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Source: JAHA:Journal of the American Heart Association

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Total 334 results found since Jan 2013.

Cerebral Microbleeds, Vascular Risk Factors, and Magnetic Resonance Imaging Markers: The Northern Manhattan Study Epidemiology
ConclusionsCMBs may represent the severity of vascular disease in this racially and ethnically diverse cohort. Larger studies are needed to elucidate the association between diabetes medication use and CMB presence.
Source: JAHA:Journal of the American Heart Association - September 16, 2016 Category: Cardiology Authors: Caunca, M. R., Del Brutto, V., Gardener, H., Shah, N., Dequatre-Ponchelle, N., Cheung, Y. K., Elkind, M. S. V., Brown, T. R., Cordonnier, C., Sacco, R. L., Wright, C. B. Tags: Epidemiology, Race and Ethnicity Original Research Source Type: research

Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvencion con DIeta MEDiterranea (PREDIMED) Trial Epidemiology
Conclusions Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels. Clinical Trial Registration URL: www.controlled-trials.com. Unique identifier: ISRCTN 35739639.
Source: JAHA:Journal of the American Heart Association - September 15, 2016 Category: Cardiology Authors: Zheng, Y., Hu, F. B., Ruiz-Canela, M., Clish, C. B., Dennis, C., Salas-Salvado, J., Hruby, A., Liang, L., Toledo, E., Corella, D., Ros, E., Fito, M., Gomez-Gracia, E., Aros, F., Fiol, M., Lapetra, J., Serra-Majem, L., Estruch, R., Martinez-Gonzalez, M. A. Tags: Etiology, Cardiovascular Disease, Diet and Nutrition, Epidemiology, Acute Coronary Syndromes Source Type: research

Quantifying the Association Between Physical Activity and Cardiovascular Disease and Diabetes: A Systematic Review and Meta-Analysis Epidemiology
Conclusions By using a single continuous metric for PA levels, we were able to make a comparison of the effect of PA on CVD incidence and mortality including myocardial infarct (MI), stroke, and heart failure, as well as T2DM. Effect sizes were generally similar for CVD and T2DM, and suggested that the greatest gain in health is associated with moving from inactivity to small amounts of PA.
Source: JAHA:Journal of the American Heart Association - September 14, 2016 Category: Cardiology Authors: Wahid, A., Manek, N., Nichols, M., Kelly, P., Foster, C., Webster, P., Kaur, A., Friedemann Smith, C., Wilkins, E., Rayner, M., Roberts, N., Scarborough, P. Tags: Epidemiology, Exercise, Primary Prevention, Health Services, Meta Analysis Source Type: research

Impact of Blood Pressure Control on Thromboembolism and Maȷor Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J-RHYTHM Registry Arrhythmia and Electrophysiology
BackgroundTo clarify the influence of hypertension and blood pressure (BP) control on thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed.Methods and ResultsA consecutive series of outpatients with atrial fibrillation was enrolled from 158 institutions. Of 7937 patients, 7406 with nonvalvular atrial fibrillation (70.8% men, 69.8±10.0 years) were followed for 2 years or until an event occurred. Hypertension was defined as a systolic BP ≥140 mm Hg, a diastolic BP ≥90 mm Hg, a history of hypertension, and/or antihyperten...
Source: JAHA:Journal of the American Heart Association - September 12, 2016 Category: Cardiology Authors: Kodani, E., Atarashi, H., Inoue, H., Okumura, K., Yamashita, T., Otsuka, T., Tomita, H., Origasa, H. Tags: Atrial Fibrillation, High Blood Pressure, Hypertension, Intracranial Hemorrhage, Ischemic Stroke Original Research Source Type: research

Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J-RHYTHM Registry Arrhythmia and Electrophysiology
Conclusions BP control appears to be more important than a history of hypertension and baseline BP values at preventing thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation. Clinical Trial Registration URL: http://www.umin.ac.jp/ctr. Unique identifier: UMIN000001569.
Source: JAHA:Journal of the American Heart Association - September 12, 2016 Category: Cardiology Authors: Kodani, E., Atarashi, H., Inoue, H., Okumura, K., Yamashita, T., Otsuka, T., Tomita, H., Origasa, H., the J-RHYTHM Registry Investigators Tags: Atrial Fibrillation, High Blood Pressure, Hypertension, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta-Analysis and Systematic Review Arrhythmia and Electrophysiology
ConclusionsUnderweight BMI is associated with an increased risk of stroke or systemic embolism, cardiovascular death, and all‐cause death in Asian patients with atrial fibrillation, whereas in all atrial fibrillation patients, overweight and obese BMI was not associated with increased risks of these outcomes.
Source: JAHA:Journal of the American Heart Association - September 9, 2016 Category: Cardiology Authors: Zhu, W., Wan, R., Liu, F., Hu, J., Huang, L., Li, J., Hong, K. Tags: Arrhythmias, Atrial Fibrillation, Obesity, Risk Factors Original Research Source Type: research

Economic Impact of Moderate-Vigorous Physical Activity Among Those With and Without Established Cardiovascular Disease: 2012 Medical Expenditure Panel Survey Health Services and Outcomes Research
ConclusionsModerate‐vigorous PA ≥30 minutes, ≥5 days/week is associated with significantly lower health care spending and resource utilization among individuals with and without established CVD.
Source: JAHA:Journal of the American Heart Association - September 7, 2016 Category: Cardiology Authors: Valero-Elizondo, J., Salami, J. A., Osondu, C. U., Ogunmoroti, O., Arrieta, A., Spatz, E. S., Younus, A., Rana, J. S., Virani, S. S., Blankstein, R., Blaha, M. J., Veledar, E., Nasir, K. Tags: Cardiovascular Disease, Exercise, Lifestyle, Risk Factors Original Research Source Type: research

Physical Activity, Parental History of Premature Coronary Heart Disease, and Incident Atherosclerotic Cardiovascular Disease in the Atherosclerosis Risk in Communities (ARIC) Study Preventive Cardiology
ConclusionsPA was associated with a reduced risk of ASCVD among individuals with and without a FHx of premature CHD.
Source: JAHA:Journal of the American Heart Association - August 30, 2016 Category: Cardiology Authors: Florido, R., Zhao, D., Ndumele, C. E., Lutsey, P. L., McEvoy, J. W., Windham, B. G., Pankow, J. S., Guallar, E., Michos, E. D. Tags: Epidemiology, Exercise, Lifestyle, Primary Prevention, Risk Factors Original Research Source Type: research

Late-Onset Asthma Predicts Cardiovascular Disease Events: The Wisconsin Sleep Cohort Epidemiology
BackgroundAsthma is a heterogeneous syndrome with different clinical subtypes that is associated with an increased risk for cardiovascular disease (CVD). We hypothesized that the late‐onset subtype of asthma is associated with a higher risk of incident CVD.Methods and ResultsParticipants from the Wisconsin Sleep Cohort free of CVD at baseline were followed for a mean (SD) of 13.9 (5.9) years for development of CVD (myocardial infarction, angina, stroke, coronary revascularization, heart failure, or CVD death). Late‐onset asthma was defined as physician‐diagnosed asthma at age ≥18 years. Multivariable Cox regressio...
Source: JAHA:Journal of the American Heart Association - August 24, 2016 Category: Cardiology Authors: Tattersall, M. C., Barnet, J. H., Korcarz, C. E., Hagen, E. W., Peppard, P. E., Stein, J. H. Tags: Cardiovascular Disease, Epidemiology Original Research Source Type: research

Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials Epidemiology
Conclusions Our meta-analysis indicated a 10% lower risk of stroke and a 4% lower risk of overall CVD with folic acid supplementation. A greater benefit for CVD was observed among participants with lower plasma folate levels and without preexisting CVD and in studies with larger decreases in homocysteine levels. Folic acid supplementation had no significant effect on risk of coronary heart disease.
Source: JAHA:Journal of the American Heart Association - August 15, 2016 Category: Cardiology Authors: Li, Y., Huang, T., Zheng, Y., Muka, T., Troup, J., Hu, F. B. Tags: Cardiovascular Disease, Diet and Nutrition Epidemiology Source Type: research

