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Source: The Journal of Heart and Lung Transplantation

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Total 231 results found since Jan 2013.

Impact of Body Mass Index on Outcomes After Left Ventricular Assist Device Placement: Evidence from a Meta-Analysis
To investigate the impact of body mass index (BMI) on mortality, rates of device-related infections and stroke/ transient ischemic attack (TIA) after left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: A. Vallakati, S. Emani, W.T. Abraham Source Type: research

Sildenafil Reduces Risk of Ischemic Stroke and Pump Thrombosis with Ongoing Low Level Hemolysis During Heart Mate II Support
Low level hemolysis after Heart Mate (HM) II implantation, as evident by an elevated discharge lactate dehydrogenase (LDH) level>400 U/L, is linked to subsequent thrombotic events. Free hemoglobin from ongoing hemolysis scavenges nitric oxide (NO) to create a NO deficiency which can augment platelet function. We hypothesized the potentiation of NO signaling during low level hemolysis with a phosphodiesterase-5 inhibitor, sildenafil, may lead to reduced thrombotic events.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: O. Saeed, S. Rangasamy, A. Luke, S.P. Patel, D.B. Sims, J. Shin, M. Reyes Gil, M.J. Slepian, H.H. Billett, D.J. Goldstein, U.P. Jorde Source Type: research

Managing Anticoagulation in LVAD Patients: The Harefield Experience
Anticoagulation management in patients with Left Ventricular Assist devices (LVAD) continues to be a challenge. Patients and their clinicians are faced with the daily challenge of needing adequate anticoagulation versus the bleeding risks that are associated with anticoagulation.Warfarin is the recommended oral anticoagulant for all currently available LVAD devices.Warfarin is known to be a difficult medication to manage due to its narrow therapeutic window, and its many interactions .Dlott et al (2014) describe in Circulation the overall time in therapeutic range for patients on warfarin as 53.7%, Time in therapeutic rang...
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: R. Hards, G. Edwards, C. Kavanagh, M. Hedger, A.R. Simon Source Type: research

The Treatment of Patients with Advanced Heart Failure Ineligible for Cardiac Transplantation with the HeartWare Ventricular Assist Device: Results of the ENDURANCE Supplement Trial
The ENDURANCE Trial previously demonstrated non-inferiority of the HeartWare centrifugal flow ventricular assist device system (HVAD) to the control HeartMate II (HMII) axial flow device in 445 end-stage heart failure patients ineligible for heart transplantation. However, the rate of strokes in the HVAD cohort was higher than expected. Analysis of early clinical trial data found that elevated mean arterial blood pressure (MAP) was a highly statistically significant independent risk factor for stroke events.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: C.A. Milano, J.G. Rogers, A.J. Tatooles, G. Bhat, M.S. Slaughter, E.J. Birks, N.A. Mokadam, C. Mahr, J.S. Miller, V. Jeevanandam, K. Leadley, K.D. Aaronson, F.D. Pagani Source Type: research

GIMVECH: A Novel Risk Score for Stroke in the Perioperative Post Transplant Period
This study was undertaken to identify risk factors in this population during the perioperative post transplant period.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: N. Nair, S. Yang, E. Gongora Source Type: research

Use of TEG/Platelet Mapping to Dose-Adjust Platelet Inhibitors in Children Supported with the Berlin EXCOR: In Search of a Correlation
There is uncertain correlation between doses of aspirin (ASA), dipyridamole (DPM) and clopidogrel (CLP) and the absolute % inhibition as measured by Platelet Mapping, a platelet function test that accompanies Thromboelastography (TEG). This is particularly relevant for children supported with the Berlin EXCOR pediatric ventricular assist device (VAD), as the TEG/PM is currently used to adjust their antiplatelet medications but the stroke rate remains unacceptably high. We sought to determine whether there was better correlation between medication doses and the relative change from baseline in the % inhibition.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: L.J. May, X. Liu, C. Sherwin, L. Yang, J. Zhender, J. Lee, S. Chen, D.N. Rosenthal, C.S. Almond Source Type: research

Increased Frequency of Bleeding Complications in Females Following LVAD Implant
While females are at increased risk for stroke after left ventricular assist device (LVAD), the impact of sex on mortality has been met with conflicting results and there is few data on sex specific bleeding rates. Bleeding is a major source of morbidity and mortality in the LVAD population. The aim of this analysis is to define the incidence and clinical impact of bleeding stratified by sex.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: Z. Yavar, J. Cowger, S. Moainie, C. Salerno, A.K. Ravichandran Source Type: research

