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Source: JAHA:Journal of the American Heart Association

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Total 334 results found since Jan 2013.

Meta-Analysis of Potassium Intake and the Risk of Stroke Genetics
Conclusions Overall, this dose–response meta-analysis confirms the inverse association between potassium intake and stroke risk, with potassium intake of 90 mmol (3500 mg)/day associated with the lowest risk of stroke.
Source: JAHA:Journal of the American Heart Association - October 6, 2016 Category: Cardiology Authors: Vinceti, M., Filippini, T., Crippa, A., de Sesmaisons, A., Wise, L. A., Orsini, N. Tags: Diet and Nutrition, Epidemiology, Primary Prevention, Risk Factors Genetics Source Type: research

Nonsustained Atrial Fibrillation in Ischemic Stroke Patients and Stroke-Free Controls From the Perspective of Stroke Pathophysiology Stroke
BackgroundShort‐lasting (
Source: JAHA:Journal of the American Heart Association - September 30, 2016 Category: Cardiology Authors: Yetim, E., Topcuoglu, M. A., Canpolat, U., Gocmen, R., Oguz, K. K., Ozer, N., Aytemir, K., Arsava, E. M. Tags: Atrial Fibrillation, Pathophysiology, Electrocardiology (ECG), Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Research Source Type: research

Left Atrial Appendage Closure Under Intracardiac Echocardiographic Guidance: Feasibility and Comparison With Transesophageal Echocardiography Interventional Cardiology
Conclusions Transcatheter left atrial appendage closure with intracardiac echocardiography guidance is safe and feasible.
Source: JAHA:Journal of the American Heart Association - September 28, 2016 Category: Cardiology Authors: Matsuo, Y., Neuzil, P., Petru, J., Chovanec, M., Janotka, M., Choudry, S., Skoda, J., Sediva, L., Kurabayashi, M., Reddy, V. Y. Tags: Atrial Fibrillation, Imaging, Ischemic Stroke, Thrombosis Interventional Cardiology Source Type: research

Race-Specific Predictors of Mortality in Intracerebral Hemorrhage: Differential Impacts of Intraventricular Hemorrhage and Age Among Blacks and Whites Stroke
BackgroundIntracerebral hemorrhage (ICH) carries high risk for short‐term mortality. We sought to identify race‐specific predictors of mortality in ICH patients.Methods and ResultsWe used 2 databases, the Johns Hopkins clinical stroke database and the Nationwide Inpatient Sample (NIS). We included 226 patients with the primary diagnosis of spontaneous ICH from our stroke database between 2010 and 2013; in the NIS, 42 077 patients met inclusion criteria. Logistic regression was used to assess differences in predictors of mortality in blacks compared to whites. In our clinical stroke database, Glasgow Coma Scale (GCS; P...
Source: JAHA:Journal of the American Heart Association - August 16, 2016 Category: Cardiology Authors: Faigle, R., Marsh, E. B., Llinas, R. H., Urrutia, V. C., Gottesman, R. F. Tags: Intracranial Hemorrhage Original Research Source Type: research

Elucidating the Association Between Depressive Symptoms, Coronary Heart Disease, and Stroke in Black and White Adults: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study Epidemiology
Conclusions Proximal depressive symptoms were associated with incident fatal and nonfatal stroke and CVD death even after controlling for multiple explanatory factors, further supporting the urgent need for timely management of depressive symptoms.
Source: JAHA:Journal of the American Heart Association - August 12, 2016 Category: Cardiology Authors: Moise, N., Khodneva, Y., Richman, J., Shimbo, D., Kronish, I., Safford, M. M. Tags: Quality and Outcomes Epidemiology Source Type: research