Consistency of Hemoglobin A1c Testing and Cardiovascular Outcomes in Medicare Patients With Diabetes Health Services and Outcomes Research
Conclusions Consistent annual hemoglobin A1c testing is associated with fewer adverse cardiovascular outcomes in this observational cohort of Medicare patients of diabetes mellitus.
Source: JAHA:Journal of the American Heart Association - August 10, 2016 Category: Cardiology Authors: Goodney, P. P., Newhall, K. A., Bekelis, K., Gottlieb, D., Comi, R., Chaudrain, S., Faerber, A. E., Mackenzie, T. A., Skinner, J. S. Tags: Diabetes, Type 1, Diabetes, Type 2, Quality and Outcomes, Peripheral Vascular Disease, Vascular Disease Health Services and Outcomes Research Source Type: research

Obesity and Subtypes of Incident Cardiovascular Disease Epidemiology
Conclusions The link between obesity and HF was stronger than those for other CVD subtypes and was uniquely unexplained by traditional risk factors. Weight management is likely critical for optimal HF prevention, and nontraditional pathways linking obesity to HF need to be elucidated.
Source: JAHA:Journal of the American Heart Association - July 28, 2016 Category: Cardiology Authors: Ndumele, C. E., Matsushita, K., Lazo, M., Bello, N., Blumenthal, R. S., Gerstenblith, G., Nambi, V., Ballantyne, C. M., Solomon, S. D., Selvin, E., Folsom, A. R., Coresh, J. Tags: Cardiovascular Disease, Epidemiology, Obesity Source Type: research

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation Epidemiology
Conclusions Exposure to PM2.5 increased the likelihood of having severe coronary artery disease and the risk of incident myocardial infarction among patients undergoing elective cardiac evaluation. These results suggest that ambient air pollution exposure may be a modifiable risk factor for risk of myocardial infarction in a highly susceptible patient population.
Source: JAHA:Journal of the American Heart Association - July 28, 2016 Category: Cardiology Authors: Hartiala, J., Breton, C. V., Tang, W. H. W., Lurmann, F., Hazen, S. L., Gilliland, F. D., Allayee, H. Tags: Epidemiology, Secondary Prevention, Quality and Outcomes, Coronary Artery Disease Source Type: research

Obesity and Subtypes of Incident Cardiovascular Disease Epidemiology
BackgroundObesity is a risk factor for various subtypes of cardiovascular disease (CVD), including coronary heart disease (CHD), heart failure (HF), and stroke. Nevertheless, there are limited comparisons of the associations of obesity with each of these CVD subtypes, particularly regarding the extent to which they are unexplained by traditional CVD mediators.Methods and ResultsWe followed 13 730 participants in the Atherosclerosis Risk in Communities (ARIC) study who had a body mass index ≥18.5 and no CVD at baseline (visit 1, 1987–1989). We compared the association of higher body mass index with incident HF, CHD, a...
Source: JAHA:Journal of the American Heart Association - July 28, 2016 Category: Cardiology Authors: Ndumele, C. E., Matsushita, K., Lazo, M., Bello, N., Blumenthal, R. S., Gerstenblith, G., Nambi, V., Ballantyne, C. M., Solomon, S. D., Selvin, E., Folsom, A. R., Coresh, J. Tags: Cardiovascular Disease, Epidemiology, Obesity Original Research Source Type: research

Critical Role of Coaptive Strain in Aortic Valve Leaflet Homeostasis: Use of a Novel Flow Culture Bioreactor to Explore Heart Valve Mechanobiology Cardiovascular Surgery
Conclusions Failure of AV to close initiates an extensive response characterized by expression changes common to progression to calcific aortic valve disease. AV coaptation, whether phasic or chronic, preserved phenotypic gene expression. These results demonstrate, for the first time, that coaptation of valve leaflets is a fundamentally important biomechanical cue driving homeostasis.
Source: JAHA:Journal of the American Heart Association - July 27, 2016 Category: Cardiology Authors: Maeda, K., Ma, X., Hanley, F. L., Riemer, R. K. Tags: Animal Models of Human Disease, Basic Science Research, Etiology, Physiology, Translational Studies Cardiovascular Surgery Source Type: research

