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Early versus late injections of Botulinumtoxin type A in post-stroke spastic movement disorder: A literature review
Toxicon. 2023 May 3:107150. doi: 10.1016/j.toxicon.2023.107150. Online ahead of print.ABSTRACTPost-stroke spastic movement disorder (PS-SMD) is one of the main causes of severe disability in the chronic phase after stroke. The prevalence of SMD rises up with time after stroke to more than 28% in the chronic phase, and its secondary complications such as contracture, abnormal postures and/or movement patterns, spasticity-associated pain, also increases with time after stroke when physical and medical management of PS-SMD had been delayed in the early stroke phase. It has been published by several controlled studies that the...
Source: Toxicon - May 5, 2023 Category: Toxicology Authors: J örg Wissel Songjin Ri Anatol Kivi Source Type: research

Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study
This study aims to clarify the role of BoNT-A in the context of non-stroke spasticity (NSS). We enrolled 86 patients affected by multiple sclerosis, spinal cord injury, and traumatic brain injury with clinical indication to perform BoNT-A treatment. Subjects were evaluated before injection and after 1, 3, and 6 months. At every visit, spasticity severity using the modified Ashworth scale, pain using the numeric rating scale, QoL using the Euro Qol Group EQ-5D-5L, and the perceived treatment effect using the Global Assessment of Efficacy scale were recorded. In our population BoNT-A demonstrated to have a significant effect...
Source: Frontiers in Neurology - April 6, 2023 Category: Neurology Source Type: research

Safety and efficacy of MT10107 in post-stroke upper limb spasticity treatment: A phase I randomized controlled trial
Conclusion: The safety and efficacy of MT10107 showed no significant difference compared to onabotulinumtoxinA in post-stroke upper limb spasticity treatment.
Source: Medicine - November 4, 2022 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Pain and muscles properties modifications after botulinum toxin type A (BTX-A) and radial Extracorporeal Shock Wave (rESWT) combined treatment.
CONCLUSIONS: Radial Extracorporeal Shock Wave Therapy could be an effective physical treatment aimed at the reduction of upper and lower limbs spasticity and could lead to the improvement of trophic conditions of the spastic muscles in post-stroke. PMID: 30843498 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 8, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Teamwork and toughness: Living with cerebral palsy
Growing up in Querétaro, Mexico, María was an exceptionally bright and inquisitive child. At just 18 months old, she spoke at the level of a 6-year-old, and could even sing the tongue-twisting “Supercalifragilisticexpialidocious” song. Her parents marveled at her intelligence at such a young age, but there was something in her development that seemed off. “At 1 year, she wasn’t crawling well and had difficulty standing,” her mother, María José, recalls. “She hadn’t learned to walk by 18 months, and she would crawl by pulling her two legs at the same time — like a little bunny.” Her parents knew that s...
Source: Thrive, Children's Hospital Boston - February 2, 2018 Category: Pediatrics Authors: Connor Ertz Tags: Our Patients’ Stories cerebral palsy Cerebral Palsy Center Child and Young Adult Hip Preservation Program Dr. Benjamin Shore Dr. Donna Nimec Source Type: news

A survey of the current practice of intramuscular Botulinum toxin injections for hemiplegic shoulder pain in the UK.
CONCLUSIONS: Current UK practice of Botulinum Toxin type A injections for hemiplegic shoulder pain associated with spasticity is highly variable. There are large gaps between current practice and available evidence with regards to muscle selection and doses used. A number of areas for further investigation have been identified to progress current understanding of this intervention. Implications for rehabilitation There are wide variations in practice for this complex intervention and clinicians should consider that their individual decision-making could be based on their own beliefs rather than available evidence. Pectoral...
Source: Disability and Rehabilitation - November 10, 2017 Category: Rehabilitation Authors: Holmes RJ, Connell LA Tags: Disabil Rehabil Source Type: research

Efficacy and safety of Botulinum Toxin type A for upper limb spasticity after stroke or traumatic brain injury: a systematic review with meta-analysis and trial sequential analysis.
CONCLUSIONS: As compared with placebo, Botulinum Toxin type A injections have beneficial effects with improved muscle tone and well-tolerated treatment for patients with upper limb spasticity post stroke or traumatic brain injury. PMID: 27834471 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - November 10, 2016 Category: Rehabilitation Authors: Dong Y, Wu T, Hu X, Wang T Tags: Eur J Phys Rehabil Med Source Type: research

Adhesive taping vs. daily manual muscle stretching and splinting after botulinum toxin type A injection for wrist and fingers spastic overactivity in stroke patients: a randomized controlled trial.
CONCLUSIONS: Adhesive taping of wrist and finger flexor muscles appeared to enhance the effect of botulinum toxin type A therapy more than daily manual muscle stretching combined with passive articular mobilization and palmar splint. PMID: 24917588 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - June 10, 2014 Category: Rehabilitation Authors: Santamato A, Micello MF, Panza F, Fortunato F, Picelli A, Smania N, Logroscino G, Fiore P, Ranieri M Tags: Clin Rehabil Source Type: research

Diagnosis and management of patients with Bell's palsy.
This article discusses potential causes of the condition and identifies the differences between Bell's palsy and stroke. In addition, appropriate strategies for the care of patients with the condition are suggested. Management includes antiviral medication, corticosteroid therapy, eye care, botulinum toxin type A injection, physiotherapy, surgery and acupuncture. Psychological and emotional care of these patients is also important because any facial disability caused by facial nerve paralysis can result in anxiety and stress. PMID: 24299386 [PubMed - in process]
Source: Nursing Standard - December 4, 2013 Category: Nursing Authors: Mooney T Tags: Nurs Stand Source Type: research

Treatment With Botulinum Toxin Improves Upper-Extremity Function Post Stroke: A Systematic Review and Meta-Analysis
Abstract: Objective: To examine whether treatment with botulinum toxin type A (BTX-A) is associated with improvements in activity capacity or performance associated with poststroke spasticity in the upper extremity.Data Sources: MEDLINE, EMBASE, Scopus, and ISI Web of Science databases were searched from 1985 to November 2011.Data Selection: Studies were included if (1) the study design was a randomized controlled trial comparing injection of BTX-A with placebo or a nonpharmacologic treatment condition; (2) at least 60% of the sample was composed of adult subjects recovering from either first or subsequent stroke; (3) sub...
Source: Archives of Physical Medicine and Rehabilitation - December 20, 2012 Category: Rehabilitation Authors: Norine Foley, Shelialah Pereira, Katherine Salter, Manuel Murie Fernandez, Mark Speechley, Keith Sequeira, Thomas Miller, Robert Teasell Tags: Review Articles (Meta-Analyses) Source Type: research