Diagnostic and Therapeutic Decision-Making Problems Evoked by Mitral Regurgitation in Heart Failure With Preserved Left Ventricular Ejection Fraction

Given that in the presence of mitral regurgitation (MR), the difference between the left ventricular (LV) end-diastolic and end-systolic volume is no longer the forward stroke volume (SVf) but becomes the sum of SVf  and regurgitant volume, it is evident that MR can increase the volumetrically measured ejection fraction (EF) correspondingly with the increased blood volume leaving the LV during the systole.1–3 With aggravation of MR, the regurgitant fraction increases to the detriment of SVf without reduction of the LVEF, even with further reduction of the SVf.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research