Nocturnal Hypoxemia Due to Obstructive Sleep Apnea Is an Independent Predictor of Poor Prognosis After Myocardial Infarction Coronary Heart Disease
ConclusionsNocturnal hypoxemia in OSA is an important predictor of poor prognosis for patients after MI. These findings suggest that routine use of low‐cost nocturnal oximetry may be an economical and practical approach to stratify risk in post‐MI patients.
Source: JAHA:Journal of the American Heart Association - July 27, 2016 Category: Cardiology Authors: Xie, J., Sert Kuniyoshi, F. H., Covassin, N., Singh, P., Gami, A. S., Wang, S., Chahal, C. A. A., Wei, Y., Somers, V. K. Tags: Risk Factors, Acute Coronary Syndromes Original Research Source Type: research

Critical Role of Coaptive Strain in Aortic Valve Leaflet Homeostasis: Use of a Novel Flow Culture Bioreactor to Explore Heart Valve Mechanobiology Cardiovascular Surgery
ConclusionsFailure of AV to close initiates an extensive response characterized by expression changes common to progression to calcific aortic valve disease. AV coaptation, whether phasic or chronic, preserved phenotypic gene expression. These results demonstrate, for the first time, that coaptation of valve leaflets is a fundamentally important biomechanical cue driving homeostasis.
Source: JAHA:Journal of the American Heart Association - July 27, 2016 Category: Cardiology Authors: Maeda, K., Ma, X., Hanley, F. L., Riemer, R. K. Tags: Animal Models of Human Disease, Basic Science Research, Etiology, Physiology, Translational Studies Original Research Source Type: research

Nocturnal Hypoxemia Due to Obstructive Sleep Apnea Is an Independent Predictor of Poor Prognosis After Myocardial Infarction Coronary Heart Disease
Conclusions Nocturnal hypoxemia in OSA is an important predictor of poor prognosis for patients after MI. These findings suggest that routine use of low-cost nocturnal oximetry may be an economical and practical approach to stratify risk in post-MI patients.
Source: JAHA:Journal of the American Heart Association - July 27, 2016 Category: Cardiology Authors: Xie, J., Sert Kuniyoshi, F. H., Covassin, N., Singh, P., Gami, A. S., Wang, S., Chahal, C. A. A., Wei, Y., Somers, V. K. Tags: Risk Factors, Acute Coronary Syndromes Coronary Heart Disease Source Type: research

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study Kidney in Cardiovascular Disease
Conclusions Even mildly reduced eGFR (under 90 mL/min per 1.73 m2) is associated with elevated 10-year Framingham risk for CHD and 10-year ASCVD risk among Chinese adults.
Source: JAHA:Journal of the American Heart Association - July 22, 2016 Category: Cardiology Authors: Lu, J., Mu, Y., Su, Q., Shi, L., Liu, C., Zhao, J., Chen, L., Li, Q., Yang, T., Yan, L., Wan, Q., Wu, S., Liu, Y., Wang, G., Luo, Z., Tang, X., Chen, G., Huo, Y., Gao, Z., Ye, Z., Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Sun, J., Tags: Cardiovascular Disease, Epidemiology, Lifestyle, Risk Factors Kidney in Cardiovascular Disease Source Type: research

Stability of High-Quality Warfarin Anticoagulation in a Community-Based Atrial Fibrillation Cohort: The Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study Epidemiology
Conclusions Nearly 60% of AF patients with high-quality TTR1 on warfarin maintained TTR ≥70% over the next 6 months. A minority deteriorated to very poor TTR. Patient features did not strongly predict TTR in the second 6-month period. Our analyses support watchful waiting for AF patients with initial high-quality warfarin anticoagulation before considering alternative anticoagulants.
Source: JAHA:Journal of the American Heart Association - July 22, 2016 Category: Cardiology Authors: Dallalzadeh, L. O., Go, A. S., Chang, Y., Borowsky, L. H., Fang, M. C., Singer, D. E. Tags: Atrial Fibrillation, Epidemiology, Primary Prevention, Anticoagulants Source Type: research

