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Source: JAHA:Journal of the American Heart Association

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Total 381 results found since Jan 2013.

Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and Peripheral Artery Disease: Insights From the ARISTOTLE Trial Arrhythmia and Electrophysiology
ConclusionsPatients with PAD in ARISTOTLE had a higher crude risk of stroke or systemic embolism compared with patients without PAD that was not present after adjustment. The benefits of apixaban versus warfarin for stroke and systemic embolism were similar in patients with and without PAD. These findings highlight the need to optimize the treatment of patients with atrial fibrillation and PAD.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00412984.
Source: JAHA:Journal of the American Heart Association - January 17, 2017 Category: Cardiology Authors: Hu, P. T., Lopes, R. D., Stevens, S. R., Wallentin, L., Thomas, L., Alexander, J. H., Hanna, M., Lewis, B. S., Verheugt, F. W. A., Granger, C. B., Jones, W. S. Tags: Arrhythmias, Atrial Fibrillation, Anticoagulants, Peripheral Vascular Disease Original Research Source Type: research

International Variation in Outcomes Among People with Cardiovascular Disease or Cardiovascular Risk Factors and Impaired Glucose Tolerance: Insights from the NAVIGATOR Trial Epidemiology
BackgroundRegional differences in risk of diabetes mellitus and cardiovascular outcomes in people with impaired glucose tolerance are poorly characterized. Our objective was to evaluate regional variation in risk of new‐onset diabetes mellitus, cardiovascular outcomes, and treatment effects in participants from the NAVIGATOR (Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research) trial.Methods and ResultsNAVIGATOR randomized people with impaired glucose tolerance and cardiovascular risk factors or with established cardiovascular disease to valsartan (or placebo) and to nateglinide (or placebo) with a ...
Source: JAHA:Journal of the American Heart Association - January 13, 2017 Category: Cardiology Authors: Harumi Higuchi dos Santos, M., Sharma, A., Sun, J.-L., Pieper, K., McMurray, J. J. V., Holman, R. R., Lopes, R. D. Tags: Cardiovascular Disease, Diabetes, Type 2, Risk Factors Original Research Source Type: research

Outcomes Associated With Familial Versus Nonfamilial Atrial Fibrillation: A Matched Nationwide Cohort Study Arrhythmia and Electrophysiology
ConclusionsAlthough family history of AF is associated with increased likelihood for development of AF, once AF developed, long‐term risks of death and thromboembolic complications were similar in familial and nonfamilial AF patients.
Source: JAHA:Journal of the American Heart Association - November 18, 2016 Category: Cardiology Authors: Gundlund, A., Olesen, J. B., Staerk, L., Lee, C., Piccini, J. P., Peterson, E. D., Kober, L., Torp-Pedersen, C., Gislason, G. H., Fosbol, E. L. Tags: Atrial Fibrillation, Epidemiology Original Research Source Type: research

Neurological Inȷury in Intermediate-Risk Transcatheter Aortic Valve Implantation Interventional Cardiology
ConclusionsObjectively measured subclinical neurological injuries remain a concern in intermediate‐risk patients undergoing TAVI and are likely to manifest with early neurocognitive changes.Clinical Trial RegistrationURL: http://www.anzctr.org.au. Australian & New Zealand Clinical Trials Registry: ACTRN12613000083796.
Source: JAHA:Journal of the American Heart Association - November 14, 2016 Category: Cardiology Authors: Fanning, J. P., Wesley, A. J., Walters, D. L., Eeles, E. M., Barnett, A. G., Platts, D. G., Clarke, A. J., Wong, A. A., Strugnell, W. E., O'Sullivan, C., Tronstad, O., Fraser, J. F. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Cerebrovascular Disease/Stroke, Cognitive Impairment Original Research Source Type: research

Impact of Insurance Status on Outcomes and Use of Rehabilitation Services in Acute Ischemic Stroke: Findings From Get With The Guidelines-Stroke Health Services and Outcomes Research
The objective was to determine whether patients without insurance or with government‐sponsored insurance had worse quality of care or in‐hospital outcomes in acute ischemic stroke.Methods and ResultsMultivariable logistic regressions with generalized estimating equations stratified by age under or at least 65 years were adjusted for patient demographics and comorbidities, presenting factors, and hospital characteristics to determine differences in in‐hospital mortality and postdischarge destination. We included 589 320 ischemic stroke patients treated at 1604 US hospitals participating in the Get With The Guideline...
Source: JAHA:Journal of the American Heart Association - November 13, 2016 Category: Cardiology Authors: Medford-Davis, L. N., Fonarow, G. C., Bhatt, D. L., Xu, H., Smith, E. E., Suter, R., Peterson, E. D., Xian, Y., Matsouaka, R. A., Schwamm, L. H. Tags: Ischemic Stroke Original Research Source Type: research

