Blood Pressure Trajectories from Mid to Late Life and Risk of Dementia: The Framingham Study (S49.003)

Conclusions:Elevated blood pressure in mid-life, persistent hypertension into late-life and, among non-hypertensives, a steep decline in blood pressure from mid-to-late life were each associated with an elevated risk of dementia in a community-based sample. Our data highlight the potential sustained cognitive benefits of lower midlife blood pressures and raise the possibility that lowering of blood pressure in older adults with borderline hypertension may be harmful to cognition, despite a beneficial impact on cardiovascular events.Study Supported by:Framingham Heart Study, (NHLBI/NIH contract HHSN268201500001I) to the Boston University School of Medicine, and by grants from the National Institute on Aging (R01 AG054076, R01 AG049607, R01 AG033193, U01 AG049505, U01 AG052409) and the National Institute for Neurological Diseases and Stroke (NS017950 and UH2 NS100605).Disclosure: Dr. McGrath has nothing to disclose. Dr. Beiser has nothing to disclose. Dr. DeCarli has received personal compensation for activities with Novartis Pharmaceuticals as a consultant. Dr. Plourde has nothing to disclose. Dr. Ramachandran has nothing to disclose. Dr. Greenberg has received personal compensation for activities with Hoffman-Laroche. Dr. Seshadri has nothing to disclose.

Source: Neurology - April 17, 2017 Category: Neurology Authors: McGrath, E., Beiser, A., DeCarli, C., Plourde, K., Ramachandran, V., Greenberg, S., Seshadri, S. Tags: Best Of: Aging and Dementia Source Type: research