Electronic Alert System for Improving Stroke Prevention Among Hospitalized Oral-Anticoagulation-Naïve Patients With Atrial Fibrillation: A Randomized Trial Preventive Cardiology
Conclusions Versus standard care, the alert system modestly improved OAC prescription among consecutive hospitalized AF patients. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT02455102.
Source: JAHA:Journal of the American Heart Association - July 22, 2016 Category: Cardiology Authors: Silbernagel, G., Spirk, D., Hager, A., Baumgartner, I., Kucher, N. Tags: Atrial Fibrillation, Anticoagulants, Quality and Outcomes Preventive Cardiology Source Type: research

Electronic Alert System for Improving Stroke Prevention Among Hospitalized Oral-Anticoagulation-Naive Patients With Atrial Fibrillation: A Randomized Trial Preventive Cardiology
ConclusionsVersus standard care, the alert system modestly improved OAC prescription among consecutive hospitalized AF patients.Clinical Trial RegistrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT02455102.
Source: JAHA:Journal of the American Heart Association - July 22, 2016 Category: Cardiology Authors: Silbernagel, G., Spirk, D., Hager, A., Baumgartner, I., Kucher, N. Tags: Atrial Fibrillation, Anticoagulants, Quality and Outcomes Original Research Source Type: research

Advanced Left Atrial Remodeling and Appendage Contractile Dysfunction in Women Than in Men Among the Patients With Atrial Fibrillation: Potential Mechanism for Stroke Arrhythmia and Electrophysiology
Conclusions More-extensive LA remodeling and deterioration in LAA function were noted in women than in men with high calculated risk of stroke in AF.
Source: JAHA:Journal of the American Heart Association - July 11, 2016 Category: Cardiology Authors: Yu, H. T., Lee, J. S., Kim, T.-H., Uhm, J.-S., Joung, B., Hong, G.-R., Lee, M.-H., Shim, C. Y., Pak, H.-N. Tags: Atrial Fibrillation Arrhythmia and Electrophysiology Source Type: research

Cystatin C Predicts Incident Cardiovascular Disease in Twins Vascular Medicine
Conclusions Variation in cystatin C relates to incident ASCVD and to stroke when adjusted for genetic confounding. In identical twins, cystatin C may be a sensitive marker of early hypertensive end-organ damage and small-vessel disease, whereas creatinine level may reflect nutritional status. The findings in disease-discordant monozygotic twins indicate that unique, possibly preventable, environmental factors are important.
Source: JAHA:Journal of the American Heart Association - June 27, 2016 Category: Cardiology Authors: Arpegard, J., Magnusson, P. K. E., Chen, X., Ridefelt, P., Pedersen, N. L., De Faire, U., Svensson, P. Tags: Nephrology and Kidney, Cardiovascular Disease, Cerebrovascular Disease/Stroke, Atherosclerosis, Coronary Artery Disease Vascular Medicine Source Type: research

Effectiveness and Safety of Dabigatran, Rivaroxaban, and Apixaban Versus Warfarin in Nonvalvular Atrial Fibrillation Health Services and Outcomes Research
Conclusions In patients with nonvalvular atrial fibrillation, apixaban was associated with lower risks of both stroke and major bleeding, dabigatran was associated with similar risk of stroke but lower risk of major bleeding, and rivaroxaban was associated with similar risks of both stroke and major bleeding in comparison to warfarin.
Source: JAHA:Journal of the American Heart Association - June 13, 2016 Category: Cardiology Authors: Yao, X., Abraham, N. S., Sangaralingham, L. R., Bellolio, M. F., McBane, R. D., Shah, N. D., Noseworthy, P. A. Tags: Atrial Fibrillation, Secondary Prevention, Anticoagulants, Transplantation, Cerebrovascular Disease/Stroke Health Services and Outcomes Research Source Type: research

