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Source: Clinical Neurophysiology
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Total 151 results found since Jan 2013.

Non-invasive brain stimulation in the modulation of cerebral blood flow after stroke: a systematic review of Transcranial Doppler studies
NIBS has been successfully explored as a biomarker and therapeutic adjunct for functional recovery after stroke. rTMS and tDCS are two such promising neuromodulatory techniques that have been widely investigated to prime the motor areas of the brain in combination with task-specific practice (Bastani et al., 2012, Hsu et al., 2012, Jodie et al., 2015, Le et al., 2014). Although these techniques have demonstrated modest efficacy, clinical translation is still limited as the underlying physiological mechanisms are not completely understood, nor is the inter-individual variability associated with these techniques resolved (L ...
Source: Clinical Neurophysiology - October 24, 2018 Category: Neuroscience Authors: Pooja C Iyer, Sangeetha Madhavan Source Type: research

P28. The functional role of the anterior intraparietal sulcus for recovery of hand function in chronic stroke patients – A combined fMRI-TMS study
After stroke, neuroimaging studies frequently show increased activation of contralesional regions such as the primary motor cortex (M1) and the anterior intraparietal sulcus (aIPS) during movements of the impaired hand (Rehme et al., 2012). There is evidence that these areas may adopt either supportive or disturbing implications for motor control, depending on multiple factors, such as age, stroke severity, and lesion location (Di Pino et al., 2014). Importantly, previous research has mainly focused on investigating this question in the contralesional M1, while other areas involved in motor control, such as the aIPS have o...
Source: Clinical Neurophysiology - July 10, 2018 Category: Neuroscience Authors: F. Lange, L. Hensel, C. Tscherpel, C. Grefkes Source Type: research

P60. Direct and long term influence of cardiovascular training on cognition in subacute stroke patients
Rehabilitation of cognitive deficits has been voted ‘#1 research priority’ for patients suffering from stroke (Saunders et al., 2014). Aerobic fitness training may modulate cognitive performance either by enhancing neuroplasticity or by increasing brain oxygenation. The majority of studies in this area have focused on motor function; its effect o n cognitive performance is not well understood yet. The current study therefore aims to evaluate the influence of aerobic fitness intervention on cognitive functions in subacute stroke patients, and tries to elucidate the mechanisms underlying this effect.
Source: Clinical Neurophysiology - July 10, 2018 Category: Neuroscience Authors: T. Rackoll, A. Nave, U. Grittner, H. Mousa, K. Villringer, M. Ebinger, A. Fl öel Source Type: research

Visual Rehabilitation Training Alters Attentional Networks in Hemianopia: an fMRI study
Post-geniculate damage of the visual system leads to homonymous hemianopia which affects about 30% or more of all cases of stroke or brain trauma (Pambakian et al. , 1997). Hemianopia greatly reduces quality of life, affecting reading, driving and spatial navigating of patients (Das et al. , 2010). Several strategies for visual field restoration have been introduced (for review see Sabel et al. (2011)). For example, Kasten et al. (1998) showed that patients trained with light detection tasks in areas of residual vision (ARV) had significantly enlarged visual fields.
Source: Clinical Neurophysiology - July 2, 2018 Category: Neuroscience Authors: Qilin Lu, Xiaoxiao Wang, Lin Li, Bensheng Qiu, Shihui Wei, Bernhard A. Sabel, Yifeng Zhou Source Type: research

O-2-17. Influence of different types of orthoses on muscle synergy control during gait in stroke patients with hemiparesis
The purpose of this study was to verify the influence of lower limb orthoses on muscle synergy control during gait in stroke patients with hemiparesis. In four subjects with acute stroke, surface EMG signals from eight muscles of the paretic lower limb were measured during gait in two conditions (ankle foot orthosis; AFO or knee ankle foot orthosis; KAFO). The number of modules, muscle weightings and activation timing profile of each module were analyzed using non-negative matrix factorization. In two subjects (Fugl Meyer Assessment; FMA  > 20) who walked with mild assistance, three modules were identified during gait ...
Source: Clinical Neurophysiology - April 26, 2018 Category: Neuroscience Authors: Masanori Wakida, Kimihiko Mori, Yuta Chujo, Eiko Hirooka, Gwang-ho Kim, Koji Ohata, Kimitaka Hase Source Type: research

