Filtered By:
Drug: Melatonin

This page shows you your search results in order of relevance. This is page number 5.

Order by Relevance | Date

Total 139 results found since Jan 2013.

Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule
We report that melatonin treatment downregulates ER stress in the ischemic period and enhances dissociation of the refractory SGs during reperfusion, thus offering dual-phase protection to BVECs in prolonged cerebral stroke. Mechanistically, melatonin enhances autophagy in BVECs, which preserves ER function and resolves refractory SGs. We, therefore, propose that melatonin is a potential treatment to extend the time window of delayed recanalization therapy in AIS.PMID:36181629 | DOI:10.1007/s12975-022-01084-7
Source: Cell Research - October 1, 2022 Category: Cytology Authors: Danli Lu Yuxin Liu Huipeng Huang Mengyan Hu Tiemei Li Shisi Wang Shishi Shen Ruizhen Wu Wei Cai Tingting Lu Zhengqi Lu Source Type: research

Neuroprotective effect of melatonin against ischemia is partially mediated by alfa‐7 nicotinic receptor modulation and HO‐1 overexpression
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - December 18, 2013 Category: Research Authors: Esther Parada, Izaskun Buendia, Rafael León, Pilar Negredo, Alejandro Romero, Antonio Cuadrado, Manuela G. López, Javier Egea Tags: Original Article Source Type: research

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha‐7 nicotinic receptor modulation and HO‐1 overexpression
In this study, we evaluated the neuroprotective/antioxidant mechanism of action of melatonin in organotypic hippocampal cultures (OHCs) as well as in photothrombotic stroke model in vivo. Melatonin (0.1, 1, and 10 μm) incubated postoxygen and glucose deprivation (OGD) showed a concentration‐dependent protection; maximum protection was achieved at 10 μm (90% protection). Next, OHCs were exposed to 10 μm melatonin at different post‐OGD times; the protective effect of melatonin was maintained at 0, 1, and 2 hr post‐OGD treatment, but it was lost at 6 hr post‐OGD. The protective effect of melatonin and the redu...
Source: Journal of Pineal Research - January 16, 2014 Category: Research Authors: Esther Parada, Izaskun Buendia, Rafael León, Pilar Negredo, Alejandro Romero, Antonio Cuadrado, Manuela G. López, Javier Egea Tags: Original Article Source Type: research

Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models.
In conclusion, Neu-P11 affords neuroprotection against brain ischemia in in vitro and in vivo models by activating a pro-survival signaling pathway that involves melatonin receptors, JAK/STAT, PI3K/Akt and MEK/ERK1/2. PMID: 26188145 [PubMed - as supplied by publisher]
Source: Neuropharmacology - July 15, 2015 Category: Drugs & Pharmacology Authors: Buendia I, Gómez-Rangel V, González-Lafuente L, Parada E, León R, Gameiro I, Michalska P, Laudon M, Egea J, López MG Tags: Neuropharmacology Source Type: research

Mortality of Shift Workers
This study strengthens the evidence of a connection between shift work and all-cause mortality. It also provides support for an association between shift work and mortality of cardiovascular disease. The mechanisms responsible for the association between shift work and disease are probably co mplex and influenced by genetics, lifestyle, sleep, social stress, and disturbed circadian rhythms (7). Further epidemiological studies and experimental studies are needed to explain the causal pathways. One issue would be to find a better variable measuring the circadian phase. Shift work is not a valid proxy since previous studies...
Source: Scandinavian Journal of Work, Environment and Health - January 25, 2017 Category: Occupational Health Tags: Editorial Source Type: research

Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury.
In this study we investigated whether ramelteon could attenuate cerebral ischemia in mice. Acute focal cerebral ischemia was induced in mice via middle cerebral artery occlusion (MCAO). We found oral administration of ramelteon (3.0 mg/kg) significantly attenuated ischemic injury even when it was given 4 h after the onset of ischemia. We showed that administration of ramelteon (3.0 mg/kg) displayed comparable protective efficacy and length of effective time window as administration of edaravone (10 mg/kg, i.p.), which was used in clinic to treat ischemic stroke. Chronic ischemic brain injury was induced in mice usi...
Source: Acta Pharmacologica Sinica - February 26, 2020 Category: Drugs & Pharmacology Authors: Wu XL, Lu SS, Liu MR, Tang WD, Chen JZ, Zheng YR, Ahsan A, Cao M, Jiang L, Hu WW, Wu JY, Chen Z, Zhang XN Tags: Acta Pharmacol Sin Source Type: research

Considerations and Current Trends in the Management of the Geriatric Patient on a Consultation –Liaison Service
AbstractPurpose of ReviewTo provide consultation –liaison psychiatrists with an updated resource that can assist in the treatment and management of geriatric patients.Recent FindingsThe current available literature has not shown any differences in efficacy between haloperidol and second-generation antipsychotics in patients with delirium. When considering relative advantages of forms of antipsychotic administration, there is no support for a superior safety profile of oral compared to intramuscular or intravenous administration. A recent meta-analysis of four randomized controlled trials concluded that when melatonin was...
Source: Current Psychiatry Reports - April 12, 2020 Category: Psychiatry Source Type: research