Outcomes of Asian-Americans Undergoing Left Ventricular Assist Device Implantations as a Bridge to Transplant or Destination Therapy: An INTERMACS Analysis
Previous studies have demonstrated significant differences between Asians and Caucasian white populations in their propensity for stroke, coronary artery disease, heart failure, inflammation, bleeding and thrombosis. Therefore, we hypothesized that Asian Americans with end stage heart failure undergoing treatment with durable left ventricular assist devices (LVAD) exhibit a different morbidity and mortality risk profile when compared to non-Asian and white Americans populations.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: J.R. Wever Pinzon, W. Wang, N. Hu, R. Larsen, T. Yu, L. Yin, I. Taleb, A. Koliopoulou, S. Mckellar, J. Stehlik, J. Fang, A. Kfoury, C. Selzman, S. Drakos Source Type: research

Low Dose tPA as a Therapeutic Strategy in Suspected Pump Thrombosis in HeartMate II
Tissue plasminogen activator (tPA) is a known treatment for DVT and thromboembolic stroke. Our study aim was to determine the safety and efficacy of a low dose tPA protocol in suspected pump thrombosis in HMII.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: A.S. Cruz-Solbes, M.I. Achi, J. Amione-Guerra, E. Karanja, B. Trachtenberg, A. Bhimaraj, J. Estep, G. Torre-Amione, I. Hussain, M. Park, B. Bruckner, A. Guha Source Type: research

Management of RVAD Thrombosis in Biventricular HVAD Supported Patients
Pump thrombosis confers significant morbidity and mortality in left ventricular assist device (LVAD) supported patients. Particularly in HVAD, therapeutic approaches including thrombolysis, or adjusting anticoagulation have been recommended as initial treatment but are associated with hemorrhagic stroke and death. Conversely, device exchange has been recommended as a preferred choice with low morbidity-mortality. Biventricular support (BIVAD) utilizing 2 HVAD systems has been proven as a novel way to manage critically ill individuals with biventricular failure.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: J. Silva Enciso, M. Brambatti, H. Tran, G.V. Pretorius, E. Adler Source Type: research

Effect of a Multifaceted Team Management Approach on Survival and Stroke Rates in Heartmate 2 Recipients
We report the effect of a comprehensive HM II management strategy on survival and stroke rates.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: U. Jorde, N. Siddiqi, A. Luke, D.B. Sims, O. Saeed, S.R. Patel, S. Murthy, J. Shin, S. Watts, E. Borukhov, S. Madan, S. Thompson, R. Bello, S. Forest, S. Vukelic, C. Nucci, S. Rangasamy, D. Goldstein Source Type: research

Characteristics and Outcome of Patients with Stroke After Lung Transplant Surgery in the Lung Allocation Score Era
With introduction of lung allocation (LAS) in 2005, increasingly sicker patients are being transplanted every year. The current study was conducted to determine the incidence of stroke early after lung transplantation (LT), describe the recipient characteristics that are independently associated with it and evaluate its impact on 1 year survival.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: A. Banga, M. Mohanka, S. Bollineni, J. Mullins, V. Kaza, F. Torres Source Type: research

Does Type of Mechanical Circulatory Support Influence Stroke Risk in the Perioperative Post Transplant Period?
This study was undertaken to assess if the type of circulatory support device used has an impact on stroke risk in this population.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: N. Nair, S. Yang, E. Gongora Source Type: research

(1205) Does Stroke in the Perioperative Post Cardiac Transplant Period Impact Survival?
This study addresses the effect of stroke on overall survival in this population.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: N. Nair, S. Yang, E. Gongora Source Type: research

Paradoxical Mechano-Energetic Costs of Acute Mechanical Intra-Ventricular Unloading: A Key to Understand Myocardial Recovery with Left-Ventricular Mechanical Support?
This study tested such hypothesis by assessing the acute effects of LVAD support on systemic hemodynamics, left-ventricular (LV) mechano-energetics and myocardial oxygen consumption (MVO2) in vivo.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: S. Bennett, C.L. del Rio, J. Noel-Morgan, E. Geist, Y. Ueyama, E. Ferris, B. Youngblood, P.I. McConnell Source Type: research