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Source: The American Journal of Cardiology
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Total 715 results found since Jan 2013.
Response to Readers ’ Comments “Effect of Anticoagulation Duration on Stroke Incidence in Asian Patients With Left Ventricular Thrombus”
We appreciate the interest and feedback that our recently published article, “Effect of Duration of Anticoagulation in the Incidence of Stroke in Patients With Left Ventricular Thrombus,” has generated.1 In our study, we found that long-term anticoagulation (LTA,>12 months) was associated with lower risk of stroke than was short-term anticoagulation (STA) in a cohort of 98 patients with left ventricular thrombus (LVT). In a Letter to the Editor, in a large well-conducted study, Goh et al2 investigated the generalizability of the results in an Asian population , reporting no differences in the incidence of stroke in p...
Source: The American Journal of Cardiology - January 21, 2023 Category: Cardiology Authors: Álvaro Lorente-Ros, Gonzalo L. Alonso-Salinas, Juan M. Monteagudo Ruiz, José L. Zamorano Gómez Source Type: research
Biventricular Noncompaction Cardiomyopathy in a Patient Presenting With a New Cerebrovascular Event
Noncompaction (NC) cardiomyopathy (NCCM) is a rare, genetically heterogeneous cardiomyopathy (CM) caused by failure to compact the intertrabecular recesses of the myocardium. This condition usually affects the apical segment of the left ventricle, yet there are noted basal segment, biventricular, and right ventricular predominant cases. NCCM is largely diagnosed in the pediatric population; however, there is increasing recognition in older patients with heart failure and stroke and patients with arrhythmias.
Source: The American Journal of Cardiology - January 6, 2023 Category: Cardiology Authors: Himani Madnawat, Issam Atallah, Ali Ahmad, Kishore Harjai Source Type: research
Impact of Age at the Time of the First ST-Elevation Myocardial Infarction on 10-Year Outcomes (from the EXAMINATION-EXTEND Trial)
The aim of this substudy of the EXAMINATION-EXTEND was to analyze 10-year outcomes according to the patient's age at the time of the first ST-elevation myocardial infarction (STEMI). Of 1,498 patients with STEMI included in the EXAMINATION-EXTEND study, those with a previous history of coronary ischemic even or ischemic stroke were excluded from this analysis. The remaining 1,375 patients were divided into 4 age groups:75 years. The primary end point was 10-year patient-oriented composite end point (POCE) of all-cause death, any MI, or any revascularization.
Source: The American Journal of Cardiology - December 20, 2022 Category: Cardiology Authors: Victor Ar évalos, Francesco Spione, Rami Gabani, Luis Ortega-Paz, Josep Gómez-Lara, Víctor Jiménez-Díaz, Marcelo Jiménez, Pilar Jiménez-Quevedo, Roberto Diletti, Javier Pineda, Gianluca Campo, Antonio Silvestro, Jaume Maristany, Xacobe Flores, Lore Source Type: research
Why Are Cardiologists Not Prescribing the New Diabetes Medications?
Randomized clinical trials and guidelines from multiple societies have established significant cardiovascular (CV) outcome benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 2 diabetes (T2D). Among patients with T2D, those with known CV disease and those at high risk who are receiving metformin have lower risks of death, myocardial infarction, and stroke if they are treated with GLP-1RAs, and those treated with SGLT2is have reduced risks of hospital admission for heart failure, CV mortality, and all-cause mortality.
Source: The American Journal of Cardiology - December 14, 2022 Category: Cardiology Authors: Lloyd W. Klein Source Type: research
Transcatheter Patent Foramen Ovale Closure in Patients With Transient Ischemic Attack
The objectives of this study were to determine the clinical and procedural characteristics and long-term outcomes of patients with TIA who underwent transcatheter PFO closure. This was a multicenter study including 1,012 consecutive patients who underwent PFO closure after a cerebrovascular event. Patients were divided into 2 groups according to their index event leading to PFO closure: TIA (n = 183 [18%]), and stroke (n = 829 [82%]).
Source: The American Journal of Cardiology - December 14, 2022 Category: Cardiology Authors: Julio I. Farjat-Pasos, Paul Guedeney, Christine Houde, Alberto Alperi, Mathieu Robichaud, M élanie Côté, Gilles Montalescot, Josep Rodés-Cabau Source Type: research
Racial Differences in Atrial Fibrillation Management Between White Patients and Black Patients in Transthyretin Cardiac Amyloid
Black patients have higher rates of stroke than White patients. Paradoxically, atrial fibrillation (AF) affects twice as many White patients compared with Black patients. Transthyretin cardiac amyloidosis (ATTR-CA) is associated with both AF and strokes. We hypothesized that although Black patients with ATTR-CA have a lower incidence of AF, when diagnosed with AF, they have increased thromboembolic events. Patients with ATTR-CA (n = 558) at 3 international centers were retrospectively identified.