Accuracy of ICD-9-CM Codes by Hospital Characteristics and Stroke Severity: Paul Coverdell National Acute Stroke Program Health Services and Outcomes Research
Conclusions We identified disagreements in stroke/TIA coding by hospital characteristics and stroke severity, particularly for milder ischemic strokes. Such systematic variations in ICD-9-CM coding practices can affect stroke case identification in epidemiological studies and may have implications for hospital-level quality metrics.
Source: JAHA:Journal of the American Heart Association - May 31, 2016 Category: Cardiology Authors: Chang, T. E., Lichtman, J. H., Goldstein, L. B., George, M. G. Tags: Health Services, Quality and Outcomes Health Services and Outcomes Research Source Type: research

Dairy Consumption and Risk of Stroke: A Systematic Review and Updated Dose-Response Meta-Analysis of Prospective Cohort Studies Arrhythmia and Electrophysiology
Conclusions Milk and cheese consumption were inversely associated with stroke risk. Results should be placed in the context of the observed heterogeneity. Future epidemiological studies should provide more details about dairy types, including fat content. In addition, the role of dairy in Asian populations deserves further attention.
Source: JAHA:Journal of the American Heart Association - May 20, 2016 Category: Cardiology Authors: de Goede, J., Soedamah-Muthu, S. S., Pan, A., Gijsbers, L., Geleijnse, J. M. Tags: Cardiovascular Disease Arrhythmia and Electrophysiology Source Type: research

Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) Stroke
Conclusions Small+medium HDL-P is significantly and inversely correlated with cIMT measurements. Correlation of small+medium HDL-P with cardioprotective paraoxonase 1 activity may reflect a functional aspect of HDL responsible for this finding.
Source: JAHA:Journal of the American Heart Association - May 20, 2016 Category: Cardiology Authors: Kim, D. S., Li, Y. K., Bell, G. A., Burt, A. A., Vaisar, T., Hutchins, P. M., Furlong, C. E., Otvos, J. D., Polak, J. F., Arnan, M. K., Kaufman, J. D., McClelland, R. L., Longstreth, W. T., Jarvik, G. P. Tags: Lipids and Cholesterol, Oxidant Stress, Cardiovascular Disease, Cerebrovascular Disease/Stroke Source Type: research

Rising Stroke Incidence in Young Adults: More Epidemiological Evidence, More Questions to Be Answered Editorial
Source: JAHA:Journal of the American Heart Association - May 11, 2016 Category: Cardiology Authors: Bejot, Y., Delpont, B., Giroud, M. Tags: Epidemiology, Cerebrovascular Disease/Stroke Editorial Source Type: research

Field Synopsis of the Role of Sex in Stroke Prediction Models Health Services and Outcomes Research
Conclusions Sex is included in a minority of published CPMs, but more frequently in models predicting incidence of first stroke. The importance of sex-specific care may be especially well established for primary prevention.
Source: JAHA:Journal of the American Heart Association - May 5, 2016 Category: Cardiology Authors: Paulus, J. K., Lai, L. Y. H., Lundquist, C., Daneshmand, A., Buettner, H., Lutz, J. S., Raman, G., Wessler, B. S., Kent, D. M. Tags: Primary Prevention, Risk Factors, Secondary Prevention, Women, Health Services Health Services and Outcomes Research Source Type: research

Heart Rhythm Monitoring Strategies for Cryptogenic Stroke: 2015 Diagnostics and Monitoring Stroke Focus Group Report Special Reports
Source: JAHA:Journal of the American Heart Association - March 15, 2016 Category: Cardiology Authors: Albers, G. W., Bernstein, R. A., Brachmann, J., Camm, J., Easton, J. D., Fromm, P., Goto, S., Granger, C. B., Hohnloser, S. H., Hylek, E., Jaffer, A. K., Krieger, D. W., Passman, R., Pines, J. M., Reed, S. D., Rothwell, P. M., Kowey, P. R. Tags: Atrial Fibrillation, Secondary Prevention, Anticoagulants, Ischemic Stroke Special Reports Source Type: research

