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Source: The American Journal of Cardiology

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Total 715 results found since Jan 2013.

Cost Effectiveness of Percutaneous Closure Versus Medical Therapy for Cryptogenic Stroke in Patients With a Patent Foramen Ovale
In patients with patent foramen ovales (PFOs) and cryptogenic stroke, observational studies have demonstrated reductions in recurrent neurologic events with transcatheter PFO closure compared with medical therapy. Randomized controlled trials and meta-analyses have shown a trend toward benefit with device closure. The cost-effectiveness of PFO closure has not been described. Therefore, a detailed cost analysis was performed using pooled weighted outcome and complication rates from published randomized controlled trials, Medicare cost tables, and wholesale medication prices.
Source: The American Journal of Cardiology - September 4, 2014 Category: Cardiology Authors: Christopher A. Pickett, Todd C. Villines, Michael A. Ferguson, Edward A. Hulten Tags: Miscellaneous Source Type: research

Impact of Transesophageal Echocardiography on Management in Patients with Suspected Cardioembolic Stroke
Transesophageal echocardiography (TEE) is frequently performed in patients with acute ischemic cerebrovascular events to exclude a cardioembolic source. We aimed to determine the clinical impact of transesophageal echocardiography on clinical management. This is a retrospective single center study of 1458 consecutive patients hospitalized with acute ischemic stroke or transient ischemic attack who underwent TEE for evaluation of a suspected cardioembolic etiology. Significant TEE findings were determined for each patient as recorded on the TEE report.
Source: The American Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: Yevgeniy Khariton, John A. House, Lynn Comer, Tina Coggins, Anthony Magalski, David G. Skolnick, Thomas H. Good, Michael L. Main Source Type: research

Atrial Fibrillation, Stroke and Mortality Rates Following Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) is considered a suitable treatment for patients with severe symptomatic aortic stenosis (AS) and high operative risk. Our aim was to evaluate the effect of pre-procedural and new-onset atrial fibrillation (NOAF) on mortality and stroke in patients undergoing TAVI. We performed a single center study of 380 consecutive patients enrolled to a TAVI registry. NOAF was defined as post-procedural atrial fibrillation (AF) occurring within 30 days following the procedure.
Source: The American Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: Lior Yankelson, Arie Steinvil, Liron Gershovitz, Eran Leshem-Rubinow, Ariel Furer, Sami Viskin, Gad Keren, Shmuel Banai, Ariel Finkelstein Source Type: research

Impact of Transesophageal Echocardiography on Management in Patients With Suspected Cardioembolic Stroke
Transesophageal echocardiography (TEE) is frequently performed in patients with acute ischemic cerebrovascular events to exclude a cardioembolic source. We aimed to determine the clinical impact of TEE on management. This is a retrospective single-center study of 1,458 consecutive patients hospitalized with acute ischemic stroke or transient ischemic attack who underwent TEE for evaluation of a suspected cardioembolic cause. Significant TEE findings were determined for each patient as recorded on the TEE report.
Source: The American Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: Yevgeniy Khariton, John A. House, Lynn Comer, Tina R. Coggins, Anthony Magalski, David G. Skolnick, Thomas H. Good, Michael L. Main Tags: Miscellaneous Source Type: research

Atrial Fibrillation, Stroke, and Mortality Rates After Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) is considered a suitable treatment for patients with severe symptomatic aortic stenosis and high operative risk. Our aim was to evaluate the effect of preprocedural and new-onset atrial fibrillation (NOAF) on mortality and stroke in patients who underwent TAVI. We performed a single-center study of 380 consecutive patients enrolled to a TAVI registry. NOAF was defined as postprocedural atrial fibrillation (AF) occurring within 30 days after the procedure.
Source: The American Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: Lior Yankelson, Arie Steinvil, Liron Gershovitz, Eran Leshem-Rubinow, Ariel Furer, Sami Viskin, Gad Keren, Shmuel Banai, Ariel Finkelstein Tags: Valvular Heart Disease Source Type: research

