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The Clinical and Neuropathological Correlates of Second-Impact Syndrome: Case Report of a 17-year-old Female Rugby Player (P6.164)
Conclusions:This is the first case study to report the clinical and neuropathological features of SIS. Larger autopsy samples are needed to systematically identify clinicopathological correlates of SIS to facilitate research on risk factors and preventative strategies (e.g., return-to-play guidelines) to prevent unnecessary fatalities in young athletes.Study Supported by: This work was supported by the National Institute of Neurological Disorders and Stroke (1U01NS086659-01, U01NS093334, R01NS078337, R56NS078337), Department of Defense (W81XWH-13-2-0064), Department of Veterans Affairs, the Veterans Affairs Biorepository (...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mian, M., Alosco, M., Mez, J., Kiernan, P., Daneshvar, D., Nowinski, C., Kowall, N., Stern, R., Katz, D., Cantu, R., McKee, A. Tags: Neuro Trauma and Sports Neurology II Source Type: research

Blood Pressure Trajectories from Mid to Late Life and Risk of Dementia: The Framingham Study (S49.003)
Conclusions:Elevated blood pressure in mid-life, persistent hypertension into late-life and, among non-hypertensives, a steep decline in blood pressure from mid-to-late life were each associated with an elevated risk of dementia in a community-based sample. Our data highlight the potential sustained cognitive benefits of lower midlife blood pressures and raise the possibility that lowering of blood pressure in older adults with borderline hypertension may be harmful to cognition, despite a beneficial impact on cardiovascular events.Study Supported by:Framingham Heart Study, (NHLBI/NIH contract HHSN268201500001I) to the Bos...
Source: Neurology - April 17, 2017 Category: Neurology Authors: McGrath, E., Beiser, A., DeCarli, C., Plourde, K., Ramachandran, V., Greenberg, S., Seshadri, S. Tags: Best Of: Aging and Dementia Source Type: research

Telomere Length, Long-Term Black Carbon Exposure, and Cognitive Function in a Cohort of Older Men: The VA Normative Aging Study
Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men. Citation: Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro A III, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. 2017. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: the VA Normative Aging Study. Environ Health Perspect 125:76–81; http://dx.doi.org/10.1289/EHP241 Address correspondence to E. Colicino, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave., Building 1, Room G03, Bos...
Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles January 2017 Source Type: research

Study reveals the protein structure of the human apoptosome
(Boston University Medical Center) Programmed cell death, or apoptosis, plays a central role in the maintenance of human health by providing a line of defense against unrestricted cell growth that occurs in many cancers and AIDS as well as in neurodegenerative diseases and stroke.Researchers from Boston University School of Medicine have for the first time mapped an active human apoptosome.
Source: EurekAlert! - Cancer - October 4, 2016 Category: Cancer & Oncology Source Type: news

Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men: The Veterans Administration Normative Aging Study
Conclusions: In this longitudinal sample of older men, the findings supported the hypothesis that long-term PM2.5 exposure negatively affects renal function and increases renal function decline. Citation: Mehta AJ, Zanobetti A, Bind MC, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. 2016. Long-term exposure to ambient fine particulate matter and renal function in older men: the VA Normative Aging Study. Environ Health Perspect 124:1353–1360; http://dx.doi.org/10.1289/ehp.1510269 Address correspondence to A.J. Mehta, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Landmark Ce...
Source: EHP Research - September 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article September 2016 Source Type: research

Exercise results in larger brain size and lowered dementia risk
FINDINGS Using the landmark Framingham Heart Study to assess how physical activity affects the size of the brain and one’s risk for developing dementia, UCLA researchers found an association between low physical activity and a higher risk for dementia in older individuals. This suggests that regular physical activity for older adults could lead to higher brain volumes and a reduced risk for developing dementia. The researchers found that physical activity particularly affected the size of the hippocampus, which is the part of the brain controlling short-term memory. Also, the protective effect of regular physical activit...
Source: UCLA Newsroom: Health Sciences - August 2, 2016 Category: Universities & Medical Training Source Type: news

ReWalk inks collab deal with Harvard to develop “soft” exosuit
ReWalk Robotics (NSDQ:RWLK) said today it inked a collaborative research with Harvard’s Wyss Institute to develop a lightweight “soft suit” exoskeleton system for lower limb disabilities. The collaboration looks to design a suit to treat stroke, multiple sclerosis and mobility limitations for the elderly as well as other applications. Through the agreement, ReWalk will pay Harvard in quarterly installment payments to fund the research, with reports from the research being relayed between the groups on a regular basis. ReWalk Robotics will be able to negotiate with Harvard to license new inventions create...
Source: Mass Device - May 17, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Prosthetics Harvard University ReWalk Robotics Wyss Institute Source Type: news