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF Arrhythmia and Electrophysiology
Conclusions In a large population of patients anticoagulated for nonvalvular atrial fibrillation, 7 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00403767.
Source: JAHA:Journal of the American Heart Association - March 8, 2016 Category: Cardiology Authors: Pokorney, S. D., Piccini, J. P., Stevens, S. R., Patel, M. R., Pieper, K. S., Halperin, J. L., Breithardt, G., Singer, D. E., Hankey, G. J., Hacke, W., Becker, R. C., Berkowitz, S. D., Nessel, C. C., Mahaffey, K. W., Fox, K. A. A., Califf, R. M., for the Tags: Atrial Fibrillation, Sudden Cardiac Death, Heart Failure, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Population-Based Data on Congenital Heart Disease and Stroke Editorial
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Opotowsky, A. R., Webb, G. D. Tags: Epidemiology, Congenital Heart Disease, Cerebrovascular Disease/Stroke, Ischemic Stroke Editorial Source Type: research

Population-Based Data on Congenital Heart Disease and Stroke Editorials
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Opotowsky, A. R., Webb, G. D. Tags: Epidemiology, Congenital Heart Disease, Cerebrovascular Disease/Stroke, Ischemic Stroke Editorials Source Type: research

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans Stroke
Conclusions The GCAS model successfully generated gradual and continuous CBF reduction over 28 days, with replication of key histological, radiological, and behavioral features associated with cerebral hypoperfusion leading to VCI.
Source: JAHA:Journal of the American Heart Association - February 22, 2016 Category: Cardiology Authors: Hattori, Y., Enmi, J.-i., Iguchi, S., Saito, S., Yamamoto, Y., Tsuji, M., Nagatsuka, K., Kalaria, R. N., Iida, H., Ihara, M. Tags: Animal Models of Human Disease, Cerebrovascular Disease/Stroke, Cognitive Impairment, Atherosclerosis, Stenosis Source Type: research

ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease Stroke
Conclusions In people with MCI and AD, the capacity of CSF to facilitate ABCA1-mediated cholesterol efflux is impaired. This lesser cholesterol efflux in MCI supports a pathophysiological role for ABCA1-mediated cholesterol transport in early neurodegeneration.
Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Yassine, H. N., Feng, Q., Chiang, J., Petrosspour, L. M., Fonteh, A. N., Chui, H. C., Harrington, M. G. Tags: Lipids and Cholesterol Stroke Source Type: research

Pacemakers as Atrial Fibrillation Detectors: Finding Racial Differences and Opportunities for Preventing Stroke Editorial
Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Meschia, J. F. Tags: Atrial Fibrillation, Epidemiology, Race and Ethnicity, Genetics, Ischemic Stroke Editorial Source Type: research

Cardiac Time Intervals Measured by Tissue Doppler Imaging M-mode: Association With Hypertension, Left Ventricular Geometry, and Future Ischemic Cardiovascular Diseases Imaging
Conclusion The cardiac time intervals identify impaired cardiac function in individuals with hypertension, not only independent of conventional risk factors but also in participants with a normal conventional echocardiographic examination. The IVRT/ET and MPI are independent predictors of future cardiovascular disease especially in participants with known hypertension.
Source: JAHA:Journal of the American Heart Association - January 19, 2016 Category: Cardiology Authors: Biering-Sorensen, T., Mogelvang, R., Schnohr, P., Jensen, J. S. Tags: Risk Factors, Hypertension, Echocardiography, Quality and Outcomes, Ischemic Stroke Imaging Source Type: research

Proteinuria Is an Independent Risk Factor for First Incident Stroke in Adults Under Treatment for Hypertension in China Kidney in Cardiovascular Disease
Conclusions In adults under treatment for hypertension in China, baseline proteinuria measured by dipstick or quantitative albumin–creatinine ratio, but not reduced eGFR, was found to be an independent risk factor for first incident stroke and ischemic stroke.
Source: JAHA:Journal of the American Heart Association - December 18, 2015 Category: Cardiology Authors: Zhang, C., Wang, X., He, M., Qin, X., Tang, G., Xu, X., Wang, Y., Huo, Y., Cai, Y., Fu, J., Zhao, G., Dong, Q., Xu, X., Wang, B., Hou, F. F. Tags: Kidney in Cardiovascular Disease Source Type: research