Risk Stratification and Stroke Prevention Therapy Care Gaps in Canadian Atrial Fibrillation Patients (From the CO-ordinated National Network to Engage physicians in the Care and Treatment of patients with Atrial Fibrillation CONNECT AF Chart Audit)
The objectives of this national chart audit (January-June 2013) of 6346 AF patients (≥18 years without a significant heart valve disorder) from 647 primary care physicians were to: 1) Describe the frequency of stroke and bleed risk assessments in patients with non-valvular atrial fibrillation (AF) by primary care physicians, including the accuracy of these assessments relative to established predictive indices; 2) outline contemporary methods of anticoagulation used; and, 3) report the time in the therapeutic range amongst patients prescribed warfarin.
Source: The American Journal of Cardiology - December 17, 2014 Category: Cardiology Authors: Ashish D. Patel, Mary K. Tan, Paul Angaran, Alan D. Bell, Murray Berall, Claudia Bucci, Andrew M. Demchuk, Vidal Essebag, Lianne Goldin, Martin S. Green, Jean C. Gregoire, Peter L. Gross, Brett Heilbron, Peter J. Lin, Krishnan Ramanathan, Allan Skanes, Br Source Type: research

Relation between Cancer and Atrial Fibrillation (from The REasons for Geographic And Racial Differences in Stroke Study)
Atrial fibrillation (AF) is common in patients with life threatening cancer and those undergoing active cancer treatment. However, data from persons with a history of non-life threatening cancer and those who do not require active cancer treatment are lacking. A total of 15,428 (mean age: 66 ± 8.9 years; 47% women; 45% blacks) participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) with baseline data on prior cancer diagnosis and AF were included. Participants with life threatening cancer and active cancer treatment within 2 years of study enrollment were excluded.
Source: The American Journal of Cardiology - January 31, 2015 Category: Cardiology Authors: Wesley T. O’Neal, Susan G. Lakoski, Waqas Qureshi, Suzanne E. Judd, George Howard, Virginia Howard, Mary Cushman, Elsayed Z. Soliman Source Type: research

Problems in addition to stroke and bleeding after left atrial appendage closure
We read the article by Waksman et al. about the discussions between the US Food and Drug Administration (FDA) and the sponsor regarding approval of the WATCHMAN-device for interventional left atrial appendage closure (LAAC).[1] We would like to stimulate the discussion by the following contribution: LAAC is primarily intended as an alternative for stroke prevention in patients with atrial fibrillation (AF) in whom oral anticoagulation (OAC) is not possible because of contraindications about a high bleeding risk.
Source: The American Journal of Cardiology - April 24, 2015 Category: Cardiology Authors: Claudia Stöllberger, Josef Finsterer, Birke Schneider Source Type: research

Meta-Analysis of the Prognostic Impact of Stroke Volume, Gradient and Ejection Fraction Following Transcatheter Aortic Valve Implantation
The prognostic implications of several baseline pre-procedural variables in patients with severe native valve aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) are unclear. The goal of this study was to determine the impact of reduced stroke volume index (SVI), low gradient (LG) and reduced ejection fraction (EF) on all-cause mortality. We searched MEDLINE, CENTRAL, EMBASE, Web of Science, and Scopus through 10/13/2014. We evaluated the association between low SVI (
Source: The American Journal of Cardiology - June 25, 2015 Category: Cardiology Authors: Mackram F. Eleid, Kashish Goel, M. Hassan Murad, Patricia J. Erwin, Rakesh M. Suri, Kevin L. Greason, Rick A. Nishimura, Charanjit S. Rihal, David R. Holmes Source Type: research

Meta-analysis of the Prognostic Impact of Stroke Volume, Gradient, and Ejection Fraction After Transcatheter Aortic Valve Implantation
The prognostic implications of several baseline preprocedural variables in patients with severe native valve aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) are unclear. The goal of this study was to determine the impact of reduced stroke volume index (SVI), low gradient (LG), and reduced ejection fraction (EF) on all-cause mortality. We searched MEDLINE, CENTRAL, EMBASE, Web of Science, and Scopus through October 13, 2014. We evaluated the association between low SVI (
Source: The American Journal of Cardiology - June 25, 2015 Category: Cardiology Authors: Mackram F. Eleid, Kashish Goel, M. Hassan Murad, Patricia J. Erwin, Rakesh M. Suri, Kevin L. Greason, Rick A. Nishimura, Charanjit S. Rihal, David R. Holmes Tags: Review Source Type: research

