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Source: The Journal of Heart and Lung Transplantation
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Total 231 results found since Jan 2013.
Two-Year Outcomes in HeartMate 3 versus HeartWare HVAD Patients Implanted as Destination Therapy
The ENDURANCE trial demonstrated noninferiority of the intrapericardial centrifugal-flow HeartWare HVAD compared to the axial-flow HeartMate II left ventricular assist device (LVAD) regarding survival in patients with advanced heart failure ineligible for heart transplantation, but stroke was more common. Most recently, the MOMENTUM 3 trial demonstrated superiority of the intrathoracic, fully magnetically levitated centrifugal-flow HeartMate 3 (HM3) LVAD compared to the HeartMate II. A clinical trial evaluating the HM3 and HVAD has not been performed, therefore the purpose of this study was to compare outcomes between these two devices.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: L. Coyle, C. Gallagher, L. Kukla, R. Paliga, R. Siemeck, G. Yost, M. Dia, A. Tatooles Tags: (1039) Source Type: research
Physiologically Significant Pulsatility Key to Reducing Adverse Events in CF LVADS
Hypertension is common in continuous flow LVAD (CFLVAD) patients and is linked to major adverse events like stroke and aortic incompetence.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: K. Balakrishnan, R. Krishnakumar Tags: (1037) Source Type: research
Pulmonary Artery Pulsatility Index (PAPi) is a Predictor of Right Ventricular Assist Device (RVAD) Use Following HeartMate 3 LVAD Implantation
Pulmonary artery pulsatility index (PAPi) recently emerged as a predictor of right ventricular failure after Heartmate II LVAD Implantation. Clinical utility of this marker in Heartmate 3 patients is unknown. We hypothesized that PAPi is a stronger predictor of RV failure compared to central venous pressure to pulmonary artery capillary wedge pressure ratio (CVP/PCWP) or RV stroke work index (RVSWI) in Heartmate 3 population.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: D. Marshall, A. Malick, L. Truby, C. Butler, J. Griffin, K. Clerkin, J. Fried, J. Raikhelkar, M. Yuzefpolskaya, P. Colombo, G. Sayer, H. Takayama, K. Takeda, Y. Naka, M. Farr, N. Uriel, V.K. Topkara Tags: (1031) Source Type: research
Increased Mean Platelet Volume is Associated with Decreased Survival in Patients Supported with Impella
Increased mean platelet volume (MPV) has been associated with elevated risk of stroke and myocardial infarction in the general population and stroke/pump thrombosis in Heartmate II recipients. It has been proposed that contact with foreign surfaces and centrifugation promote prothrombotic states with platelet activation and increased MPV. An association between MPV and outcomes of patients treated with percutaneous short-term circulatory devices has not been investigated.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: M. Harutyunyan, K. Doshi, H. Nazeer, E. Joye, O. Saeed, M. Torosoff, U. Jorde, D. Belov Tags: (1029) Source Type: research
Survival Impact of Bacteremia on Left Ventricular Assist Device Patients Who Have Suffered Strokes
Strokes and infection are two potential complications in patients with left ventricular assist devices (LVADs). The combination of infection and stroke is particularly concerning for LVAD recipients and may be interrelated. We evaluated the impact of concomitant bacteremia in LVAD patients who suffered a stroke.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: A.A. Phancao, S. George, A.M. El Banayosy, N.M. Chelikani, M.C. Corder, D.A. Horstmanshof, J.W. Long Tags: (1253) Source Type: research
Natural Antibodies and Left Ventricular Assist Device Complications
Left ventricular assist devices (LVAD) are widely used as a support strategy for advanced heart failure. Complications such as thrombosis and bleeding have been linked to LVAD. We observed that LVAD implantation was followed by a sharp increase in serum levels of IgG natural antibodies (Nabs) recognizing oxidation-specific epitopes (OSE) and apoptotic cells. Nabs have been implicated in inflammatory reactions related to atherosclerosis, ischemic stroke and primary graft dysfunction following heart transplantation.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: S.B. See, D. Onat, E. Hittesdorf, F. McDougan, M. Yuzefpolskaya, A.R. Garan, V.K. Topkara, Y. Naka, H. Takayama, K. Takeda, G.P. Milligan, D. Wencker, S.A. Hall, M. Askar, P. Kimball, G. Wagener, P. Colombo, E. Zorn Tags: (1211) Source Type: research
Left ventricular assist systems and strokes: Statins to the rescue?
The development of durable left ventricular assist systems (LVASs) has been critical in providing an option for management of end-stage heart disease and addressing the increasing gap between demand and supply of donor cardiac allografts for management of end-stage heart disease. The technology also provides an alternative to heart transplantation in many patients. Unfortunately, the long-term use of LVASs has been associated with significant morbidities, the most devastating of which may relate to the thrombogenicity of the artificial devices, leading to ischemic stroke or pump thrombosis.
Source: The Journal of Heart and Lung Transplantation - March 16, 2020 Category: Transplant Surgery Authors: Jignesh K. Patel Tags: EDITORIAL COMMENTARY Source Type: research
Left Ventricular Assist Systems and Strokes- Statins to the Rescue?
The development of durable left ventricular assist systems (LVAS) has been critical in providing an option for management of end-stage heart disease and addressing the increasing gap between demand and supply of donor cardiac allografts for management of end-stage heart disease. The technology also provides an alternative to heart transplantation in many patients. Unfortunately, the long-term use of LVAS has been associated with significant morbidities, the most devastating of which may relate to the thrombogenicity of the artificial devices, leading to ischemic stroke or pump thrombosis.
