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Source: The American Journal of Cardiology
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Total 715 results found since Jan 2013.
Another Step Forward in Our Ability to Predict Percutaneous Coronary Intervention Outcomes
Despite advancements in devices, technique, and patient selection, adverse events including bleeding, vascular complications, myocardial infarction, stroke, and death still occur during percutaneous coronary intervention (PCI). Accurate and up-to-date risk-adjusted models that predict mortality after PCI are important to inform clinical decision making, identify patient factors that increase risk, provide a standardized format to measure programmatic quality, and drive continuous quality improvement efforts to improve operator outcomes.
Source: The American Journal of Cardiology - September 18, 2023 Category: Cardiology Authors: Araba Ofosu-Somuah, Matthew A. Cavender, George A. Stouffer Tags: Editorial Source Type: research
Direct Oral Anticoagulants: Patients Benefit When Prescribers Get the Message
Direct oral anticoagulants (DOACs) have demonstrated similar or better efficacy to warfarin in reducing stroke and systemic embolic events in large-scale prospective trials.1 –4 In addition, these trials demonstrated either noninferiority or superiority in reducing bleeding events compared with warfarin. To treat high-risk patients with atrial fibrillation (AF) and avoid bleeding in low-risk patients, current guidelines recommend oral anticoagulants in high-risk patien ts with AF with CHA2DS2VASc scores of ≥2 in men and ≥3 in women.
Source: The American Journal of Cardiology - September 5, 2023 Category: Cardiology Authors: Gerald V. Naccarelli Tags: Editorial Source Type: research
Electrocardiographic Morphology-Voltage-P-Wave-Duration (MVP) Score to Select Patients for Continuous Atrial Fibrillation Screening to Prevent Stroke
Morphology-voltage-P-wave-duration (MVP) score combining P-wave duration (PWD), P-wave voltage in lead I (PWVI), and interatrial block (IAB) has been demonstrated to predict atrial fibrillation (AF). Therefore, this study aimed to examine MVP score and its P-wave components as potential predictors of AF screening effects on stroke prevention. This was a secondary analysis of the LOOP Study (Atrial Fibrillation detected by Continuous ECG Monitoring using Implantable Loop Recorder to prevent Stroke in High-risk Individuals) which randomized older persons (aged 70 to 90 years) with additional stroke risk factors to either c...
Source: The American Journal of Cardiology - September 2, 2023 Category: Cardiology Authors: Lucas Yixi Xing, S øren Zöga Diederichsen, Søren Højberg, Derk Krieger, Claus Graff, Morten Salling Olesen, Jonas Bille Nielsen, Axel Brandes, Lars Køber, Ketil Jørgen Haugan, Jesper Hastrup Svendsen Source Type: research
Prevalence and Outcomes of Patients With Acute Ischemic Stroke and Concomitant Non –ST-Elevation Myocardial Infarction (Results from the National Inpatient Sample 2016 to 2019)
We examined hospitalized patients with acute ischemic stroke and a concomitant NSTEMI diagnosis who were included in the National Inpatient Sample 2016 to 2019. Acute ischemic stroke and NSTEMI were defined by using the Inter national Classification of Diseases, Tenth Revision codes. Patients with ST-elevation MI were excluded.
Source: The American Journal of Cardiology - August 26, 2023 Category: Cardiology Authors: Shivani Mehta, Roxana Mehran, Shahzad Hassan, Jasmeet Kaur, Anupam Sule, Camelia Arsene, Geetha Krishnamoorthy, Moyses Szklo Source Type: research
Outcomes of Concomitant Coronary Artery Bypass Grafting in Patients With Infective Endocarditis: A Systematic Review and Meta-Analysis
It is current practice to perform concomitant coronary artery bypass grafting (CABG) in patients with infective endocarditis who have relevant coronary artery disease. However, CABG may add complexity to the operation. We performed a systematic review and a meta-analysis of studies that presented outcomes from patients who underwent valve surgery because of infective endocarditis with or without concomitant CABG. Three databases were assessed. Perioperative mortality was the primary outcome. Long-term mortality and postoperative stroke were the secondary outcomes.
Source: The American Journal of Cardiology - August 26, 2023 Category: Cardiology Authors: Tulio Caldonazo, Hristo Kirov, Torsten Doenst, Panagiotis Tasoudis, Alexandros Moschovas, Gloria Faerber, Ricardo E. Treml, Michel Pompeu S á, Murat Mukharyamov, Mahmoud Diab Source Type: research
Angiotensin Receptor –Neprilysin Inhibitor Effects on Atherosclerotic Cardiovascular Disease Events: A Meta-Analysis of Randomized Controlled Trials
Sacubitril-valsartan is an angiotensin receptor –neprilysin inhibitor (ARNI) associated with a decreased risk of death and hospitalization for selected patients with heart failure (HF). However, its association with improved atherosclerotic cardiovascular disease (ASCVD) events remains unclear. We performed a meta-analysis to evaluate the assoc iation of ARNI with ASCVD events in patients with HF. We systematically searched PubMed, Embase, Cochrane, and ClinicalTrials.gov for studies comparing ARNIs with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) in terms of myocardial infarc...
