:PMC9112101 | DOI:10.1016/j.nmni.2022.100980
Source: Atherosclerosis - May 20, 2022 Category: Cardiology Authors: M Keikha M Karbalaei Source Type: research

Intracranial Large Artery Stenosis and Past Infectious Exposures: Results From the NOMAS Cohort
CONCLUSIONS: Chronic infectious exposures, specifically herpes simplex virus 2 and cytomegalovirus were associated with asymptomatic ILAS as seen on magnetic resonance angiogram imaging. This may represent an additional target of intervention in the ongoing effort to stem the substantial global burden of strokes related to ILAS.PMID:35105181 | DOI:10.1161/STROKEAHA.121.036793
Source: Herpes - February 2, 2022 Category: Infectious Diseases Authors: Amol Mehta Farid Khasiyev Clinton B Wright Tatjana Rundek Ralph L Sacco Mitchell S V Elkind Jose Gutierrez Source Type: research

Infection and atherosclerosis: TLR-dependent pathways.
This article reviews the role of TLRs in the process of atherosclerosis after C. pneumoniae and other infections and the current status of treatment, with a view to providing a new direction and potential therapeutic targets for the study of ASVD. PMID: 32002588 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Life Sciences : CMLS - January 29, 2020 Category: Cytology Authors: Li B, Xia Y, Hu B Tags: Cell Mol Life Sci Source Type: research

Psychosis Polyrisk Score (PPS) for the Detection of Individuals At-Risk and the Prediction of Their Outcomes
Conclusions The combination of risk/protective factors encompassing genetic (PRS) and non-genetic information (PPS) holds promise for overcoming the epidemiological weakness of the CHR-P paradigm. The PPS conceptually and empirically developed here will facilitate future research in this field and hopefully advance our ability to detect individuals at-risk for psychosis and forecast their clinical outcomes. Ethics Statement This study was supported by the King's College London Confidence in Concept award from the Medical Research Council (MRC) (MC_PC_16048) to PF-P. This study also represents independent researc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

A True Hematologic Emergency
​BY GREGORY TAYLOR, DO, & JACKLYN M​CPARLANE, DO​A 33-year-old woman with a past medical history of sickle cell SS presented to the emergency department with chest pain, difficulty breathing, and a cough for two days. Her chest pain was diffuse, without radiation, and partially reproducible. Her cough was nonproductive, and she also reported fever and chills.The patient noted this was different from her normal back and leg pain from past sickle cell crises. She was following up with a sickle cell specialist, and was compliant with her hydroxyurea treatment.Her temperature was 102.8°F, blood pressure was 94/60 mm...
Source: The Case Files - June 26, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Carotid intima media thickness and blood biomarkers of atherosclerosis in patients after stroke or myocardial infarction.
CONCLUSIONS: Our study supports linear correlations between CIMT and IC and hs-CRP levels. However, these associations seem to depend on the type of vascular burden. PMID: 28051279 [PubMed - in process]
Source: Croatian Medical Journal - December 30, 2016 Category: Journals (General) Authors: Kurkowska-Jastrzebska I, Karlinski MA, Błazejewska-Hyzorek B, Sarzynska-Dlugosz I, Filipiak KJ, Czlonkowska A Tags: Croat Med J Source Type: research

Infectious Burden and Cognitive Decline in the Northern Manhattan Study
ConclusionA quantitative stroke risk‐weighted measure of IB explained variability in baseline executive function performance and associated with decline in memory. Past exposure to common infections may contribute to vascular cognitive impairment and warrants further study.
Source: Journal of the American Geriatrics Society - August 20, 2015 Category: Geriatrics Authors: Clinton B. Wright, Hannah Gardener, Chuanhui Dong, Mitsuhiro Yoshita, Charles DeCarli, Ralph L. Sacco, Yaakov Stern, Mitchell S. V. Elkind Tags: Clinical Investigations Source Type: research

CDC National Health Report: Leading Causes of Morbidity and Mortality and Associated Behavioral Risk and Protective Factors-United States, 2005-2013.
This report reviews population health in the United States and provides an assessment of recent progress in meeting high-priority health objectives. The health status indicators described in this report were selected because of their direct relation to the leading causes of death and other substantial sources of morbidity and mortality and should be the focus of prevention efforts. REPORTING PERIOD COVERED: Data are reported starting in 2005 (or the earliest available year since 2005) through the current data year. Because data sources and specific indicators vary regarding when data are available, the most recent yea...
Source: MMWR Surveill Summ - October 31, 2014 Category: Epidemiology Authors: Johnson NB, Hayes LD, Brown K, Hoo EC, Ethier KA Tags: MMWR Surveill Summ Source Type: research

Novel Inflammatory Biomarkers and Their Correlation to Chlamydia pneumoniae Titres in Acute Ischemic Stroke
Conclusions: The study demonstrated high levels of hsp 65 and neopterin levels in AIS correlated to significantly elevated IgA titres of C pneumoniae. Elevated levels of hsp 65 were associated with stroke severity.
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2014 Category: Neurology Authors: M.V. Padma Srivastava, Ashu Bhasin, Rama Chaudhry, Sakshi Sharma, Vivekanandhan Subbaiah, Rohit Bhatia, Manjari Tripathi Tags: Original Articles Source Type: research

Chlamydia pneumoniae infection and cerebral infarction risk: a meta‐analysis
Conclusion(1) This meta‐analysis indicated that C. pneumoniae infection was significantly associated with an increased risk of cerebral infarction. (2) Compared with anti‐C. pneumoniae immunoglobulin G, anti‐C. pneumoniae immunoglobulin A seemed more effective for predicting the risk of cerebral infarction. (3) No evidence existed that anti‐C. pneumoniae‐immunoglobulin G detected by enzyme‐linked immunosorbent assay could predict the risk of cerebral infarction.
Source: International Journal of Stroke - March 5, 2014 Category: Neurology Authors: Xing Su, Hong‐Lin Chen Tags: Systematic review Source Type: research

Chlamydia pneumoniae infection and cerebrovascular disease: a systematic review and meta-analysis
Conclusion: Association between C.pneumoniae infection and CV disease depends on the analytical method adopted, which seems stronger with stroke due to large artery atherosclerosis. Establishing a causal relationship between C.peumoniae infection and CV disease will require more prospective studies with combination of techniques and stratified by etiological subtypes.
Source: BMC Neurology - November 21, 2013 Category: Neurology Authors: Juan ChenMeijia ZhuGaoting MaZhangning ZhaoZhongwen Sun Source Type: research

Infectious burden and cognitive function: The Northern Manhattan Study
Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
Source: Neurology - March 25, 2013 Category: Neurology Authors: Katan, M., Moon, Y. P., Paik, M. C., Sacco, R. L., Wright, C. B., Elkind, M. S. V. Tags: All Infections, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia ARTICLE Source Type: research