Meta-Analysis of the Outcomes of Peri-Device Leak After Left Atrial Appendage Closure

Left atrial appendage closure (LAAC) reduces the risk of thromboembolic stroke in atrial fibrillation. Peri-device leak (PDL) after LAAC may affect the subsequent risk of thromboembolism. We conducted a systematic review and meta-analysis to evaluate the effect of PDL after LAAC. We searched PubMed/Medline, Embase, and Google Scholar for studies reporting outcomes of PDL after LAAC from inception through October 2022. The primary outcome was the composite of stroke, transient ischemic attack (TIA), or systemic embolism (SE).

https://www.ajconline.org/article/S0002-9149(23)00635-5/fulltext?rss=yes

Source: The American Journal of Cardiology - August 10, 2023 Category: Cardiology Authors: Mostafa Reda Mostafa, Mohamed Magdi Eid, Mohamed Abuelazm, Ahmad Al-Abdouh, Mostafa Najim, Abdul Rhman Hassan, Amro A. El-Sakka, Sarath Lal Mannumbeth Renjithal, Muhammad Ahmed Malik, Sarah Mohamed, Mallory Balmer-Swain, Timir K. Paul, Andrew M. Goldsweig Source Type: research