N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) Levels are Increased in Patients With Transient Ischemic Attack Accompanied by Nonfocal Symptoms Stroke
Conclusion NT-proBNP levels are increased in patients with TIA accompanied by nonfocal symptoms.
Source: JAHA:Journal of the American Heart Association - December 15, 2015 Category: Cardiology Authors: Plas, G. J. J., Jurg, S. D., Brusse-Keizer, M., Dippel, D. W. J., Koudstaal, P. J., den Hertog, H. M. Tags: Stroke Source Type: research

Long-Term Risk of Stroke in Patients With Type 1 and Type 2 Diabetes Following Coronary Artery Bypass Grafting Cardiovascular Surgery
Conclusions The long-term risk for stroke after coronary artery bypass grafting was increased in patients with type 1 and type 2 diabetes, compared to patients with no diabetes.
Source: JAHA:Journal of the American Heart Association - November 9, 2015 Category: Cardiology Authors: Nystrom, T., Holzmann, M. J., Sartipy, U. Tags: Cardiovascular Surgery Source Type: research

Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia Stroke
Conclusions The protective effects of H2S are mediated by thiosulfate that is transported across cell membrane by NaS-2 and exerts antiapoptotic effects via persulfidation of caspase-3. Given the established safety track record, thiosulfate may be therapeutic against ischemic brain injury.
Source: JAHA:Journal of the American Heart Association - November 6, 2015 Category: Cardiology Authors: Marutani, E., Yamada, M., Ida, T., Tokuda, K., Ikeda, K., Kai, S., Shirozu, K., Hayashida, K., Kosugi, S., Hanaoka, K., Kaneki, M., Akaike, T., Ichinose, F. Tags: Stroke Source Type: research

Risk of Recurrent Stroke and Death After First Stroke in Long-Distance Ski Race Participants Epidemiology
Conclusions This large cohort study supports the hypothesis that patients with a stroke and with prior regular physical activity have a lower risk of death, while their risk for recurrent stroke is similar to that of nonskiers. The skiers had a higher incidence of atrial fibrillation, but still no increased risk of recurring stroke.
Source: JAHA:Journal of the American Heart Association - September 24, 2015 Category: Cardiology Authors: Hallmarker, U., Asberg, S., Michaelsson, K., Arnlov, J., Hellberg, D., Lindback, J., Wester, P., James, S. Tags: Epidemiology Source Type: research

Association Between High-Sensitivity C-Reactive Protein and Total Stroke by Hypertensive Status Among Men Arrhythmia and Electrophysiology
Conclusions Elevated hsCRP levels were associated with a greater risk of total stroke, even after adjustment for potential confounders and cardiovascular risk factors. Risk of total stroke was significantly higher among hypertensive men with elevated hsCRP compared with normotensive men with low hsCRP.
Source: JAHA:Journal of the American Heart Association - September 21, 2015 Category: Cardiology Authors: Jimenez, M. C., Rexrode, K. M., Glynn, R. J., Ridker, P. M., Gaziano, J. M., Sesso, H. D. Tags: Arrhythmia and Electrophysiology Source Type: research

Differences in Quality of Life Between Atrial Fibrillation Patients with Low Stroke Risk Treated With and Without Catheter Ablation Health Services and Outcomes Research
Conclusions QoL was balanced at baseline and improved at 6 months in both groups from this observational propensity-matched cohort based on the AFEQT questionnaire. However, RFA treatment was only associated with small-to-moderate superiorities over non-RFA treatment. The role of RFA in QoL improvement among AF patients with low stroke risk requires further research.
Source: JAHA:Journal of the American Heart Association - September 16, 2015 Category: Cardiology Authors: Bai, Y., Bai, R., Wu, J.-H., Zhang, T., Liu, N., Shi, X.-B., Liu, X.-Y., Liu, X.-H., Du, X., Dong, J.-Z., Ma, C.-S. Tags: Health Services and Outcomes Research Source Type: research