Impact of South Asian Ethnicity on Long-Term Outcomes After Coronary Artery Bypass Grafting Surgery: A Large Population-Based Propensity Matched Study Cardiovascular Surgery
Conclusions Contrary to existing notions, our study finds that being a SA is protective with respect to freedom from long-term major adverse cardiac and cerebrovascular events and mortality after CABG. More studies are required to corroborate and explore causal factors of these findings.
Source: JAHA:Journal of the American Heart Association - July 22, 2016 Category: Cardiology Authors: Deb, S., Tu, J. V., Austin, P. C., Ko, D. T., Rocha, R., Mazer, C. D., Kiss, A., Fremes, S. E. Tags: Clinical Studies, Race and Ethnicity, Cardiovascular Surgery, Revascularization, Mortality/Survival Source Type: research

Stability of High-Quality Warfarin Anticoagulation in a Community-Based Atrial Fibrillation Cohort: The Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study Epidemiology
BackgroundWarfarin reduces ischemic stroke risk in atrial fibrillation (AF) but increases bleeding risk. Novel anticoagulants challenge warfarin as stroke‐preventive therapy for AF. They are available at fixed doses but are more costly. Warfarin anticoagulation at a time in therapeutic range (TTR) ≥70% is similarly as effective and safe as novel anticoagulants. It is unclear whether AF patients with TTR ≥70% will remain stably anticoagulated and avoid the need to switch to a novel anticoagulant. We assessed stability of warfarin anticoagulation in AF patients with an initial TTR ≥70%.Methods and ResultsWithin the c...
Source: JAHA:Journal of the American Heart Association - July 22, 2016 Category: Cardiology Authors: Dallalzadeh, L. O., Go, A. S., Chang, Y., Borowsky, L. H., Fang, M. C., Singer, D. E. Tags: Atrial Fibrillation, Epidemiology, Primary Prevention, Anticoagulants Original Research Source Type: research

Diagnostic Performance of a Smartphone-Based Photoplethysmographic Application for Atrial Fibrillation Screening in a Primary Care Setting Arrhythmia and Electrophysiology
Conclusions The Cardiio Rhythm smartphone PPG application provides an accurate and reliable means to detect AF in patients at risk of developing AF and has the potential to enable population-based screening for AF.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Chan, P.-H., Wong, C.-K., Poh, Y. C., Pun, L., Leung, W. W.-C., Wong, Y.-F., Wong, M. M.-Y., Poh, M.-Z., Chu, D. W.-S., Siu, C.-W. Tags: Atrial Fibrillation Arrhythmia and Electrophysiology Source Type: research

Incidence and Predictors of Complications During Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions In a large contemporary cohort, cryoballoon PVI is associated with low procedural risk, including lower rates of PNI than previously reported. Older age and 23-mm balloon use were associated with PNI. Our low rate of PNI may reflect more sensitive detection methods, including compound motor action potential monitoring and forced double-deflation.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Guhl, E. N., Siddoway, D., Adelstein, E., Bazaz, R., Mendenhall, G. S., Nemec, J., Saba, S., Schwartzman, D., Voigt, A., Wang, N. C., Jain, S. K. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Arrhythmia and Electrophysiology Source Type: research

Diagnostic Performance of a Smartphone-Based Photoplethysmographic Application for Atrial Fibrillation Screening in a Primary Care Setting Arrhythmia and Electrophysiology
ConclusionsThe Cardiio Rhythm smartphone PPG application provides an accurate and reliable means to detect AF in patients at risk of developing AF and has the potential to enable population‐based screening for AF.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Chan, P.-H., Wong, C.-K., Poh, Y. C., Pun, L., Leung, W. W.-C., Wong, Y.-F., Wong, M. M.-Y., Poh, M.-Z., Chu, D. W.-S., Siu, C.-W. Tags: Atrial Fibrillation Original Research Source Type: research

