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Total 15 results found since Jan 2013.
Leukocyte Count Predicts Carotid Artery Stenosis in Men with Ischemic Stroke: Sub Study of the Preventive Antibiotics in Stroke Study (PASS)
Conclusions: We conclude that blood leukocyte count independently predicts ICAS in men after acute stroke, but not in women. Clinical Trial unique identifier: ISRCTN66140176.PMID:36555901 | PMC:PMC9784109 | DOI:10.3390/jcm11247286
Source: Atherosclerosis - December 23, 2022 Category: Cardiology Authors: Twan J van Velzen Jeffrey Stolp Willeke F Westendorp Yvo B W E M Roos Diederik van de Beek Paul J Nederkoorn Source Type: research
Chronic Unexpected Mild Stress Destroys Synaptic Plasticity of Neurons through a Glutamate Transporter, GLT-1, of Astrocytes in the Ischemic Stroke Rat.
Conclusion: Our study shows that CUMS destroys synaptic plasticity of regenerated neurons in the hippocampus through a glutamate transporter, GLT-1, of astrocytes in the ischemic stroke rats. This may indicate one potential pathogenesis of poststroke depression.
PMID: 31019528 [PubMed - in process]
Source: Neural Plasticity - April 27, 2019 Category: Neurology Authors: Yu D, Cheng Z, Ali AI, Wang J, Le K, Chibaatar E, Guo Y Tags: Neural Plast Source Type: research
Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1
1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom
Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research
Pre-Stroke Use of Beta-Blockers Does Not Lower Post-Stroke Infection Rate: An Exploratory Analysis of the Preventive Antibiotics in Stroke Study
This study is aimed at investigating the association between BB treatment at baseline and post-stroke infection in the Preventive Antibiotics in Stroke Study (PASS), a prospective clinical trial.Methods: We performed an exploratory analysis in PASS, 2,538 patients with acute phase of stroke (24 h after onset) were randomized to ceftriaxone (intravenous, 2 g per day for 4 days) in addition to stroke unit care, or standard stroke unit care without preventive antibiotic treatment. All clinical data, including use of BBs, was prospectively collected. Infection was diagnosed by the treating physician, and independently by an ex...
Source: Cerebrovascular Diseases - October 4, 2016 Category: Neurology Source Type: research
Preventive Ceftriaxone in Patients with Stroke Treated with Intravenous Thrombolysis: Post Hoc Analysis of the Preventive Antibiotics in Stroke Study
Conclusions: According to the post-hoc analysis of PASS, preventive ceftriaxone may improve the functional outcome in IVT-treated patients with acute stroke, despite a trend towards an increased rate of post-IVT-sICH.Cerebrovasc Dis 2016;42:361-369
Source: Cerebrovascular Diseases - June 24, 2016 Category: Neurology Source Type: research
Correspondence Parenteral antibiotics are not enough to prevent pneumonia in stroke
The Preventive Antibiotics in Stroke Study (PASS; April 18, p 1519)1 reported that parenteral ceftriaxone did not significantly reduce pneumonia. We would like to comment on these results.
Source: LANCET - August 14, 2015 Category: Journals (General) Authors: Luciano Silvestri, Hendrick K F van Saene, Marco Milanese, Silvia Ros, Durk F Zandstra Tags: Correspondence Source Type: research
Azithromycin is not associated with QT prolongation in hospitalized patients with community‐acquired pneumonia
ConclusionsAzithromycin treatment was not associated with QT prolongation in patients with severe CAP. Nonetheless, in a large majority of hospitalized CAP patients, QT prolongation and pathological QTc develop regardless of the antibiotic used, especially in patients with previous stroke or a higher pneumonia score. Copyright © 2015 John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - August 2, 2015 Category: Drugs & Pharmacology Authors: Lee Hilary Goldstein, Ahmad Gabin, Abdallah Fawaz, Nahum Adam Freedberg, Naama Schwartz, Mazen Elias, Walid Saliba Tags: Original Report Source Type: research
The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial
Publication date: Available online 20 January 2015 Source:The Lancet Author(s): Willeke F Westendorp , Jan-Dirk Vermeij , Elles Zock , Imke J Hooijenga , Nyika D Kruyt , Hans J L W Bosboom , Vincent I H Kwa , Martijn Weisfelt , Michel J M Remmers , Robert ten Houten , A H C M (Tobien) Schreuder , Sarah E Vermeer , Ewout J van Dijk , Diederik W J Dippel , Marcel G W Dijkgraaf , Lodewijk Spanjaard , Marinus Vermeulen , Tom van der Poll , Jan M Prins , Frederique H Vermeij , Yvo B W E M Roos , Ruud P Kleyweg , Henk Kerkhoff , Matthijs C Brouwer , Aeilko H Zwinderman , Diederik van de Beek , Paul J Nederkoorn Background In a...