Source: The Journal of Heart and Lung Transplantation - March 16, 2020 Category: Transplant Surgery Authors: Jignesh Patel Tags: Editorial Source Type: research
The Impact of Statin Therapy on Neurological Events Following Left Ventricular Assist System Implantation in Advanced Heart Failure
Stroke is a leading cause of disability and death in advanced heart failure patients supported with continuous-flow left ventricular assist systems (CF-LVAS). Statins (HMG-CoA Reductase Inhibitors) reduce the risk of major cardiovascular and neurological events, such as stroke, but their impact has not been evaluated in patients implanted with CF-LVAS. We sought to explore the association between use of statin therapy and subsequent occurrence of neurological events, particularly stroke, following CF-LVAS implantation.
Source: The Journal of Heart and Lung Transplantation - March 3, 2020 Category: Transplant Surgery Authors: Jefferson L. Vieira, Michael Pfeffer, Brian L. Claggett, Garrick C. Stewart, Michael M. Givertz, Lara Coakley, Hari R. Mallidi, Mandeep R. Mehra Tags: Original Clinical Science Source Type: research
Understanding Risk Factors and Predictors for Stroke Subtypes in the ENDURANCE Trials
We report a comprehensive analysis of stroke subtypes in the ENDURANCE (DT) and ENDURANCE Supplemental (DT2) trials.
Source: The Journal of Heart and Lung Transplantation - January 27, 2020 Category: Transplant Surgery Authors: Sung-Min Cho, Randall C. Starling, Jeffrey Teuteberg, Joseph Rogers, Francis Pagani, Palak Shah, Ken Uchino, Nicholas Hiivala Tags: Original Clinical Science Source Type: research
This is Your Brain on LVAD
The utilization and duration of left ventricular assist device (LVAD) support has increased steadily over the last decade and recent changes in the UNOS heart allocation system, implemented in October 2018, portend a further increase in the duration of mechanical circulatory support for many patients (1). Though four-year survival rates have improved to 60% following LVAD implantation, the leading cause of death in these patients is neurological injury, specifically ischemic and hemorrhagic stroke (spontaneous subarachnoid hemorrhage or intraparenchymal hemorrhage [IPH]) (2).
Source: The Journal of Heart and Lung Transplantation - January 24, 2020 Category: Transplant Surgery Authors: Jennifer A. Frontera Tags: Editorial Source Type: research
First Human Implantation of A Miniaturized Axial Flow Ventricular Assist Device in a Child with End-Stage Heart Failure
Small children with end-stage heart failure who require left ventricular assist device (LVAD) support to heart transplant have limited device options leading to high morbidity and mortality and chronic hospitalization until transplant.1,2 The only FDA-approved durable LVAD for children is a paracorporeal pulsatile device that carries a high stroke risk and lacks portability precluding hospital discharge.1 Temporary paracorporeal continuous flow (CF) devices have also been used off-label for bridge-to-transplant but carry higher mortality, require lengthy paracorporeal cannulas prone to circuit thrombus, and typically requi...
Source: The Journal of Heart and Lung Transplantation - September 10, 2019 Category: Transplant Surgery Authors: Antonio Amodeo, Sergio Filippelli, Gianluigi Perri, Roberta Iacobelli, Rachele Adorisio, Francesca Iodice, Alessandra Rizza, M. Patricia Massicotte, J. Timothy Baldwin, Christopher S.D. Almond Tags: Case Anecdotes, Comments and Opinions Source Type: research
Peripheral Component Malfunction of a Fully Magnetically Levitated Centrifugal Pump Masquerading as Pump Thrombosis
We present the case of a HM-3 controller malfunction, resembling pump thrombosis based on acute changes to pump parameters and abnormal LVAD log file analysis.
Source: The Journal of Heart and Lung Transplantation - June 18, 2019 Category: Transplant Surgery Authors: Ioannis Mastoris, Mohamed El Khashab, Travis Abicht Tags: CASE ANECDOTES, COMMENTS AND OPINIONS Source Type: research
Ventricular Assist Device Deactivation in Children: Preparedness Planning and Procedural Checklist
Key difference exist between adult and pediatric Ventricular Assist Device (VAD) care. For many adult patients, VADs are commonly implanted as destination therapy in contrast to pediatric patients who more often receive VAD therapy as a bridge to transplant. Adult patients/families may be better prepared for the anticipated and enivadable complications that occur at the end of destination therapy, but receive benefit from VAD therapy for both prolonged quantity and quality of life. Despite the success of VAD as a bridge to heart transplantation in children, adverse and debilitating events, including stroke, thrombosis, inf...
Source: The Journal of Heart and Lung Transplantation - June 18, 2019 Category: Transplant Surgery Authors: Desiree S. Machado, Seth A. Hollander, Jenna Murray, Joseph Philip, Mark Bleiweis, Sheri Kittelson Tags: Letter to the Editor Source Type: research
Cessation of Anticoagulation for Bleeding and Thrombosis Events with a Fully Magnetically Levitated Centrifugal Left Ventricular Assist Device
Anticoagulation therapy for patients supported by a left ventricular assist device (LVAD) has not been adequately evaluated in relevance to newer pumps, such as the fully magnetically levitated HeartMate 3 pump. Current anticoagulation guidelines target a goal INR of 2.0 –3.0 with vitamin K antagonists to mitigate the risk of pump thrombosis and ischemic stroke, but are based on historical trials with older devices. Long-term outcomes associated with newer devices, such as the centrifugal-flow HeartMate 3 (HM3), have demonstrated a marked decrease in the incidence of pump thrombosis compared to mechanical bearing axial-f...
Source: The Journal of Heart and Lung Transplantation - April 28, 2019 Category: Transplant Surgery Authors: Igor Gosev, Brian Ayers, Katherine Wood, Bryan Barrus, Sunil Prasad Tags: Case Anecdotes, Comments and Opinions Source Type: research
