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Source: The American Journal of Cardiology
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Total 715 results found since Jan 2013.
Meta-Analysis Comparing the Frequency of Stroke After Transcatheter Versus Surgical Aortic Valve Replacement
Stroke is one of the most feared complications of aortic valve replacement. Although the outcomes of transcatheter aortic valve implantation (TAVI) improved substantially over time, concerns remained about a potentially higher incidence of stroke with TAVI compared with surgical replacement (SAVR). However, comparative data are sparse. We performed a meta-analysis comparing the incidence of stroke among patients undergoing TAVI versus SAVR. Of the 5067 studies screened, 28 eligible studies (22 propensity-score matched studies and 6 randomized trials) were analyzed.
Source: The American Journal of Cardiology - July 5, 2018 Category: Cardiology Authors: Kuldeep Shah, Zakeih Chaker, Tatiana Busu, Vinay Badhwar, Fahad Alqahtani, Muhammad Alvi, Amelia Adcock, Mohamad Alkhouli Source Type: research
Comparison of Frequency of Ischemic Stroke in Patients With Versus Without Coronary Heart Disease and Without Atrial Fibrillation
We examined ischemic stroke risk in patients without atrial fibrillation who underwent coronary angiography between 2004 and 2012. Patients were stratified according to presence or absence of CAD and further stratified by extent of CAD (0 vessel disease [VD], 1 VD, 2 VD, 3 VD, and diffuse VD).
Source: The American Journal of Cardiology - October 30, 2018 Category: Cardiology Authors: Kevin Kris Warnakula Olesen, Kamilla Steensig, Morten Madsen, Troels Thim, Lisette Okkels Jensen, Bent Raungaard, John Eikelboom, Steen Dalby Kristensen, Hans Erik B øtker, Michael Maeng Source Type: research
Meta-analysis of Stroke and Bleeding Risk in Patients with Various Atrial Fibrillation Patterns Receiving Oral Anticoagulants
Oral anticoagulation therapy (OAT) is a mainstay for stroke prevention in atrial fibrillation (AF) patients. However, whether the risks of stroke/systemic embolic events (SEE) and bleeding events are affected by the type, duration, and frequency of AF in patients receiving OAT has been previously debated. We aimed to determine the risk of stroke/SEE and bleeding events associated with paroxysmal AF compared to persistent or permanent AF among patients who received OAT. Comprehensive literature searches of the Cochrane Library, PubMed/MEDLINE, and EMBASE databases were conducted from inception to July 2018.
Source: The American Journal of Cardiology - December 19, 2018 Category: Cardiology Authors: Weifang Zhang, Youwen Xiong, Lingling Yu, Aizhen Xiong, Huihui Bao, Xiaoshu Cheng Source Type: research
Relation of Left Atrial Appendage Morphology Determined by Computed Tomography to Prior Stroke or to Increased Risk of Stroke in Patients With Atrial Fibrillation
This study aimed to assess inter-observer and intra-observer agreements in LAA morphology and its real value in stroke prediction. A total of 2264 atrial fibrillation (AF) patients who underwent computed tomography (CT) to explore the LAA anatomy were enrolled.
Source: The American Journal of Cardiology - January 23, 2019 Category: Cardiology Authors: Lingmin Wu, Erpeng Liang, Siyang Fan, Lihui Zheng, Zhongpeng Du, Shangyu Liu, Feng Hu, Xiaohan Fan, Gang Chen, Ligang Ding, Yan Yao Source Type: research
Relation of Fontan Baffle Stroke Volume to Fontan Failure and Lower Exercise Capacity in Patients With an Atriopulmonary Fontan
Fontan failure remains a significant problem, especially in patients with an atriopulmonary Fontan. Fontan baffle volume change during the cardiac cycle (Fontan baffle stroke volume) may affect outcomes in Fontan circulation. Assuming that increased Fontan baffle stroke volume is associated with increased energy loss in the baffle, we hypothesized that higher baffle stroke volume is associated with worse exercise capacity and increased incidence of Fontan failure. Patients from 6 centers with an atriopulmonary or lateral tunnel Fontan operation were included if they had a cardiac magnetic resonance (CMR) study and an adequ...
