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Source: The American Journal of Cardiology

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Total 715 results found since Jan 2013.

Stroke Risk Based on CHA2DS2-VASc Score in the Absence of Atrial Fibrillation
Ording et al investigated the stroke risk in hospitalized individuals without atrial fibrillation (AF) and found it quite comparable to those with AF, especially in the setting of high (>5) CHA2DS2-VASc scores (13.3% vs 14.6% in those without and with AF respectively).1 In fact, in men age5 without presence of AF, the risk of stoke was slightly higher than those with AF counterparts.
Source: The American Journal of Cardiology - November 27, 2019 Category: Cardiology Authors: Raj Nayyar, Dwijesh Sheth, Lovely Chhabra Source Type: research

Validation of Acute Ischemic Stroke Codes Using the International Classification of Diseases Tenth Revision
Administrative databases have increasingly become a platform for clinical investigations aiming to address trends in the prevalence, patterns of care, and outcomes of major cardiovascular diseases including strokes1-4. Identification of acute ischemic stroke (AIS) events in these databases is dependent on billing codes. Hence, accurate querying of administrative databases for research purposes require proper validation of those billing codes. Several studies have previously validated the use of certain International Classification of Diseases-Ninth Revision-Clinical Modification (ICD-9-CM) codes to discern hospitalizations for AIS.
Source: The American Journal of Cardiology - January 7, 2020 Category: Cardiology Authors: Mohamed Alhajji, Akram Kawsara, Mohamad Alkhouli Source Type: research

Comparison of the Effect of Atrial Fibrillation Detection Algorithms in Patients with Cryptogenic Stroke Using Implantable Loop Recorders
Occult atrial fibrillation (AF) can be the underlying cause for cryptogenic stroke (CS). Implantable loop recorders (ILRs) have become an important tool for long-term arrhythmia monitoring in CS patients. Office-based ILR implantation by non-electrophysiologist physicians is increasingly common. To report the real world diagnostic yield and accuracy of remote ILR monitoring in high risk CS patients, we retrospectively analyzed 145 consecutive patients with CS who underwent ILR implantation between October 2014 and October 2018 at New York University Langone Health.
Source: The American Journal of Cardiology - May 21, 2020 Category: Cardiology Authors: Ehud Chorin, Connor Peterson, Edward Kogan, Chirag Barbhaiya, Anthony Aizer, Douglas Holmes, Scott Bernstein, Michael Schole, Harish Duraiswami, Michael Spinelli, David Park, Larry Chinitz, Lior Jankelson Source Type: research

Chronotropic Response to Exercise Testing and the Risk of Stroke
Although the chronotropic response to exercise testing, defined as an inadequate heart rate response to incremental exercise to volitional fatigue, is associated with adverse cardiovascular outcomes, it remains unclear whether this response is related to the future risk of cerebrovascular events. We tested the hypothesis that the chronotropic response to exercise is associated with an increased risk of stroke in a general population. This prospective study was based on a population sample of 2,036 men aged 42-60 years in the Kuopio Ischemic Heart Disease cohort study.
Source: The American Journal of Cardiology - December 18, 2020 Category: Cardiology Authors: Sae Young Jae, Kevin Heffernan, Sudhir Kurl, Setor K. Kunutsor, Barry A. Franklin, Kai Savonen, Jari A. Laukkanen Source Type: research

Prevalence and Determinants of Atrial Fibrillation-associated In-hospital Ischemic Stroke in patients with Acute Myocardial Infarction undergoing Percutaneous Coronary Intervention
Atrial Fibrillation (AF) is an established risk factor ischemic stroke (IS) and is commonly encountered in patient hospitalized with acute myocardial infarction (AMI). Uncommonly, IS can occur as a complication resulting from percutaneous coronary intervention (PCI). There is limited real world data regarding AF-associated in-hospital IS (IH-IS) in patients admitted with AMI undergoing PCI. We queried the National Inpatient Sample database from January 2010 to December 2014 to identify patients admitted with AMI who underwent PCI.
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Shivaraj Patil, Karthik Gonuguntla, Chaitanya Rojulpote, Manish Kumar, Srinivas Nadadur, Robert J. Nardino, Christopher Pickett Source Type: research

