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Source: The Journal of Heart and Lung Transplantation

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Total 231 results found since Jan 2013.

RVOT-VTI/PASP Is a Novel Noninvasive Parameter of Pulmonary Artery Compliance and Improves After Treatment with Pulmonary Hypertension-Specific Therapy
Pulmonary artery compliance (PAC) is an independent predictor of mortality in patients with pulmonary hypertension (PH). We have previously shown that the ratio of echocardiography derived right ventricular outflow tract velocity time integral (RVOT-VTI; an estimate of stroke volume) to pulmonary artery systolic pressure (PASP) correlates with PAC measured by right heart catheterization. We sought to determine whether PH-specific therapy improves PAC in patients with pulmonary arterial hypertension (PAH).
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: M.S. Tanna, A. Fox, G.S. Troutman, P.T. Bhattacharya, J.N. Menachem, F. Mao, E.Y. Birati, P.R. Forfia, A. Vaidya, J.A. Mazurek Source Type: research

Surgical occlusion of the left atrial appendage and thromboembolic complications in patients with left ventricular assist devices
Thromboembolic complications (TECs) are major adverse events for patients supported by left ventricular assist devices (LVADs). Despite anti-coagulation, TECs such as stroke or pump thrombosis occur in 6.5% of patients.1 Risk of TECs increases with longer duration of device support, and the risk is likely greater in patients receiving LVADs as destination therapy. Surgical or percutaneous occlusion of the left atrial appendage (LAA) reduces TECs in patients with atrial fibrillation.2,3 The LAA may also be a source of thromboembolism for patients with systolic heart failure, including patients in sinus rhythm.
Source: The Journal of Heart and Lung Transplantation - January 29, 2017 Category: Transplant Surgery Authors: Rebecca S. Lewis, Lian Wang, Kateri J. Spinelli, Gary Y. Ott, Jacob Abraham Tags: Research Correspondence Source Type: research

Surgical occlusion of the left atrial appendage and thromboembolic complications in left ventricular assist device patients
Thromboembolic complications (TEC) are major adverse events for patients supported by left ventricular assist devices (LVADs). Despite anticoagulation, TEC such as stroke or pump thrombosis still occur in 6.5% of patients.1 Risk of TEC increases with longer duration of device support and is likely a greater risk in destination therapy patients. Surgical or percutaneous occlusion of the left atrial appendage (LAAO) reduces TEC in patients with atrial fibrillation.2,3 The LAA may also be a source of thromboembolism for systolic heart failure patients, even in sinus rhythm.
Source: The Journal of Heart and Lung Transplantation - January 29, 2017 Category: Transplant Surgery Authors: Rebecca S. Lewis, Lian Wang, Kateri J. Spinelli, Gary Y. Ott, Jacob Abraham Source Type: research

Risk Factors, Mortality and Timing of Ischemic and Hemorrhagic Stroke with Left Ventricular Assist Devices
Stroke is a major cause of mortality following left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - December 22, 2016 Category: Transplant Surgery Authors: Jennifer A. Frontera, Randall Starling, Sung-Min Cho, Amy S. Nowacki, Ken Uchino, M. Shazam Hussain, Maria Mountis, Nader Moazami Tags: Original Clinical Science Source Type: research

Risk factors, mortality, and timing of ischemic and hemorrhagic stroke with left ventricular assist devices
Stroke is a major cause of mortality after left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - December 22, 2016 Category: Transplant Surgery Authors: Jennifer A. Frontera, Randall Starling, Sung-Min Cho, Amy S. Nowacki, Ken Uchino, M. Shazam Hussain, Maria Mountis, Nader Moazami Tags: Original Clinical Science Source Type: research

Outcomes after stroke complicating left ventricular assist device
We present a large single-center experience on stroke outcome and transplant eligibility by stroke sub-type and severity in CF-LVAD patients.
Source: The Journal of Heart and Lung Transplantation - March 29, 2016 Category: Transplant Surgery Authors: Joshua Z. Willey, Michael V. Gavalas, Pauline N. Trinh, Melana Yuzefpolskaya, A. Reshad Garan, Allison P. Levin, Koji Takeda, Hiroo Takayama, Justin Fried, Yoshifumi Naka, Veli K. Topkara, Paolo C. Colombo Tags: Original Clinical Science Source Type: research

Outcomes After Stroke Complicating Left Ventricular Assist Device
We present a large single center experience on stroke outcome and transplant eligibility by stroke subtype and severity in CF-LVAD patients.
Source: The Journal of Heart and Lung Transplantation - March 29, 2016 Category: Transplant Surgery Authors: Joshua Z. Willey, Michael V. Gavalas, Pauline N. Trinh, Melana Yuzefpolskaya, A. Reshad Garan, Allison P. Levin, Koji Takeda, Hiroo Takayama, Justin Fried, Yoshifumi Naka, Veli K. Topkara, Paolo C. Colombo Source Type: research

Outcome, incidence and risk factors for stroke after pediatric heart transplantation: An analysis of the International Society for Heart and Lung Transplantation registry
In the registry of the International Society for Heart and Lung Transplantation (ISHLT), cerebrovascular accidents are the fifth most common cause for mortality after pediatric heart transplantation (PHTx), but details are lacking in the literature. The purpose of this analysis of the ISHLT registry was to determine the prevalence, risk factors and outcomes of stroke after PHTx.
Source: The Journal of Heart and Lung Transplantation - March 17, 2016 Category: Transplant Surgery Authors: Conall Thomas Morgan, Cedric Manlhiot, Brian W. McCrindle, Anne I. Dipchand Tags: Original Clinical Science Source Type: research