Incidence and Predictors of Complications During Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation Arrhythmia and Electrophysiology
ConclusionsIn a large contemporary cohort, cryoballoon PVI is associated with low procedural risk, including lower rates of PNI than previously reported. Older age and 23‐mm balloon use were associated with PNI. Our low rate of PNI may reflect more sensitive detection methods, including compound motor action potential monitoring and forced double‐deflation.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Guhl, E. N., Siddoway, D., Adelstein, E., Bazaz, R., Mendenhall, G. S., Nemec, J., Saba, S., Schwartzman, D., Voigt, A., Wang, N. C., Jain, S. K. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Original Research Source Type: research

Universal Classification System Type of Incident Myocardial Infarction in Patients With Stable Atherosclerosis: Observations From Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2{degrees}P)-TIMI 50 Coronary Heart Disease
Conclusions Among stable patients with established atherosclerosis, the most common type of incident MI is spontaneous MI, and the reduction in MI with vorapaxar was consistent across MIs of varying type and size, including spontaneous infarctions ≥10x upper reference limit. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT00526474.
Source: JAHA:Journal of the American Heart Association - July 18, 2016 Category: Cardiology Authors: Kidd, S. K., Bonaca, M. P., Braunwald, E., De Ferrari, G. M., Lewis, B. S., Merlini, P. A., Murphy, S. A., Scirica, B. M., White, H. D., Morrow, D. A. Tags: Clinical Studies, Ischemia, Platelets Coronary Heart Disease Source Type: research

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms Genetics
Conclusions Although there was no evidence for polygenic overlap between IAs, AAAs, and TAAs, we found nominally significant effects of two established risk loci for IAs and TAAs in AAAs. These two loci will require further replication.
Source: JAHA:Journal of the American Heart Association - July 14, 2016 Category: Cardiology Authors: van t Hof, F. N. G., Ruigrok, Y. M., Lee, C. H., Ripke, S., Anderson, G., de Andrade, M., Baas, A. F., Blankensteijn, J. D., Böttinger, E. P., Bown, M. J., Broderick, J., Bijlenga, P., Carrell, D. S., Crawford, D. C., Crosslin, D. R., Ebeling, C., Tags: Inflammation, Vascular Biology, Ischemic Stroke Genetics Source Type: research

Prevalence of Eligibility Criteria for the Systolic Blood Pressure Intervention Trial in US Adults Among Excluded Groups: Age
Conclusions A substantial percentage of US adults with diabetes mellitus or history of stroke and a small percentage <50 years old meet the other SPRINT eligibility criteria.
Source: JAHA:Journal of the American Heart Association - July 12, 2016 Category: Cardiology Authors: Bress, A. P., Tanner, R. M., Hess, R., Gidding, S. S., Colantonio, L. D., Shimbo, D., Muntner, P. Tags: Epidemiology, High Blood Pressure, Hypertension Source Type: research

Atrial Fibrillation Patients Treated With Long-Term Warfarin Anticoagulation Have Higher Rates of All Dementia Types Compared With Patients Receiving Long-Term Warfarin for Other Indications Cardiovascular Surgery
Conclusions The presence of AF significantly increases risk of dementia, including Alzheimer's disease, compared with matched patients receiving warfarin anticoagulation for other reasons. Quality of anticoagulation management remains an important risk factor for dementia in all patients.
Source: JAHA:Journal of the American Heart Association - July 11, 2016 Category: Cardiology Authors: Bunch, T. J., May, H. T., Bair, T. L., Crandall, B. G., Cutler, M. J., Day, J. D., Jacobs, V., Mallender, C., Osborn, J. S., Stevens, S. M., Weiss, J. P., Woller, S. C. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation Cardiovascular Surgery Source Type: research

Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women Vascular Medicine
Conclusions The foremost difference in cardiovascular regulation between sexes was higher upright hemodynamic workload for the heart in men, a finding not explained by known cardiovascular risk factors or hormonal differences before menopause. Heart rate variability analyses indicated higher sympathovagal balance in men regardless of body position. The deviations in upright hemodynamics could play a role in the differences in cardiovascular risk between men and women. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01742702.
Source: JAHA:Journal of the American Heart Association - June 21, 2016 Category: Cardiology Authors: Kangas, P., Tahvanainen, A., Tikkakoski, A., Koskela, J., Uitto, M., Viik, J., Kähönen, M., Kööbi, T., Mustonen, J., Pörsti, I. Tags: Autonomic Nervous System, Clinical Studies, Hemodynamics Vascular Medicine Source Type: research

Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease Coronary Heart Disease
Conclusions Although high Lp-PLA2 activity was associated with increased risk of cardiovascular events, pharmacological lowering of Lp-PLA2 activity by 65% did not significantly reduce cardiovascular events in patients with stable coronary heart disease, regardless of the baseline level or the magnitude of change of Lp-PLA2 activity. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT00799903.
Source: JAHA:Journal of the American Heart Association - June 21, 2016 Category: Cardiology Authors: Wallentin, L., Held, C., Armstrong, P. W., Cannon, C. P., Davies, R. Y., Granger, C. B., Hagström, E., Harrington, R. A., Hochman, J. S., Koenig, W., Krug-Gourley, S., Mohler, E. R., Siegbahn, A., Tarka, E., Steg, P. G., Stewart, R. A. H., Weiss, Tags: Biomarkers, Risk Factors, Pharmacology, Treatment, Coronary Artery Disease Coronary Heart Disease Source Type: research

Impact of Sleep-Disordered Breathing on Long-Term Outcomes in Patients With Acute Coronary Syndrome Who Have Undergone Primary Percutaneous Coronary Intervention Coronary Heart Disease
Conclusions The study's results showed that the presence of SDB among patients with acute coronary syndrome following primary percutaneous coronary intervention is associated with a higher incidence of major adverse cardiocerebrovascular events during long-term follow-up.
Source: JAHA:Journal of the American Heart Association - June 15, 2016 Category: Cardiology Authors: Mazaki, T., Kasai, T., Yokoi, H., Kuramitsu, S., Yamaji, K., Morinaga, T., Masuda, H., Shirai, S., Ando, K. Tags: Risk Factors, Quality and Outcomes, Acute Coronary Syndromes Coronary Heart Disease Source Type: research

Circulating Levels of IL-6 Receptor and gp130 and Long-Term Clinical Outcomes in ST-Elevation Myocardial Infarction Coronary Heart Disease
Conclusion High levels of sIL-6R were associated with future cardiovascular events and mortality in STEMI patients, suggesting an important role of the IL-6 signaling system.
Source: JAHA:Journal of the American Heart Association - June 13, 2016 Category: Cardiology Authors: Ritschel, V. N., Seljeflot, I., Arnesen, H., Halvorsen, S., Eritsland, J., Fagerland, M. W., Andersen, G. O. Tags: Biomarkers, Inflammation, Ischemia Coronary Heart Disease Source Type: research

High-Fat-Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders Vascular Medicine
Conclusions High-fat diet, independently of metabolic disorders, significantly promotes the progression of AD-like pathology through enhancement of cerebral amyloid angiopathy and oxidative stress.
Source: JAHA:Journal of the American Heart Association - June 13, 2016 Category: Cardiology Authors: Lin, B., Hasegawa, Y., Takane, K., Koibuchi, N., Cao, C., Kim-Mitsuyama, S. Tags: Diet and Nutrition, Cerebrovascular Disease/Stroke, Cognitive Impairment Vascular Medicine Source Type: research