Thoracic Aortic Calcium For The Prediction Of Stroke Mortality (From The Coronary Artery Calcium Consortium)
Thoracic aortic calcium(TAC) is an important marker of extra-coronary atherosclerosis with established predictive value for all-cause mortality. We sought to explore the predictive value of TAC for stroke mortality, independent of the more established coronary artery calcium(CAC) score. The CAC Consortium is a retrospectively assembled database of 66,636 patients aged ≥18 years with no prior history of cardiovascular disease, baseline CAC scans for risk stratification, and follow-up for 12±4 years.
Source: The American Journal of Cardiology - March 2, 2021 Category: Cardiology Authors: Olufunmilayo H. Obisesan, Albert D. Osei, Daniel Berman, Zeina A. Dardari, S.M Iftekhar Uddin, Omar Dzaye, Olusola A. Orimoloye, Matthew J. Budoff, Michael D Miedema, John Rumberger, Mohammadhassan Mirbolouk, Ellen Boakye, Michelle C. Johansen, Alan Rozan Source Type: research

Meta-Analysis of Usefulness of Antiplatelet Therapy in Ischemic Stroke or Transient Ischemic Attack
The efficacy of early administration of dual antiplatelet therapy (DAPT) for secondary prevention after acute ischemic stroke or transient ischemic attack (TIA) is uncertain. This systematic review and meta-analysis compares the safety and efficacy of early administration (
Source: The American Journal of Cardiology - July 2, 2021 Category: Cardiology Authors: Giorgio A. Medranda, Cheng Zhang, Gheorghe Doros, Charan Yerasi, Brian C. Case, William S. Weintraub, Ron Waksman Source Type: research

Meta-Analysis of Implantable Loop Recorder for Atrial Fibrillation Detection in Patients With Ischemic Stroke
Atrial fibrillation (AF) is the most common arrhythmia in adults and it is responsible for about one-third of all ischemic strokes.1 Although prior studies have found more frequently detected AF following stroke with longer duration of monitoring, ambiguity remains regarding the optimal duration of ambulatory cardiac monitoring.1 Therefore, we conducted a meta-analysis of solely randomized clinical trials (RCTs) to evaluate the efficacy and safety of implantable loop recorder (ILR) in AF detection, and subsequent reduction of recurrent strokes in patients with recent ischemic strokes.
Source: The American Journal of Cardiology - November 15, 2021 Category: Cardiology Authors: Babikir Kheiri, Saket Sanghai, Hani Alhamoud, Mohammed Osman, Eric Stecker, Charles A. Henrikson, Babak Nazer Source Type: research

Relation of Abdominal Obesity to Risk of Atrial Fibrillation (From the Reasons for Geographic and Racial Differences in Stroke REGARDS Study)
Our knowledge of the association between abdominal obesity (AO) and the risk of atrial fibrillation (AF) after adjusting for body mass index (BMI) is limited. We included 11,617 Black and White participants (mean age 63.0 ± 8.4 years) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) national cohort study who were free of AF at baseline. A multivariable logistic regression model was used to estimate the odds ratio (OR) with 95% confidence interval (CI) of incident AF associated with AO.
Source: The American Journal of Cardiology - December 11, 2021 Category: Cardiology Authors: Joonseok Kim, Pankaj Arora, Soo Y. Kwon, Vibhu Parcha, Emily B. Levitan, Byron C. Jaeger, Elsayed Z. Soliman, Virginia J. Howard Source Type: research

Meta-Analysis of 5-Year Risk of All-Cause Death or Stroke After Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement
Transcatheter aortic valve implantation (TAVI) is an established alternative to surgical aortic valve replacement (SAVR) for patients with severe symptomatic aortic stenosis.1,2 Its indication has expanded from high-risk to include a low surgical risk younger population. Although the short-term results of TAVI and SAVR in patients with intermediate or high surgical risk are similar,1,2 outcomes beyond short-term periods remain unclear. Recently, the results of 5-year follow-up of the Surgical Replacement and Transcatheter Aortic Valve Implantation (SURTAVI) trial has been reported, which showed a similar rate of the compos...
Source: The American Journal of Cardiology - January 3, 2022 Category: Cardiology Authors: Yujiro Yokoyama, Toshiki Kuno, Tomo Ando, Tadahisa Sugiura, Azeem Latib Source Type: research