Histological Findings and Predictors of Cerebral Debris From Transcatheter Aortic Valve Replacement: The ALSTER Experience Arrhythmia and Electrophysiology
ConclusionThis study showed a high rate of embolic debris consisting of typical anatomic structures known to be altered in patients with aortic stenosis undergoing transcatheter aortic valve replacement. Female patients with diabetes mellitus have increased risk of embolic debris and should be protected by a cerebral protection system during transcatheter aortic valve replacement. Because valve tissue embolizes more often in patients with predilation, procedural planning should consider this finding. Both cerebral arteries (brachiocephalic trunk, left carotid artery) should be protected in the same way.
Source: JAHA:Journal of the American Heart Association - November 9, 2016 Category: Cardiology Authors: Schmidt, T., Akdag, O., Wohlmuth, P., Thielsen, T., Schewel, D., Schewel, J., Alessandrini, H., Kreidel, F., Bader, R., Romero, M., Ladich, E., Virmani, R., Schafer, U., Kuck, K.–H., Frerker, C. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Catheter-Based Coronary and Valvular Interventions, Treatment Original Research Source Type: research

Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromso Study Epidemiology
ConclusionsThe risk of VTE increased during the first 3 months after an ischemic stroke. The particularly high risk of provoked VTE suggests that additional predisposing factors, such as immobilization, potentiate the VTE risk in patients with ischemic stroke.
Source: JAHA:Journal of the American Heart Association - November 6, 2016 Category: Cardiology Authors: Rinde, L. B., Smabrekke, B., Mathiesen, E. B., Lochen, M.–L., Nȷolstad, I., Hald, E. M., Wilsgaard, T., Brakkan, S. K., Hansen, J.–B. Tags: Epidemiology, Risk Factors, Ischemic Stroke, Thrombosis Original Research Source Type: research

Coronary Artery Calcium Score Improves the Prediction of Occult Coronary Artery Stenosis in Ischemic Stroke Patients Stroke
BackgroundCoronary heart disease is a significant cause of morbidity and mortality in stroke patients. The coronary artery calcium score (CACS) has emerged as a robust and noninvasive predictor of coronary events. We assessed the predictive ability of CACS to identify stroke patients with severe (≥50%) occult coronary artery stenosis in a stroke/transient ischemic attack population, in addition to the PRECORIS score, based on Framingham Risk Score and presence of cervicocephalic artery stenosis, which was derived and validated for that purpose.Methods and ResultsWe enrolled consecutive patients aged 45 to 75 years refer...
Source: JAHA:Journal of the American Heart Association - October 30, 2016 Category: Cardiology Authors: Beigneux, Y., Sablayrolles, J.-L., Varenne, O., Mas, J.-L., Calvet, D. Tags: Computerized Tomography (CT), Ischemic Stroke, Transient Ischemic Attack (TIA), Atherosclerosis, Coronary Artery Disease Original Research Source Type: research

Hypertensive Disorders of Pregnancy and Offspring Cardiac Structure and Function in Adolescence Epidemiology
ConclusionsAdolescent offspring exposed to maternal preeclampsia had greater relative wall thickness and reduced left ventricular end‐diastolic volume, which could be early signs of concentric remodeling and affect future cardiac function as well as risk of cardiovascular disease.
Source: JAHA:Journal of the American Heart Association - October 30, 2016 Category: Cardiology Authors: Timpka, S., Macdonald-Wallis, C., Hughes, A. D., Chaturvedi, N., Franks, P. W., Lawlor, D. A., Fraser, A. Tags: Epidemiology, Pediatrics, Primary Prevention, Risk Factors, Remodeling Original Research Source Type: research

Short-Term Risk of Bleeding During Heparin Bridging at Initiation of Vitamin K Antagonist Therapy in More Than 90 000 Patients With Nonvalvular Atrial Fibrillation Managed in Outpatient Care Epidemiology
BackgroundSeveral studies have recently examined the risks of bleeding and of ischemic stroke and systemic embolism associated with perioperative heparin bridging anticoagulation in patients with nonvalvular atrial fibrillation. However, few studies have investigated bridging risks during vitamin K antagonist initiation in outpatient settings.Methods and ResultsA retrospective cohort study was conducted on individuals starting oral anticoagulation between January 2010 and November 2014 for nonvalvular atrial fibrillation managed in outpatient care and identified from French healthcare insurance. Bleeding and ischemic strok...
Source: JAHA:Journal of the American Heart Association - October 30, 2016 Category: Cardiology Authors: Bouillon, K., Bertrand, M., Boudali, L., Ducimetiere, P., Dray-Spira, R., Zureik, M. Tags: Atrial Fibrillation, Epidemiology Original Research Source Type: research

