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Source: JAHA:Journal of the American Heart Association

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Total 381 results found since Jan 2013.

Post-Acute Care Data for Predicting Readmission After Ischemic Stroke: A Nationwide Cohort Analysis Using the Minimum Data Set Stroke
Conclusions Individual clinical characteristics from the post–acute care setting resulted in only modest improvement in the c-statistic relative to previous models that used only Medicare Part A data. Individual-level characteristics do not sufficiently account for the risk of acute hospital readmission.
Source: JAHA:Journal of the American Heart Association - September 22, 2015 Category: Cardiology Authors: Fehnel, C. R., Lee, Y., Wendell, L. C., Thompson, B. B., Potter, N. S., Mor, V. Tags: Stroke Source Type: research

Association of Acute and Chronic Hyperglycemia With Acute Ischemic Stroke Outcomes Post-Thrombolysis: Findings From Get With The Guidelines-Stroke Stroke
Conclusion Acute and chronic hyperglycemia are both associated with increased mortality and worse clinical outcomes in AIS patients treated with tPA. Controlled trials are needed to determine whether acute correction of hyperglycemia can improve outcomes after thrombolysis.
Source: JAHA:Journal of the American Heart Association - September 25, 2015 Category: Cardiology Authors: Masrur, S., Cox, M., Bhatt, D. L., Smith, E. E., Ellrodt, G., Fonarow, G. C., Schwamm, L. Tags: Stroke Source Type: research

Interferon-{beta} Modulates Inflammatory Response in Cerebral Ischemia Stroke
Conclusions Our results demonstrate that IFNβ exerts a protective effect against ischemic stroke through its anti-inflammatory properties and suggest that IFNβ is a potential therapeutic agent, targeting the reperfusion damage subsequent to the treatment with tissue plasminogen activator.
Source: JAHA:Journal of the American Heart Association - January 8, 2016 Category: Cardiology Authors: Kuo, P.-C., Scofield, B. A., Yu, I.-C., Chang, F.-L., Ganea, D., Yen, J.-H. Tags: Inflammation, Translational Studies, Treatment, Ischemic Stroke Source Type: research

Effect of Adherence to Oral Anticoagulants on Risk of Stroke and Major Bleeding Among Patients With Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions Adherence to anticoagulation is poor in practice and may be modestly improved with NOACs. Adherence to therapy appears to be most important in patients with CHA2DS2-VASc score ≥2, whereas the benefits of anticoagulation may not outweigh the harms in patients with CHA2DS2-VASc score 0 or 1.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Yao, X., Abraham, N. S., Alexander, G. C., Crown, W., Montori, V. M., Sangaralingham, L. R., Gersh, B. J., Shah, N. D., Noseworthy, P. A. Tags: Arrhythmias, Atrial Fibrillation, Secondary Prevention, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

An Approach to Working Up Cases of Embolic Stroke of Undetermined Source Stroke
Conclusions Our data indicate that patients with cryptogenic embolic stroke show distinct clinical and radiological features depending on the underlying causes.
Source: JAHA:Journal of the American Heart Association - March 21, 2016 Category: Cardiology Authors: Ryoo, S., Chung, J.-W., Lee, M. J., Kim, S. J., Lee, J. S., Kim, G.-M., Chung, C.-S., Lee, K. H., Hong, J. M., Bang, O. Y. Tags: Etiology, Risk Factors, Magnetic Resonance Imaging (MRI), Ischemic Stroke Source Type: research

Intravenous Thrombolysis for Acute Ischemic Stroke in Patients Receiving Antiplatelet Therapy: A Systematic Review and Meta-analysis of 19 Studies Stroke
Conclusions Patients with acute ischemic stroke receiving long-term antiplatelet medications were associated with greater risks of developing symptomatic intracranial hemorrhage after systemic thrombolysis. However, the overall independent association between prestroke antiplatelet therapy and unfavorable outcomes or mortality was insignificant.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Luo, S., Zhuang, M., Zeng, W., Tao, J. Tags: Meta Analysis, Quality and Outcomes, Ischemic Stroke Source Type: research

MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice Stroke
ConclusionsMKEY injection protects against stroke‐induced brain injury, probably by inhibiting MoMΦ‐mediated neuroinflammation.
Source: JAHA:Journal of the American Heart Association - September 14, 2016 Category: Cardiology Authors: Fan, Y., Xiong, X., Zhang, Y., Yan, D., Jian, Z., Xu, B., Zhao, H. Tags: Ischemic Stroke, Neuroprotectants Original Research Source Type: research

Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice Stroke
ConclusionsWe conclude that brain ischemia induces the formation of β‐hydroxybutyrate (ketogenesis) in the liver and the consumption of β‐hydroxybutyrate in the brain. This effect seems to be mediated by β‐adrenergic receptors.
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Koch, K., Berressem, D., Konietzka, J., Thinnes, A., Eckert, G. P., Klein, J. Tags: Ischemia, Metabolism, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Research Source Type: research

