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Source: JAHA:Journal of the American Heart Association

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Total 381 results found since Jan 2013.

Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry Health Services and Outcomes Research
Conclusions In a contemporary AF cohort, use of OAC overall and use of NOACs were not significantly lower among Medicaid patients relative to others. However, among warfarin users, Medicaid patients spent less time in therapeutic range compared with those with other forms of insurance.
Source: JAHA:Journal of the American Heart Association - May 3, 2016 Category: Cardiology Authors: O'Brien, E. C., Kim, S., Thomas, L., Fonarow, G. C., Kowey, P. R., Mahaffey, K. W., Gersh, B. J., Piccini, J. P., Peterson, E. D. Tags: Atrial Fibrillation, Primary Prevention, Health Services, Quality and Outcomes Health Services and Outcomes Research Source Type: research

Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials Epidemiology
Conclusions Our meta-analysis indicated a 10% lower risk of stroke and a 4% lower risk of overall CVD with folic acid supplementation. A greater benefit for CVD was observed among participants with lower plasma folate levels and without preexisting CVD and in studies with larger decreases in homocysteine levels. Folic acid supplementation had no significant effect on risk of coronary heart disease.
Source: JAHA:Journal of the American Heart Association - August 14, 2016 Category: Cardiology Authors: Li, Y., Huang, T., Zheng, Y., Muka, T., Troup, J., Hu, F. B. Tags: Cardiovascular Disease, Diet and Nutrition Epidemiology Source Type: research

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation Epidemiology
Conclusions Exposure to PM2.5 increased the likelihood of having severe coronary artery disease and the risk of incident myocardial infarction among patients undergoing elective cardiac evaluation. These results suggest that ambient air pollution exposure may be a modifiable risk factor for risk of myocardial infarction in a highly susceptible patient population.
Source: JAHA:Journal of the American Heart Association - July 27, 2016 Category: Cardiology Authors: Hartiala, J., Breton, C. V., Tang, W. H. W., Lurmann, F., Hazen, S. L., Gilliland, F. D., Allayee, H. Tags: Epidemiology, Secondary Prevention, Quality and Outcomes, Coronary Artery Disease Source Type: research

Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta-Analysis and Systematic Review Arrhythmia and Electrophysiology
Conclusions Underweight BMI is associated with an increased risk of stroke or systemic embolism, cardiovascular death, and all-cause death in Asian patients with atrial fibrillation, whereas in all atrial fibrillation patients, overweight and obese BMI was not associated with increased risks of these outcomes.
Source: JAHA:Journal of the American Heart Association - September 8, 2016 Category: Cardiology Authors: Zhu, W., Wan, R., Liu, F., Hu, J., Huang, L., Li, J., Hong, K. Tags: Arrhythmias, Atrial Fibrillation, Obesity, Risk Factors Arrhythmia and Electrophysiology Source Type: research

Obesity and Subtypes of Incident Cardiovascular Disease Epidemiology
BackgroundObesity is a risk factor for various subtypes of cardiovascular disease (CVD), including coronary heart disease (CHD), heart failure (HF), and stroke. Nevertheless, there are limited comparisons of the associations of obesity with each of these CVD subtypes, particularly regarding the extent to which they are unexplained by traditional CVD mediators.Methods and ResultsWe followed 13 730 participants in the Atherosclerosis Risk in Communities (ARIC) study who had a body mass index ≥18.5 and no CVD at baseline (visit 1, 1987–1989). We compared the association of higher body mass index with incident HF, CHD, a...
Source: JAHA:Journal of the American Heart Association - July 27, 2016 Category: Cardiology Authors: Ndumele, C. E., Matsushita, K., Lazo, M., Bello, N., Blumenthal, R. S., Gerstenblith, G., Nambi, V., Ballantyne, C. M., Solomon, S. D., Selvin, E., Folsom, A. R., Coresh, J. Tags: Cardiovascular Disease, Epidemiology, Obesity Original Research Source Type: research

Short-Term Risk of Bleeding During Heparin Bridging at Initiation of Vitamin K Antagonist Therapy in More Than 90 000 Patients With Nonvalvular Atrial Fibrillation Managed in Outpatient Care Epidemiology
BackgroundSeveral studies have recently examined the risks of bleeding and of ischemic stroke and systemic embolism associated with perioperative heparin bridging anticoagulation in patients with nonvalvular atrial fibrillation. However, few studies have investigated bridging risks during vitamin K antagonist initiation in outpatient settings.Methods and ResultsA retrospective cohort study was conducted on individuals starting oral anticoagulation between January 2010 and November 2014 for nonvalvular atrial fibrillation managed in outpatient care and identified from French healthcare insurance. Bleeding and ischemic strok...
Source: JAHA:Journal of the American Heart Association - October 30, 2016 Category: Cardiology Authors: Bouillon, K., Bertrand, M., Boudali, L., Ducimetiere, P., Dray-Spira, R., Zureik, M. Tags: Atrial Fibrillation, Epidemiology Original Research Source Type: research