Transcatheter Aortic Valve Implantation With or Without Preimplantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-Analysis Interventional Cardiology
Conclusions Our analysis suggests that TAVI procedures with or without preimplantation BAV were associated with similar outcomes for a number of clinically relevant end points. Further studies including a large number of patients are needed to ascertain the impact of TAVI without preimplantation BAV as a standard practice.
Source: JAHA:Journal of the American Heart Association - June 13, 2016 Category: Cardiology Authors: Bagur, R., Kwok, C. S., Nombela-Franco, L., Ludman, P. F., de Belder, M. A., Sponga, S., Gunning, M., Nolan, J., Diamantouros, P., Teefy, P. J., Kiaii, B., Chu, M. W. A., Mamas, M. A. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Catheter-Based Coronary and Valvular Interventions Interventional Cardiology Source Type: research

Pacemakers as Atrial Fibrillation Detectors: Finding Racial Differences and Opportunities for Preventing Stroke Correction
Source: JAHA:Journal of the American Heart Association - May 12, 2016 Category: Cardiology Tags: Correction Source Type: research

Associations of Trauma Exposure and Posttraumatic Stress Symptoms With Venous Thromboembolism Over 22 Years in Women Epidemiology
Conclusions Women with the highest PTSD symptom levels had nearly a 2-fold increased risk of VTE compared to women without trauma exposure in fully adjusted models. Trauma exposure alone was also associated with elevated VTE risk. Trauma and PTSD symptoms may be associated with a hypercoagulable state. Treatment providers should be aware that women with trauma exposure and PTSD symptoms may be vulnerable to VTE.
Source: JAHA:Journal of the American Heart Association - May 12, 2016 Category: Cardiology Authors: Sumner, J. A., Kubzansky, L. D., Kabrhel, C., Roberts, A. L., Chen, Q., Winning, A., Gilsanz, P., Rimm, E. B., Glymour, M. M., Koenen, K. C. Tags: Epidemiology, Mental Health, Women Source Type: research

Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry Health Services and Outcomes Research
Conclusions In a contemporary AF cohort, use of OAC overall and use of NOACs were not significantly lower among Medicaid patients relative to others. However, among warfarin users, Medicaid patients spent less time in therapeutic range compared with those with other forms of insurance.
Source: JAHA:Journal of the American Heart Association - May 4, 2016 Category: Cardiology Authors: O'Brien, E. C., Kim, S., Thomas, L., Fonarow, G. C., Kowey, P. R., Mahaffey, K. W., Gersh, B. J., Piccini, J. P., Peterson, E. D. Tags: Atrial Fibrillation, Primary Prevention, Health Services, Quality and Outcomes Health Services and Outcomes Research Source Type: research

Association of Thoracic Aorta Calcium Score With Exercise Blood Pressure Response and Clinical Outcomes in Elderly Individuals: Differential Impact of Aorta Calcification Compared With Coronary Artery Calcification Preventive Cardiology
Conclusions Aortic calcification was related to SBP response during exercise and was an independent predictor for outcomes, especially stroke, regardless of resting SBP or CACS.
Source: JAHA:Journal of the American Heart Association - April 22, 2016 Category: Cardiology Authors: Cho, I.-J., Chang, H.-J., Cho, I., Heo, R., Lee, S.-E., Shim, C. Y., Hong, G.-R., Chung, N. Tags: Computerized Tomography (CT) Preventive Cardiology Source Type: research

Comparative Effectiveness of Generic Atorvastatin and Lipitor(R) in Patients Hospitalized with an Acute Coronary Syndrome Health Services and Outcomes Research
Conclusions Among older adults discharged alive after ACS hospitalization, we found no significant difference in cardiovascular outcomes or serious, infrequent side effects in patients prescribed generic atorvastatin compared with those prescribed Lipitor® at 1 year. Our findings support the use of generic atorvastatin in ACS, which could lead to substantial cost saving for patients and health care plans without diminishing population clinical effectiveness.
Source: JAHA:Journal of the American Heart Association - April 19, 2016 Category: Cardiology Authors: Jackevicius, C. A., Tu, J. V., Krumholz, H. M., Austin, P. C., Ross, J. S., Stukel, T. A., Koh, M., Chong, A., Ko, D. T. Tags: Atrial Fibrillation, Quality and Outcomes Health Services and Outcomes Research Source Type: research