Source: The American Journal of Cardiology - August 22, 2023 Category: Cardiology Authors: Lis Victoria Ravani, Douglas Mesadri Gewehr, Pedro Calomeni, Mateus de Miranda Gauza, Jussara Pereira, Rhanderson Cardoso, Henrique Barbosa Ribeiro, Edimar Bocchi Source Type: research
Trends in Cardiovascular Mortality in Patients With Atrial Fibrillation and Cancer in the United States (1999 to 2020)
Cancer has been identified as an independent risk factor for atrial fibrillation (AF). Although the development of novel therapeutic agents has led to significant improvement in cancer-related outcomes, there is also a rising concern regarding the long-term impact of treatment-emergent cardiac adverse events such as AF.1 AF portends a poor prognosis in patients with cancer and is also associated with a twofold increase in the risk of stroke as compared with patients with AF without cancer.2 However, population-level data on the impact of AF on overall cardiovascular mortality in patients with cancer remain limited.
Source: The American Journal of Cardiology - August 19, 2023 Category: Cardiology Authors: Aakash R. Sheth, Udhayvir S. Grewal, Sahith R. Thotamgari, Harsh P. Patel, Paari Dominic Tags: Brief Report Source Type: research
Direct Oral Anticoagulants in the Setting of Percutaneous Coronary Intervention: “There Will Be Blood”
Direct oral anticoagulants (DOACs) are being increasingly used in clinical practice for various indications ranging from treatment of venous thromboembolism1 to stroke thromboprophylaxis in atrial fibrillation.2 Clinical practice guidelines now endorse DOACs in preference to vitamin K antagonists (VKAs) for thromboprophylaxis in patients with atrial fibrillation and after venous thromboembolism, reflecting the favorable efficacy and safety profile of this anticoagulant class compared with VKA.3 Despite increasing DOAC utilization, the optimal periprocedural antithrombotic management for patients treated with DOAC who under...
Source: The American Journal of Cardiology - August 12, 2023 Category: Cardiology Authors: Maximillian T. Bourdillon, Konstantinos Charitakis Tags: Editorial Source Type: research
Systematic Review and Meta-Analysis of Direct Oral Anticoagulants Versus Warfarin in Atrial Fibrillation With Low Stroke Risk
Oral anticoagulation (OAC) in patients with atrial fibrillation (AF) has been shown to prevent thromboembolic complications, but concerns about the increased risk of major bleeding warrant judicious consideration of the risks and benefits.1 Current guidelines recommend OAC prescription for patients with AF at high risk of stroke, as measured by CHA2DS2-VASc scores of ≥2 and ≥3 in men and women respectively.2–4 Men and women with scores of 1 and 2 respectively (i.e., a single nongender-related stroke risk factor) are deemed to be at low-moderate risk of stroke and OAC prescription may be considered to reduce thromboem...
Source: The American Journal of Cardiology - August 11, 2023 Category: Cardiology Authors: Khi Yung Fong, Yiong Huak Chan, Colin Yeo, Gregory Y.H. Lip, Vern Hsen Tan Source Type: research
Meta-Analysis of the Outcomes of Peri-Device Leak After Left Atrial Appendage Closure
Left atrial appendage closure (LAAC) reduces the risk of thromboembolic stroke in atrial fibrillation. Peri-device leak (PDL) after LAAC may affect the subsequent risk of thromboembolism. We conducted a systematic review and meta-analysis to evaluate the effect of PDL after LAAC. We searched PubMed/Medline, Embase, and Google Scholar for studies reporting outcomes of PDL after LAAC from inception through October 2022. The primary outcome was the composite of stroke, transient ischemic attack (TIA), or systemic embolism (SE).
Source: The American Journal of Cardiology - August 10, 2023 Category: Cardiology Authors: Mostafa Reda Mostafa, Mohamed Magdi Eid, Mohamed Abuelazm, Ahmad Al-Abdouh, Mostafa Najim, Abdul Rhman Hassan, Amro A. El-Sakka, Sarath Lal Mannumbeth Renjithal, Muhammad Ahmed Malik, Sarah Mohamed, Mallory Balmer-Swain, Timir K. Paul, Andrew M. Goldsweig Source Type: research
Age-Related Differences in the Contribution of Systolic Blood Pressure and Biomarkers to Cardiovascular Disease Risk Prediction: The Atherosclerosis Risk in Communities (ARIC) Study
We sought to determine how biomarkers known to be associated with hypertension-induced end-organ injury complement the use of systolic blood pressure (SBP) for cardiovascular disease (CVD) risk prediction at different ages. Using data from visits 2 (1990 to 1992) and 5 (2011 to 2013) of the Atherosclerosis Risk in Communities (ARIC) study, 3 models were used to predict CVD (composite of coronary heart disease, stroke, and heart failure). Model A included traditional risk factors (TRFs) except SBP, model B —TRF plus SBP, and model C—TRF plus biomarkers (high-sensitivity troponin T [hsTnT] and N-terminal pro-B-type natri...