Relative Contributions of Arterial Stiffness and Hypertension to Cardiovascular Disease: The Framingham Heart Study Epidemiology
ConclusionsA substantial proportion of treated hypertensives have high arterial stiffness, a finding that may explain some of the notable residual CVD risk associated with even well‐controlled hypertension. High PWV is associated with a trend towards increasing CVD risk in both nonhypertensives and hypertensives, a finding that may support the use of arterial stiffness measurements in both populations.
Source: JAHA:Journal of the American Heart Association - October 25, 2016 Category: Cardiology Authors: Niiranen, T. J., Kalesan, B., Hamburg, N. M., Benjamin, E. J., Mitchell, G. F., Vasan, R. S. Tags: Cardiovascular Disease, Epidemiology, High Blood Pressure, Hypertension, Vascular Disease Original Research Source Type: research

Impact of Proton Pump Inhibitor Use on the Comparative Effectiveness and Safety of Prasugrel Versus Clopidogrel: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study Health Services and Outcomes Research
Conclusions PPIs did not significantly affect the MACE and bleeding risk associated with prasugrel use, relative to clopidogrel. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT01088503.
Source: JAHA:Journal of the American Heart Association - October 20, 2016 Category: Cardiology Authors: Jackson, L. R., Peterson, E. D., McCoy, L. A., Ju, C., Zettler, M., Baker, B. A., Messenger, J. C., Faries, D. E., Effron, M. B., Cohen, D. J., Wang, T. Y. Tags: Quality and Outcomes Health Services and Outcomes Research Source Type: research

Relationship Between QT Interval and Outcome in Low-Flow Low-Gradient Aortic Stenosis With Low Left Ventricular Ejection Fraction Valvular Heart Disease
Conclusions In patients with LF-LG AS and reduced LVEF, longer QTc interval was associated with worse LV function and increased risk of death. Assessment of QTc may provide a simple and inexpensive tool to enhance risk stratification in LF-LG AS patients. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT 01835028.
Source: JAHA:Journal of the American Heart Association - October 19, 2016 Category: Cardiology Authors: Dahou, A., Toubal, O., Clavel, M.-A., Beaudoin, J., Magne, J., Mathieu, P., Philippon, F., Dumesnil, J. G., Puri, R., Ribeiro, H. B., Larose, E., Rodes-Cabau, J., Pibarot, P. Tags: Heart Failure, Valvular Heart Disease, Echocardiography, Electrocardiology (ECG), Prognosis Source Type: research

Relationship Between QT Interval and Outcome in Low-Flow Low-Gradient Aortic Stenosis With Low Left Ventricular Eȷection Fraction Valvular Heart Disease
ConclusionsIn patients with LF‐LG AS and reduced LVEF, longer QTc interval was associated with worse LV function and increased risk of death. Assessment of QTc may provide a simple and inexpensive tool to enhance risk stratification in LF‐LG AS patients.Clinical Trial RegistrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT 01835028.
Source: JAHA:Journal of the American Heart Association - October 19, 2016 Category: Cardiology Authors: Dahou, A., Toubal, O., Clavel, M.–A., Beaudoin, J., Magne, J., Mathieu, P., Philippon, F., Dumesnil, J. G., Puri, R., Ribeiro, H. B., Larose, E., Rodes-Cabau, J., Pibarot, P. Tags: Heart Failure, Valvular Heart Disease, Echocardiography, Electrocardiology (ECG), Prognosis Original Research Source Type: research

Use of Chronic Oral Anticoagulation and Associated Outcomes Among Patients Undergoing Percutaneous Coronary Intervention Epidemiology
Conclusions Chronic OAC therapy is frequent among contemporary patients undergoing PCI. After adjustment for potential confounders, OAC-treated patients experienced greater in-hospital bleeding, more readmissions, and decreased long-term survival following PCI. Efforts are needed to reduce the occurrence of adverse events in this population.
Source: JAHA:Journal of the American Heart Association - October 16, 2016 Category: Cardiology Authors: Secemsky, E. A., Butala, N. M., Kartoun, U., Mahmood, S., Wasfy, J. H., Kennedy, K. F., Shaw, S. Y., Yeh, R. W. Tags: Epidemiology, Risk Factors, Percutaneous Coronary Intervention, Complications, Quality and Outcomes Source Type: research