Source: The Lancet - January 21, 2015 Category: Journals (General) Source Type: research
Otitis Media Leads to Brain Abscess Presenting as Stroke
By Mikhail Elfond, DO; Esi Quayson, MD; & Joseph V.M. Kelly, MD, MBA
A 65-year-old man presented to the ED via EMS with symptoms of stroke. The paramedics stated his right-sided weakness and speech difficulty started 40 minutes prior to presentation in the ED. En route to the hospital, paramedics observed four episodes of facial twitching.
Vitals signs were significant for a rectal temperature of 100.2°F and a fingerstick blood sugar of 220 mg/dL. History of present illness was significant for a diagnosis of left otitis media treated with Augmentin and Vicodin at an urgent care center one day prior to prese...
Source: The Case Files - January 20, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Articles The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial
Preventive ceftriaxone does not improve functional outcome at 3 months in adults with acute stroke. The results of our trial do not support the use of preventive antibiotics in adults with acute stroke.
Source: LANCET - January 20, 2015 Category: Journals (General) Authors: Willeke F Westendorp, Jan-Dirk Vermeij, Elles Zock, Imke J Hooijenga, Nyika D Kruyt, Hans J L W Bosboom, Vincent I H Kwa, Martijn Weisfelt, Michel J M Remmers, Robert ten Houten, A H C M (Tobien) Schreuder, Sarah E Vermeer, Ewout J van Dijk, Diederik W J Tags: Articles Source Type: research
Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial
This study is registered with ClinicalTrials.gov, number NCT00349622. Findings Stage 3 included 66 participants from stages 1 and 2 and 448 new participants. In total, 340 participants were randomly allocated to ceftriaxone and 173 to placebo. During stages 1 and 2, mean ALSFRS-R declined more slowly in participants who received 4 g ceftriaxone than in those on placebo (difference 0·51 units per month, 95% CI 0·02 to 1·00; p=0·0416), but in stage 3 functional decline between the treatment groups did not differ (0·09, −0·06 to 0·24; p=0·2370). No significant differences in survival between the groups were recorde...
Source: The Lancet Neurology - October 17, 2014 Category: Neurology Source Type: research
Update of the Preventive Antibiotics in Stroke Study (PASS): statistical analysis plan
Conclusions:
The data from PASS will establish whether preventive antibiotic therapy in acute stroke improves functional outcome by preventing infection and will be analyzed according to this pre-specified SAP.Trial registration: Current controlled trials; ISRCTN66140176. Date of registration: 6 April 2010.
Source: Trials - October 1, 2014 Category: Journals (General) Authors: Willeke WestendorpJan-Dirk VermeijDiederik DippelMarcel DijkgraafTom van der PollJan PrinsFrederique VermeijYvo RoosMatthijs BrouwerAeilko ZwindermanDiederik van de BeekPaul Nederkoorn Source Type: research
Update on the Preventive Antibiotics in Stroke Study (PASS): a randomised controlled phase 3 clinical trial
Conclusion:
The data from PASS will establish whether preventive antibiotic therapy in acute stroke improves functional outcome by preventing infection. In this update, we changed our primary outcome analysis from dichotomisation to ordinal regression analysis.Trial registration: Current controlled trials; ISRCTN66140176. Date of registration: 6 April 2010.
Source: Epidemiologic Perspectives and Innovations - April 21, 2014 Category: Epidemiology Authors: Willeke F WestendorpJan-Dirk VermeijNan van GelovenDiederik WJ DippelMarcel GW DijkgraafTom van der PollJan M PrinsLodewijk SpanjaardFrederique H VermeijPaul J NederkoornDiederik van de Beek Source Type: research
Autoimmune gabab antibody encephalitis associated with non-malignant lung lesion
GABAb receptor autoimmune encephalitis is a potentially treatable disorder characterised by seizures, memory deficits, increased anxiety and mood dysregulation. In some patients it is associated with small–cell lung cancer and with other autoantibodies. We are presenting a case of GABAb receptor autoimmune encephalitis which was associated with non–malignant lung lesion, likely inflammatory in nature.
A 62 year old woman presented with recent onset depression and tonic–clonic seizures. CT head showed patchy white matter changes particularly in the left frontal lobe. Initial treatment for suspected infecti...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Wysota, B., Teare, L., Karim, A., Jacob, S. Tags: Immunology (including allergy), Epilepsy and seizures, Infection (neurology), Stroke, Drugs: psychiatry, Memory disorders (psychiatry), Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics) Association of British Neurologists (AB Source Type: research