S21-1. A new analysis method using surface electromyography to assess finger function in patients with severe stroke
We have conducted our research into kinesthetic illusions induced by visual stimuli (KiNvis), which are sensations of being in motion that result from watching artificial images of the body part moving. Our previous studies revealed characteristic neural networks related to KiNvis; since then, we have initiated clinical studies adapting KiNvis in patients with stroke. In patients with severe stroke, it is often difficult to measure joint angles, because voluntary movement does not occur or simultaneous contraction of the agonist and antagonist muscles prevent controlled voluntary joint exercise.
Source: Clinical Neurophysiology - April 26, 2018 Category: Neuroscience Authors: Fuminari Kaneko Source Type: research

S3-3. Clinical application of electroencephalogram-based brain-machine interfaces
A large number of electroencephalogram-based brain-machine interface (BMI) systems developed by industry and academia are now available for neurorehabilitation. However, the lack of phase 1 –2 clinical trials for BMI interventions to post-stroke hemiplegia has been limited their treatment outcome. To test the safety and feasibility of BMI interventions, we conducted trials with a customly developed BMI system for patients with acute/subacute hemiparetic stroke. Four inpatients partic ipated in this study in the early phase (7–24 days from stroke onset).
Source: Clinical Neurophysiology - April 26, 2018 Category: Neuroscience Authors: Yasunari Hashimoto, Toshiyuki Kakui, Junichi Ushiba, Meigen Liu, Kyousuke Kamada, Tetsuo Ota Source Type: research

Stroke causes a transient imbalance of interhemispheric information flow in EEG during Non-REM sleep
Stroke is one of the leading causes of disabilities and represents a major medical and socio-economical burden (Adamson et al., 2004; Global Burden of Disease Study Collaborators, 2015; Ovbiagele et al., 2013). Ischemic strokes account for more than 2/3 of all strokes (Feigin et al., 2009). In the minutes to weeks following the onset of a focal cerebral ischemia, a variety of local but also more distant changes in connectivity occur (Silasi and Murphy, 2014; Xerri et al., 2014). In particular, functional neuroimaging studies have highlighted a “hyperactivity” of the homotopic contralesional region following a unilatera...
Source: Clinical Neurophysiology - April 17, 2018 Category: Neuroscience Authors: Frederic Zubler, Andrea Seiler, Thomas Horvath, Corinne Roth, Silvia Miano, Christian Rummel, Heidemarie Gast, Lino Nobili, Kaspar A. Schindler, Claudio L. Bassetti Source Type: research

S3-3. Clinical application of electroencephalogram-based brain-machine interfaces
A large number of electroencephalogram-based brain-machine interface (BMI) systems developed by industry and academia are now available for neurorehabilitation. However, the lack of phase 1 –2 clinical trials for BMI interventions to post-stroke hemiplegia has been limited their treatment outcome. To test the safety and feasibility of BMI interventions, we conducted trials with a customly developed BMI system for patients with acute/subacute hemiparetic stroke. Four inpatients partic ipated in this study in the early phase (7–24 days from stroke onset).
Source: Clinical Neurophysiology - March 30, 2018 Category: Neuroscience Authors: Yasunari Hashimoto, Toshiyuki Kakui, Junichi Ushiba, Meigen Liu, Kyousuke Kamada, Tetsuo Ota Source Type: research