Source: The American Journal of Cardiology - December 14, 2022 Category: Cardiology Authors: Lindsey R. Mitrani, Robert A. Tumasian, Silvia Vilches, Jeffeny De Los Santos, Esther Gonzalez-Lopez, Angelo Giuseppe Caponetti, Giulia Saturi, Jesus G. Mirelis, Simone Longhi, Christian Gagliardi, Jeff Goldsmith, Claudio Rapezzi, Pablo Garc ía-Pavía, M Source Type: research
The “Heart” of Environmental Justice
Environmental exposures, especially air pollution, have been linked with heart disease.1 Air pollution alone is estimated to cause 6 to 9 million deaths globally annually, mostly attributable to ischemic heart disease and stroke.1 The health impact of environmental exposures varies significantly depending on the susceptibility and vulnerability of the exposed populations.2 Underrepresented minorities and people of color often face higher exposures to various pollutants, owing to historic inequities and structural racism, which impact cardiovascular disease disparities.
Source: The American Journal of Cardiology - December 14, 2022 Category: Cardiology Authors: Issam Motairek, Sanjay Rajagopalan, Sadeer Al-Kindi Source Type: research
Risk of Stroke in Older Adults With Heart Failure
Heart failure (HF) is a risk factor for incident stroke. However, less is known about the independent nature of this association and to what extent various baseline characteristics may mediate this risk. Of the 5,795 community-dwelling adults aged ≥65 years in the Cardiovascular Health Study, 5,448 were free of baseline stroke, of whom 229 had baseline HF. We used a multivariable-adjusted Cox regression model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for centrally adjudicated incident stroke associated with HF.
Source: The American Journal of Cardiology - December 10, 2022 Category: Cardiology Authors: Elizabeth Bierbower, Nayrana Griffith, Venkatesh K. Raman, Vijaywant Brar, Jeffrey Roseman, Prakash Deedwania, Gregg C. Fonarow, Richard M. Allman, Charles Faselis, Sijian Zhang, George Howard, Ali Ahmed, Phillip H. Lam Source Type: research
Clinical Validation of a Continuous Monitoring Mobile Cardiac Detection Device for Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, with stroke being among the most prevalent and harmful outcomes.1 Because nearly 25% of patients with AF appear asymptomatic, questions regarding the screening of patients at risk for AF (e.g., based on CHA2DS2-VASc score) could help clinical decisions to prescribe prophylactic anticoagulation therapy for effective stroke prevention.2,3 Current evidence highlights new approaches of real-time continuous assessment of rhythmic states of AF, non-AF, and paroxysmal AF (PAF).
Source: The American Journal of Cardiology - December 9, 2022 Category: Cardiology Authors: Subhash Banerjee, Tony Das, Jerrold Grodin, Nicole Minniefield, Shirling Tsai, Rahul Banerjee, Ken Persen, Scott Novak Source Type: research
Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials
Transcatheter aortic valve replacement (TAVR) has become a mainstay treatment option for most patients with severe symptomatic aortic stenosis. Although the majority of TAVR-related complications have decreased overtime, stroke rates remained relatively unchanged.1,2 Hence, numerous efforts have been devoted to developing effective strategies to mitigate the risk of post-TAVR strokes. We performed an updated meta-analysis to assess the efficacy and safety of cerebral embolic protection (CEP) during TAVR.
Source: The American Journal of Cardiology - November 14, 2022 Category: Cardiology Authors: Abdullah Al-Abcha, Yehia Saleh, Muhannad Abbasi, Edward El-Am, Mohamad Alkhouli Source Type: research
Bending the Cardiovascular Event Curve by Evaluating the Potential Impact of Achieving Low-Density Lipoprotein Cholesterol Goal Across a Large Health System Among Secondary Prevention Patients
Guidelines recommend aggressive low-density lipoprotein cholesterol (LDL-C) lowering in patients with atherosclerotic cardiovascular disease (ASCVD). However, the recommended threshold of LDL-C ≤70 mg/dL is often not achieved. We used data from the Duke University Health System electronic health record to characterize patterns of lipid levels and lipid management in patients with ASCVD to estimate the number of clinical events that could be prevented by achieving LDL-C ≤70 mg/dL . A mu ltivariable logistic regression model was developed to predict the 1-year composite of all-cause mortality, myocardial infarction, stro...