Individual and Combined Risk Factors for Incident Atrial Fibrillation and Incident Stroke: An Analysis of 3 Million At-Risk US Patients Arrhythmia and Electrophysiology
Conclusions Adults with combinations of known risk factors are at increased risk of incident AF and stroke, but combinations of risk factors are not always additive.
Source: JAHA:Journal of the American Heart Association - July 23, 2015 Category: Cardiology Authors: Chyou, J. Y., Hunter, T. D., Mollenkopf, S. A., Turakhia, M. P., Reynolds, M. R. Tags: Arrhythmia and Electrophysiology Source Type: research

Stroke and Bleeding Risk Associated With Antithrombotic Therapy for Patients With Nonvalvular Atrial Fibrillation in Clinical Practice Health Services and Outcomes Research
Conclusions Continuation of antithrombotic therapy as well as maintaining an adequate level of TTR is beneficial to prevent strokes while minimizing bleeding events.
Source: JAHA:Journal of the American Heart Association - July 17, 2015 Category: Cardiology Authors: An, J., Niu, F., Lang, D. T., Jazdzewski, K. P., Le, P. T., Rashid, N., Meissner, B., Mendes, R., Dills, D. G., Aranda, G., Bruno, A. Tags: Health Services and Outcomes Research Source Type: research

New York State: Comparison of Treatment Outcomes for Unruptured Cerebral Aneurysms Using an Instrumental Variable Analysis Stroke
Conclusions Using a comprehensive all-payer cohort of patients in New York State with unruptured cerebral aneurysms, we did not identify an association of treatment method with mortality or 30-day readmission. Clipping was associated with a higher rate of discharge to rehabilitation and longer length of stay.
Source: JAHA:Journal of the American Heart Association - July 13, 2015 Category: Cardiology Authors: Bekelis, K., Missios, S., Coy, S., Singer, R. J., MacKenzie, T. A. Tags: Stroke Source Type: research

Changes in Depressive Symptoms and Incidence of First Stroke Among Middle-Aged and Older US Adults Epidemiology
Conclusions In this cohort, persistently high depressive symptoms were associated with increased stroke risk. Risk remained elevated even if depressive symptoms remitted over a 2-year period, suggesting cumulative etiologic mechanisms linking depression and stroke.
Source: JAHA:Journal of the American Heart Association - May 13, 2015 Category: Cardiology Authors: Gilsanz, P., Walter, S., Tchetgen Tchetgen, E. J., Patton, K. K., Moon, J. R., Capistrant, B. D., Marden, J. R., Kubzansky, L. D., Kawachi, I., Glymour, M. M. Tags: Epidemiology Source Type: research

Quantitative Tissue-Tracking Cardiac Magnetic Resonance (CMR) of Left Atrial Deformation and the Risk of Stroke in Patients With Atrial Fibrillation Imaging
Conclusions Depressed LA reservoir function assessed by tissue-tracking cardiac magnetic resonance is significantly associated with a prior history of stroke/transient ischemic attack in patients with AF. Our findings suggest that assessment of LA reservoir function can improve the risk stratification of cerebrovascular events in AF patients.
Source: JAHA:Journal of the American Heart Association - April 27, 2015 Category: Cardiology Authors: Inoue, Y. Y., Alissa, A., Khurram, I. M., Fukumoto, K., Habibi, M., Venkatesh, B. A., Zimmerman, S. L., Nazarian, S., Berger, R. D., Calkins, H., Lima, J. A., Ashikaga, H. Tags: Imaging Source Type: research