O-2-17. Influence of different types of orthoses on muscle synergy control during gait in stroke patients with hemiparesis
The purpose of this study was to verify the influence of lower limb orthoses on muscle synergy control during gait in stroke patients with hemiparesis. In four subjects with acute stroke, surface EMG signals from eight muscles of the paretic lower limb were measured during gait in two conditions (ankle foot orthosis; AFO or knee ankle foot orthosis; KAFO). The number of modules, muscle weightings and activation timing profile of each module were analyzed using non-negative matrix factorization. In two subjects (Fugl Meyer Assessment; FMA  > 20) who walked with mild assistance, three modules were identified during gait ...
Source: Clinical Neurophysiology - March 30, 2018 Category: Neuroscience Authors: Masanori Wakida, Kimihiko Mori, Yuta Chujo, Eiko Hirooka, Gwang-ho Kim, Koji Ohata, Kimitaka Hase Source Type: research

S21-1. A new analysis method using surface electromyography to assess finger function in patients with severe stroke
We have conducted our research into kinesthetic illusions induced by visual stimuli (KiNvis), which are sensations of being in motion that result from watching artificial images of the body part moving. Our previous studies revealed characteristic neural networks related to KiNvis; since then, we have initiated clinical studies adapting KiNvis in patients with stroke. In patients with severe stroke, it is often difficult to measure joint angles, because voluntary movement does not occur or simultaneous contraction of the agonist and antagonist muscles prevent controlled voluntary joint exercise.
Source: Clinical Neurophysiology - March 30, 2018 Category: Neuroscience Authors: Fuminari Kaneko Source Type: research

P06-Cortical somatosensory processing after botulinum toxin therapy in post-stroke spasticity
In movement disorders, neurophysiology and functional MRI demonstrated abnormalities of sensorimotor processing, responding to peripheral botulinum toxin A (BoNT) treatment. We used Modified Ashworth scale (MAS) to assess spasticity and median nerve somatosensory evoked potentials (SEP) to study changes in sensorimotor cortical areas after BoNT therapy of post-stroke arm spasticity.Seventeen patients (10 men, 7 women, average age 60.2  years) with post-stroke arm spasticity were treated with BoNT into the affected muscles.
Source: Clinical Neurophysiology - March 13, 2018 Category: Neuroscience Authors: P. Hlu štík, T. Veverka, P. Hok, P. Otruba, A. Krobot, J. Zapletalová, P. Kaňovský Source Type: research

Interhemispheric motor interactions in hemiparetic children with perinatal stroke: Clinical correlates and effects of neuromodulation therapy
Perinatal ischemic stroke (PS) is the occlusion of arteries or veins that results in cerebral damage between 20 weeks gestation and 28 days of life (Raju, 2007; Nelson and Lynch, 2004). PS is common, occurring in>1:3000 live births, and accounts for most hemiparetic cerebral palsy (CP) (Kirton and DeVeber, 2013). Children with PS-induced hemiparetic CP typically manifest motor asymmetry and early hand preference in the first 4-6 months of life (Kirton et al., 2010b). How the motor system develops following such early unilateral brain injury is increasingly defined by animal (Martin et al., 2007) and human (Eyre, 2007; Staudt, 2007) studies.
Source: Clinical Neurophysiology - November 25, 2017 Category: Neuroscience Authors: Derek Eng, Ephrem Zewdie, Patrick Ciechanski, Omar Damji, Adam Kirton Source Type: research

35. Association of robot-assisted rehabilitation and non-invasive brain stimulation to improve upper limb function in chronic stroke patients
Previous studies suggested that both robotic rehabilitation and non-invasive brain stimulation could produce improvement in chronic stroke patients. It is still unknown whether their combination can produce synergistic effects. We designed a proof-of-principle, double-blinded, semi-randomized, sham-controlled trial to assess the safety and efficacy of this combination.Twenty severe upper limb-impaired chronic stroke patients were randomized to robot-assisted therapy associated with real or sham cTBS, delivered for 10 working days.
Source: Clinical Neurophysiology - November 11, 2017 Category: Neuroscience Authors: F. Capone, G. Di Pino, G. Pellegrino, L. Florio, L. Zollo, D. Simonetti, F. Ranieri, N. Brunelli, M. Corbetto, S. Miccinilli, M. Bravi, S. Milighetti, E. Guglielmelli, S. Sterzi, V. Di Lazzaro Source Type: research