Systolic Blood Pressure Within 24 Hours After Thrombectomy for Acute Ischemic Stroke Correlates With Outcome Stroke
ConclusionsHigher peak values of systolic blood pressure independently correlated with worse 90‐day modified Rankin scale and a higher rate of hemorrhagic complications. Further prospective studies are warranted to identify whether systolic blood pressure is a therapeutic target to improve outcomes.
Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Mistry, E. A., Mistry, A. M., Nakawah, M. O., Khattar, N. K., Fortuny, E. M., Cruz, A. S., Froehler, M. T., Chitale, R. V., James, R. F., Fusco, M. R., Volpi, J. J. Tags: High Blood Pressure, Revascularization, Complications, Quality and Outcomes, Ischemic Stroke Original Research Source Type: research

Door-to-Puncture: A Practical Metric for Capturing and Enhancing System Processes Associated With Endovascular Stroke Care, Preliminary Results From the Rapid Reperfusion Registry Stroke
Conclusions The time interval of D2P presents a clinically relevant time frame by which system processes can be targeted to streamline the delivery of IAT care nationally. At present, there is much opportunity to enhance outcomes through reducing D2P.
Source: JAHA:Journal of the American Heart Association - April 25, 2014 Category: Cardiology Authors: Sun, C.-H. J., Ribo, M., Goyal, M., Yoo, A. J., Jovin, T., Cronin, C. A., Zaidat, O., Nogueira, R., Nguyen, T., Hussain, M. S., Menon, B. K., Mehta, B., Jindal, G., Horev, A., Norbash, A., Leslie-Mazwi, T., Wisco, D., Gupta, R. Tags: Stroke Source Type: research

Reducing Door-to-Puncture Times for Intra-Arterial Stroke Therapy: A Pilot Quality Improvement Project Stroke
Conclusions In-hospital delays are a major obstacle to timely IAT. A simple approach for achieving substantial time savings is to mobilize the NI and anesthesia teams during patient evaluation and treatment decision making. This parallel workflow resulted in a >30-minute (25%) reduction in median door-to-puncture times.
Source: JAHA:Journal of the American Heart Association - November 11, 2014 Category: Cardiology Authors: Mehta, B. P., Leslie-Mazwi, T. M., Chandra, R. V., Bell, D. L., Sun, C.-H. J., Hirsch, J. A., Rabinov, J. D., Rost, N. S., Schwamm, L. H., Goldstein, J. N., Levine, W. C., Gupta, R., Yoo, A. J. Tags: Stroke Source Type: research

Perception Versus Actual Performance in Timely Tissue Plasminogen Activation Administration in the Management of Acute Ischemic Stroke Stroke
Conclusions Hospitals often overestimate their ability to deliver timely tPA to treated patients. Our findings indicate the need to routinely provide comparative provider performance rates as a key step to improving the quality of acute stroke care.
Source: JAHA:Journal of the American Heart Association - July 22, 2015 Category: Cardiology Authors: Lin, C. B., Cox, M., Olson, D. M., Britz, G. W., Constable, M., Fonarow, G. C., Schwamm, L., Peterson, E. D., Shah, B. R. Tags: Stroke Source Type: research

Racial Disparities in Intravenous Recombinant Tissue Plasminogen Activator Use Persist at Primary Stroke Centers Stroke
Conclusions Racial disparities in intravenous rt-PA use were not reduced by presentation to PSCs. Black patients were less likely to receive thrombolytic treatment than white patients at both non-PSCs and PSCs. Hispanic patients were less likely to be seen at PSCs relative to white patients and were less likely to receive intravenous rt-PA in the fully adjusted model.
Source: JAHA:Journal of the American Heart Association - October 14, 2015 Category: Cardiology Authors: Aparicio, H. J., Carr, B. G., Kasner, S. E., Kallan, M. J., Albright, K. C., Kleindorfer, D. O., Mullen, M. T. Tags: Stroke Source Type: research

Rates of Atrial Fibrillation in Black Versus White Patients With Pacemakers Stroke
Conclusions In a population-based sample of patients with pacemakers, black patients had a lower rate of AF compared with white patients. These findings indicate that the persistent racial disparities in rates of ischemic stroke are likely to be related to factors other than undiagnosed AF.
Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Kamel, H., Kleindorfer, D. O., Bhave, P. D., Cushman, M., Levitan, E. B., Howard, G., Soliman, E. Z. Tags: Arrhythmias, Atrial Fibrillation, Epidemiology, Race and Ethnicity, Risk Factors Stroke Source Type: research

Ischemic Stroke or Systemic Embolism After Transseptal Ablation of Arrhythmias in Patients With Cardiac Implantable Electronic Devices Arrhythmia and Electrophysiology
Conclusion CIEDs are associated with an increased risk of stroke, TIA, or systemic embolism after transseptal ablation, but this risk is attenuated with postablation OAC use. Role of anticoagulation post-transseptal ablation in patients with CIED warrants further investigation.
Source: JAHA:Journal of the American Heart Association - April 12, 2016 Category: Cardiology Authors: Madhavan, M., Yao, X., Sangaralingham, L. R., Asirvatham, S. J., Friedman, P. A., McLeod, C. J., Sugrue, A. M., DeSimone, C. V., Noseworthy, P. A. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation, Ischemic Stroke, Transient Ischemic Attack (TIA) Arrhythmia and Electrophysiology Source Type: research