Traumatic Brain Injury Disrupts Cerebrovascular Tone Through Endothelial Inducible Nitric Oxide Synthase Expression and Nitric Oxide Gain of Function Stroke
Conclusions The mechanism of profound cerebral artery vasodilation after TBI is a gain of function in vascular NO production by 60-fold over controls, resulting from upregulation of the inducible isoform of NO synthase in the endothelium.
Source: JAHA:Journal of the American Heart Association - December 19, 2014 Category: Cardiology Authors: Villalba, N., Sonkusare, S. K., Longden, T. A., Tran, T. L., Sackheim, A. M., Nelson, M. T., Wellman, G. C., Freeman, K. Tags: Stroke Source Type: research

Declining Rates of Fatal and Nonfatal Intracerebral Hemorrhage: Epidemiological Trends in Australia Stroke
Conclusions Overall and fatal ICH rates have fallen in this large Australian population. Improvements in cardiovascular prevention and acute care may explain declining rates. There was no evidence of an increase in devastated survivors because the longer term mortality of 30-day survivors has not increased over time.
Source: JAHA:Journal of the American Heart Association - December 8, 2014 Category: Cardiology Authors: Gattellari, M., Goumas, C., Worthington, J. Tags: Stroke Source Type: research

Management of Vascular Risk Factors in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) Stroke
Conclusions Site-based risk-factor control improved significantly in the first 6 months and over the long term in CREST but was often suboptimal. Intensive medical management should be considered for future trials of carotid revascularization. Clinical Trial Registration URL: ClinicalTrials.gov. Unique identifier: NCT00004732.
Source: JAHA:Journal of the American Heart Association - November 26, 2014 Category: Cardiology Authors: Meschia, J. F., Voeks, J. H., Leimgruber, P. P., Mantese, V. A., Timaran, C. H., Chiu, D., Demaerschalk, B. M., Howard, V. J., Hughes, S. E., Longbottom, M., Howard, A. G., Brott, T. G. Tags: Stroke Source Type: research

Peripheral Arterial Disease and Risk of Atrial Fibrillation and Stroke: The Multi-Ethnic Study of Atherosclerosis Coronary Heart Disease
Conclusions PAD is associated with an increased risk of AF and stroke in MESA. Potentially, the relationship between PAD and stroke is not mediated by AF.
Source: JAHA:Journal of the American Heart Association - November 17, 2014 Category: Cardiology Authors: O'Neal, W. T., Efird, J. T., Nazarian, S., Alonso, A., Heckbert, S. R., Soliman, E. Z. Tags: Coronary Heart Disease Source Type: research

Consciousness Level and Off-Hour Admission Affect Discharge Outcome of Acute Stroke Patients: A J-ASPECT Study Health Services and Outcomes Research
Conclusions The well-known off-hour effect might be attributed to the severely ill patient population. Thus, sustained stroke care that is sufficient to treat severely ill patients during off-hours is important.
Source: JAHA:Journal of the American Heart Association - October 21, 2014 Category: Cardiology Authors: Kamitani, S., Nishimura, K., Nakamura, F., Kada, A., Nakagawara, J., Toyoda, K., Ogasawara, K., Ono, J., Shiokawa, Y., Aruga, T., Miyachi, S., Nagata, I., Matsuda, S., Miyamoto, Y., Iwata, M., Suzuki, A., Ishikawa, K. B., Kataoka, H., Morita, K., Kobayash Tags: Health Services and Outcomes Research Source Type: research

Circulating microRNAs Serve as Novel Biological Markers for Intracranial Aneurysms Stroke
Conclusions Our data suggest that circulating miRNAs may be novel biological markers that are useful in assessing the likelihood of IA occurrence.
Source: JAHA:Journal of the American Heart Association - September 23, 2014 Category: Cardiology Authors: Li, P., Zhang, Q., Wu, X., Yang, X., Zhang, Y., Li, Y., Jiang, F. Tags: Stroke Source Type: research