A multicenter study of the HeartWare ventricular assist device in small children
Continuous-flow ventricular assist devices (CF-VADs), designed for patients with a body surface area (BSA) ≥1.2 m2, have improved survival free from stroke and device failure in adults compared with pulsatile devices.1 Initial experiences in larger children with these CF-VADs have been promising2; however, a large proportion of children needing long-term support as a bridge to heart transplantation (HTx) have a BSA of ≤1 m2. These small children can be successfully supported with paracorporeal pulsatile devices,3 yet rates of thromboembolic events continue to be an ongoing concern.
Source: The Journal of Heart and Lung Transplantation - January 18, 2016 Category: Transplant Surgery Authors: Oliver Miera, Richard Kirk, Holger Buchholz, Katharina R.L. Schmitt, Christina VanderPluym, Ivan M. Rebeyka, Neil Wrightson, Felix Berger, Massimo Griselli, Jennifer Conway Tags: Research Correspondence Source Type: research

A multicenter study of the HeartWare HVAD ventricular assist device in small children
Continuous-flow ventricular assist devices (CF-VADs), designed for body surface areas (BSA) ≥1.2 m², have improved survival free from stroke and device failure in adults compared to pulsatile device.1 First experiences in larger children with these CF-VADs have been promising.2 However, a large proportion of children needing long-term support as a bridge to heart transplantation (HTx) have a BSA of ≤1m². These small children can be successfully supported with paracorporeal pulsatile devices.3 However, the rate of thromboembolic events continue to be an ongoing concern.
Source: The Journal of Heart and Lung Transplantation - January 18, 2016 Category: Transplant Surgery Authors: O. Miera, R. Kirk, H. Buchholz, K.R.L. Schmitt, C. VanderPluym, I.M. Rebeyka, N. Wrightson, F. Berger, M. Griselli, J. Conway Source Type: research

Gender differences in the risk of stroke during support with continuous flow left ventricular assist device
There is increasing recognition that the risk of stroke after left ventricular assist device (LVAD) varies based on gender, with a higher risk in female patients. We reviewed our own data to determine gender differences in the risk of stroke.
Source: The Journal of Heart and Lung Transplantation - September 3, 2015 Category: Transplant Surgery Authors: Alanna A. Morris, Ann Pekarek, Kris Wittersheim, Robert T. Cole, Divya Gupta, Duc Nguyen, S. Raja Laskar, Javed Butler, Andrew Smith, J. David Vega Source Type: research

Gender differences in the risk of stroke during support with continuous-flow left ventricular assist device
There is increasing recognition that the risk of stroke after left ventricular assist device (LVAD) implantation varies based on gender, with a higher risk in female patients. We reviewed our own data to determine gender differences in the risk of stroke.
Source: The Journal of Heart and Lung Transplantation - September 3, 2015 Category: Transplant Surgery Authors: Alanna A. Morris, Ann Pekarek, Kris Wittersheim, Robert T. Cole, Divya Gupta, Duc Nguyen, S. Raja Laskar, Javed Butler, Andrew Smith, J. David Vega Tags: Original Clinical Science Source Type: research

CHA2DS2-Vasc and HAS-BLED Scores as Predictors of Ischemic and Hemorrhagic Stroke Risk After Left Ventricular Assist Device Implantation
CHA2DS2-VASc score predicts thromboembolic event risk and HAS-BLED score predicts major bleeding risk in patients on anticoagulation with atrial fibrillation. We aimed to evaluate if these scoring systems would be predictive of ischemic stroke and intracranial bleeding complications following continuous-flow left ventricular assist device (CF-LVAD) implantation.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: H.S. Kemal, S. Ertugay, S. Nalbantgil, M. Zoghi, C. Engin, T. Yagdi, M. Ozbaran Source Type: research

Outcome, Prevalence and Risk Factors for Stroke Following Pediatric Heart Transplantation: An Analysis of the ISHLT Registry
In the ISHLT Registry, cerebrovascular accidents are the fifth commonest cause for mortality following pediatric heart transplantation (PHTx); but details are lacking in the reported literature. The purpose of this analysis of the ISHLT registry was to determine the prevalence, risk factors and outcomes of stroke after PHTx.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: C. Morgan, C. Manlhiot, B.W. McCrindle, A. Dipchand Source Type: research

Circulating Histone-Induced Lung Injury: A Novel Model of Damaged Lungs From Brain-Dead Donors
Histones, a component of nucleosomes, are released from dying cells into the blood circulation in patients with stroke. It has been also known that circulating histones can cause endothelial injury of the pulmonary vasculature. We hypothesized that a transient release of histones in the circulation cause endothelial damages in the brain-dead donor lungs that can lead severe re-perfusion injury after lung transplantation.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: T. Murayama, M. Anraku, T. Murakawa, T. Yoshioka, M. Inui, N. Hiyama, M. Kawashima, T. Tsuchiya, J. Ichinose, H. Hino, K. Nagayama, J. Nitadori, K. Kakimi, J. Nakajima Source Type: research