Source: The American Journal of Cardiology - April 8, 2019 Category: Cardiology Authors: Tarek Alsaied, Jelle P.G. van der Ven, Saeed Juggan, Lynn A. Sleeper, Nina Azcue, Lucia J Kroft, Andrew J. Powell, Willem A. Helbing, Rahul H. Rathod Source Type: research
Meta-Regression to Identify Patients Deriving the Greatest Benefit from Dual Antiplatelet Therapy After Stroke or Transient Ischemic Attack Without Thrombolytic or Thrombectomy Treatment
The patient's profile drawing the greatest benefit from dual antiplatelet therapy (DAPT) after a non-cardioembolic, ischemic cerebrovascular event is not well characterized. Aim of this meta-regression analysis was to compare DAPT versus single antiplatelet therapy (SAPT) in patients with stroke or transient ischemic attack (TIA). We searched randomized trials evaluating clinical outcome with aspirin plus a P2Y12 inhibitor versus SAPT in patients with non-cardioembolic stroke or TIA. Primary endpoint was the incidence of recurrent stroke; safety outcome measure was major bleeding.
Source: The American Journal of Cardiology - May 24, 2019 Category: Cardiology Authors: Giuseppe Patti, Alessandro Sticchi, Antonio Bisignani, Francesco Pelliccia, Vincenzo Pasceri, Giulio Speciale, Maria Penco Source Type: research
Atrial Septal Defect and the Risk of Ischemic Stroke in the Perioperative Period of Noncardiac Surgery
Stroke is a serious complication of non-cardiac surgery. Congenital defects of the interatrial septum may be a potent risk factor for perioperative stroke. The aim of the present study was to determine the association between atrial septal defect (ASD) or patent foramen ovale (PFO) and in-hospital perioperative ischemic stroke after non-cardiac surgery in a large nationwide cohort of patients hospitalized in the United States. Patients undergoing noncardiac surgery between 2004 and 2014 were identified using the Healthcare Cost and Utilization Project's National Inpatient Sample.
Source: The American Journal of Cardiology - July 14, 2019 Category: Cardiology Authors: Nathaniel R. Smilowitz, Varun Subashchandran, Jeffrey S. Berger Source Type: research
Incidence and Outcomes of Acute Ischemic Stroke Following Percutaneous Coronary Interventions in Men Versus Women
Comparative data on the incidence and outcomes of stroke after percutaneous coronary interventions (PCI) between men and women are limited. We identified hospitalizations for PCI in the National-Inpatient-Sample between January 1st 2003 and December 31st 2016. We compared the incidence of post-PCI stroke and in-hospital complications, mortality, and cost of post-PCI strokes between men and women. Among 8,753,574 weighted hospitalizations for PCI, 49,097 (0.56%) were complicated with ischemic stroke.
Source: The American Journal of Cardiology - November 6, 2019 Category: Cardiology Authors: Mohamad Alkhouli, Fahad Alqahtani, Mohamed Farouk Elsisy, Akram Kawsara, Mirvat Alasnag Source Type: research
Risk of Stroke in Older Adults With Heart Failure
Heart failure (HF) is a risk factor for incident stroke. However, less is known about the independent nature of this association and to what extent various baseline characteristics may mediate this risk. Of the 5,795 community-dwelling adults aged ≥65 years in the Cardiovascular Health Study, 5,448 were free of baseline stroke, of whom 229 had baseline HF. We used a multivariable-adjusted Cox regression model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for centrally adjudicated incident stroke associated with HF.
Source: The American Journal of Cardiology - December 10, 2022 Category: Cardiology Authors: Elizabeth Bierbower, Nayrana Griffith, Venkatesh K. Raman, Vijaywant Brar, Jeffrey Roseman, Prakash Deedwania, Gregg C. Fonarow, Richard M. Allman, Charles Faselis, Sijian Zhang, George Howard, Ali Ahmed, Phillip H. Lam Source Type: research
Response to Readers ’ Comments “Effect of Anticoagulation Duration on Stroke Incidence in Asian Patients With Left Ventricular Thrombus”
We appreciate the interest and feedback that our recently published article, “Effect of Duration of Anticoagulation in the Incidence of Stroke in Patients With Left Ventricular Thrombus,” has generated.1 In our study, we found that long-term anticoagulation (LTA,>12 months) was associated with lower risk of stroke than was short-term anticoagulation (STA) in a cohort of 98 patients with left ventricular thrombus (LVT). In a Letter to the Editor, in a large well-conducted study, Goh et al2 investigated the generalizability of the results in an Asian population , reporting no differences in the incidence of stroke in p...
Source: The American Journal of Cardiology - January 21, 2023 Category: Cardiology Authors: Álvaro Lorente-Ros, Gonzalo L. Alonso-Salinas, Juan M. Monteagudo Ruiz, José L. Zamorano Gómez Source Type: research
Atrial Cardiopathy: Redefining Stroke Risk Beyond Atrial Fibrillation
Atrial fibrillation (AF) and ischemic stroke are dual epidemics in society, both associated with poor clinical outcomes, patient disability, and significant healthcare expenditure. The conditions are interrelated and share complex causal pathways. Risk stratification algorithms such as the CHADS2 and CHA2DS2-VASc score offer predictive value in stroke and systemic embolism risk in the AF population, however, have limitations. Recent evidence suggests that an intrinsically prothrombotic atrial substrate may precede and promote AF and lead to thromboembolic events independent of the arrhythmia, allowing for a window of inter...