Molecules, Vol. 26, Pages 811: Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis
Changwei Liu Carotid artery stenosis (CAS) is an atherosclerotic disease characterized by a narrowing of the artery lumen and a high risk of ischemic stroke. Risk factors of atherosclerosis, including smoking, hypertension, hyperglycemia, hyperlipidemia, aging, and disrupted circadian rhythm, may potentiate atherosclerosis in the carotid artery and further reduce the arterial lumen. Ischemic stroke due to severe CAS and cerebral ischemic/reperfusion (I/R) injury after the revascularization of CAS also adversely affect clinical outcomes. Melatonin is a pluripotent agent with potent anti-inflammatory, anti-oxidative, an...
Source: Molecules - February 4, 2021 Category: Chemistry Authors: Rui Zhang Leng Ni Xiao Di Baitao Ma Shuai Niu Zhihua Rong Changwei Liu Tags: Review Source Type: research

Delayed Therapeutic Administration of Melatonin Enhances Neuronal Survival Through AKT and MAPK Signaling Pathways Following Focal Brain Ischemia in Mice
AbstractMelatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed post-acute effect of melatonin was examined on recovery of the cell survival and apoptosis after stroke. Melatonin was administered (4  mg/kg/day) intraperitoneally for 45 days, starting 3 days after 30 min of middle cerebral artery occlusion. The genes and proteins related to the cell survival and apoptosis were investigated by immunofluorescence, western blotting, and RT-PCR techniques aft...
Source: Journal of Molecular Neuroscience - March 21, 2022 Category: Neuroscience Source Type: research

Ischemic brain injury: new insights on the protective role of melatonin.
Abstract Stroke represents one of the most common causes of brain's vulnerability for many millions of people worldwide. The plethora of physiopathological events associated with brain ischemia are regulate through multiple signaling pathways leading to the activation of oxidative stress process, Ca2+ dyshomeostasis, mitochondrial dysfunction, proinflammatory mediators, excitotoxicity and/or programmed neuronal cell death. Understanding this cascade of molecular events is mandatory in order to develop new therapeutic strategies for stroke. In this review article, we have highlighted the pleiotropic effects of mela...
Source: Free Radical Biology and Medicine - January 4, 2017 Category: Biology Authors: Ramos E, Patiño P, Reiter RJ, Gil-Martín E, Marco-Contelles J, Parada E, Los Rios C, Romero A, Egea J Tags: Free Radic Biol Med Source Type: research

Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs
Neonatal lambs, as other neonates, have physiologically a very low plasma melatonin concentration throughout the 24-h. Previously, we found that melatonin given for 5 days decreased heart’s weight, changed plasma cortisol and gene expression in the adrenal and heart. Whether these changes could compromise the responses to life challenges is not known. Therefore, firstly we studied acute effects of melatonin on the defense mechanisms to acute hypoxia in the neonate. Eleven lambs, 2 weeks old were instrumented and submitted to an episode of acute isocapnic hypoxia, consisting of four 30 min periods: normoxia (room air); no...
Source: Frontiers in Endocrinology - July 11, 2019 Category: Endocrinology Source Type: research

GSE147578 Comparison of miRNA between normal rat plasma exosomes and melatonin pretreated rat plasma exosomes
This study suggests plasma exosome with melatonin pretreatment might be a more effective strategy for patients with ischemic brain injury. Further exploration of ke y molecules in plasma exosome may devote more therapeutic value for cerebral ischemic injury.
Source: GEO: Gene Expression Omnibus - March 27, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Rattus norvegicus Source Type: research

Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis
AbstractStroke is one of the highest incidence neurological disorder with great morbidity and mortality rate. The secondary neuroinflammation contributed by microglial activation is a consequential response observed in the pathogenesis of stroke. High-mobility group box  1, a non-histone nuclear protein, interacts with immune cells, such as microglia, and leads to a cascade amplification of the secondary neuroinflammatory responses, which are related to neuronal damage later. Melatonin is a neurohormone, well-known as its anti-oxidative and anti-inflammatory effec ts. However, until now, more findings are required for bet...
Source: Journal of Molecular Neuroscience - September 9, 2020 Category: Neuroscience Source Type: research

Ramelteon Mitigates Free Fatty Acid (FFA)-Induced Attachment of Monocytes to Brain Vascular Endothelial Cells
In conclusion, Ramelteon mitigated FFA-induced attachment of monocytes to brain vascular endothelial cells by increasing the expression of KLF2 and reducing the expression of E-selectin.PMID:34792763 | DOI:10.1007/s12640-021-00422-1
Source: Cell Research - November 18, 2021 Category: Cytology Authors: Guijie Wang Fang Tian Yu Li Yang Liu Chunfeng Liu Source Type: research