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Source: JAHA:Journal of the American Heart Association

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Total 381 results found since Jan 2013.

Efficacy and Safety of Vorapaxar as Approved for Clinical Use in the United States Coronary Heart Disease
Conclusions In patients with prior MI or PAD who have not had a previous stroke or TIA, vorapaxar added to standard therapy is effective for long-term secondary prevention of thrombotic CV events, while increasing moderate or severe bleeding. Clinical Trial Registration URL: clinicaltrials.gov Unique Identifier: NCT00526474.
Source: JAHA:Journal of the American Heart Association - March 19, 2015 Category: Cardiology Authors: Magnani, G., Bonaca, M. P., Braunwald, E., Dalby, A. J., Fox, K. A. A., Murphy, S. A., Nicolau, J. C., Oude Ophuis, T., Scirica, B. M., Spinar, J., Theroux, P., Morrow, D. A. Tags: Coronary Heart Disease Source Type: research

Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study Vascular Medicine
Conclusions Aortic root dilatation is associated with high diastolic blood pressure, high stroke volume, central fat distribution, and inflammatory status. In contrast, at a given diastolic blood pressure and stroke volume, aortic root dilatation is associated with lower pulse pressure and systolic blood pressure.
Source: JAHA:Journal of the American Heart Association - September 28, 2015 Category: Cardiology Authors: de Simone, G., Roman, M. J., De Marco, M., Bella, J. N., Izzo, R., Lee, E. T., Devereux, R. B. Tags: Vascular Medicine Source Type: research

Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015 AHA Conference Proceedings
Conclusion There was a consensus across stakeholder domains that Big Data holds great promise for revolutionizing the way cardiovascular and stroke research is conducted and clinical care is delivered; however, there is a clear need for the creation of a vision of how to use it to achieve the desired goals. Potential roles for the AHA center around facilitating a discussion of standards, providing education, and helping establish a cardiovascular digital ecosystem. This ecosystem should be interoperable and needs to interface with the rapidly growing digital object environment of the modern-day healthcare system.
Source: JAHA:Journal of the American Heart Association - November 5, 2015 Category: Cardiology Authors: Antman, E. M., Benjamin, E. J., Harrington, R. A., Houser, S. R., Peterson, E. D., Bauman, M. A., Brown, N., Bufalino, V., Califf, R. M., Creager, M. A., Daugherty, A., Demets, D. L., Dennis, B. P., Ebadollahi, S., Jessup, M., Lauer, M. S., Lo, B., MacRae Tags: AHA Conference Proceedings Source Type: research

Incidence, Time Trends, and Predictors of Intracranial Hemorrhage During Long-Term Follow-up After Acute Myocardial Infarction Coronary Heart Disease
Conclusion The 1-year incidence of ICH after AMI remained stable, at 0.35%, over the study period. Advanced age, decreased renal function, and previous ischemic or hemorrhagic stroke are predictive of increased ICH risk.
Source: JAHA:Journal of the American Heart Association - December 11, 2015 Category: Cardiology Authors: Graipe, A., Binsell-Gerdin, E., Soderstrom, L., Mooe, T. Tags: Coronary Heart Disease Source Type: research

Atrial Fibrillation and Outcomes in Heart Failure With Preserved Versus Reduced Left Ventricular Ejection Fraction Arrhythmia and Electrophysiology
Conclusions AF is a potent risk factor for adverse outcomes in patients with HF-PEF or HF-REF. Effective interventions are needed to improve the prognosis of these high-risk patients.
Source: JAHA:Journal of the American Heart Association - February 1, 2013 Category: Cardiology Authors: McManus, D. D., Hsu, G., Sung, S. H., Saczynski, J. S., Smith, D. H., Magid, D. J., Gurwitz, J. H., Goldberg, R. J., Go, A. S., for the Cardiovascular Research Network PRESERVE Study Tags: Arrhythmia and Electrophysiology Source Type: research

Effectiveness of Percutaneous Coronary Intervention With Drug-Eluting Stents Compared With Bypass Surgery in Diabetics With Multivessel Coronary Disease: Comprehensive Systematic Review and Meta-analysis of Randomized Clinical Data Coronary Heart Disease
Conclusions These data demonstrate that CABG in diabetic patients with MVD at low to intermediate surgical risk (defined as EUROSCORE <5) is superior to MVD PCI with DES. CABG decreased overall death, nonfatal myocardial infarction, and repeat revascularization at the expense of an increase in stroke risk.
Source: JAHA:Journal of the American Heart Association - August 7, 2013 Category: Cardiology Authors: Hakeem, A., Garg, N., Bhatti, S., Rajpurohit, N., Ahmed, Z., Uretsky, B. F. Tags: Coronary Heart Disease Source Type: research

New-Onset Atrial Fibrillation is Associated With Cardiovascular Events Leading to Death in a First Time Myocardial Infarction Population of 89 703 Patients With Long-Term Follow-Up: A Nationwide Study Coronary Heart Disease
Conclusions New-onset AF after first-time MI is associated with increased mortality, which is largely explained by more cardiovascular deaths. Focus on the prognostic impact of post-infarct AF is warranted.
Source: JAHA:Journal of the American Heart Association - January 21, 2014 Category: Cardiology Authors: Bang, C. N., Gislason, G. H., Greve, A. M., Bang, C. A., Lilja, A., Torp-Pedersen, C., Andersen, P. K., Kober, L., Devereux, R. B., Wachtell, K. Tags: Coronary Heart Disease Source Type: research