Study Links Living Close To Highways With Heart Attack, Stroke
BOSTON (CBS) — A new study conducted by Boston-area researchers shows evidence that links living near highways to increased health risks. The study by researchers at Tufts University School of Medicine and Boston University School of Health claims people living close to the Massachusetts Turnpike and Interstate 93 were at higher risk of suffering a heart attack or stroke. The study used mobile labs to study ultrafine particles–microscopic metals and chemicals in the air–in Chinatown, Dorchester, and South Boston. Tufts University professor Doug Brugge said he and his colleagues worked on the study for...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 14, 2016 Category: Consumer Health News Authors: Jon Palmer Tags: Health Local News Syndicated Local Boston University Pollution Tufts University Source Type: news

Incorporating Quality Improvement into the Third-Year Neurology Curriculum (P2.380)
Conclusions: We present an initiative that gives medical students quality improvement experience and may help reduce patient readmissions. Data analysis is ongoing with final results anticipated in Spring 2016.Disclosure: Dr. Liyanage-Don has nothing to disclose. Dr. Hohler has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Liyanage-Don, N., Hohler, A. Tags: Research Methodology and Education: Patient Safety and Quality Source Type: research

Social Relationships, Serum Brain-Derived Neurotrophic Factor, and the Risk for Stroke and Dementia: The Framingham Heart Study (P1.098)
Conclusions: In our large community sample, greater social support was associated with increased BDNF levels and, in certain dimensions of support, reduced risk of subsequent dementia and stroke. Further study of the biological and social mechanisms through which support from social networks reduce these risks is needed to determine whether relatively simple social interventions may help protect against age-related neurologic disease. Study Supported by: Boston University School of Medicine, a contract from NHLBI (N01-HC 25195), and by grants from the NINDS (NS017950) and NIA (AG031287, AG008122, AG033193).Disclosure: Dr. ...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Salinas, J. Tags: Epidemiology of Aging and Dementias Source Type: research

Framingham Study Suggests Dementia Rates May Be Falling
Many experts predict that as people live longer, the prevalence of dementia will climb. However, a study published in the New England Journal of Medicine now suggests the incidence of dementia may be falling.Researchers from Boston University School Medicine analyzed data from 5,205 people aged 60 and older who were participants in the Framingham Heart Study, a community-based, longitudinal cohort study that was initiated in 1948. Since 1975, the cognitive status of the original cohort has been regularly monitored via the Mini-Mental State Examination, neurological and neuropsychological examinations, and subjective memory...
Source: Psychiatr News - February 18, 2016 Category: Psychiatry Tags: dementia Framingham Heart Study stroke risk Source Type: research

Sugary drinks linked to increased fat levels around vital organs
Conclusion This US cohort study found drinking sugar-sweetened beverages on a daily basis is associated with the highest increase in fat accumulation around the abdominal organs, compared with people who do not consume them. But there was an average increase in the amount of this fat in all people who took part in the study, although this was lowest in people who never consumed sugar-sweetened beverages. The study was prospective, which limits some sources of bias, but it has some limitations. For example, the food frequency questionnaire was only conducted once, at baseline. The results are therefore reliant on the p...
Source: NHS News Feed - January 12, 2016 Category: Consumer Health News Tags: Food/diet Diabetes Heart/lungs Obesity Source Type: news

A Nearly $16 Million C.T.E. Grant, but N.F.L. Does Not Fund It
Researchers are seeking to unlock mysteries about the brain disease linked to repeated head hits, including how to diagnose C.T.E. in living patients.
Source: NYT Health - December 22, 2015 Category: Consumer Health News Authors: KEN BELSON Tags: National Institute of Neurological Disorders and Stroke Brain Boston University Chronic Traumatic Encephalopathy Source Type: news

$16 Million for Brain Research, but $0 from N.F.L.
The league will not help pay for a study to try to find a way to diagnose a degenerative brain disease, despite its potential implications for football players.
Source: NYT Health - December 22, 2015 Category: Consumer Health News Authors: KEN BELSON Tags: National Institute of Neurological Disorders and Stroke Brain Boston University Chronic Traumatic Encephalopathy Source Type: news

Sleep Apnea Tied To Gout Risk And Flare-Ups
(Reuters Health) - Sleep apnea may increase the risk of developing gout and experiencing flare-ups, according to a new study. The intense pain and swelling of a joint, often a big toe, that marks gout is caused by the deposition of uric acid crystals in joints and tissues. Sleep apnea, the study team notes, causes periods of oxygen deprivation during the night when people stop breathing, which triggers overproduction of uric acid in the bloodstream. But little was known about the relationship between the two conditions, the study team writes in Arthritis and Rheumatology.  In 2007-2008, almost six percent of men and t...
Source: Healthy Living - The Huffington Post - October 31, 2015 Category: Consumer Health News Source Type: news