Effect of Falls on Frequency of Atrial Fibrillation and Mortality Risk (From the REasons for Geographic And Racial Differences in Stroke REGARDS Study)
It is unclear if persons who have atrial fibrillation (AF) have a higher fall risk compared with those in the general population and if falls increase mortality beyond that observed in AF. A total of 24,117 (mean age=65±9.3; 55% female; 38% black) participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were included. AF was identified from baseline electrocardiogram data and by self-reported history. Falls were considered present if participants reported 2 or more falls within the year prior to the baseline examination.
Source: The American Journal of Cardiology - July 28, 2015 Category: Cardiology Authors: Wesley T. O’Neal, Waqas T. Qureshi, Suzanne E. Judd, C. Barrett Bowling, Virginia J. Howard, George Howard, Elsayed Z. Soliman Source Type: research

Usefulness of Holter Monitoring for Detecting Atrial Fibrillation After Stroke or Transient Ischemic Attack
The sensitivity of a diagnostic test is ideally calculated by comparing the test assessments to a truth determined by another (perfect) test considered to be the gold standard. However, in many cases, there is no perfect gold standard.1 When it exists, assessment by the gold standard can be inaccessible, costly, or highly invasive. Using the best available but imperfect diagnostic test as gold standard can lead to substantial error in the estimation of diagnostic accuracy.1 The detection of atrial fibrillation (AF) after ischemic stroke is not an exception to this phenomenon.
Source: The American Journal of Cardiology - November 11, 2015 Category: Cardiology Authors: Lauren E. Cipriano, Luciano A. Sposato Tags: Readers' Comments Source Type: research

Impact Of Testosterone Replacement Therapy On Myocardial Infarction, Stroke, And Death In Men With Low Testosterone Concentrations In An Integrated Healthcare System
The aim of this study was to assess the effect of testosterone replacement therapy (TRT) on cardiovascular (CV) outcomes. Males (January 1, 1996-December 31, 2011) with a low initial total testosterone concentration, a subsequent testosterone level, and>3 years of follow-up were studied. Levels were correlated with testosterone supplement use. The primary outcome was major adverse cardiovascular events (MACE), defined as a composite of death, nonfatal myocardial infarction and stroke at 3 years.
Source: The American Journal of Cardiology - December 13, 2015 Category: Cardiology Authors: Jeffrey L. Anderson, Heidi T. May, Donald L. Lappé, Tami Bair, Viet Le, John F. Carlquist, Joseph B. Muhlestein Source Type: research

Estimating the Sensitivity of Holter to Detect Atrial Fibrillation After Stroke or Transient Ischemic Attack Without a Gold Standard is Challenging
The sensitivity of a diagnostic test is ideally calculated by comparing the test assessments to a truth determined by another (perfect) test considered to be the gold standard. However, in many cases, there is no perfect gold standard.1 When it exists, assessment by the gold standard can be inaccessible, costly, or highly invasive. Using the best available but imperfect diagnostic test as gold standard can lead to substantial error in the estimation of diagnostic accuracy.1 The detection of atrial fibrillation (AF) after ischemic stroke is not an exception to this phenomenon.
Source: The American Journal of Cardiology - November 11, 2015 Category: Cardiology Authors: Lauren E. Cipriano, Luciano A. Sposato Tags: Readers' Comments Source Type: research

Meta-Analysis of Anticoagulation Use, Stroke, Thromboembolism, Bleeding and Mortality in Patients with Atrial Fibrillation on Dialysis
Atrial fibrillation (AF) is common in patients on dialysis. While randomized trials of anticoagulation for AF have demonstrated striking reductions in stroke, these trials did not recruit dialysis patients. We thus undertook this systematic review and meta-analysis of observational studies. Electronic databases were searched for studies including AF patients on dialysis that reported observational associations of anticoagulation use. Twenty-one studies involving 530,031 individuals and 31,611 AF patients on dialysis were identified.
Source: The American Journal of Cardiology - April 12, 2016 Category: Cardiology Authors: Christopher X. Wong, Ayodele Odutayo, Connor A. Emdin, Ned J. Kinnear, Michelle T. Sun Source Type: research