Population Attributable Risks of Hypertension and Diabetes for Cardiovascular Disease and Stroke in the Northern Manhattan Study Epidemiology
Conclusions HTN and diabetes have important effects on the burden of stroke, particularly among those younger than age 80 and Hispanics. Public health campaigns targeted at specific risk factors in specific populations can lead to a greater reduction in CVD.
Source: JAHA:Journal of the American Heart Association - September 16, 2014 Category: Cardiology Authors: Willey, J. Z., Moon, Y. P., Kahn, E., Rodriguez, C. J., Rundek, T., Cheung, K., Sacco, R. L., Elkind, M. S. V. Tags: Epidemiology Source Type: research

Impact of Heme and Heme Degradation Products on Vascular Diameter in Mouse Visual Cortex Stroke
Conclusions We identified individual components of the oxidative bilirubin degradation that led to vasoconstriction of cerebral arterioles. The vasoconstrictive effect of Z-BOX A and Z-BOX B was mediated by BKCa channel activity that might represent a signaling pathway in the occurrence of delayed cerebral vasospasm in subarachnoid hemorrhage patients.
Source: JAHA:Journal of the American Heart Association - August 28, 2014 Category: Cardiology Authors: Joerk, A., Seidel, R. A., Walter, S. G., Wiegand, A., Kahnes, M., Klopfleisch, M., Kirmse, K., Pohnert, G., Westerhausen, M., Witte, O. W., Holthoff, K. Tags: Stroke Source Type: research

Adult Moyamoya Disease in an Urban Center in the United States Is Associated With a High Burden of Watershed Ischemia Stroke
Conclusions We observed a high burden of ischemia, mostly watershed pattern on neuroimaging in our adult moyamoya disease patients. Long-term monitoring of adult moyamoya disease patients in the United States would be useful to better understand the natural history of this condition.
Source: JAHA:Journal of the American Heart Association - July 18, 2014 Category: Cardiology Authors: Zafar, S. F., Bershad, E. M., Gildersleeve, K. L., Newmark, M. E., Calvillo, E., Suarez, J. I., Venkatasubba Rao, C. P. Tags: Stroke Source Type: research

The Impact of Acute Kidney Injury on the Long-term Risk of Stroke Kidney in Cardiovascular Disease
Conclusions The patients who recovered from AKI had a higher incidence of developing incident stroke and mortality than the patients without AKI, and the impact was similar to diabetes. Our results suggest that a public health initiative is needed to enhance postdischarge follow-up of renal function and to control the subsequent incidence of stroke among patients who recover from AKI after dialysis.
Source: JAHA:Journal of the American Heart Association - July 15, 2014 Category: Cardiology Authors: Wu, V.-C., Wu, P.-C., Wu, C.-H., Huang, T.-M., Chang, C.-H., Tsai, P.-R., Ko, W.-J., Chen, L., Wang, C.-Y., Chu, T.-S., Wu, K.-D., The National Taiwan University Study Group on Acute Renal Failure (NSARF) Group Tags: Kidney in Cardiovascular Disease Source Type: research

HDL-3 is a Superior Predictor of Carotid Artery Disease in a Case-Control Cohort of 1725 Participants Stroke
Conclusions This study is the first to contrast the associations of HDL-2 and HDL-3 with CAAD. We found that HDL-3 levels were more predictive of CAAD status than HDL-2, HDL-C, or apolipoprotein A1. In addition, for men, paraoxonase 1 activity improved the overall model prediction for CAAD independently and additively with HDL-3 levels. Further investigation into the molecular mechanisms through which HDL-3 is associated with protection from CAAD is warranted.
Source: JAHA:Journal of the American Heart Association - June 25, 2014 Category: Cardiology Authors: Kim, D. S., Burt, A. A., Rosenthal, E. A., Ranchalis, J. E., Eintracht, J. F., Hatsukami, T. S., Furlong, C. E., Marcovina, S., Albers, J. J., Jarvik, G. P. Tags: Stroke Source Type: research