Source: The American Journal of Cardiology - June 28, 2023 Category: Cardiology Authors: Jessica Chu Zhang, Aditya Bhat Source Type: research
An Explainable Artificial Intelligence Approach for Discovering Social Determinants of Health and Risk Interactions for Stroke in Patients With Atrial Fibrillation
Stroke remains the primary source of morbidity and mortality associated with atrial fibrillation (AF), despite major advances in prevention. Although effective stroke-prevention strategies are available, optimal implementation of these treatments is limited by (1) rudimentary stroke risk stratification tools (i.e., CHADS2-VA2Sc), and (2) disparities in care and outcomes of AF. Over 150,000 yearly strokes in the United States occur in patients with AF.1 Many of these occur in patients with AF who are misclassified as low-risk or fail to receive appropriate therapies because of healthcare disparities.
Source: The American Journal of Cardiology - June 28, 2023 Category: Cardiology Authors: Raquel M. Zimmerman, Edgar J. Hernandez, W. Scott Watkins, Nathan Blue, Martin Tristani-Firouzi, Mark Yandell, Benjamin A. Steinberg Source Type: research
Guideline-Directed Low-Density Lipoprotein Cholesterol Management After Acute Ischemic Stroke: Findings from a National Health Care Service
Patients with ischemic stroke are at high risk for future cardiovascular events and should be treated intensively with lipid-modifying agents. Combination lipid-lowering therapies are often needed to achieve updated guideline-directed treatment goals. However, real-world data on intensification of lipid-lowering therapies and attainment of low-density lipoprotein cholesterol (LDL-C) targets early after ischemic stroke are limited. We extracted data from the largest healthcare provider in Israel on patients hospitalized with acute ischemic stroke between January 2020 and February 2022.
Source: The American Journal of Cardiology - July 28, 2023 Category: Cardiology Authors: Barak Zafrir, Amir Aker, Ibrahim Naoum, Walid Saliba Source Type: research
Electrocardiographic Morphology-Voltage-P-Wave-Duration (MVP) Score to Select Patients for Continuous Atrial Fibrillation Screening to Prevent Stroke
Morphology-voltage-P-wave-duration (MVP) score combining P-wave duration (PWD), P-wave voltage in lead I (PWVI), and interatrial block (IAB) has been demonstrated to predict atrial fibrillation (AF). Therefore, this study aimed to examine MVP score and its P-wave components as potential predictors of AF screening effects on stroke prevention. This was a secondary analysis of the LOOP Study (Atrial Fibrillation detected by Continuous ECG Monitoring using Implantable Loop Recorder to prevent Stroke in High-risk Individuals) which randomized older persons (aged 70 to 90 years) with additional stroke risk factors to either c...
Source: The American Journal of Cardiology - September 2, 2023 Category: Cardiology Authors: Lucas Yixi Xing, S øren Zöga Diederichsen, Søren Højberg, Derk Krieger, Claus Graff, Morten Salling Olesen, Jonas Bille Nielsen, Axel Brandes, Lars Køber, Ketil Jørgen Haugan, Jesper Hastrup Svendsen Source Type: research
Initial Experience With a Novel Percutaneous Left Atrial Appendage Exclusion Device in Patients With Atrial Fibrillation, Increased Stroke Risk, and Contraindications to Anticoagulation
Atrial fibrillation (AF) increases by fivefold a patient's risk for thromboembolic stroke. The main source of emboli in AF is the left atrial appendage (LAA). Therefore, LAA closure could reduce the risk for thromboembolic events in AF. The investigators report the first United States experience with a novel percutaneous LAA closure device, the Lariat snare device, and its outcomes in 21 patients with AF, CHADS2 scores ≥2, and contraindications to anticoagulation. The LAA was closed with a snare containing suture from within the pericardial space. The intraoperative success of the procedure was confirmed by left atrial a...
Source: The American Journal of Cardiology - January 11, 2013 Category: Cardiology Authors: Ali Massumi, Mihail Gabriel Chelu, Alireza Nazeri, Stephen Allen May, Hamid Afshar-Kharaghan, Mohammad Saeed, Mehdi Razavi, Abdi Rasekh Tags: Arrhythmias and Conduction Disturbances Source Type: research