Relationship Between Time in Therapeutic Range and Comparative Treatment Effect of Rivaroxaban and Warfarin: Results From the ROCKET AF Trial Arrhythmia and Electrophysiology
Conclusions The treatment effect of rivaroxaban compared with warfarin for the prevention of stroke and systemic embolism is consistent regardless of cTTR.
Source: JAHA:Journal of the American Heart Association - April 22, 2014 Category: Cardiology Authors: Piccini, J. P., Hellkamp, A. S., Lokhnygina, Y., Patel, M. R., Harrell, F. E., Singer, D. E., Becker, R. C., Breithardt, G., Halperin, J. L., Hankey, G. J., Berkowitz, S. D., Nessel, C. C., Mahaffey, K. W., Fox, K. A. A., Califf, R. M., ROCKET AF Investig Tags: Arrhythmia and Electrophysiology Source Type: research

Plasma Levels of the Proinflammatory Chitin-Binding Glycoprotein YKL-40, Variation in the Chitinase 3-Like 1 Gene (CHI3L1), and Incident Cardiovascular Events Epidemiology
Conclusions Among initially healthy U.S. women, plasma levels of the proinflammatory chitenase-like protein, YKL-40, were influenced by environmental as well as genetic factors and predicted incident thromboembolic stroke, but not MI, a differential effect consistent with limited previous data.
Source: JAHA:Journal of the American Heart Association - June 23, 2014 Category: Cardiology Authors: Ridker, P. M., Chasman, D. I., Rose, L., Loscalzo, J., Elias, J. A. Tags: Epidemiology Source Type: research

Identifying Future Research Priorities Using Value of Information Analyses: Left Atrial Appendage Occlusion Devices in Atrial Fibrillation Health Services and Outcomes Research
Conclusion The relative efficacy of stroke reduction with left atrial appendage occlusion devices in relation to warfarin is an important source of uncertainty. Improving estimates of this parameter should be the priority for future research in this area.
Source: JAHA:Journal of the American Heart Association - September 16, 2014 Category: Cardiology Authors: Micieli, A., Bennell, M. C., Pham, B., Krahn, M., Singh, S. M., Wijeysundera, H. C. Tags: Health Services and Outcomes Research Source Type: research

Ideal Cardiovascular Health Predicts Functional Status Independently of Vascular Events: The Northern Manhattan Study Epidemiology
Conclusions Ideal CVH predicts functional status, even after accounting for incident vascular events. Vascular functional impairment is an important outcome that can be reduced by optimizing vascular health.
Source: JAHA:Journal of the American Heart Association - February 12, 2015 Category: Cardiology Authors: Dhamoon, M. S., Dong, C., Elkind, M. S. V., Sacco, R. L. Tags: Epidemiology Source Type: research

Effectiveness and Safety of Dabigatran and Warfarin in Real-World US Patients With Non-Valvular Atrial Fibrillation: A Retrospective Cohort Study Health Services and Outcomes Research
Conclusions Dabigatran could be a safe and potentially more effective alternative to warfarin in patients with atrial fibrillation managed in routine practice settings.
Source: JAHA:Journal of the American Heart Association - April 10, 2015 Category: Cardiology Authors: Lauffenburger, J. C., Farley, J. F., Gehi, A. K., Rhoney, D. H., Brookhart, M. A., Fang, G. Tags: Health Services and Outcomes Research Source Type: research

Reducing the Blood Pressure-Related Burden of Cardiovascular Disease: Impact of Achievable Improvements in Blood Pressure Prevention and Control Epidemiology
Conclusions Modest population-wide shifts in systolic blood pressure could have a substantial impact on cardiovascular disease incidence and should be developed in parallel with interventions targeting populations with blood pressure above goal.
Source: JAHA:Journal of the American Heart Association - October 27, 2015 Category: Cardiology Authors: Hardy, S. T., Loehr, L. R., Butler, K. R., Chakladar, S., Chang, P. P., Folsom, A. R., Heiss, G., MacLehose, R. F., Matsushita, K., Avery, C. L. Tags: Epidemiology Source Type: research

Hydroxychloroquine Use Is Associated With Decreased Incident Cardiovascular Events in Rheumatoid Arthritis Patients Preventive Cardiology
Conclusion In this hypothesis-generating study, hydroxychloroquine use was associated with a 72% decrease in the risk of incident CVD in RA patients. If these preliminary results are confirmed in larger studies, our findings may be used as a rationale for a randomized study of hydroxychloroquine use for primary prevention of CVD in RA or nonrheumatic high-risk patients.
Source: JAHA:Journal of the American Heart Association - January 4, 2016 Category: Cardiology Authors: Sharma, T. S., Wasko, M. C. M., Tang, X., Vedamurthy, D., Yan, X., Cote, J., Bili, A. Tags: Cardiovascular Disease, Primary Prevention Preventive Cardiology Source Type: research

Association of Thoracic Aorta Calcium Score With Exercise Blood Pressure Response and Clinical Outcomes in Elderly Individuals: Differential Impact of Aorta Calcification Compared With Coronary Artery Calcification Preventive Cardiology
Conclusions Aortic calcification was related to SBP response during exercise and was an independent predictor for outcomes, especially stroke, regardless of resting SBP or CACS.
Source: JAHA:Journal of the American Heart Association - April 21, 2016 Category: Cardiology Authors: Cho, I.-J., Chang, H.-J., Cho, I., Heo, R., Lee, S.-E., Shim, C. Y., Hong, G.-R., Chung, N. Tags: Computerized Tomography (CT) Preventive Cardiology Source Type: research