Source: The American Journal of Cardiology - August 9, 2023 Category: Cardiology Authors: Mahmoud Al Rifai, George E. Taffet, Kunihiro Matsushita, Salim S. Virani, James De Lemos, Amit Khera, Jarrett Berry, Chiadi Ndumele, David Aguilar, Caroline Sun, Ron C. Hoogeveen, Elizabeth Selvin, Christie M. Ballantyne, Vijay Nambi Source Type: research
Temporal Trends in Risk Factors of Periprocedural Stroke in Patients Undergoing Percutaneous Coronary Intervention: Insights from the ACC NCDR CathPCI Registry
Periprocedural stroke complicates up to 1% of patients undergoing percutaneous coronary intervention (PCI) and is associated with increased morbidity, mortality, and subsequent health care resource utilization.1 –5 Contemporary reports suggest that despite iterative procedural evolution in PCI (e.g., smaller catheters, radial access, and potent pharmacotherapy), periprocedural stroke rates have not improved over the last few years, with our recent analysis suggesting these rates may be in fact be rising, likely as a result of an increasingly co-morbid population3 and higher procedural complexity.
Source: The American Journal of Cardiology - August 8, 2023 Category: Cardiology Authors: Adam J. Nelson, Rebecca Young, Imran H. Tarrar, Daniel Wojdyla, Tracy Y. Wang, Rajendra H. Mehta Tags: Brief Report Source Type: research
Antithrombotic Medication and Major Complications After Mechanical Aortic Valve Replacement
Patients with mechanical aortic valve replacement (AVR) require lifelong vitamin K antagonist (VKA) therapy for stroke and systemic embolism prevention. However, VKA treatment predisposes patients to various types of bleeding. In the present study, we sought to assess the success of antithrombotic therapy and the occurrence and timing of strokes and bleeding events after mechanical AVR. A total of 308 patients who underwent isolated mechanical AVR were included in the study, and follow-up data were completed for 306 patients (99.4%).
Source: The American Journal of Cardiology - August 5, 2023 Category: Cardiology Authors: Rikhard Bj örn, Joonas Lehto, Markus Malmberg, Vesa Anttila, K.E. Juhani Airaksinen, Jarmo Gunn, Tuomas Kiviniemi Source Type: research
Effect of Concomitant Cardiac Arrest on Outcomes in Patients With Acute Coronary Syndrome-Related Cardiogenic Shock
Patients with acute coronary syndrome (ACS)-related cardiogenic shock (CS) with or without concomitant CA may have disparate prognoses. We compared clinical characteristics and outcomes of patients with CS secondary to ACS with and without cardiac arrest (CA). Between 2014 and 2020, 1,573 patients with ACS-related CS with or without CA who underwent percutaneous coronary intervention enrolled in a multicenter Australian registry were analyzed. Primary outcome was 30-day major adverse cardiovascular and cerebrovascular events (MACCE) (composite of mortality, myocardial infarction, stent thrombosis, target vessel revascularization and stroke).
Source: The American Journal of Cardiology - August 2, 2023 Category: Cardiology Authors: Wayne C. Zheng, Diem Dinh, Samer Noaman, Jason E. Bloom, Riley J. Batchelor, Jeffrey Lefkovits, Angela L. Brennan, Christopher M. Reid, Omar Al-Mukhtar, James A. Shaw, Dion Stub, Yang Yang, Craig French, David M. Kaye, Nicholas Cox, William Chan Source Type: research
Is Improving Educational Attainment Key to Reducing the Burden Because of Cardiovascular Diseases?
Cardiovascular diseases (CVDs) impose a substantial global public health burden, accounting for significant mortality and disability worldwide, particularly because of conditions like coronary heart disease and stroke. The economic consequences of CVDs, including healthcare expenses, decreased productivity, and diminished quality of life, further contribute to this burden. Lifestyle factors such as unhealthy diets, physical inactivity, tobacco use, and excessive alcohol consumption are closely associated with CVDs.
Source: The American Journal of Cardiology - August 1, 2023 Category: Cardiology Authors: Jari Antero Laukkanen, Setor Kwadzo Kunutsor Tags: Editorial Source Type: research