Source: The American Journal of Cardiology - November 10, 2022 Category: Cardiology Authors: Nishant P. Shah, Courtney Page, Cynthia L. Green, Michael Gao, Joanna Cavalier, Robert W. McGarrah, Tracy A. DeWald, Devdutta Sangvai, Manesh R. Patel, Neha J. Pagidipati Source Type: research
Diagnostic and Therapeutic Decision-Making Problems Evoked by Mitral Regurgitation in Heart Failure With Preserved Left Ventricular Ejection Fraction
Given that in the presence of mitral regurgitation (MR), the difference between the left ventricular (LV) end-diastolic and end-systolic volume is no longer the forward stroke volume (SVf) but becomes the sum of SVf and regurgitant volume, it is evident that MR can increase the volumetrically measured ejection fraction (EF) correspondingly with the increased blood volume leaving the LV during the systole.1–3 With aggravation of MR, the regurgitant fraction increases to the detriment of SVf without reduction of the LVEF, even with further reduction of the SVf.
Source: The American Journal of Cardiology - November 3, 2022 Category: Cardiology Authors: Michael Dandel Source Type: research
Advanced Echocardiography With Left Atrial Strain and Indexed Left Atrial Three-Dimensional Volume for Predicting Underlying Atrial Fibrillation After Cryptogenic Stroke
Cryptogenic stroke (CS) represents 1/3 of ischemic strokes. Atrial fibrillation (AF) can be detected in up to 30% of CS. Therefore, there is a clinical need for predicting AF to guide the optimal secondary prevention strategy. The evidence about the role of advanced echocardiography, including left atrial 3-dimensional (3D) index volume and left atrial strain (LAS) techniques, to predict underlying AF in this setting is lacking. From April 2019 to November 2021, 78 consecutive patients with ischemic stroke or transient ischemic attack with ABCD2 scale ≥4 of unknown etiology were prospectively recruited.
Source: The American Journal of Cardiology - October 25, 2022 Category: Cardiology Authors: Alberto Vera, Alberto Cecconi, Álvaro Ximénez-Carrillo, Carmen Ramos, Pablo Martínez-Vives, Beatriz Lopez-Melgar, Ancor Sanz-García, Guillermo Ortega, Clara Aguirre, José Vivancos, Luis Jesús Jiménez-Borreguero, Fernando Alfonso, DECRYTORING Study Source Type: research
Effect of Duration of Anticoagulation in the Incidence of Stroke in Patients With Left-Ventricular Thrombus
The optimal duration of anticoagulation in patients with left-ventricular thrombus (LVT) is unclear. In the present study, we aimed to analyze the effect of treatment duration ( ≤12 months [short-term anticoagulation, (STA)] versus>12 months [long-term anticoagulation, (LTA)]) in the incidence of stroke and other secondary outcomes (acute myocardial infarction, bleeding, and mortality). Multivariate Cox regression was used to determine the association between treatment duration and stroke, adjusted for baseline embolic risk.
Source: The American Journal of Cardiology - October 12, 2022 Category: Cardiology Authors: Álvaro Lorente-Ros, Gonzalo L. Alonso-Salinas, Juan M. Monteagudo Ruiz, María Abellás-Sequeiros, José M. Vieítez-Florez, Diego Sánchez Vega, Jesús Álvarez-Garcia, Marcelo Sanmartín-Fernández, Marta Lorente-Ros, Susana del Prado Díaz, Covadonga Source Type: research
Reply to the Comment on “Comparison of Dabigatran Versus Warfarin Treatment for Prevention of New Cerebral Lesions in Valvular Atrial Fibrillation”
We thank Dr. Abrahim et al for their interest and valuable comment on our study.1 In the methodology section, we intended to recruit stable patients who were able to use the standard anticoagulation in the outpatient setting. Therefore, we excluded the patients with acute stroke within 2 weeks or patients with high-bleeding risk. All the patients received standard rate control therapy according to the relevant guideline.2 The proportion of medications for rate control such as β blocker (56% of overall patients), calcium channel blocker (24%), or digitalis (31%) were already prese nted, and the mean heart rate was 74.1 ± 14.2 beats/min.
Source: The American Journal of Cardiology - October 10, 2022 Category: Cardiology Authors: Min Soo Cho, Duk-Hyun Kang, Kee-Joon Choi Source Type: research
