Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice Stroke

ConclusionsWe conclude that brain ischemia induces the formation of β‐hydroxybutyrate (ketogenesis) in the liver and the consumption of β‐hydroxybutyrate in the brain. This effect seems to be mediated by β‐adrenergic receptors.
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Ischemia, Metabolism, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Research Source Type: research

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Conditions:   Stroke, Ischemic;   Stroke, Acute Interventions:   Drug: Tenecteplase;   Drug: Placebo Sponsors:   Hospital Moinhos de Vento;   Ministry of Health, Brazil;   Boehringer Ingelheim;   Medtronic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Cardiovascular and Haematological Disorders - Drug Targets - Category: Cardiology Authors: Tags: Research article Source Type: research
Medicine (Baltimore). 2021 Dec 3;100(48):e28155. doi: 10.1097/MD.0000000000028155.ABSTRACTAtraumatic convexity subarachnoid hemorrhage (c-SAH) concomitant with large artery atherosclerosis (LAA) stroke has been rarely discussed in the literature. Our aim in this study is to characterize the clinical and neuroradiological features of patients with LAA stroke and c-SAH.A retrospective study from a single institution was performed between January 2016 and June 2020. Only patients diagnosed with c-SAH and LAA stoke were included in this study. The clinical presentation and neuroimaging finding were summarized by our experience...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Medicine (Baltimore). 2021 Dec 3;100(48):e27973. doi: 10.1097/MD.0000000000027973.ABSTRACTThe incidence of stroke may be increased in patients with coronary artery disease (CAD). We aimed to investigate the specific risk factors for the development of ischaemic and haemorrhagic stroke in stable CAD patients.Patients with stable CAD were prospectively enrolled for future cardiovascular events in Taiwan. All the patients had received coronary interventions and were stable for least 1 month before enrolment. The incidence of ischaemic stroke was identified and confirmed by telephone and hospital records. Baseline characterist...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
ConclusionNo relationship was identified between the use of SSRIs and the time course of PSF in all patients. However, these drugs might be effective in PSF patients with depression.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
A genome-wide association study (GWAS) reported PLCL2 on chromosome 3p24. 3 (rs4618210:A>G) as a novel susceptibility locus for myocardial infarction in the Japanese population. As the most common pathological process, atherosclerosis leads to metabolic syndrome (MetS)-related ischaemic stroke (IS) and myocardial infarction. Hypothesizing that polymorphisms of the PLCL2 gene might be associated with the onset and prognosis of IS in MetS patients, we performed the following study in a Chinese Han population. A total of 709 cases (patients with MetS plus IS) and 711 controls (patients with MetS) were enrolled. A fine-mapp...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsWe suggest alternative diagnostic criteria for acute headache attributed to ischemic stroke and new diagnostic criteria for sentinel headache with high sensitivity and specificity.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
Ischemic stroke (IS), as a leading cause of disability worldwide, affects intestinal bacterial communities and their metabolites, while recent discoveries have highlighted the importance of the intestinal microflora in the development of IS. Systematic investigations of complex intestinal bacterial communities and their metabolites during ischemic brain injury contribute to elucidate the promising therapeutic targets for IS. However, the associations between intestinal microbiota and related circulating metabolic processes in IS remained unclear. Hence, to identify the changed microflora and their metabolites in IS of NaoM...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
The American Academy of Neurology has issued a new position statement on"Consent Issues in the Management of Acute Ischemic Stroke," the first update in more than 20 years.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
University of Arizona Health Sciences researchers suggest the risk of developing dementia after a stroke might be reduced by a drug that could help immune cells process the cholesterol-rich debris generated by a stroke. Today University of Arizona Health SciencesHealthBIO5College of Medicine - TucsonCollege of PharmacyExploration Media contact(s)Anna Christensen University of Arizona Health Sciencesachristensen@arizona.edu520-626-7383University of Arizona Health Sciences researchers discovered a potential treatment to reduce the risk of post-stroke dementia, which may be influenced by the immune response to dead...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research
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