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Specialty: Endocrinology
Drug: Insulin
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Total 211 results found since Jan 2013.
Potentially Inappropriate Medication Use Among Older Patients with
Diabetes in a Chinese Community
Conclusions Given the higher rate of PIM use among older adults with
diabetes, strategies and interventions targeting this population are needed to
minimize PIM use. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Experimental and Clinical Endocrinology and Diabetes - September 6, 2023 Category: Endocrinology Authors: Zhao, Xingxing Li, Lei Guo, Xiujun Wang, Jianqiang Yan, Yingying Le, Yunyi Tags: Article Source Type: research
Investigation of Pancreatic-beta cells Role in the Biological Process of Ageing
CONCLUSION: Aging accelerates beta cell senescence by generating premature cell senescence, which is mostly mediated by high glucose levels. Despite higher plasma glucose levels, hepatic gluconeogenesis accelerates and adipose tissue lipolysis rises, resulting in an increase in free fatty acid levels in the blood and worsening insulin resistance throughout the body.PMID:37608675 | DOI:10.2174/1871530323666230822095932
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 23, 2023 Category: Endocrinology Authors: Rishabh Chaudhary Janvi Khanna Manni Rohilla Sumeet Gupta Seema Bansal Source Type: research
Role of GLP-1 receptor agonist in diabetic cardio-renal disorder: Recent updates of clinical and pre-clinical evidence
Curr Diabetes Rev. 2023 Aug 9. doi: 10.2174/1573399820666230809152148. Online ahead of print.ABSTRACTCardiovascular complications and renal disease is the growing cause of mortality in patients with diabetes. The subversive complications of diabetes such as hyperglycemia, hyperlipidemia and insulin resistance lead to an increase in the risk of myocardial infarction (MI), stroke, heart failure (HF) as well as chronic kidney disease (CKD). Among the commercially available anti-hyperglycemic agents, incretin-based medications appear to be safe and effective in the treatment of type 2 diabetes mellitus (T2DM) and associated ca...
Source: Current Diabetes Reviews - August 10, 2023 Category: Endocrinology Authors: Sanket Seksaria Bhaskar Jyoti Dutta Mandeep Kaur Ghanshyam Das Gupta Surendra H Bodakhe Amrita Singh Source Type: research
Mets-IR as a predictor of cardiovascular events in the middle-aged and elderly population and mediator role of blood lipids
Conclusionets-IR is associated with an increased risk of cardiovascular disease/stroke/cardiac issues, with LDL-C mediating these relationships. Improving insulin sensitivity and lipid regulation may be essential and effective preventive measures for cardiovascular events.
Source: Frontiers in Endocrinology - July 17, 2023 Category: Endocrinology Source Type: research
CRP, C-Peptide, and Risk of First-Time Cardiovascular Events and Mortality in Early Type 2 Diabetes: A Danish Cohort Study
CONCLUSIONSThe finding of high hs-CRP as a stronger prognostic biomarker of all-cause mortality than of CVEs may facilitate improved early detection and prevention of deadly diseases besides CVEs. Conversely, elevated C-peptide as a strong CVE biomarker supports the need to target hyperinsulinemia/insulin resistance in T2D CVE prevention.
Source: Diabetes Care - March 17, 2023 Category: Endocrinology Source Type: research
The impact of the metabolic score for insulin resistance on cardiovascular disease: a 10-year follow-up cohort study
ConclusionThe elevated METS-IR was independently associated with incident CVD, suggesting that the METS-IR might be a valuable indicator for risk stratification and early intervention of CVD.
Source: Journal of Endocrinological Investigation - March 1, 2023 Category: Endocrinology Source Type: research
Insulin-like Growth Factor 1 and Risk of Cardiovascular Disease: Results from the UK Biobank Cohort Study
CONCLUSION: This study indicates that both low and high levels of circulating IGF-1 are associated with increased risk of CVD in general population. These results highlight the importance of monitoring IGF-1 status on cardiovascular health.PMID:36810801 | DOI:10.1210/clinem/dgad105
Source: The Journal of Clinical Endocrinology and Metabolism - February 22, 2023 Category: Endocrinology Authors: Jiayang Lin Linjie Yang Junlin Huang Yating Liu Xuzhen Lei Ruxin Chen Bingyan Xu Chensihan Huang Weijuan Dou Xueyun Wei Deying Liu Peizhen Zhang Yan Huang Zhimin Ma Huijie Zhang Source Type: research
The impact of the metabolic score for insulin resistance on cardiovascular disease: a 10-year follow-up cohort study
ConclusionThe elevated METS-IR was independently associated with incident CVD, suggesting that the METS-IR might be a valuable indicator for risk stratification and early intervention of CVD.
Source: Journal of Endocrinological Investigation - February 17, 2023 Category: Endocrinology Source Type: research
New insights on the cardiovascular effects of IGF-1
DiscussionWe anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.
Source: Frontiers in Endocrinology - February 9, 2023 Category: Endocrinology Source Type: research
Cardiovascular complications in insulin resistance and endocrine diseases
Endocr J. 2023 Feb 8. doi: 10.1507/endocrj.EJ22-0457. Online ahead of print.ABSTRACTCerebrovascular diseases, such as stroke and cardiovascular disease, are one of the leading causes of death in Japan. Type 2 diabetes is the most common form of diabetes and an important risk factor for these diseases. Among various pathological conditions associated with type 2 diabetes, insulin resistance has already been reported to be an important risk factor for diabetic complications. The major sites of insulin action in glucose metabolism in the body include the liver, skeletal muscle, and adipose tissue. However, insulin signaling m...
Source: Endocrine Journal - February 8, 2023 Category: Endocrinology Authors: Kyoichiro Tsuchiya Source Type: research