Relation of Hemoglobin A1C Levels to Risk of Ischemic Stroke and Mortality in Patients With Diabetes Mellitus and Atrial Fibrillation
This study aimed to assess the incidence and risks of ischemic stroke and mortality according to baseline HbA1c levels in patients with DM and AF. We conducted a cohort study using Clalit Health Services electronic medical records. The study population included all Clalit Health Services members aged ≥25 years, with the first diagnosis of AF between January 1, 2010, and December 31, 2016, who had a diagnosis of DM.
Source: The American Journal of Cardiology - March 29, 2022 Category: Cardiology Authors: Louise Kezerle, Moti Haim, Amichay Akriv, Adi Berliner Senderey, Asaf Bachrach, Maya Leventer-Roberts, Meytal Avgil Tsadok Source Type: research

Stroke Risk Stratification With the CHADS2 Score in Patients Without Atrial Fibrillation Who Underwent Percutaneous Coronary Intervention
The clinical significance of the CHADS2 score remains unclear in patients with coronary artery disease (CAD) without atrial fibrillation (AF). Therefore, the purpose of this study was to evaluate the association between the CHADS2 score and the long-term risk of ischemic stroke and its severity in patients with CAD with and without AF. Using the CREDO (Coronary Revascularization Demonstrating Outcome study)-Kyoto Registry Cohort-3, the present study population consisted of 11,516 patients with CAD who underwent percutaneous coronary intervention without oral anticoagulants at discharge.
Source: The American Journal of Cardiology - August 13, 2022 Category: Cardiology Authors: Yuki Obayashi, Hiroki Shiomi, Takeshi Morimoto, Yodo Tamaki, Moriaki Inoko, Ryusuke Nishikawa, Kazuhisa Kaneda, Ko Yamamoto, Yasuaki Takeji, Akihiro Komasa, Kyohei Yamaji, Satoshi Shizuta, Tomohisa Tada, Kazuya Nagao, Satoru Suwa, Toshihiro Tamura, Hiroki Source Type: research

Adverse Impact of Peri-Procedural Stroke in Patients Who Underwent Percutaneous Coronary Intervention
Peri-procedural stroke (PPS) is an important complication in patients who underwent percutaneous coronary intervention (PCI). The extent to which PPS impacts mortality and outcomes remains to be defined. Consecutive patients who underwent PCI enrolled in the Victorian Cardiac Outcomes Registry (2014 to 2018) were categorized into PPS and no PPS groups. The primary outcome was 30-day major adverse cardiovascular events (MACEs) (composite of mortality, myocardial infarction, stent thrombosis, and unplanned revascularization).
Source: The American Journal of Cardiology - August 20, 2022 Category: Cardiology Authors: Noah Z. Wexler, Sara Vogrin, Angela L. Brennan, Samer Noaman, Omar Al-Mukhtar, Kawa Haji, Jason E. Bloom, Diem T. Dinh, Wayne C. Zheng, James A. Shaw, Stephen J. Duffy, Jeffrey Lefkovits, Christopher M. Reid, Dion Stub, David M. Kaye, Nicholas Cox, Willia Source Type: research

Comparison of Stroke and Bleeding Risk Profile in Patients With Atrial Fibrillation and Chronic Kidney Disease
This study explores the impact of glomerular filtration rate (GFR) in the embolic-hemorrhagic balance among a large cohort of patients with AF. The study cohort included 15,457 patients diagnosed with AF between January 2014 and April 2020. The risk of ischemic stroke and major bleeding was determined by competing risk regression.
Source: The American Journal of Cardiology - April 12, 2023 Category: Cardiology Authors: Jos é Antonio Parada Barcia, Sergio Raposeiras Roubin, Emad Abu-Assi, Pablo Domínguez Erquicia, Andrea Lizancos Castro, Lucía Rioboo Lestón, Juan Ocampo Míguez, Inmaculada González Bermúdez, Andrés Íñiguez-Romo Source Type: research

Effectiveness and Safety of Direct Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation Patients With Extreme Obesity
Direct oral anticoagulants (DOACs) are a favored treatment to prevent stroke in patients with atrial fibrillation (AF). There are limited data concerning the efficacy and safety of DOACs in obese. Obesity leads to wide structural and physiological changes that may affect the pharmacokinetics and pharmacodynamics of drugs. The optimal dosing strategies for DOACs in this significant and growing sub-group remain unknown. The study aimed to evaluate on a large scale the safety and efficacy of DOAC treatment in extreme obese patients with AF.
Source: The American Journal of Cardiology - July 18, 2023 Category: Cardiology Authors: Boaz Elad, Nimra Maman, Snait Ayalon, Lee Hilary Goldstein Source Type: research