Local Ancestry and Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in Communities Study Genetics
ConclusionsFuture studies are needed to replicate and/or determine the causal variants driving our associations and explore clinical applications for those consistently associated with CVEs.
Source: JAHA:Journal of the American Heart Association - April 10, 2017 Category: Cardiology Authors: Shendre, A., Irvin, M. R., Wiener, H., Zhi, D., Limdi, N. A., Overton, E. T., Shrestha, S. Tags: Cardiovascular Disease, Epidemiology, Race and Ethnicity, Risk Factors, Heart Failure Original Research Source Type: research

Cardiovascular Disease and Patterns of Change in Functional Status Over 15 Years: Findings From the Atherosclerosis Risk in Communities (ARIC) Study Epidemiology
ConclusionsThis study documents that a decline in FS precedes incidence of CVD‐related hospitalization by at least 2 years, providing a strong argument for routine preventative assessment of FS among older adults.
Source: JAHA:Journal of the American Heart Association - March 1, 2017 Category: Cardiology Authors: Kucharska-Newton, A., Griswold, M., Yao, Z. H., Foraker, R., Rose, K., Rosamond, W., Wagenknecht, L., Koton, S., Pompeii, L., Windham, B. G. Tags: Cardiovascular Disease, Epidemiology, Primary Prevention, Women Original Research Source Type: research

Impact of Proton Pump Inhibitor Therapy on the Efficacy of Clopidogrel in the CAPRIE and CREDO Trials Coronary Heart Disease
Conclusions In CREDO, the efficacy of clopidogrel was not significantly affected by PPI use. However, in CAPRIE, clopidogrel was beneficial to non-PPI users while apparently harmful to PPI users. Whether this negative interaction is clinically important for patients receiving clopidogrel without aspirin needs further study.
Source: JAHA:Journal of the American Heart Association - January 15, 2013 Category: Cardiology Authors: Dunn, S. P., Steinhubl, S. R., Bauer, D., Charnigo, R. J., Berger, P. B., Topol, E. J. Tags: Coronary Heart Disease Source Type: research

Diminished Antioxidant Activity of High-Density Lipoprotein-Associated Proteins in Chronic Kidney Disease Coronary Heart Disease
Conclusions In patients with CKD, decreased serum arylesterase activity, a measure of diminished antioxidant properties of PON-1, predicts higher risk of incident long-term adverse cardiovascular events (heart attack, stroke, or death) in multivariable models adjusting for established clinical and biochemical risk factors.
Source: JAHA:Journal of the American Heart Association - April 4, 2013 Category: Cardiology Authors: Kennedy, D. J., Wilson Tang, W. H., Fan, Y., Wu, Y., Mann, S., Pepoy, M., Hazen, S. L. Tags: Coronary Heart Disease Source Type: research

Simple Integer Risk Score to Determine Prognosis of Patients With Hypertension and Chronic Stable Coronary Artery Disease Coronary Heart Disease
Conclusion Readily available clinical variables can rapidly stratify patients with hypertension and chronic stable CAD into useful risk categories.
Source: JAHA:Journal of the American Heart Association - August 15, 2013 Category: Cardiology Authors: Bavry, A. A., Kumbhani, D. J., Gong, Y., Handberg, E. M., Cooper-DeHoff, R. M., Pepine, C. J. Tags: Coronary Heart Disease Source Type: research

Association of Ideal Cardiovascular Health Metrics and Retinal Microvascular Findings: The Atherosclerosis Risk in Communities Study Epidemiology
Conclusions Few adults had ideal cardiovascular health. Those with the best level of health were less likely to have retinopathy signs, wide retinal venules, and narrow retinal arterioles, which are associated with increased stroke and coronary heart disease risk.
Source: JAHA:Journal of the American Heart Association - November 19, 2013 Category: Cardiology Authors: Ogagarue, E. R., Lutsey, P. L., Klein, R., Klein, B. E., Folsom, A. R. Tags: Epidemiology Source Type: research

Early Adoption of Dabigatran and Its Dosing in US Patients With Atrial Fibrillation: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation Health Services and Outcomes Research
Conclusions Patients receiving dabigatran were younger and at a lower risk of stroke and bleeding. Patients appeared to drive switching from warfarin, whereas clinical characteristics influenced de novo start of dabigatran. These data suggest cautious early uptake of dabigatran, and more careful attention to dosing adjustments is warranted. Clinical Trial Registration URL: Clinicaltrials.gov. Unique identifier: NCT01165710.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Steinberg, B. A., Holmes, D. N., Piccini, J. P., Ansell, J., Chang, P., Fonarow, G. C., Gersh, B., Mahaffey, K. W., Kowey, P. R., Ezekowitz, M. D., Singer, D. E., Thomas, L., Peterson, E. D., Hylek, E. M., The Outcomes Registry for Better Informed Treatme Tags: Health Services and Outcomes Research Source Type: research

Haptoglobin 2-2 Genotype is Not Associated With Cardiovascular Risk in Subjects With Elevated Glycohemoglobin--Results From the Bruneck Study Genetics
Conclusions Subjects with the Hp 2-2 genotype and elevated HbA1c compared with subjects with other Hp genotypes and elevated HbA1c did not show increased CVD risk.
Source: JAHA:Journal of the American Heart Association - May 16, 2014 Category: Cardiology Authors: Pechlaner, R., Kiechl, S., Willeit, P., Demetz, E., Haun, M., Weger, S., Oberhollenzer, F., Kronenberg, F., Bonora, E., Weiss, G., Willeit, J. Tags: Genetics Source Type: research